2024-11-01 08:15:30, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS XM_036163955 5912 bp mRNA linear ROD 07-FEB-2024 DEFINITION PREDICTED: Mus musculus transforming growth factor, beta receptor I (Tgfbr1), transcript variant X1, mRNA. ACCESSION XM_036163955 VERSION XM_036163955.1 DBLINK BioProject: PRJNA169 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Updated annotation Annotation Name :: GCF_000001635.27-RS_2024_02 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.2 Annotation Method :: Best-placed RefSeq; Gnomon; RefSeqFE; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 02/01/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5912 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6J" /db_xref="taxon:10090" /chromosome="4" gene 1..5912 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="transforming growth factor, beta receptor I; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 mRNAs, 19 ESTs, 776 long SRA reads, 52 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 1 sample with support for all annotated introns" /db_xref="GeneID:21812" /db_xref="MGI:MGI:98728" CDS 129..1763 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /codon_start=1 /product="TGF-beta receptor type-1 isoform X1" /protein_id="XP_036019848.1" /db_xref="GeneID:21812" /db_xref="MGI:MGI:98728" /translation="
MRPGLKLLGRGRAPAWRRSGAGRLEGSPEGRKGRRGQRPRVGRTADEYGSLNSKKLYFLRGRSNKVSISALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTTTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
misc_feature 339..563 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="extracellular domain (ECD) found in activin receptor-like kinase 5 (ALK-5) and similar proteins; Region: TFP_LU_ECD_ALK5; cd23537" /db_xref="CDD:467067" misc_feature 777..860 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="Transforming growth factor beta type I GS-motif; Region: TGF_beta_GS; pfam08515" /db_xref="CDD:462503" misc_feature 876..1739 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; Region: STKc_TGFbR1_ACVR1b_ACVR1c; cd14143" /db_xref="CDD:271045" misc_feature order(882..896,906..908,939..941,945..947,1029..1031, 1089..1100,1110..1112,1116..1118,1248..1250,1254..1256, 1260..1265,1269..1271,1302..1304,1311..1313,1371..1382) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="active site" /db_xref="CDD:271045" misc_feature order(882..902,906..908,939..941,945..947,1089..1094, 1098..1100,1110..1112,1260..1265,1269..1271,1302..1304) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:271045" misc_feature order(894..896,1110..1112,1116..1118,1248..1250, 1254..1256,1260..1262,1311..1313,1371..1382) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:271045" misc_feature order(975..980,987..992,999..1004,1044..1046,1050..1052) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="FKBP12 binding site [polypeptide binding]; other site" /db_xref="CDD:271045" misc_feature 1299..1382 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="activation loop (A-loop); other site" /db_xref="CDD:271045" ORIGIN
