LOCUS       XM_017313856            7047 bp    mRNA    linear   ROD 10-APR-2023
DEFINITION  PREDICTED: Mus musculus Ros1 proto-oncogene (Ros1), transcript
            variant X3, mRNA.
ACCESSION   XM_017313856
VERSION     XM_017313856.1
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000076.7) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2023_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/05/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="10"
     gene            1..7047
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Ros1 proto-oncogene; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 1 sample with
                     support for all annotated introns"
                     /db_xref="GeneID:19886"
                     /db_xref="MGI:MGI:97999"
     CDS             442..6996
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase ROS
                     isoform X3"
                     /protein_id="XP_017169345.1"
                     /db_xref="GeneID:19886"
                     /db_xref="MGI:MGI:97999"
                     /translation="

MKNICWLTLKLVKFVVLGCIIWISVAQSTVLSSCLTSCVTNLGRQLDSGTRYNLSEACIHGCQFWNSVDQETCALKCNDTYATICERESCEVGCSNAEGSYEEEVLESTELPTAPFASSIGSHGVTLRWNPANISGVKYIIQWKYAQLPGSWTFTETVSKLSYTVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPYGVPETAPLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKNQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIHHNITGISVYAQQQVVYFSEGTVIWMKGAANMSDVSDLRIFYQGSGLVSSISIDWLYQRMYFIMDKLVYVCELKNCSNLEEITPFSLIAPQKVVVDSYNGYLFYLLRDGIYRVNLPLPSGRDTKAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRVLPWVPLVTVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWTPPALAIGASPSAWQNWTYEVKVYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKGPGPWSAPSVGTTLVPATEPPFIMAVKEDGLWSKPLCSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHIPSIVGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGGDATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPKVIPDPVQESSFRIEGHTSSFQILWNEPPAVDWGIVFYSVEFSTHSKFLIIEQQSLPIFTVEGLEPYTLFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSSGRYTKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQVRVFTSKGPGPFSDIVMSKTSEIKPCPYLISLLGNKIVFLDMDQNQVLWTFSLEGDVSTVGYTTDDEMGYFAQGDTLFLLNLRNHSSSKLFQDALVSDIRVIAVDWIARHLYFALKASQNGTQIFNVDLEHKVKSPREVKTCKAHTTIISFSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQHGRSQCSCNVTESELSGAMTVDTSDPDRPWIYFTKRQEIWAMDLEGCQCWKVIMVPTIPAGKRIISLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDKAYLSLASDMVEATILYATNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSSDRRHKMLESQENVARIEGLQPFSMYMIQIAVKNYYSEPLEHLPLGKEIQGQTKSGVPGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAKLSLLITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFDTPEKPSALVPENTSLQLDWKARSNVNLTGFWFELQKWKYNEFYHVKASCSQGPVYVCNITDLQPYTSYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKGTFQFRAVAANEIGLGEYSEISEDITLVEDGVWITETSFILTIIVGIFLVATVPLTFVWHRSLKSHKASKEGLSVLNDNDKELAELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPREKLSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDL"

     misc_feature    775..978
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    order(1006..1011,1015..1020)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1060..1314
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1282..1287,1291..1296)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2143..2433
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(2143..2145,2350..2352,2395..2397)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(2398..2403,2407..2412)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    3550..3870
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(3550..3552,3787..3789,3832..3834)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(3835..3840,3844..3849)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    5095..5334
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    5392..5667
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(5632..5637,5641..5646)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    5680..5961
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(5935..5940,5944..5949)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    6286..6993
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl21453"
                     /db_xref="CDD:451246"
ORIGIN      

