2024-05-05 00:07:46, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001007755 2176 bp mRNA linear ROD 23-MAR-2023 DEFINITION Rattus norvegicus selenocysteine lyase (Scly), mRNA. ACCESSION NM_001007755 XM_343627 VERSION NM_001007755.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2176) AUTHORS Seale LA, Hashimoto AC, Kurokawa S, Gilman CL, Seyedali A, Bellinger FP, Raman AV and Berry MJ. TITLE Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice JOURNAL Mol Cell Biol 32 (20), 4141-4154 (2012) PUBMED 22890841 REFERENCE 2 (bases 1 to 2176) AUTHORS Omi R, Kurokawa S, Mihara H, Hayashi H, Goto M, Miyahara I, Kurihara T, Hirotsu K and Esaki N. TITLE Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase JOURNAL J Biol Chem 285 (16), 12133-12139 (2010) PUBMED 20164179 REMARK GeneRIF: ESI-MS analysis of wild-type and C375A mutant SCL revealed that the catalytic reaction proceeds via the formation of an enzyme-bound selenopersulfide intermediate on the catalytically essential Cys-375 residue. REFERENCE 3 (bases 1 to 2176) AUTHORS Jafari C, Panzer U, Steinmetz OM, Zahner G, Stahl RA and Harendza S. TITLE Enhanced expression of selenocysteine lyase in acute glomerulonephritis and its regulation by AP-1 JOURNAL Cell Mol Biol Lett 11 (3), 424-437 (2006) PUBMED 16874457 REMARK GeneRIF: An enhancer element between bp -152 and -298 of the SCL 5'-regulatory region was identified, with protein binding to an AP-1 binding site that may be involved in the regulation of SCL-RNA in vivo in an endogenous feedback mechanism. REFERENCE 4 (bases 1 to 2176) AUTHORS Mihara H, Kurihara T, Watanabe T, Yoshimura T and Esaki N. TITLE cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase. Candidate for selenium delivery protein in selenoprotein synthesis JOURNAL J Biol Chem 275 (9), 6195-6200 (2000) PUBMED 10692412 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JACYVU010000215.1. On Jan 10, 2023 this sequence version replaced NM_001007755.1. ##Evidence-Data-START## Transcript exon combination :: BC079358.1, SRR8487227.300561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00132261, SAMD00132262 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-103 JACYVU010000215.1 24960025-24960127 104-216 JACYVU010000215.1 24962268-24962380 217-317 JACYVU010000215.1 24965377-24965477 318-498 JACYVU010000215.1 24967337-24967517 499-626 JACYVU010000215.1 24969679-24969806 627-791 JACYVU010000215.1 24970007-24970171 792-898 JACYVU010000215.1 24971185-24971291 899-935 JACYVU010000215.1 24974898-24974934 936-1019 JACYVU010000215.1 24976505-24976588 1020-1119 JACYVU010000215.1 24977037-24977136 1120-1195 JACYVU010000215.1 24978776-24978851 1196-2176 JACYVU010000215.1 24979658-24980638 FEATURES Location/Qualifiers source 1..2176 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="9" /map="9q36" gene 1..2176 /gene="Scly" /note="selenocysteine lyase" /db_xref="GeneID:363285" /db_xref="RGD:1359514" exon 1..103 /gene="Scly" /inference="alignment:Splign:2.1.0" CDS 51..1349 /gene="Scly" /EC_number="4.4.1.16" /codon_start=1 /product="selenocysteine lyase" /protein_id="NP_001007756.1" /db_xref="GeneID:363285" /db_xref="RGD:1359514" /translation="
MDVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLEGPV"
