LOCUS       NM_001100722            2510 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus leucine rich repeat and Ig domain containing 1
            (Lingo1), mRNA.
ACCESSION   NM_001100722 XM_001068291 XM_001070567 XM_001070615 XM_236268
VERSION     NM_001100722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Wu H, Ding L, Wang Y, Zou TB, Wang T, Fu W, Lin Y, Zhang X, Chen K,
            Lei Y, Zhong C and Luo C.
  TITLE     MiR-615 Regulates NSC Differentiation In Vitro and Contributes to
            Spinal Cord Injury Repair by Targeting LINGO-1
  JOURNAL   Mol Neurobiol 57 (7), 3057-3074 (2020)
   PUBMED   32462552
  REMARK    GeneRIF: MiR-615 Regulates NSC Differentiation In Vitro and
            Contributes to Spinal Cord Injury Repair by Targeting LINGO-1.
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Youssef AEH, Dief AE, El Azhary NM, Abdelmonsif DA and El-Fetiany
            OS.
  TITLE     LINGO-1 siRNA nanoparticles promote central remyelination in
            ethidium bromide-induced demyelination in rats
  JOURNAL   J Physiol Biochem 75 (1), 89-99 (2019)
   PUBMED   30759305
  REMARK    GeneRIF: LINGO-1 siRNA nanoparticles silencing promoted central
            remyelination in ethidium bromide-induced demyelination in rats.
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Song XJ, Han W, He R, Li TY, Xie LL, Cheng L, Chen HS and Jiang L.
  TITLE     Alterations of Hippocampal Myelin Sheath and Axon Sprouting by
            Status Convulsion and Regulating Lingo-1 Expression with RNA
            Interference in Immature and Adult Rats
  JOURNAL   Neurochem Res 43 (3), 721-735 (2018)
   PUBMED   29383653
  REMARK    GeneRIF: in both immature and adult brains, Lingo-1 signaling plays
            important roles in seizure-induced damage to myelin sheaths and
            axon growth
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Shao Z, Lee X, Huang G, Sheng G, Henderson CE, Louvard D, Sohn J,
            Pepinsky B and Mi S.
  TITLE     LINGO-1 Regulates Oligodendrocyte Differentiation through the
            Cytoplasmic Gelsolin Signaling Pathway
  JOURNAL   J Neurosci 37 (12), 3127-3137 (2017)
   PUBMED   28193690
  REMARK    GeneRIF: Myelin loss and subsequent axon degeneration contributes
            to a variety of neurological diseases, such as multiple sclerosis
            (MS).
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Meabon JS, de Laat R, Ieguchi K, Serbzhinsky D, Hudson MP, Huber
            BR, Wiley JC and Bothwell M.
  TITLE     Intracellular LINGO-1 negatively regulates Trk neurotrophin
            receptor signaling
  JOURNAL   Mol Cell Neurosci 70, 1-10 (2016)
   PUBMED   26546150
  REMARK    GeneRIF: We propose that LINGO-1 functions as a negative feedback
            regulator of signaling by cognate receptor tyrosine kinases
            including TrkA, TrkB and TrkC.
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   Fu QL, Li X, Yip HK, Shao Z, Wu W, Mi S and So KF.
  TITLE     Combined effect of brain-derived neurotrophic factor and LINGO-1
            fusion protein on long-term survival of retinal ganglion cells in
            chronic glaucoma
  JOURNAL   Neuroscience 162 (2), 375-382 (2009)
   PUBMED   19422885
REFERENCE   7  (bases 1 to 2510)
  AUTHORS   Zhao XH, Jin WL, Wu J, Mi S and Ju G.
  TITLE     Inactivation of glycogen synthase kinase-3beta and up-regulation of
            LINGO-1 are involved in LINGO-1 antagonist regulated survival of
            cerebellar granular neurons
  JOURNAL   Cell Mol Neurobiol 28 (5), 727-735 (2008)
   PUBMED   18183482
  REMARK    GeneRIF: Taken together, these results suggest a new mechanism of
            LINGO-1 antagonist regulated neuronal survival involving protein
            synthesis of LINGO-1 and inactivation of GSK-3 pathway.
REFERENCE   8  (bases 1 to 2510)
  AUTHORS   Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard
            H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S and Isacson O.
  TITLE     Inhibition of the leucine-rich repeat protein LINGO-1 enhances
            survival, structure, and function of dopaminergic neurons in
            Parkinson's disease models
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14430-14435 (2007)
   PUBMED   17726113
REFERENCE   9  (bases 1 to 2510)
  AUTHORS   Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu
            M, Miller RH, Chan JR and Mi S.
  TITLE     NGF regulates the expression of axonal LINGO-1 to inhibit
            oligodendrocyte differentiation and myelination
  JOURNAL   J Neurosci 27 (1), 220-225 (2007)
   PUBMED   17202489
REFERENCE   10 (bases 1 to 2510)
  AUTHORS   Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang
            J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z,
            Jung V, McCoy JM and Pepinsky RB.
  TITLE     LINGO-1 negatively regulates myelination by oligodendrocytes
  JOURNAL   Nat Neurosci 8 (6), 745-751 (2005)
   PUBMED   15895088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE108045.1, BF547075.1 and BC092632.1.
            
