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2024-03-28 18:31:31, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_001042354            4005 bp    mRNA    linear   ROD 22-JAN-2023
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            beta (Camk2b), transcript variant 1, mRNA.
ACCESSION   NM_001042354
VERSION     NM_001042354.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4005)
  AUTHORS   Yang C, Zhang M, Li S, Yi F, Huang H, Xie H, Liu H, Huang R and
            Zhou J.
  TITLE     Effects of Camk2b Overexpression and Underexpression on the
            Proteome of Rat Hippocampal Neurons
  JOURNAL   Neuroscience 503, 58-68 (2022)
   PUBMED   36041587
  REMARK    GeneRIF: Effects of Camk2b Overexpression and Underexpression on
            the Proteome of Rat Hippocampal Neurons.
REFERENCE   2  (bases 1 to 4005)
  AUTHORS   Liu W, Li L, Kuang H, Xia Y, Wang Z, Liu S and Yin D.
  TITLE     Proteomic Profile of Carbonylated Proteins Screen Regulation of
            Apoptosis via CaMK Signaling in Response to Regular Aerobic
            Exercise
  JOURNAL   Biomed Res Int 2018, 2828143 (2018)
   PUBMED   30662904
  REMARK    GeneRIF: Significantly upregulated the expression levels of
            CaMKIIbeta.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4005)
  AUTHORS   Yamazaki H, Sasagawa Y, Yamamoto H, Bito H and Shirao T.
  TITLE     CaMKIIbeta is localized in dendritic spines as both
            drebrin-dependent and drebrin-independent pools
  JOURNAL   J Neurochem 146 (2), 145-159 (2018)
   PUBMED   29675826
  REMARK    GeneRIF: This study provides the first evidence to show that
            CaMKIIbeta interacts with drebrin in dendritic spines.
REFERENCE   4  (bases 1 to 4005)
  AUTHORS   Kury S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X,
            Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF,
            Pujol A, Distel B, Robak LA, Bernstein JA, Denomme-Pichon AS, Lesca
            G, Sellars EA, Berg J, Carre W, Busk OL, van Bon BWM, Waugh JL,
            Deardorff M, Hoganson GE, Bosanko KB, Johnson DS, Dabir T, Holla
            OL, Sarkar A, Tveten K, de Bellescize J, Braathen GJ, Terhal PA,
            Grange DK, van Haeringen A, Lam C, Mirzaa G, Burton J, Bhoj EJ,
            Douglas J, Santani AB, Nesbitt AI, Helbig KL, Andrews MV, Begtrup
            A, Tang S, van Gassen KLI, Juusola J, Foss K, Enns GM, Moog U,
            Hinderhofer K, Paramasivam N, Lincoln S, Kusako BH, Lindenbaum P,
            Charpentier E, Nowak CB, Cherot E, Simonet T, Ruivenkamp CAL, Hahn
            S, Brownstein CA, Xia F, Schmitt S, Deb W, Bonneau D, Nizon M,
            Quinquis D, Chelly J, Rudolf G, Sanlaville D, Parent P,
            Gilbert-Dussardier B, Toutain A, Sutton VR, Thies J, Peart-Vissers
            LELM, Boisseau P, Vincent M, Grabrucker AM, Dubourg C, Tan WH,
            Verbeek NE, Granzow M, Santen GWE, Shendure J, Isidor B, Pasquier
            L, Redon R, Yang Y, State MW, Kleefstra T, Cogne B, Petrovski S,
            Retterer K, Eichler EE, Rosenfeld JA, Agrawal PB, Bezieau S, Odent
            S, Elgersma Y and Mercier S.
  CONSRTM   Undiagnosed Diseases Network; GEM HUGO; Deciphering Developmental
            Disorders Study
  TITLE     De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause
            Intellectual Disability
  JOURNAL   Am J Hum Genet 101 (5), 768-788 (2017)
   PUBMED   29100089
REFERENCE   5  (bases 1 to 4005)
  AUTHORS   Yan X, Liu J, Ye Z, Huang J, He F, Xiao W, Hu X and Luo Z.
  TITLE     CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced
            BDNF mRNA Transcription and Neurite Outgrowth Promoted by
            Electrical Stimulation
  JOURNAL   PLoS One 11 (9), e0162784 (2016)
   PUBMED   27611779
  REMARK    GeneRIF: these data establish a potential signaling pathway of
            Ca2+-CaMKII-CREB in neuronal activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4005)
  AUTHORS   Bayer KU, Harbers K and Schulman H.
  TITLE     alphaKAP is an anchoring protein for a novel CaM kinase II isoform
            in skeletal muscle
  JOURNAL   EMBO J 17 (19), 5598-5605 (1998)
   PUBMED   9755160
REFERENCE   7  (bases 1 to 4005)
  AUTHORS   Urquidi V and Ashcroft SJ.
