2024-11-01 08:07:24, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS XM_017313858 7691 bp mRNA linear ROD 07-FEB-2024 DEFINITION PREDICTED: Mus musculus Ros1 proto-oncogene (Ros1), transcript variant X5, mRNA. ACCESSION XM_017313858 VERSION XM_017313858.1 DBLINK BioProject: PRJNA169 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.7) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Updated annotation Annotation Name :: GCF_000001635.27-RS_2024_02 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.2 Annotation Method :: Best-placed RefSeq; Gnomon; RefSeqFE; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 02/01/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..7691 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6J" /db_xref="taxon:10090" /chromosome="10" gene 1..7691 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Ros1 proto-oncogene; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 Protein, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 1 sample with support for all annotated introns" /db_xref="GeneID:19886" /db_xref="MGI:MGI:97999" CDS 77..6538 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /codon_start=1 /product="proto-oncogene tyrosine-protein kinase ROS isoform X5" /protein_id="XP_017169347.1" /db_xref="GeneID:19886" /db_xref="MGI:MGI:97999" /translation="
MEICPTSRKLDFHGVPETAPLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKNQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIHHNITGISVYAQQQVVYFSEGTVIWMKGAANMSDVSDLRIFYQGSGLVSSISIDWLYQRMYFIMDKLVYVCELKNCSNLEEITPFSLIAPQKVVVDSYNGYLFYLLRDGIYRVNLPLPSGRDTKAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRVLPWVPLVTVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWTPPALAIGASPSAWQNWTYEVKVYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKGPGPWSAPSVGTTLVPATEPPFIMAVKEDGLWSKPLCSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHIPSIVGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGGDATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPKVIPDPVQESSFRIEGHTSSFQILWNEPPAVDWGIVFYSVEFSTHSKFLIIEQQSLPIFTVEGLEPYTLFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSSGRYTKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQVRVFTSKGPGPFSDIVMSKTSEIKPCPYLISLLGNKIVFLDMDQNQVLWTFSLEGDVSTVGYTTDDEMGYFAQGDTLFLLNLRNHSSSKLFQDALVSDIRVIAVDWIARHLYFALKASQNGTQIFNVDLEHKVKSPREVKTCKAHTTIISFSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQHGRSQCSCNVTESELSGAMTVDTSDPDRPWIYFTKRQEIWAMDLEGCQCWKVIMVPTIPAGKRIISLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDKAYLSLASDMVEATILYATNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSSDRRHKMLESQENVARIEGLQPFSMYMIQIAVKNYYSEPLEHLPLGKEIQGQTKSGVPGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAKLSLLITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFDTPEKPSALVPENTSLQLDWKARSNVNLTGFWFELQKWKYNEFYHVKASCSQGPVYVCNITDLQPYTSYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKGTFQFRAVAANEIGLGEYSEISEDITLVEDGVWITETSFILTIIVGIFLVATVPLTFVWHRSLKSHKASKEGLSVLNDNDKELAELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPREKLSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNVSHCGEAAPTGGVINKGFEGEDDEMVTLNSDDTMPVALMETKNQEGLNYMVLATKCSQGEGSYEGPLGPKELGSCDLKKDKKQPQADKDFCQEPQVAYGSPGLSEGLNYACLAHSEHGDVSE"
