LOCUS       NM_001024365            2026 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Rattus norvegicus carboxylesterase-like 1 (Cesl1), mRNA.
ACCESSION   NM_001024365 XM_576653
VERSION     NM_001024365.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2026)
  AUTHORS   Yan B, Yang D, Brady M and Parkinson A.
  TITLE     Rat kidney carboxylesterase. Cloning, sequencing, cellular
            localization, and relationship to rat liver hydrolase
  JOURNAL   J Biol Chem 269 (47), 29688-29696 (1994)
   PUBMED   7961958
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079129.1.
            
            On May 27, 2005 this sequence version replaced XM_576653.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079129.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00155306, SAMD00155307
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2026
                     /gene="Cesl1"
                     /note="carboxylesterase-like 1"
                     /db_xref="GeneID:501232"
                     /db_xref="RGD:1565666"
     exon            1..82
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    65..67
                     /gene="Cesl1"
                     /note="upstream in-frame stop codon"
     exon            83..179
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1813
                     /gene="Cesl1"
                     /EC_number="3.1.1.1"
                     /note="liver carboxylesterase B-1; liver microsomal
                     carboxylesterase"
                     /codon_start=1
                     /product="liver carboxylesterase B-1 precursor"
                     /protein_id="NP_001019536.1"
                     /db_xref="GeneID:501232"
                     /db_xref="RGD:1565666"
                     /translation="

MCLRSLFLVSLATCVVCGNPSSPPVVDTMKGKVLGKYASLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDATKGQRMNDLLTNRKEKVHLQFSEDCLYLNIYTPADFTKDSRMPVMVWIHGGGLTQGGASTYDGQVLSAYENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLSKNLYHRAISESGVVLITELFTKDVRPAAKQIADMAGCKTTTSAIIVHCLRQKTEEELLEIMEKMNLIKLSSQRDTKESYHFLSTVIDDVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMRFVPPDVKLDKKMAIMLLEKFASIYGIPEDIIPVAIEKYRKGSDDPIKIRDGILAFIGDALFCIPSVMVSRDHRDAGAPTYVYEYQYYPSFSSPQRPKDVVGDHADDVYSVFGAPILRDGASEEEIKLSKMVMKFWANFARNGNPNGRGLPHWPQYDQKEEYLQIGATTQQSQGLKAEEVAFWTQLLAKRQPQPHHNEL"

     sig_peptide     128..181
                     /gene="Cesl1"
                     /note="/evidence=ECO:0000269|PubMed:8597091; propagated
                     from UniProtKB/Swiss-Prot (Q63010.1)"
     mat_peptide     182..1810
                     /gene="Cesl1"
                     /product="Liver carboxylesterase B-1. /id=PRO_0000008582"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63010.1)"
     misc_feature    191..1762
                     /gene="Cesl1"
                     /note="Carboxylesterase family; Region: COesterase;
                     pfam00135"
                     /db_xref="CDD:395084"
     misc_feature    362..364
                     /gene="Cesl1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q63010.1); glycosylation site"
     misc_feature    order(548..556,785..793,800..802,1271..1273,1283..1285,
                     1382..1384,1526..1528,1535..1537)
                     /gene="Cesl1"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:238191"
     misc_feature    order(788..790,1184..1186,1523..1525)
                     /gene="Cesl1"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238191"
     misc_feature    1799..1810
                     /gene="Cesl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63010.1);
                     Region: Prevents secretion from ER.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU10138"
     exon            180..384
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..529
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..663
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..817
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..922
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1027
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1066
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1207
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1288
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1436
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1568
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1641
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..2001
                     /gene="Cesl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caactgtgcagcccggagagtctccaaaacttttcagtctgtaataagaagccccccacctcactaaagctttgcactgcctaccagagtcagagactctattgactggagtatctgcccacgcaagatgtgcctcaggtccctgttcctggtgtccctagcaacctgtgtggtttgtggaaacccctcttcaccacctgtggtggacaccatgaaaggcaaggtcctggggaagtatgccagtttagaaggagtcacacagtctgtagccgtcttcctgggagtcccttttgccaagccccctcttggatctctgaggtttgctccaccacagcctgcagagccctggagcttcgtgaagaacaccaccacctatccacctatgtgctcccaagatgcaacaaaagggcagaggatgaatgatctcctaaccaacagaaaggagaaagtccatctccagttttctgaagattgtctctacctgaatatttacactcctgcagactttacaaaggatagcaggatgccagtgatggtgtggatccatggaggtggactaacacagggcggggcatcaacctatgatggccaggtcctctctgcctatgaaaacgtggtggtagtggccattcaatatcgcctgggcatctggggattcttcagcacaggggatgaacacagcaggggaaactggggtcatttggaccaagtagctgcgctgcactgggtccaggacaacattgccaactttgggggtgacccaggctctgtgaccatctttggagagtcagcaggaggtttcagtgtctctgttcttgtgttgtccccactgtccaagaacctctaccacagggccatttctgagagtggggtggtcctcattactgaattgtttactaaggatgttaggccagccgctaagcaaattgctgatatggctggatgtaaaaccaccacctctgccatcattgttcactgcctgcgtcaaaagacagaagaggagctcttagagatcatggaaaaaatgaatctgattaaactcagttcacaaagggataccaaagagagctaccactttttgtcaactgtgattgacgatgtggtgctgccaaaggacccaaaagagatcctggctgagaagaacttcaacaccgtgccctacattgtgggaatcaacaagcaagagtgtggctggcttctgccaacgatgatgagatttgtaccacctgatgtaaaattggacaagaagatggccattatgctcctggagaaatttgcttccatatatggtataccagaggatattattccagttgctattgagaagtacagaaaaggtagtgatgaccccatcaagatcagagatggaatccttgcctttattggggatgcgttattttgtatcccatcagtgatggtgtcccgtgaccacagagatgctggagctcccacctacgtgtatgagtatcaatactacccaagcttctcatcaccccaaagacccaaggatgtagtaggagaccatgcagatgatgtctactctgtctttggtgccccaattttaagagatggtgcctcagaagaggagatcaagctcagcaagatggtgatgaaattttgggccaactttgctcggaatgggaaccctaatggccgagggctacctcattggccacagtatgaccagaaagaagaatatctgcagattggtgccaccacccagcaatcgcagggactgaaagcagaggaagtggctttttggacacagttactggctaagagacaacctcagccccaccacaatgagctgtgaatgcaagtctctgtcagcttcagaacaagcaagccaagatattgttcttccagtaaagatgtttgtaaatgaaagatggatctggaggatcctgaagaattttgtaatagagacagggagaacccaggaaagagaaatatttgtacttggcatcaatttagagaataaatgacatttttacagttaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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