LOCUS       NM_001033970            4187 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Rattus norvegicus phosphatidylinositol-4-phosphate 5-kinase type 1
            gamma (Pip5k1c), transcript variant b, mRNA.
ACCESSION   NM_001033970
VERSION     NM_001033970.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4187)
  AUTHORS   Tan X, Sun Y, Thapa N, Liao Y, Hedman AC and Anderson RA.
  TITLE     LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling,
            lysosomal sorting, and degradation
  JOURNAL   EMBO J 34 (4), 475-490 (2015)
   PUBMED   25588945
REFERENCE   2  (bases 1 to 4187)
  AUTHORS   Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI,
            Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK,
            McEver RP, Weisel JW, Hartwig JH and Abrams CS.
  TITLE     Platelets lacking PIP5KIgamma have normal integrin activation but
            impaired cytoskeletal-membrane integrity and adhesion
  JOURNAL   Blood 121 (14), 2743-2752 (2013)
   PUBMED   23372168
REFERENCE   3  (bases 1 to 4187)
  AUTHORS   Saheki Y and De Camilli P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4187)
  AUTHORS   Unoki T, Matsuda S, Kakegawa W, Van NT, Kohda K, Suzuki A,
            Funakoshi Y, Hasegawa H, Yuzaki M and Kanaho Y.
  TITLE     NMDA receptor-mediated PIP5K activation to produce PI(4,5)P is
            essential for AMPA receptor endocytosis during LTD
  JOURNAL   Neuron 73 (1), 135-148 (2012)
   PUBMED   22243752
REFERENCE   5  (bases 1 to 4187)
  AUTHORS   Volpicelli-Daley LA, Lucast L, Gong LW, Liu L, Sasaki J, Sasaki T,
            Abrams CS, Kanaho Y and De Camilli P.
  TITLE     Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol
            4,5-bisphosphate synthesis in the brain
  JOURNAL   J Biol Chem 285 (37), 28708-28714 (2010)
   PUBMED   20622009
REFERENCE   6  (bases 1 to 4187)
  AUTHORS   Di Paolo G, Moskowitz HS, Gipson K, Wenk MR, Voronov S, Obayashi M,
            Flavell R, Fitzsimonds RM, Ryan TA and De Camilli P.
  TITLE     Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces
            defects in synaptic vesicle trafficking
  JOURNAL   Nature 431 (7007), 415-422 (2004)
   PUBMED   15386003
REFERENCE   7  (bases 1 to 4187)
  AUTHORS   Giudici ML, Emson PC and Irvine RF.
  TITLE     A novel neuronal-specific splice variant of Type I
            phosphatidylinositol 4-phosphate 5-kinase isoform gamma
  JOURNAL   Biochem J 379 (Pt 2), 489-496 (2004)
   PUBMED   14741049
REFERENCE   8  (bases 1 to 4187)
  AUTHORS   Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K and Haucke V.
  TITLE     ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by
            activating phosphatidylinositol phosphate kinase type Igamma
  JOURNAL   J Cell Biol 162 (1), 113-124 (2003)
   PUBMED   12847086
REFERENCE   9  (bases 1 to 4187)
  AUTHORS   Wenk MR, Pellegrini L, Klenchin VA, Di Paolo G, Chang S, Daniell L,
            Arioka M, Martin TF and De Camilli P.
  TITLE     PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at
            the synapse
  JOURNAL   Neuron 32 (1), 79-88 (2001)
   PUBMED   11604140
REFERENCE   10 (bases 1 to 4187)
  AUTHORS   Ishihara H, Shibasaki Y, Kizuki N, Wada T, Yazaki Y, Asano T and
            Oka Y.