  TITLE     A novel pancreatic beta-cell isoform of
            calcium/calmodulin-dependent protein kinase II (beta 3 isoform)
            contains a proline-rich tandem repeat in the association domain
  JOURNAL   FEBS Lett 358 (1), 23-26 (1995)
   PUBMED   7821422
REFERENCE   8  (bases 1 to 4005)
  AUTHORS   Ochiishi T, Terashima T and Yamauchi T.
  TITLE     Specific distribution of Ca2+/calmodulin-dependent protein kinase
            II alpha and beta isoforms in some structures of the rat forebrain
  JOURNAL   Brain Res 659 (1-2), 179-193 (1994)
   PUBMED   7820660
REFERENCE   9  (bases 1 to 4005)
  AUTHORS   Malinow R, Schulman H and Tsien RW.
  TITLE     Inhibition of postsynaptic PKC or CaMKII blocks induction but not
            expression of LTP
  JOURNAL   Science 245 (4920), 862-866 (1989)
   PUBMED   2549638
REFERENCE   10 (bases 1 to 4005)
  AUTHORS   Bennett,M.K. and Kennedy,M.B.
  TITLE     Deduced primary structure of the beta subunit of brain type II
            Ca2+/calmodulin-dependent protein kinase determined by molecular
            cloning
  JOURNAL   Proc Natl Acad Sci U S A 84 (7), 1794-1798 (1987)
   PUBMED   3470758
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB616255.1, X83375.1, CO395982.1, CO406099.1 and JACYVU010000254.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X83375.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CB616255.1         1-38
            39-1787             X83375.1           1-1749
            1788-2430           CO395982.1         20-662
            2431-2561           CO406099.1         349-479
            2562-4005           JACYVU010000254.1  34546551-34547994   c
FEATURES             Location/Qualifiers
     source          1..4005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4005
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="calcium/calmodulin-dependent protein kinase II
                     beta"
                     /db_xref="GeneID:24245"
                     /db_xref="RGD:2262"
     exon            1..147
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1852
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /EC_number="2.7.11.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium/calmodulin-dependent protein kinase type II beta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit beta; caMK-II subunit beta; caM-kinase II beta
                     chain; caM kinase II subunit beta;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II beta; Ca++/calmodulin-dependent protein kinase II beta
                     subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit beta isoform 1"
                     /protein_id="NP_001035813.1"
                     /db_xref="GeneID:24245"
                     /db_xref="RGD:2262"
                     /translation="
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSAAKSLLNKKADGVKPQTNSTKNSSAITSPKGSLPPAALESSDSTNTTIEDEDAKAPRISDILNSVRRGCGTPEAEGPLSVGPPPCLSPGLLGPLPTPSPRISDILNSVRRGSGTPEAEGLPPVGPPPCPSPTLPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ"
     misc_feature    116..991
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(140..154,164..166,203..205,209..211,302..304,
                     350..361,371..373,377..379,485..490,494..496,500..505,
                     509..511,548..553,560..562,605..619,623..625)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(140..151,164..166,203..205,209..211,302..304,
                     350..361,371..373,500..505,509..511,548..553)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(152..154,371..373,377..379,485..490,494..496,
                     500..502,560..562,605..619,623..625)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(548..580,587..619)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(962..964,968..991)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1451..1834
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            148..242
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            243..302
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            303..357
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            358..423
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            424..496
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            497..599
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            600..683
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            684..778
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            779..901
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            902..985
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1028
