2024-05-04 22:20:43, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001100493 1217 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus N-acetylglucosamine-1-phosphate transferase subunit gamma (Gnptg), mRNA. ACCESSION NM_001100493 XM_001059345 XM_213240 VERSION NM_001100493.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1217) AUTHORS Encarnacao M, Kollmann K, Trusch M, Braulke T and Pohl S. TITLE Post-translational modifications of the gamma-subunit affect intracellular trafficking and complex assembly of GlcNAc-1-phosphotransferase JOURNAL J Biol Chem 286 (7), 5311-5318 (2011) PUBMED 21173149 REFERENCE 2 (bases 1 to 1217) AUTHORS Qian Y, Lee I, Lee WS, Qian M, Kudo M, Canfield WM, Lobel P and Kornfeld S. TITLE Functions of the alpha, beta, and gamma subunits of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase JOURNAL J Biol Chem 285 (5), 3360-3370 (2010) PUBMED 19955174 REFERENCE 3 (bases 1 to 1217) AUTHORS Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and Yates JR. TITLE Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT) JOURNAL J Proteome Res 8 (3), 1304-1314 (2009) PUBMED 19199708 REFERENCE 4 (bases 1 to 1217) AUTHORS Raas-Rothschild A, Cormier-Daire V, Bao M, Genin E, Salomon R, Brewer K, Zeigler M, Mandel H, Toth S, Roe B, Munnich A and Canfield WM. TITLE Molecular basis of variant pseudo-hurler polydystrophy (mucolipidosis IIIC) JOURNAL J Clin Invest 105 (5), 673-681 (2000) PUBMED 10712439 REFERENCE 5 (bases 1 to 1217) AUTHORS Lukong KE, Elsliger MA, Mort JS, Potier M and Pshezhetsky AV. TITLE Identification of UDP-N-acetylglucosamine-phosphotransferase-binding sites on the lysosomal proteases, cathepsins A, B, and D JOURNAL Biochemistry 38 (1), 73-80 (1999) PUBMED 9890884 REFERENCE 6 (bases 1 to 1217) AUTHORS Madiyalakan,R., Chowdhary,M.S., Rana,S.S. and Matta,K.L. TITLE Lysosomal-enzyme targeting: the phosphorylation of synthetic D-mannosyl saccharides by UDP-N-acetyl-glucosamine:lysosomal-enzyme N-acetylglucosamine-phosphotransferase from rat-liver microsomes and fibroblasts JOURNAL Carbohydr Res 152, 183-194 (1986) PUBMED 3021329 REFERENCE 7 (bases 1 to 1217) AUTHORS Lang,L., Reitman,M., Tang,J., Roberts,R.M. and Kornfeld,S. TITLE Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes JOURNAL J Biol Chem 259 (23), 14663-14671 (1984) PUBMED 6094568 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC158818.1. On or before Jun 4, 2008 this sequence version replaced XM_213240.4, XM_001059345.1. ##Evidence-Data-START## Transcript exon combination :: BC158818.1, BC098716.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..1217 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="10" /map="10q12" gene 1..1217 /gene="Gnptg" /gene_synonym="Gnptag" /note="N-acetylglucosamine-1-phosphate transferase subunit gamma" /db_xref="GeneID:287134" /db_xref="RGD:1311614" exon 1..68 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" CDS 17..937 /gene="Gnptg" /gene_synonym="Gnptag" /note="N-acetylglucosamine-1-phosphotransferase, gamma subunit; N-acetylglucosamine-1-phosphate transferase, gamma subunit; N-acetylglucosamine-1-phosphotransferase subunit gamma" /codon_start=1 /product="N-acetylglucosamine-1-phosphotransferase subunit gamma precursor" /protein_id="NP_001093963.1" /db_xref="GeneID:287134" /db_xref="RGD:1311614" /translation="
MAGRLTGFLMLLGLAAQGPAPTHAGKMKVVEEPNTFGLNNPFLPQASRLQPKREPSAVSGPPHLFRLAGKCFSLVESTYKYEFCPFHNVTQHEQTFRWNAYSGILGIWHEWEIVNNTFKGMWMTDGDSCHSRSRQSKVELTCGKTNRLAHVSEPSTCVYALTFETPLVCHPHSLLVYPTLSEALQQRWDQVEQDLADELITPQGYEKLLRALFEDAGYLKVPGETHPTQLAGDSKGLGLETLDICRKAHAELSREVQRLTSLLEQHGIPHTQPTETTHSQLLGQQLPVGEISEQLRGDPGLRGNIL"
sig_peptide 17..88 /gene="Gnptg" /gene_synonym="Gnptag" /inference="COORDINATES: ab initio prediction:SignalP:4.0" misc_feature 221..403 /gene="Gnptg" /gene_synonym="Gnptag" /note="Glucosidase II beta subunit-like protein; Region: PRKCSH; pfam07915" /db_xref="CDD:400321" exon 69..126 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 127..194 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 195..249 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 250..333 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 334..427 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 428..542 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 543..625 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 626..757 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 758..839 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" exon 840..1176 /gene="Gnptg" /gene_synonym="Gnptag" /inference="alignment:Splign:2.1.0" ORIGIN
tgcgaccctgggagcgatggcggggcggctgactggcttcctgatgttgctggggctcgcggcgcaggggcctgcgccgacacatgccgggaagatgaaggtggtggaggagcccaacactttcgggctgaataacccgttcttgccccaggcaagccgacttcagcccaagagagagccttcggctgtatctgggcccccgcatctcttcagactcgctggcaagtgcttcagcctagtggagtccacgtacaagtatgaattctgccctttccacaacgtgacccagcatgagcagaccttccgttggaacgcctacagcgggatccttggcatctggcatgagtgggagatcgtcaacaacaccttcaagggcatgtggatgactgatggggactcctgtcactcccggagccggcagagcaaggtggagctcacctgtggaaagaccaaccgactggcccacgtgtctgaaccaagcacctgcgtctatgcattgacatttgagacccctcttgtctgccatccccactctctgttagtgtatccaaccctgtcagaggccctgcagcagcgctgggaccaggtggaacaggacctggcggacgagctgatcacaccgcagggctatgagaagttgctgagggcactttttgaggatgctggctacttaaaggtcccaggagaaacccaccccacccagctggcaggagattccaagggcctggggcttgagactctggacatttgcagaaaggcacacgcagagctgtcacgggaggtacaaagactgacaagtctgctcgaacagcatggaatcccacacactcagcccacagaaaccacccactctcagctcctgggtcagcagctcccggtaggtgaaatctcagagcagttgcggggcgacccaggactacgagggaacatcctgtgagccaggcggccatgaagaacagaaatgttctgagccttgagtgtcttttcagagagaggccaagtgtggtctcagcagagtgcaccaaactggtgtggtgtggacatggcttcttttggcatcttctaggccagacaatatcactgacaagagggacctgctggccagcctttgttgtgcccaaagatccagacaaaataaagattcgaagttttaattaattccatactcataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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