  TITLE     Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the
            third isoform and deletion/substitution analysis of members of this
            novel lipid kinase family
  JOURNAL   J Biol Chem 273 (15), 8741-8748 (1998)
   PUBMED   9535851
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CB557931.1,
            BC101909.1, CK366332.1, AY850259.1 and CB696331.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101909.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CB557931.1         12-39
            29-507              BC101909.1         1-479
            508-630             CK366332.1         497-619
            631-714             BC101909.1         603-686
            715-716             CK366332.1         705-706
            717-1881            BC101909.1         689-1853
            1882-1969           AY850259.1         1821-1908
            1970-2244           BC101909.1         1942-2216
            2245-2405           CB696331.1         265-425
            2406-4187           BC101909.1         2378-4159
FEATURES             Location/Qualifiers
     source          1..4187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..4187
                     /gene="Pip5k1c"
                     /note="phosphatidylinositol-4-phosphate 5-kinase type 1
                     gamma"
                     /db_xref="GeneID:314641"
                     /db_xref="RGD:1309938"
     exon            1..155
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1972
                     /gene="Pip5k1c"
                     /EC_number="2.7.1.68"
                     /note="isoform b is encoded by transcript variant b;
                     PIP5KIgamma; ptdInsPKIgamma; ptdIns(4)P-5-kinase gamma;
                     PIP5K1-gamma; ptdIns(4)P-5-kinase 1 gamma;
                     phosphatidylinositol 4-phosphate 5-kinase type I gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 5-kinase type-1
                     gamma isoform b"
                     /protein_id="NP_001029142.1"
                     /db_xref="GeneID:314641"
                     /db_xref="RGD:1309938"
                     /translation="

MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEELHAEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQASDEEDAPSTDIYF"

     misc_feature    203..274
                     /gene="Pip5k1c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5I6B8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    287..1408
                     /gene="Pip5k1c"
                     /note="Phosphatidylinositol phosphate kinase (PIPK)
                     catalytic domain found in phosphatidylinositol 4-phosphate
                     5-kinase type-1 gamma (PIP5K1gamma) and similar proteins;
                     Region: PIPKc_PIP5K1C; cd17308"
                     /db_xref="CDD:340445"
     misc_feature    order(359..376,380..382,488..490,668..670,677..682,
                     692..697,971..973,980..982,992..994)
                     /gene="Pip5k1c"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:340445"
     misc_feature    order(569..580,584..586,590..592,617..619,623..625,
                     773..784,818..820,881..883,1019..1021,1250..1255)
                     /gene="Pip5k1c"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:340445"
     misc_feature    854..856
                     /gene="Pip5k1c"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O60331; propagated from
                     UniProtKB/Swiss-Prot (Q5I6B8.1); acetylation site"
     misc_feature    863..865
                     /gene="Pip5k1c"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O60331; propagated from
                     UniProtKB/Swiss-Prot (Q5I6B8.1); acetylation site"
     misc_feature    1436..1438
                     /gene="Pip5k1c"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:O70161;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:O70161; propagated from
                     UniProtKB/Swiss-Prot (Q5I6B8.1); methylation site"
     misc_feature    1634..1756
                     /gene="Pip5k1c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5I6B8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1721..1723
                     /gene="Pip5k1c"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5I6B8.1); phosphorylation site"
     misc_feature    1835..1948
                     /gene="Pip5k1c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5I6B8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1964..1966
                     /gene="Pip5k1c"
                     /note="Phosphotyrosine, by EGFR.
                     /evidence=ECO:0000250|UniProtKB:O70161; propagated from
                     UniProtKB/Swiss-Prot (Q5I6B8.1); phosphorylation site"
     exon            156..187
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            188..280
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            281..411
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            412..529
