LOCUS       XM_017320100           14553 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus argonaute RISC catalytic subunit 3 (Ago3),
            transcript variant X10, mRNA.
ACCESSION   XM_017320100
VERSION     XM_017320100.2
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000070.7) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 21, 2020 this sequence version replaced XM_017320100.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="4"
     gene            1..14553
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="argonaute RISC catalytic subunit 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 8 mRNAs, 11 ESTs, 632 long SRA reads, 5 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 9 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:214150"
                     /db_xref="MGI:MGI:2446634"
     CDS             54..1811
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X4"
                     /protein_id="XP_017175589.1"
                     /db_xref="GeneID:214150"
                     /db_xref="MGI:MGI:2446634"
                     /translation="

MRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNFFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    <54..326
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="PAZ domain; Region: PAZ; pfam02170"
                     /db_xref="CDD:460472"
     misc_feature    405..1682
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(816..818,828..830,864..875,882..884,906..908,
                     915..917,927..929,939..941)
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1020..1022,1026..1028,1236..1238,1650..1652)
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

cagtcccccaaaccaattagagtctgaaagttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacgagaaggcctgccagccaccaaacctttcctttacagctagaaaatggccaaactgtggagaggactgtggctcagtatttcagagaaaagtacacgctgcagctgaagtacccacaccttccctgcctgcaagtggggcaggagcagaagcatacatacctgccactagaagtctgtaatattgtggctgggcaaaggtgtatcaagaaactaacggacaatcagacttctacaatgataaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcagtttaaagtgcgggatgaaatggcccatgtgacaggacgtgtacttccagcacctatgctccagtacggaggacggaaccggacagtagccacacccagccacggagtatgggacatgcgaggaaaacagttccacacaggagtcgaaatcaaaatgtgggctattgcttgctttgccacacagaggcagtgcagagaagaaatactaaaaggtttcacagaccagcttcggaagatttccaaggatgcagggatgcccatccagggtcagccatgcttctgcaaatacgcacagggggcagacagcgtggagcccatgttccggcatctcaagaacacctactcaggactgcagctcattatcgtcatcctgcccgggaagacaccagtgtatgcggaagtgaaacgtgtgggagatacacttttgggtatggccacacagtgtgtacaagtcaagaatgtaataaaaacatctcctcaaactctttcaaacttgtgcctaaagatcaatgttaaacttggaggaatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatcttcctgggcgcagatgtcacacacccgcctgctggtgacggaaaaaagccctccattgctgctgttgtaggtagtatggatgcccatccaagcagatactgtgccacagtaagagttcagagaccccgacaggaaatcatccaggacttggcctccatggtccgggaactgctcatccaattttataaatcaacccgattcaaacctactcgtataatcttctatcgggatggtgtttcagaaggacagttcagacaggtattatattatgagctactggcaattcgagaagcctgtatcagtttggaaaaagactatcaacctggaataacctacattgttgttcagaagagacatcatacacggttgttctgtgctgataggacagaaagggttggaagaagcggcaacatcccagctggaaccacggtggataccgacattactcacccatatgaattcgacttttatctctgtagccatgctggaatacagggtaccagccgtccttcacactatcatgttttatgggatgacaacttctttactgcagatgaacttcagctgctcacttaccagctctgtcacacttacgtacgctgtacaagatctgtttctatccctgcaccagcatattacgctcacctggtggcattcagagccagatatcatcttgtggacaaggaacatgacagtgctgaaggaagccatgtttcaggacagagcaatgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtacttcgcttaacaagtccaagtttattctccgtgacaaagagatgaaaagtgaatcaacatacaatgtatgtttccaatggagtcaatttgctggggaggcctccagccatacagaagccagtactatgtagaggtcaggtccttatgttgatccaaggaaaatcgtttacactgtcaaagaacgcagcaccattgtacactagggagccagccgctgcttttttgcagtctcctgtagaagatgcatcaccattgtttattctcacttcttacagtctaacccttttaatgcctttacctcaagttgcttagcagcacaactatctctgcaaaaaagtaaagaaaaattgaatggtggtttaaaaacacacaattacacaaataatgattgttcagttatatgtgcagaaaaagtaatgtgcatctattcttgtaaaggagtctgtattttcaataccctcacattacttcatgtgcatatgtatctagatctaggttactgatgtatatgtgtctgtgtgtatatcttatagttcatttccctggagaactctttccttgtatccctccttaggccgcactcgtttcctttactgtctcccttgccttcagcatctatactttggtccctatagctacaagtgacattcctatgttcacacatatggttcacttgaaggaaggtttgacaaattagacttctggttttctttatgtccctattcctagctcctttcactcacacaggagtcctcagctcctgacgccatgtttgtgagcgtctgctcccttttgctctggatttaccacatgtgcactgtgtttggaaacagtggcaacctggggattcttttttgtagtgagtttgttaaagctgctctaaatacgaaaccttgtcggacatctttctgatcagtgcaaatgttctaaagcctctgtttgtatgagttatacctggaaatccctccaaaactcgataggatggaaaaaggaaggaattagggttggtttggtttgttttttgctagtttactcactgcccttataccttaatgtgattttctcacatataaatatatacatacacacacacacattgaagtatagctccctttgcctttatgttcattagaatagtgctttaataattataaactatataggctatatcttttctagaactagaatcgtgtttaagaatggagacagttttttgctctcttttagtgcaataagcagttttacaggaaagttctgtctgtcatcctcaccgtggatagcaggaagaacagacatccgtagtttaaagggaacaaagtaatacagccttaatttcagaaggagagcttcataattttcagttttaaagcaattccttaaaataattttagccaaaggagtaaaaccgatcaaaggcgcctcagctgtgaggtcagaagcatagttgaacttaagtttttaaaaatgacagtgaacagcttaagatttaaatattctttcttacttattgaagaattgtgcttctttgactaacaggaattgagaaaatacaggatgatttttttctatctttttaccagtataactttctctttaaaaataagatggcaatgatgaaggaaattaggactttggtcatttaaaattagtaaaatttccgaaatacagtgaaaactttgcaaaaacttagttttctccacttctttaatcaataaccttaataacgttggagctgtcaaagctgagtgtctcagtaatggcaggttcagggaactttgcactttgtaagtcatgaacattgcatgtgagttttctctgttgtccccaccctggctctgaggacagacactacagatgtttgtggaatgcactgtcggcctttcagaagccccaccccgccatgaacaggaatgcagttatgtcttcatttgctctctttagtccacattgtagccaatttactacatttcaatataaaatctgagccatgtcctacaggcatgaattcttctgtccctttgccagaacataaagaaagtactgtattttatatttttattgcttgaagtatctaaaattcgattctcaatactgttttaaagctgtttactgtttacaaaggattttcatgtggtttatacatttttctccttccaaaatattcccatctcaaccctggcaaaagaaaactccttacaacatatttggggtgggttggtttgcttgcttgttttggagacaacgtctctctctattgcccatgctggcctccaacccctgggctccagcagtcttcttaacctctctggtagttggaaccattgggctccttccatcatgcctggctgtcggggagcatggccaaaagaatagagtggtgcaggctccatggtaaaagtctttgcctgggttgtgtttgctcagtagaagtaaacatgtttttcagcccctgcacattcacatgaggagctttagggagtcgcatgggccctgtccctttcctgacctttggtctcacacatgccagagtgaagcccttacttttaattcttatttaaaaggattttttaaggggaagaattttttttctaaaatataaggttttatcttttaaatggcttcttttttagaatgcatttatattattcagtcttgctagtttaagataattaacttaggatatgtatagtgtatttctgttttgcctactaataaattgttataccaaacttaatgccaacaaactttatgcttagaattttaagattaaaaggcctatagaaaatacttcttgaaatttatactatttttccatttctggttagaattcctaatctttttcttaagttcctttcagtttaaacatcatgaagccatagtaacatttctcctctaccgtactcttgctcctagctgatgaatgtcagcttgtggggtttttttgttttttatggtatggcttataaaactgactaaaatgtcaatctgaacaacttatagaatcgattctcttgttaagaagagttgagagtttaatgtatattcttgatggcaaatgtgtctgtagagtgtgcatgttacatgtctatattacagtatctaagcactggcattgataccatatattaataattctgtagctgctatatttattgaggcagagtctgacatttactgcactaaacaatgagacaagcaa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