misc_feature 131..385 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:238020" misc_feature order(353..358,362..367) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Cytokine receptor motif [active]" /db_xref="CDD:238020" misc_feature 1214..1504 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:238020" misc_feature order(1214..1216,1421..1423,1466..1468) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Interdomain contacts [active]" /db_xref="CDD:238020" misc_feature order(1469..1474,1478..1483) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Cytokine receptor motif [active]" /db_xref="CDD:238020" misc_feature 2342..2581 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:238020" misc_feature order(2342..2344,2528..2530,2573..2575) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Interdomain contacts [active]" /db_xref="CDD:238020" misc_feature 2621..2941 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:238020" misc_feature order(2621..2623,2858..2860,2903..2905) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Interdomain contacts [active]" /db_xref="CDD:238020" misc_feature order(2906..2911,2915..2920) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Cytokine receptor motif [active]" /db_xref="CDD:238020" misc_feature <4016..>4771 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Fibronectin type 3 domain [General function prediction only]; Region: FN3; COG3401" /db_xref="CDD:442628" misc_feature 4463..4738 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:238020" misc_feature order(4703..4708,4712..4717) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Cytokine receptor motif [active]" /db_xref="CDD:238020" misc_feature 4751..5032 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:238020" misc_feature order(5006..5011,5015..5020) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Cytokine receptor motif [active]" /db_xref="CDD:238020" misc_feature 5357..6142 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="Catalytic domain of the Protein Tyrosine Kinase, C-ros; Region: PTKc_c-ros; cd05044" /db_xref="CDD:270640" misc_feature order(5357..5359,5369..5371,5426..5428,5432..5434, 5570..5581,5588..5593,5729..5731,5741..5746,5750..5752, 5798..5800,5852..5866,5891..5893,5993..5995) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="active site" /db_xref="CDD:270640" misc_feature order(5357..5359,5369..5371,5426..5428,5432..5434, 5570..5581,5588..5593,5741..5746,5750..5752,5798..5800) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270640" misc_feature order(5729..5731,5741..5743,5852..5866,5891..5893, 5993..5995) /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270640" misc_feature 5795..5872 /gene="Ros1" /gene_synonym="c-ros; Ros-1" /note="activation loop (A-loop); other site" /db_xref="CDD:270640" ORIGIN
catcttccattggaagtcatggtgtgacattacgctggaaccctgccaacatctctggagtcaaatacataattcaatggaaatatgcccaacttccaggaagctggactttcacggagttccagaaactgcacctctcatcctgaacatggaaagctggagccctgatactgtggaggtcagctgggctccacctcatttcccaggtggacctattttgggttataatttaaggctcatcagtaaaaatcaaaaattagattcagggacacagagaaccagtttccagttttattctactctaccaaacaccacctacaggttttctatcgcagcagtcaatgaagttggtgaggggccagaagcagaatctacagttaccactccatccccatcagttcaagaagaagaacaatggctctttttatccagaaaaacttctctaagaaagaggtctttgaagtacttagtagatgaagcacattgcctttggtcagatgctatacaccataatattacaggaatatcagtctatgctcagcagcaagtggtttatttttcagaaggaactgtcatctggatgaagggggctgccaacatgtctgatgtgtctgacctgagaattttttaccaaggctcaggtctagtgtcttctatctccatagactggctgtaccaaaggatgtatttcatcatggataaactggtatatgtctgtgaattaaagaattgctcaaatttagaggaaatcactcccttctctcttattgcacctcagaaagttgtggttgactcctacaatgggtacctcttttatctcctgagagacggcatctacagagtcaatctccctttgccatctggcagggacaccaaagctgtgcgtattgtggagagtggcacattaaaggactttgcagtaaagccccaatccaagcgaatcatttacttcaatgacaccatgcaactcttcatgtcaacgtttctggatggctctgccttccaccgggtcctgccttgggtcccccttgtgactgtgaagagctttgcttgtgaaaacaatgacttcctcatcacagatggcaaggccatttttcagcaggactccctgtctttcaatgaattcatcgtgggatgtgacctgagtcacatagaagagtttgggtttggtaacttggtcatctttggctcctctgtccagtcataccctctgccaggacatccacaggaggtctcagtgctgtttggttctcgagaggcccttattcagtggacgcctcctgctctcgccataggagccagtccttccgcctggcagaactggacttatgaagtcaaagtttattcccaggacatccttgaaatcactcaagttttctcgaacataagcgggaccatgcttaatgtacccgaactgcagagttctacaaagtacactgtctctgtgagagcaagttctcctaaaggcccaggcccctggtcagcaccatcagtgggtaccaccttggtaccagctactgaaccaccattcatcatggctgtgaaagaagatgggctctggagcaaaccactctgtagttttggtccaggagaattcctgtcctctgatgtaggaaacgtgtcagatatggattggtacaacaacagcctctactacagtgacacaaaaggcaacgtttatgtgcggcctctgaatgggatggatatctcagagaattatcacatacccagcattgtaggagctggggctttggcctttgaatggctgggtcactttctctactgggctgggaagacatatgtgatccaaaggcagtctgtgttgacgggacacacggacattgtgactcatgtgaagctgttggtgaatgacatggctgtggattcagttggtggctatctctattggacaacactctactcagttgaaagcaccagactcaatggagaaagttctcttgtactacaggctcagccctggctctctggaaaaaaggttattgctctaacactagacctcagtgatgggctcctgtattggctggtgcaggacaatcagtgtattcatctgtacacagctgttcttcgaggatggagtggtggggatgctaccatcacagagtttgcagcctggagtacttctgaaatctcccagaatgcactgatgtactacagtggtagactcttctggatcaatggatttaggatcattacagcacaggaaataggtcagagaaccagtgtgtctgtttcggagccagcgaaattcaatcagttcacaattatacagacatctctcaagcctctgccaggaaacttttcctctactcccaaggttatcccagatcctgttcaggagtcttcatttcgaattgaaggacacacttcaagtttccaaatcctgtggaatgagccccctgcggtggactggggcatcgttttctacagtgtggaatttagcactcattccaagttcctgattattgaacaacagtctttacctatttttactgtggaaggactggagccctataccttatttaatctttctgtcactccttatacctactggggaaagggccaaaaaacatctctatcatttcgtgcacctgaatcagttccatcagcaccagaaaaccccagaatatttatattgtcaagcggaagatacaccaagaagaatgaagttgtggtagagttcaggtggaataaacctaagcatgaaaatggagtgctaaccaaatttgaaatcttctatcacatatctaaacaaagtggcacaaatagatcaactgaagactggatgtctgccagtgttatacccccagtgatgtcttttcaacttgaggctgtgagtcctgagtatactgttgccttccaggttagagtcttcacatccaaagggccagggccattttctgatatagtgatgtctaaaacatcagaaatcaagccatgtccgtatctcatatctcttctcggcaataagatcgtgtttctagacatggatcaaaatcaagttttgtggacattttccctggagggagacgtcagcacagtggggtacacaacagacgatgaaatggggtatttcgctcaaggagacacgctcttccttctgaatttgcgtaatcattccagttccaagcttttccaggatgcactggtttctgacattagagttattgctgttgattggattgcaaggcacctctactttgctctgaaagcatcacaaaacggaacacagatattcaatgttgaccttgaacacaaggtgaaatcccccagggaggtgaagacttgcaaagcacatacaacaataatttctttctctatatatcccctcttgagtcgcttgtattggacagaagtttcagatctgggccatcagatgttctactgcaatattagcaatcacacctcgcaacatgttctacaacccaaggcttcaaaccaacatggaaggagtcaatgttcttgtaatgtgacagaatctgagttaagtggggcaatgactgtggatacctctgacccagacagaccatggatatactttaccaaaaggcaagagatctgggccatggatctggaaggatgtcagtgttggaaagtcatcatggtacctactatccctgcaggaaaaagaatcattagcttaacagtggatggggagtttatatattggatcatgaaaacaaaggatgatgcccaaatttatcaagcaaagaagggaagcggggccatcctttcccaagtgaaggcctccaggagtaagcatatcttggcttacagttctgctctgcagccttttccagataaagcatatctgtctctagcttcagatatggtagaagcaactatattatatgccaccaacaccagcctcacactcaaattacctccagtcaagacaaacctcacgtggcatggtattacccaccccacgtcaacatacctgatttactatatggaagctaatagggcaaacagctctgacaggagacacaaaatgctggaatcacaggagaatgtagcccggattgaaggtctgcagccattttcaatgtacatgattcagatagctgtgaagaactattattcagagcctttagaacatttacctcttggaaaagagattcaaggacaaactaaaagtggagtgcctggggcagtttgtcatatcaacgcaactgtgttgtcggacaccagtctccatgtattctggacagaatcccataagccaaacggaccaaaagagtcagtccgctatcagctggttatgtcatacctggctcccattcctgagactcctctaagacagggtgaatttccaagtgccaagctttctctgctcatcactaaactatctggtggacagctctatgtgatgaaggttctggcgtgccaccctgaggaaatgtggtgtactgagagtcatcctgtcagtgtcaacatgtttgacacaccagagaaaccctctgccttggttccagagaacactagtctgcagttagattggaaggctcgatcaaacgttaacctcaccggattttggtttgaactccagaagtggaaatataatgagttttaccatgtcaaagcttcatgcagccaaggtccagtttatgtctgtaacatcacagatctacaaccttacacctcctataacattcgagtggtggtggtctatacgacaggagaaaatagctcctccattccagagagtttcaagacaaaagccggagtcccaagcaaaccaggtattcctaaattactagaagggagtaaaaattccatccagtgggaaaaagctgaagataatgggagcagattgatgtactacacccttgaggtcagaaaaggcatttcaaatgactcacagaaccagagttcaaggtggaaggtggtgtttaatgggtcctgcagtagcatttgcacatggagatcaaaaaacctaaaaggaacatttcagttcagagcagttgctgcaaatgaaattggacttggagaatatagtgaaatcagtgaagacattacattagtggaagatggtgtttggataacagaaacaagttttatacttactatcatagttgggatatttctggttgctacagtcccactgacctttgtctggcatagaagcttgaaaagtcacaaagcttccaaggaaggcctctcggttctcaacgacaacgacaaagagttggctgagcttcgaggtctggcggctggagtgggactggccaatgcctgctacgcagtacatactgttccaacccaagaagagattgaaaatcttcctgccttccctcgggagaagctgagcctgcgtcttttgttgggaagtggagcttttggagaagtgtatgaaggcacagctatagacatcctaggcgtgggaagtggagaaatcaaagtggcagtgaagaccttgaagaaaggttcaacagaccaggagaagattgagttcctgaaggaggcgcacctgatgagcaagtttaatcaccccaacattctgaagcagctgggagtctgtctgttaggcgaaccccagtacattattctggaactgatggaagggggagaccttctaagctatctgcgcaaagctcgggggacaacgtttcatggtccttcactcaccttgcttgaccttgtagagctgtgtgtagatatttcaaaaggctgcgtctacttggagcagatgcacttcattcacagggatctggcagctcggaattgccttgtatcagtgaaagactacaccagtcctcgggtagtcaagattggtgactttggattggcaagagaaatctataaaaatgattattatagaaagagaggggaaggcctgcttcctgttcggtggatggctcctgaaaacttgatggacggaatcttcacttctcagtctgatgtatggtcctttggaattttggtgtgggagattttaactctcggtcatcaaccttatccagcgcattccaaccttgatgttttaaactatgtgcaagcaggagggagactggagccaccaagaaattgtcctgatgatctgtggaatttaatgtcccaatgctgggctcaagaacctgaccaaagacccactttccataacattcaaaaccagcttcagttattcagaaatgttttcttaaacaatgtttctcattgtggagaagcagctcccaccggtggagtcatcaacaaaggctttgaaggtgaagatgatgaaatggtcactttgaactcagatgacacgatgccagttgccttgatggaaaccaagaaccaagaaggattaaattatatggtgcttgccacaaaatgtagccaaggtgaaggaagttatgagggtcctctaggccctaaggaacttgggtcatgtgatctgaagaaagacaagaagcaaccacaggcagacaaagatttctgccaggaaccacaggtggcttatggctctcctggcctgtctgaaggcctgaattatgcctgtcttgctcacagtgaacatggagatgtgtctgaataatagtgtctcgtaggaaatacagcactgagatcaacatcgtgttaagttacttgcagaaaagaataaagttgtggtggcagttgactctgaattgacacagtgaagttcctaagttctgatcttggttccaagagccatttggtttcactcagtgttctctttacctaaccttcagtggattatcagaggaacctttgcatacctggatatccctaagacaaatcctaagtctcggaagaaaacatcgctgttcctctcttctgaagtcctttacttcagagtactgcccaccctgatgtctgcggtgcagtaaaaacatctttgccaagtgggcagtgacaggaataggtccatgcaaggctgtgcgtgggggtggagtgggagtctgctgaggaccacctgaactgcagattaccttaaagaggatgcaggaaacaattagagacacatacaggaggggccagctcatgtgccatgaggaatcatctgtcacgctattattccaataaaatatcccctttaatcatcaccgtaaacccttttgtattttggaagcttggatgaacagctttaggcatagcaaaaatgggaccatgaaaatctctggatctcaaactttgacatttttgtggtctttaggtggcatacaaattatcttgtgatttaaaaaaatgatttttaatctattttttattttgtgtgtgtgagcgtttgcctgctggaggggagtgttggagctccgagaactggagttacaggtggctgtgaggtgccacagtgagttatgggaactgacctgcatccccctggaagaacagacagctcaccgaacccctgaccgtactcagctcctgtcttgtgatttttatgccaccatgaaaactggtgtaaggattgtttgggagaagacactgggatgtagctcaacaaagagcatttgactagcgtgaatgaaccccgtggttgtctccagcaccacacacacatgcgctcacactcactcatcattgtttcttgtcagacctattttatactaaaaatctagagtaaataatccttaaaatcagatgtaagtgactgtacacttttaattcaaaccgtgtaatttttatcacctgcatagaataataaacaattacatgaggacaattga
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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