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            530..682
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            683..982
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1188
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1272
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1321
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1406
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1568
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1707
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1740
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1842
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1969
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..4177
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gccgagctcgggtgcatcctcgggcccgccgccgccgccgctgccgccggagcgcgcggccatggagctagaggtgccggacgaggcagagagcgccgaagcaggggccgtgacagcggaggcggcctggtctgcggagagtggggcggcggcaggtatgacccagaagaaggctatccttgcagaggccccgttggtgacagggcagccaggccctggccatgggaagaagctgggccatcgaggcgtggatgcgtctggagagactacgtataagaagaccacctcgtccaccctgaagggtgccatccaactggggattgggtacacggtgggcaacctcagctctaagccagaacgcgatgtgctcatgcaggacttctatgtggtggagagcatcttctttcccagcgaagggagcaaccttacccccgcccaccacttccaggatttccgtttcaagacctatgcacctgttgccttccgttacttccgggagctctttggtatccgtccggacgattacttgtactcactctgcaacgagccactcattgagctgtccaacccgggtgccagtggctccgtcttctacgtcaccagcgatgacgagttcatcattaagactgtcatgcacaaggaggcggagttcctgcagaaactgctgcctggctactatatgaacctcaaccagaacccccggaccttgctgcccaagttctatgggctgtactgtgtgcagtccggcggcaagaacattcgagtggtggtcatgaacaatgtgctgccccgtgtcgtcaagatgcacctcaagttcgacctcaagggctccacgtacaagcgcagggccagcaagaaggagaaggagaagagcctgcccacctacaaggacctggacttcatgcaggacatgccagaggggctgctactggactctgacacctttggcgccctggtcaagacgctgcagcgagactgcctggtgttggagagcttcaagataatggactacagcctgctgctgggtgtgcacaacattgaccagcaggagcgggagcgccaggccgagggcgcccagagcaaggctgacgagaagcggccggtggcccagaaggccctctactccacagccatggagtccattcagggcggagctgcccgtggggaggccattgagacagatgacacgatgggtgggatcccagccgtgaatgggcgtggggagcgcttgctcctacacatcggaatcattgacattctgcagtcctacaggttcatcaagaagttagaacacacctggaaggccctcgtccacgatggggataccgtctcagtccaccggcccagcttctatgccgagcgcttcttcaagttcatgagcagcacggtcttccggaagagttcctccctcaagtcctctccatctaagaaagggcgtggcgccctgctcgcagtcaagcccctggggcccaccgcagccttctcagctagccagatccccagtgagagagaggatgtgcagtacgacctgcggggggcccgcagctaccccacgctggaggatgaaggccggcctgacctcctgccctgcaccccaccgtcctttgaggaagccaccacagcctctatcgccaccaccctgtcatccacctccctctccatcccagagcggtccccttcagacacatcagagcagccccggtacaggcggcgtacgcagtcttcaggccaggatggccggccccaggaggagctgcatgcggaagacctgcagaagataactgtgcaggtggagccagtgtgtggtgtgggggttgtcgtccccaaggagcagggtgcaggagtggaggttcccccatctggggcatcggcagcagccacggtggaagtagacgctgccagccaggcctcagagcccgccagccaagcctctgatgaggaagatgcgccttccacagacatctatttttaacttctatgcagtccccaatctggagcccagcgtccttctgccaccccagccacttcctggaggcgctgccccccactggggctcagagctcagcgacatcaccccgatggccctggcccgaccttgttctctccctccccactgacggacgccattggccaggcccagccccaggataggtcaggcctccatctgctgctacctgtgcctgttggggcggcaagatttggagtgcacattctgtatttattttgggtccacccctcccccccctttttttggacggagagggagcacaggagtgtttttctaggaaaaagacaagacacaaaaaacccaggaagaggctgcagccaccagccttggtggatcaggttctatgtgtctcagtaccctggggacagtggccaggtagctccagtaaaccccacacactccagagctcgttatgactggcagaggagacaggccctggagccgcggcttgccgtcccgggtctgtgttcctgagttgggtcgcctcaacagagcccctccttcacctcaggtttgggacccaagcaaaccaggactagtcatgccctgtggtctttctgcatctgtttactgccactggaaggatgtccctacgcatgtcttgtggctacaatcacctgatgctgactgggaggttccatattgtctgcctctcatccccatgaaaccctgagctggtgctgtgggtcccctcaactcccagggaaatctctgcccccaagaagggcacagccaggcttcaggctgcagagtgagagtttggtccttaccttggttgaagagagtaagaaagggacatcacctcagcaaagccaaccatatctactgaccaccagggagatcgcagcaagcattctccgctgggcagaccccagtgtgttgggtgcagtccagctatgctatgcctctgtttcgtggatgttccacccacggtaggcggagtcaagcaggaatgttctgaaagcacgcagccacaggacacaacctttgggtcagcttcatgggcctcttgggttgcaccttcagggacaggggctatctggcttccaaggactgtagcagcctgtggaggcagtgtggagcatgacactgccatcgtggccagaaaaggcatggccagggagaggacccctggagggggagagtaggagagatgggcagatgcctgtccctggacctcacatcagcccccttcctgttgaggaatgcacagtgaacacaccgtggggagctgctgcatgagttaactaaggggttggggcttgcacacaccaggcaagcatgtcacacctgccatccctgaacttggaaagttaaggcaggagggttgtggcaagttccaggctcgcgtgggttagagtaaaacgagaccaaaaggaaaaaaaaaatcacagggctggccctaccactcagtgggcagaactcacccagctgcataaaccctgagttccattccagcaccacagaaaccagattgggaggcacacagctgccatccctcgcttgggaaacaggcagaaagagcaggagtgcaaggccatccttggctgtatccagttgaaggccagcctgggctacatgagactctctcaaaagagaatctgtaaatatcttcgtgaccccacctcccatcctgttctctatgatggccgctatcgccccaccgtggacggtgtgtgaactgtactgtaaaggcctgcctgggggcgcctccaaggctgaagaggtgccctccccggcccgcctctgttctcctcaagccatcccagcaagtcccctgtccagccccacaccaacctcagtgcaatatgcccttcccgtggggtcccctggcacggtactgtctctgcagccccttgtctcttacccctagctcctctctcccagtggttaaaaatcacatcgcacatcctcccccacatcctgtttttattgttgaatccattctgtaaactacaaacctcctgtgtcttactcatcaggaatagggatcccgggtcctcagcccatgtgatctggtgtttgacaatccaagtacagtgtccccttggcaccaaccagtggggcctgtccctccagcgcagccggcaaatgtatgcagcccaggttcccgctccacctgtcacacccctctttttgagatctgtaataaatctctaataagaaacaaaaaaaaaaa

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