agcaccgagcagaggccggccctcttgggctcccggggggcagcggctggcgagcctgccgaggtcgggggctgcccttaggggtgcgaggccggccgggaccgtggccccctgattccactgcctaaatgcgccccggcctgaagctgttggggcgtgggcgggcaccggcgtggaggcgctccggggccgggcgcttggagggctccccggagggtcgaaaggggcgccgtgggcagagaccccgggtgggccgcaccgccgatgaatatgggtctctgaattcaaagaagttatattttcttaggggaagaagtaataaagtcagcatttctgcattacagtgtttctgccacctctgtacaaaggataattttacctgtgagacagatggtctttgctttgtctcagtcactgagaccacagacaaagttatacacaatagtatgtgtatagctgaaattgacctaattcctcgagacaggccatttgtatgtgcaccatcttcaaaaacaggggcagttactacaacatattgctgcaatcaggaccactgcaataaaatagaactcccaactacaggacctttttcagaaaagcagtcagctggccttggtcctgtggagctggcagctgtcattgctggtccagtctgcttcgtctgcattgcacttatgctgatggtctatatctgccataaccgcactgtcattcaccaccgtgtgccaaatgaagaggatccatcactagatcgccctttcatttcagagggcaccaccttaaaagatttaatttatgatatgacaacatcagggtctggatcaggtttaccactgcttgttcaaagaacaattgccaggaccattgtgttacaagaaagcattggcaaaggtcggtttggagaagtttggcgaggcaaatggcggggagaagaagttgctgtgaagatattctcttctagagaagagcgttcatggttccgagaggcagagatttatcagactgtaatgttacgccatgaaaatatcctgggatttatagcagcagacaacaaagacaatgggacatggacgcagctgtggttggtgtcagattatcatgagcatggatcccttttcgattacttgaatagatacactgttactgtggaaggaatgatcaagcttgctctgtccacagcaagtggtcttgcccatcttcacatggagattgttggtacccaaggaaaaccagctattgcccatagagatttgaaatcaaagaatatcttggtgaagaaaaatggaacctgttgtattgcagacttgggacttgctgtgagacatgattctgccacagatacaattgatattgctccaaaccacagagtaggcactaaaaggtacatggcccctgaagttctagatgattccataaatatgaaacattttgaatccttcaaacgcgctgacatctatgcaatgggcttagtgttctgggaaattgctcgacgctgttctattggtggaatccatgaagactatcagttgccttattatgatcttgtaccttctgatccatcggttgaagaaatgagaaaagtagtttgcgaacagaagttaaggccaaatattccaaacagatggcagagctgtgaggccttgagagtgatggctaaaattatgagagaatgctggtatgccaatggagcagcaaggctgacagctttgcgaattaaaaaaacattgtcacaactcagccaacaggaaggcatcaaaatgtaactgaaacaccgtgggaactctgctctcttcatatctgctcctgggtgtttaggaggctggttgttctacctcactgagagaacagagggctctgcttcctcttgcagcagtggaatatggtcaactgaaagcttcccagggtttctctgggcccagaggcagccgtggggtcctttctgtgcactatggatacttcttccagacagttacagaatgttgtgtagtctacttttgtttttattaacaaagcttgtttttaaagacaactgccagcccttagggagctgctgtgctgttgaccttctgtaagggtgaaggagctggggtgtggcactaaatgaagcacttctgattttcactcctagtagtacattctcagaggactctgaaccactagtgtttccttggttcactttgaatgtactgttctataatttttcaagatcttaaactaacactttaaactctatagtctaaaaaatatgacctcgtggaggcgtgggggcacagttgctccgttgtatttgtgcacagctccttcacactctgaacacaacacaccttcacagtagggttgtgctacaccagtaagtgctacttttgcatctgtctaagtggaaacgaacagaactacttaaaggcggtgttaagtcctgtatcattttcattcaaaaagtttatttttctgagtaacctaaaccttttctgggtttgtttttgttttttgagggtttttgtgatagatgtcattcagtcttcatgcctttctcctacccagatgtgcttgaaccactgaggcaaggctgtagcattgataagcagtgactgccatgcgggaacaccccacaggagcactggagctctgcagttgagacgtttagcctgagtttattttaagaagtgaagtggcactccaaacatgtacagtgctttatggatgtaatcattatggtatacagactccttttgaaaggggaggcttgtctattgccgaaggaaaagttgtatgctgttctgtaagccatttctttttctttatttgatcaaagcagtgttttgttttgttttgatttttcttttttggaaaggaattgcatttaaaattcaaatgtggttaatgttaaataataggcctttttctaggaaggcagatatagttaatatgaatgtacaagtgtaggtgactttcacatgttatgtagctgtaagtatttgtggattctatcttgggaagggtagagttagtggagttttgaggtctcactaccctttgaggaaggcagcttttaattcagtctttttatctcatatgtgcagatcttgcaactgcttgatttacatggtagcaatgaattcagtgccacgttgatactaggagaagcagcaactaatagctattctgagtagaggctctcttcatatattcttggtcatattaaatgtcaaagtcagtccgttgggtcttctcactgctgctggagttaggtggttgagcctgggttttacttcagtgctgtcaaatctttgcagggcttgtgtggctttcaaagtcctttttatcactgtgatcatattctgggcggggaaatgttatcatcattgcttgagacgagatgttgaacatagtgataccaatccccagataaaaaggtcaaaataacctttagtgtttagccaagaagagattgtgactattgatctgaagcagctgggctctgttaatgtcttatttcaaacctagcatacatttgaagactatttggtcttaaaccaaagtaactgtaggacgaatgacatactacctagacattagtgtccgtttcatacgtcagaaacaccatgggaaaaagtacctagagattagtatctttaatacaaatctgagttttttctgtaattatcatgatttcatcaatgtaagtaagggtttgttgttacagttgtatcacctgcttaaataagctcttgtgctataatcaggtacttttggggcctttgttttcagttttttccatttctaacccttcgagatctgctttatagaaatccagggaccaatgtattttatcactaaaactgtttttatataattttaagaccataccaaaagttatctgagttaaagttgtaatacgtttcttactttcttgcaaggaaatgggtttttactgaagacacttctcatgatatctgaagttgaagaatcattatgtttttcttacctaagtggataaaatgtgctttgatgaatcagggaattttttaaagttcgaatttagttctaaattgagtttacatgtttacagctaattttttgtgtagggatagtttgattctctaggtggccaatactgaatataaaaataacttaaaaattgagataggtcatggttaatgtggctataactatatatacatctaattagagaaatatttctatgtaattttgtagtgcagtctgttgtttctattgccaatcaaagacttccccccagccccaaagtgtagtatggctaagacatatcttctgacaaattacatattatcttgtcaataccctggttaagctagcatgaaggaagtatgacttactgaggcttacacaacttgagtcccttatatcttcagctctgtttttcccactctgcctttctgctgccccctggctcagagacttagtgttcctgaccccacctccagcctttggacctaagagctgcttttgagacctaaaatgaagtgattgatggaagctgtgtgacatttttccacttccttgagtcactgggtgttatgagggagtgatctgcaaattggggtagggggtgcccctactggtagccctgctttgatgtcagctctgggcaaagattagggtgacagctaagtggcagtggaagttggcctcagaagtagtggccagctgtgtctctagtaggacagtaaaggcatgaagctcagcctgtaatcctgctactacagtagtactccagaagtgccttgaggccctgtgtggggctgtggccatcaagaattccagattttggttctcgctgcagacttaagtggccatgtagccatttttgtaatccatacatgtttgactcttccctctgcaaattgtcagatacgtaaaaccaatgacaaactactacttaacatgcacaccaaaatctgcccagaagacattgtgatttcattccatgcactgaaggaatgattgtaaatcatttctttgttccttggtcatgggagtgttctggttctacattgtggagattccagctgttgttctgttatagcccagcagaacaagtcgacgtgttgaaattctgaagaatagtttgggagtgcagtacagcttcatgtgttggatgttgaaactttcatgggccctctttagaaaagcagaggactgtcagcacattatttttaatcctgttatgcactcgtacttattgtcagtaacaataagtacgagtattgaaaatattgtcagtaacattcagtctctttcttaaagtgaatttgcttatttttcaatgagatttgtgagtttaatattatgaactgtgttttgataatccctttttcacattgtgccaatggaatggaatatttgatatttctttatatgtcaaggagatgcttcaatatgtcatttgctttaaacttaaattacctctcaagagaccaaggtacatttacctcattgtgtatataatgtttaatatttgtcagcatccaccaggtttgcaattttatttctataaagtgtgagtgttacgttgctaagttactcagatggtactgtattgtttatatctgtaccccaaatgacatcatctagactttgttttctgtgtcttattgtatttgtgcagtcctttaaccctgttggtgtgattgctgccctttcagatatgtgcaggtgtctatagaaattctcatttaaggtgaatggttttgagaaacctgtgaagagagaagcataaactgcatttccccatcagttttttaaatgtacattgtatgtgtagtaatattccagatgaattgtaaataaaagctagggagatgcttaaatttcatcctaacactacagtagaaaatggaagcaatgcaaataaacaactttttcccaccagt
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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