            On or before Nov 22, 2008 this sequence version replaced
            XM_001070615.1, XM_001070567.1, XM_236268.4, XM_001068291.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE108045.1, BF414924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132284, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               BE108045.1         1-467
            468-841             BF547075.1         8-381               c
            842-2510            BC092632.1         301-1969
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2510
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine rich repeat and Ig domain containing 1"
                     /db_xref="GeneID:315691"
                     /db_xref="RGD:1308668"
     exon            1..239
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="upstream in-frame stop codon"
     CDS             234..2096
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine rich repeat neuronal 6A; leucine-rich
                     repeat and immunoglobulin-like domain-containing nogo
                     receptor-interacting protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     precursor"
                     /protein_id="NP_001094192.1"
                     /db_xref="GeneID:315691"
                     /db_xref="RGD:1308668"
                     /translation="

MQVSERMLAGGMRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI"

     sig_peptide     234..356
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    354..458
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    444..>1346
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    450..521
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    522..593
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    594..665
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    666..809
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    810..881
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    882..1025
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1026..1097
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1098..1169
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1170..1241
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1242..1304
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1254..>1496
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    1500..1775
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Immunoglobulin I-set domain of the Leucine-rich
                     repeat and immunoglobin-like domain-containing protein 1
                     (Lingo-1); Region: IgI_Lingo-1; cd20969"
                     /db_xref="CDD:409561"
     misc_feature    1500..1511
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409561"
     misc_feature    1524..1538
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409561"
     misc_feature    1554..1583
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409561"
     misc_feature    1596..1613
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409561"
     misc_feature    1620..1628
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409561"
     misc_feature    1653..1664
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409561"
     misc_feature    1671..1694
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409561"
     misc_feature    1710..1736
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409561"
     misc_feature    1743..1775
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409561"
     exon            240..2484
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cggccgcggcctcagcctccgcccccgactcctgagctcctgccctagggccggctgggctcccgcccgcgtgggacagacagacggaaagccagccctgcgagggcgcgcggaccgggcggaggtgttgtaggaggagacggaggaggggggctgggctggggctggggccgcgccggcaagagagacatgcgattggtgaccaagccgagcggacggacagcgcgcccgagatgcaggtgagcgagaggatgctggcagggggtatgagaagcatgcccagccccctcctggcctgctggcagcccatcctcctgctggtcctgggctctgtgctgtcaggctccgccaccggctgcccgccccgctgcgagtgctcagcgcaggaccgagcagtgctctgtcaccgcaagcgctttgtggcggtgcccgagggcatccccaccgagactcgcctgctggacctgggcaaaaaccgcatcaagacactcaaccaggacgagtttgccagtttcccacacctggaggagctagaactcaatgagaacattgtgagcgctgtggagccgggcgccttcaacaacctcttcaacctgaggacgctggggcttcgcagcaaccgcctgaagctcatcccgctgggcgtcttcaccggcctcagcaacttgaccaagctggacatcagcgagaacaagatcgtcatcctgctagactacatgttccaagacctatacaacctcaagtcgctggaggtcggcgacaatgacctcgtctacatctcccatcgagccttcagcggcctcaacagcctggaacagctgacgctggagaaatgcaatctgacctccatccccactgaggcactctcccacctgcatggcctcatcgtcctgcggctacgacacctcaacatcaatgccatacgggactactccttcaagaggctgtaccgactcaaggtcttagagatctcccactggccctacctggacaccatgacccccaactgcctctacggcctcaacctgacatccctatctatcacgcactgcaacctgacagccgtgccctatctggcagtgcgccacctggtctatctccgtttcctcaatctttcctacaaccccatcggtacaatcgagggctccatgctgcatgagctgctgcggttgcaagagatccaactggtgggcgggcagctggccgtggtggagccctacgcctttcgtgggctcaattacctgcgtgtgctcaatgtttctggcaaccagctgaccaccctggaggagtcagccttccactcggtgggcaacctggagacgctcattctggactccaacccactggcctgtgactgccggctgctgtgggtgttccggcgccgctggcggctcaacttcaacaggcagcagcctacctgcgccacacctgagttcgtccagggcaaggagttcaaggacttccccgatgtgctcctacccaactacttcacctgccgccgggcccacatccgggaccgcaaggcacagcaggtgtttgtagatgagggccacacggtgcagttcgtatgccgggcagatggcgaccctccaccagctatcctttggctctcaccccgcaagcacttggtctcagccaagagcaatgggcggctcacagtcttccctgatggcacgctggaggtgcgctacgcccaggtacaggacaacggcacgtacctgtgcatcgcagccaatgcaggcggcaacgactccatgcccgcccacttgcatgtgcgcagctactcgcctgactggccccatcaacccaacaagaccttcgccttcatctccaaccagccaggcgagggagaggccaacagcacccgcgccactgtgcctttccccttcgacatcaagacgctcatcatcgccaccaccatgggcttcatctccttcctgggcgtggtcctattctgcctggtgctgctgtttctatggagccggggcaaaggcaacacaaagcacaacatcgaaattgaatatgtgccccggaaatcggacgcaggcatcagctcagctgatgcaccccgcaagttcaacatgaagatgatatgaggatggggcagggtgggggcgcagggaccccccacttccgggggaacactgggcagggaaggtgcctggctgctgcccactcacccccaggccttcccacctttccctgccctcctcacacactctcccctccccccacgcgcccccgctgccacgccagcctcgccctcaccgcctgccctccttctaccaggatttcagaaggccaggcctgaggaccccgcctacataggggccagagttgacagacgaatccaaagccgacgaaccacgcggcagagtcaataattcaattaaaaaaaaagttacaaacttcctctgtaacttgggtttcaataattaatggatttttatgaaaacttgaaataataaaaaaagaaaaaaactaaaaaaaaaaaaaaaaaaaaaaaaaaa

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