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2024-03-29 23:34:03, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_001010964            1014 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus killer cell lectin like receptor B1A (Klrb1a),
            mRNA.
ACCESSION   NM_001010964 XM_342765
VERSION     NM_001010964.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1014)
  AUTHORS   Kovalska J, Cervinkova M, Chmelikova E, Planska D, Cizkova J and
            Horak V.
  TITLE     Immunohistochemical Evidence of the Involvement of Natural Killer
            (CD161+) Cells in Spontaneous Regression of Lewis Rat Sarcoma
  JOURNAL   In Vivo 33 (1), 47-52 (2019)
   PUBMED   30587601
  REMARK    GeneRIF: Based on the differences in number and distribution of the
            immune cell subpopulations, we believe that natural killer
            (CD161(+)) cells play a major role in the destruction of cancer
            cells during Spontaneous regression tumours in this Lewis rat model
REFERENCE   2  (bases 1 to 1014)
  AUTHORS   Aust JG, Gays F, Mickiewicz KM, Buchanan E and Brooks CG.
  TITLE     The expression and function of the NKRP1 receptor family in C57BL/6
            mice
  JOURNAL   J Immunol 183 (1), 106-116 (2009)
   PUBMED   19535641
REFERENCE   3  (bases 1 to 1014)
  AUTHORS   Kveberg L, Dai KZ, Westgaard IH, Daws MR, Fossum S, Naper C and
            Vaage JT.
  TITLE     Two major groups of rat NKR-P1 receptors can be distinguished based
            on chromosomal localization, phylogenetic analysis and Clr ligand
            binding
  JOURNAL   Eur J Immunol 39 (2), 541-551 (2009)
   PUBMED   19130483
REFERENCE   4  (bases 1 to 1014)
  AUTHORS   Voigt S, Mesci A, Ettinger J, Fine JH, Chen P, Chou W and Carlyle
            JR.
  TITLE     Cytomegalovirus evasion of innate immunity by subversion of the
            NKR-P1B:Clr-b missing-self axis
  JOURNAL   Immunity 26 (5), 617-627 (2007)
   PUBMED   17462921
REFERENCE   5  (bases 1 to 1014)
  AUTHORS   Li J, Rabinovich BA, Hurren R, Shannon J and Miller RG.
  TITLE     Expression cloning and function of the rat NK activating and
            inhibitory receptors NKR-P1A and -P1B
  JOURNAL   Int Immunol 15 (3), 411-416 (2003)
   PUBMED   12618485
REFERENCE   6  (bases 1 to 1014)
  AUTHORS   Campbell KS and Giorda R.
  TITLE     The cytoplasmic domain of rat NKR-P1 receptor interacts with the
            N-terminal domain of p56(lck) via cysteine residues
  JOURNAL   Eur J Immunol 27 (1), 72-77 (1997)
   PUBMED   9022000
  REMARK    Erratum:[Eur J Immunol. 1997 Mar;27(3):802. PMID: 9079826]
REFERENCE   7  (bases 1 to 1014)
  AUTHORS   Giorda R, Weisberg EP, Ip TK and Trucco M.
  TITLE     Genomic structure and strain-specific expression of the natural
            killer cell receptor NKR-P1
  JOURNAL   J Immunol 149 (6), 1957-1963 (1992)
   PUBMED   1517565
REFERENCE   8  (bases 1 to 1014)
  AUTHORS   Giorda R, Rudert WA, Vavassori C, Chambers WH, Hiserodt JC and
            Trucco M.
  TITLE     NKR-P1, a signal transduction molecule on natural killer cells
  JOURNAL   Science 249 (4974), 1298-1300 (1990)
   PUBMED   2399464
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000150.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001010964.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62891.1, FJ416340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JACYVU010000150.1  4702828-4702931     c
            105-203             JACYVU010000150.1  4700622-4700720     c
            204-275             JACYVU010000150.1  4699422-4699493     c
            276-430             JACYVU010000150.1  4693476-4693630     c
            431-546             JACYVU010000150.1  4693018-4693133     c
            547-1014            JACYVU010000150.1  4689458-4689925     c
FEATURES             Location/Qualifiers
     source          1..1014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1014
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /note="killer cell lectin like receptor B1A"
                     /db_xref="GeneID:362443"
                     /db_xref="RGD:1586149"
     exon            1..104
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..688
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /note="NKR-P1 3.2.3; antigen 3.2.3; CD161 antigen-like
                     family member A; killer cell lectin-like receptor
                     subfamily B, member 1A; natural killer cell surface
                     protein P1-3.2.3"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1A"
                     /protein_id="NP_001010964.1"
                     /db_xref="GeneID:362443"
                     /db_xref="RGD:1586149"
                     /translation="
MDTARVYLSLKPSKTAAGAQCVSPPSLPPDACRCPRSHRLALKLSCAGLILLVLALVGMSILVRVLVQKPSVEPCRVLIQENLSKTGSPAKLKCPKDWLSHRDKCFHVSQTSITWKESLADCGGKGATLLLVQDQEELRFLRNLTKRISSSFWIGLSYTLSDENWKWINGSTLNSDVLSITGDTEKDSCASVSQDKVLSESCDSDNIWVCQKELKCECMCNDS"
     misc_feature    110..121
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P27471.1);
                     Region: LCK-binding motif"
     misc_feature    146..205
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P27471.1);
                     transmembrane region"
     misc_feature    296..652
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(467..469,551..553,602..604,608..613)
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
     exon            105..203
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            204..275
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            276..430
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            547..1014
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
gcctctcccaagtacaatggacacagcacgtgtctacctcagtttaaagccatccaagactgccgcgggggctcagtgtgtatcacctccatctcttcccccagatgcctgtcggtgcccacgttcacacaggttggctttgaagctcagctgcgctgggctgatccttcttgtcttggccctggttgggatgagtattttagtgcgagtcttagttcaaaaaccatcagtggagccatgccgagtgcttattcaagagaacctgagtaaaacaggtagtccagctaagttaaagtgcccaaaagactggctttcacaccgagataaatgctttcatgtttctcaaacttccatcacttggaaggaaagtctagctgactgtggtggaaaaggagccacgttgctgctcgttcaagaccaagaagaactgagattcctacggaacttgacaaagagaataagcagctcattctggattggattaagttacacattgtcagacgagaactggaagtggataaacggctcgactttaaattctgatgtattaagcatcactggtgacactgaaaaggacagctgtgcctccgtctcacaggacaaagtgctttctgagagctgtgattcagacaatatatgggtctgccaaaaggaactaaaatgtgaatgcatgtgtaatgactcctgactgcgaatcacacctggattactttaccatccacaccagatctctgcctgacctgtctgtctctgctgcctgcctcccagtgcagcactggcacaaagcatggactctgaaagcactgagtcttatagagtcttcgttgtgtagatgtaaacgtacgcagacacagatgtgccatcctgtgagggagttctgtggaaagaagaccaggcagctgagggtcactggattctaatcctggagtctgtgtgaccttcgttggtctctgtgtctgaggtcatctgcaaaatagccatttgcaaaaatcattaaaatgctcctctgcaggg
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]