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1069
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1141
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1190
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1319
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1448
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1524
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1619
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1853
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..4005
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
cgccgccgtgcccgcgagcgggagccggagtcgccgccgcccgagcgcagccgagcgcacgccgagcccaatcgccaccgccatggccaccacggtgacctgcacccgtttcacggacgagtaccagctatacgaggatattggcaagggggctttctctgtggtccgacgctgtgtcaagctctgcaccggccatgagtatgcagctaagatcattaacaccaagaagctgtcagctagagatcaccagaagctggagagggaggctcggatctgccgcctgctgaagcattccaacattgtacgcctccatgacagcatctctgaagagggcttccactacctggtcttcgacctggtcactggtggggagctctttgaagacattgtggcgagagagtactacagtgaggctgacgccagtcactgtatccagcagatcctggaggctgttctccattgtcaccaaatgggggtcgtccacagagacctcaagcctgaaaacctgctcctggccagcaaatgcaaaggggccgcagtgaaactggcagacttcggcctggccatcgaggttcagggagaccagcaggcatggtttggatttgcgggaacaccaggctacctgtctcccgaagttcttcggaaggaggcctatggcaaaccagtggatatctgggcatgtggggtgatcctgtatatcctgctggtgggatacccacctttctgggatgaggaccagcacaagctgtaccagcagatcaaggctggggcctatgacttcccatcccccgagtgggacaccgttacccctgaagccaaaaacctcatcaaccagatgttgaccatcaaccccgccaagcgcatcacggcccacgaggccctgaagcacccatgggtctgccaacgatccacggtggcctccatgatgcacagacaggagactgtggaatgtctgaagaagttcaatgcaaggaggaagctcaagggagccatcctcaccactatgctggccacacggaatttctcagcagccaagagtttactcaacaagaaagcagacggagtcaagccccagacaaacagcaccaaaaacagctcggccatcaccagccccaaaggatccctccctcctgccgccctggaatcttccgacagcaccaacacaaccatagaggacgaagatgccaaagcccccaggatctctgacatcctgaactcagtgagaaggggctgtggaaccccagaagccgagggacccctatcagtggggcccccgccctgcttgtctccgggtctcctaggccccctgcccaccccgtcccccaggatctctgacatcctcaactcagtgaggcggggctcagggaccccagaagctgagggcctcccaccagtgggccccccaccctgcccatctccgactctccctggccccttgcccaccccatcccggaagcaggaaatcatcaagaccacagagcagctcatcgaggccgtcaacaacggcgactttgaggcctatgcgaaaatctgtgacccaggcctgacctcatttgagcctgaagctctgggcaacctggtcgaagggatggatttccacagattctactttgagaacctgctggccaagaacagcaagccgatccacaccactatcctgaacccgcacgtgcacgtcatcggcgaggatgcagcctgcatcgcttacatccgcctcacacagtacatcgacggccagggcagaccccgcaccagccagtccgaagagacccgtgtgtggcaccgccgcgacggcaagtggcagaatgtccatttccactgctcgggcgctccagtggccccactgcagtgagagctgcgcctggtttcaccggacagagttggtgtttggagcccagccgccctcgggcgcacggcctgcctgtcgcatgtttgtgtctgcctcgtcccctcccctggtgcctgtgtctgcagaaaaacaagaccagatgtgatttgtttttttaaaaaaaaaaaaaaagtaagatgatgacaacgacaaccacatgcaaacaaacaaacaaaaaatattggcatcggatgaaatggaaaacaaacaaacaaacctaaagaaaggaaaaagctgtaaaaatctggcatttgtggggccgcccccccacccaagctccacatgtgtctgttgcgctcctggctttggggaccctcagggcgtgaatgtgcccatgccgactgtgttagtctgtaggtaccgcactcaccccacaccttgggcgtctgcatcctcctcccatgcatgggccccacgtgctaacctggctgttgtggcgtcaggtgtcttgggaagggctgggggctgcctcctttcctgctagttgtgcctgaaagctgctgctgttcctgcttcccctacccgtccctcatcccgagaaggactgggagggtgctcctctagccaaggacctacctttgccccatggagtgtgtaggagaagctcgtcctcaagatcatcagaaagtaacctggttctttggggagtgaggtatggaggtatgtatctcgcctccaagcctctcgcctggcagggattggttaggaaggcaggctggctgcagcacccacccatctagctacgaagagaggactgggcagggatggactccttcctgtttggggttcttgtcccttccctgccaccagcagctgagcgagagtggcccacccctggcccgggcagttcctctctgaagttggcaacagaccctcacgaagacggagttgccgagatactggacagagctgggagcagacgctggctgcatctagggggtttgtccactgagcttgaagtctgggtgctcgagacttggttaaatgttgcagaatgtgataaagaggggccagaagtcgggttttagactgctgggcaatgcaggtccatgtgagggtttgatggtaggagtgctttcctaacctgagcctagagaagaaataagccagaggatgtgcctcctcagaggcacatggaaggccaaaattggttaggtagggctgtattgtgtgaggcctttccaggtaggccagagatacgtagtagagagaaggcaggctgggggcagagatatatgggtgtggggcctggataccagtgggtggagggagggtccattaggacagtgtgccacccccagggcccagtggtgctcctaggtgccggctgcctggactcgtgggtggcccttggtgacagagggaatcatcaaggctggacatgttacaaagtcaggctagggagataggtataaagccgggttgggtgggggtggtcaggggctttgatcgcagaggtccgtgggcctccaccccaatgctgcccactttaaattcacgtcattttcaaccaggattttctttatcttttactacaaatcaagccaagggaggggcacgaagtggggaacgggacacaggatcctaaactccaaggggactgtccacctacagacactcagtggataccacctttgatccacactgtgcccaggacagctgccccctacccatggacacagggtaaacatctgccaggctccatgagtggcccaaggccatggaatagaggcagggcttgtcacagacagcgtgaggccctgtggcctgccaccctgacatcctggggtctcctttcctctcccacccaccttgttatctccacaaagctgcctgtctgggataatttggggattttttttctgggggacaattcttttgcatgaccctctaaagagcaggacacgtctgctctactggctaggtgttcgcaggtggtggcgtcgactgtggccagtgctggagcgtgtcactgcctgcagtactggtgaccctcctctcttctctttttgctgagttccattgtcttttctttccgagccttgtaggtgtacaaaacttattcttattttgttctgtctcgggaaactgcaaataaaaaaaaaaaaaaaaaaaaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]