misc_feature 51..110 /gene="Scly" /note="propagated from UniProtKB/Swiss-Prot (Q68FT9.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 51..53 /gene="Scly" /note="N-acetylmethionine. /evidence=ECO:0000250|UniProtKB:Q96I15; propagated from UniProtKB/Swiss-Prot (Q68FT9.1); acetylation site" misc_feature 102..1334 /gene="Scly" /note="Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]; Region: NifS; COG1104" /db_xref="CDD:224029" misc_feature 399..401 /gene="Scly" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q96I15; propagated from UniProtKB/Swiss-Prot (Q68FT9.1); phosphorylation site" exon 104..216 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 217..317 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 318..498 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 499..626 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 627..791 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 792..898 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 899..935 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 936..1019 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 1020..1119 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 1120..1195 /gene="Scly" /inference="alignment:Splign:2.1.0" exon 1196..2176 /gene="Scly" /inference="alignment:Splign:2.1.0" ORIGIN
ggagtctaaggggtgctcagtcttggggttaccggccagcgatcagggagatggacgtggcgcggaatggcgcgcggggcagtgtggagagcccgcccaacaggaaggtctatatggactacaatgccaccacacctctagagcccgaagtcatccaggctgtgacggaagccatgaaagaagcctggggaaaccccagcagctcatatgtagcaggtaggaaggccaaggacattataaacacagctcgggcaagcctggccaagatgatagggggaaagccccaggacatcatcttcacttctgggggcaccgagtccaataatttagtaatccactctacggtgagatgcttccatgagcagcagaccctgcaggggcgcacggttgaccagatcagccctgaggaggggaccaggccccattttatcacttgcacggtggagcatgactccatccggctgcccctggagcacctggtggaagatcaagtggcagaggtcacttttgtcccagtgtcgaaggtaaatgggcaggtagaagttgaggatatcctggccgctgtccgtcccacaacatgccttgtgaccatcatgttggccaataacgagactggtgtcatcatgcccatctctgagatcagtcgtcgcattaaagccctgaaccagatccgggctgcctcggggctaccccgagtcctggtgcacacagacgctgctcaggcactggggaaaaggcgagtggatgtcgaggacctgggcgtggacttcctgaccatcgtggggcataagttctacggccccaggatcggtgctctgtatgtgcgaggggtcggtaaacttacccccctgtaccccatgctgtttggaggtggacaagagcggaatttcaggccagggaccgagaacacgcccatgattgctggccttgggaaggctgcggatctggtgagtgagaactgcgagacttatgaggcccacatgagagacatccgggattacctggaggagaggctggaggctgaatttggtaagagaatccatttgaacagccgctttccaggagtggagaggcttccgaacacctgcaacttttccatccaggggtcccagcttcgagggtacatggtccttgcacagtgccagacactgctggccagcgtgggagcttcatgccactcggatcatgaggaccggccatccccagtgctgctgagctgtggtattcctgtggatgtggcccggaacgcagtccggctcagtgtgggccgcagtaccactagggctgaagtggacctcatcgtgcaggacctgaagcaggccgtgaaccagctggaaggcccggtctagagctagcagccactctctccctcagcggccagctggactttggccactcaatccataggaaaccgcttgtgaaagttcctggcccctaagctgtcccttctcaagagctgcactgagatgactgtcctactatggggtgcaaagtgacagggggctgcccactgcacagtatcccactctagtgcccatgcttataagctcaggacagccgtgtcacataggacgtcccctgtcacctccgacaagccacaggggaataggaatatcccagttatcaggcagcctgacaggaccacccgaccccagaagacactttgatcagaagacaaaacctacgtcttggtctactgtcacttagctgctcatgtgagaataggaagttgatttcgtctccacccatggcctcccgtgtgcacctacagacaacacccctcccccatgctgccctgcccttctcctctgccctcagcctgccactgcccacctgcctccctggcctgatggtccccagacgaggtctcatgccttgttcccagaggtcacagctcaccctgtcttctacacagggatggctgccgggaggctgctgcctgatctttgccaaagtgggaaatccggtcatttctcactcagattcaattttaattttatctgcaaagggttctgtcatcttgaggatgtgtggcacacatcacacccatgtttatataggaaatgtcttcttggaggacacttttagcacgtgggtctgtgggccaaaggatgacgcagcatgtggaaacagttgtcagaagttaaatgaactaatgaaagatgcctgcacttgc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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