catagtcaaaacccaatttcctgcatagctcagtcaacctcaaagaagtgcggtggctgaccgacctaagtgtcctgtgtcaggattgtgtggcctggctcgctggaaagcaatctaagtttctcctgtttatttagcatgtgtagagctcttcctggatctaacttttagccagggaatgtcttttgttatgggagcaaaaggaagctaaactataaaatagccttgctgcgatgttctgggctatctaagatccaaaggtctaaactaatccaaaggcctcaatattctttttaaagagagaatgatattctaacattgcgaaagaaaacagaaaacctacttgtcacacttgcaactgaagtatgaagcctaaagagttcttaaagcaaggtggagctatgaggaccccagctgtgtaggaagccagccctcctgaggatgaagaacatctgctggctcaccctgaaacttgtgaagtttgtggtccttgggtgcatcatatggatttctgtggcacagagtacagttctgagcagctgcctaacgtcctgtgtaactaacctgggcaggcagcttgacagtggcacacggtacaatctgagtgaggcgtgcatccatggatgtcagttttggaactctgtagatcaggaaacgtgtgctttaaagtgtaatgacacctacgccaccatttgtgagagggagtcctgtgaggtcggctgcagcaatgcggagggtagctacgaagaggaagtgctggaaagcacagaacttcctacagcaccctttgcatcttccattggaagtcatggtgtgacattacgctggaaccctgccaacatctctggagtcaaatacataattcaatggaaatatgcccaacttccaggaagctggactttcacggagaccgtgtccaagctctcatacacggtggaacccctgcatccattcacagaatatatttttcgagtggtttggatcttcacagcccaactgcatctttattccccaccaagtcccagttacaggactcatccttatggagttccagaaactgcacctctcatcctgaacatggaaagctggagccctgatactgtggaggtcagctgggctccacctcatttcccaggtggacctattttgggttataatttaaggctcatcagtaaaaatcaaaaattagattcagggacacagagaaccagtttccagttttattctactctaccaaacaccacctacaggttttctatcgcagcagtcaatgaagttggtgaggggccagaagcagaatctacagttaccactccatccccatcagttcaagaagaagaacaatggctctttttatccagaaaaacttctctaagaaagaggtctttgaagtacttagtagatgaagcacattgcctttggtcagatgctatacaccataatattacaggaatatcagtctatgctcagcagcaagtggtttatttttcagaaggaactgtcatctggatgaagggggctgccaacatgtctgatgtgtctgacctgagaattttttaccaaggctcaggtctagtgtcttctatctccatagactggctgtaccaaaggatgtatttcatcatggataaactggtatatgtctgtgaattaaagaattgctcaaatttagaggaaatcactcccttctctcttattgcacctcagaaagttgtggttgactcctacaatgggtacctcttttatctcctgagagacggcatctacagagtcaatctccctttgccatctggcagggacaccaaagctgtgcgtattgtggagagtggcacattaaaggactttgcagtaaagccccaatccaagcgaatcatttacttcaatgacaccatgcaactcttcatgtcaacgtttctggatggctctgccttccaccgggtcctgccttgggtcccccttgtgactgtgaagagctttgcttgtgaaaacaatgacttcctcatcacagatggcaaggccatttttcagcaggactccctgtctttcaatgaattcatcgtgggatgtgacctgagtcacatagaagagtttgggtttggtaacttggtcatctttggctcctctgtccagtcataccctctgccaggacatccacaggaggtctcagtgctgtttggttctcgagaggcccttattcagtggacgcctcctgctctcgccataggagccagtccttccgcctggcagaactggacttatgaagtcaaagtttattcccaggacatccttgaaatcactcaagttttctcgaacataagcgggaccatgcttaatgtacccgaactgcagagttctacaaagtacactgtctctgtgagagcaagttctcctaaaggcccaggcccctggtcagcaccatcagtgggtaccaccttggtaccagctactgaaccaccattcatcatggctgtgaaagaagatgggctctggagcaaaccactctgtagttttggtccaggagaattcctgtcctctgatgtaggaaacgtgtcagatatggattggtacaacaacagcctctactacagtgacacaaaaggcaacgtttatgtgcggcctctgaatgggatggatatctcagagaattatcacatacccagcattgtaggagctggggctttggcctttgaatggctgggtcactttctctactgggctgggaagacatatgtgatccaaaggcagtctgtgttgacgggacacacggacattgtgactcatgtgaagctgttggtgaatgacatggctgtggattcagttggtggctatctctattggacaacactctactcagttgaaagcaccagactcaatggagaaagttctcttgtactacaggctcagccctggctctctggaaaaaaggttattgctctaacactagacctcagtgatgggctcctgtattggctggtgcaggacaatcagtgtattcatctgtacacagctgttcttcgaggatggagtggtggggatgctaccatcacagagtttgcagcctggagtacttctgaaatctcccagaatgcactgatgtactacagtggtagactcttctggatcaatggatttaggatcattacagcacaggaaataggtcagagaaccagtgtgtctgtttcggagccagcgaaattcaatcagttcacaattatacagacatctctcaagcctctgccaggaaacttttcctctactcccaaggttatcccagatcctgttcaggagtcttcatttcgaattgaaggacacacttcaagtttccaaatcctgtggaatgagccccctgcggtggactggggcatcgttttctacagtgtggaatttagcactcattccaagttcctgattattgaacaacagtctttacctatttttactgtggaaggactggagccctataccttatttaatctttctgtcactccttatacctactggggaaagggccaaaaaacatctctatcatttcgtgcacctgaatcagttccatcagcaccagaaaaccccagaatatttatattgtcaagcggaagatacaccaagaagaatgaagttgtggtagagttcaggtggaataaacctaagcatgaaaatggagtgctaaccaaatttgaaatcttctatcacatatctaaacaaagtggcacaaatagatcaactgaagactggatgtctgccagtgttatacccccagtgatgtcttttcaacttgaggctgtgagtcctgagtatactgttgccttccaggttagagtcttcacatccaaagggccagggccattttctgatatagtgatgtctaaaacatcagaaatcaagccatgtccgtatctcatatctcttctcggcaataagatcgtgtttctagacatggatcaaaatcaagttttgtggacattttccctggagggagacgtcagcacagtggggtacacaacagacgatgaaatggggtatttcgctcaaggagacacgctcttccttctgaatttgcgtaatcattccagttccaagcttttccaggatgcactggtttctgacattagagttattgctgttgattggattgcaaggcacctctactttgctctgaaagcatcacaaaacggaacacagatattcaatgttgaccttgaacacaaggtgaaatcccccagggaggtgaagacttgcaaagcacatacaacaataatttctttctctatatatcccctcttgagtcgcttgtattggacagaagtttcagatctgggccatcagatgttctactgcaatattagcaatcacacctcgcaacatgttctacaacccaaggcttcaaaccaacatggaaggagtcaatgttcttgtaatgtgacagaatctgagttaagtggggcaatgactgtggatacctctgacccagacagaccatggatatactttaccaaaaggcaagagatctgggccatggatctggaaggatgtcagtgttggaaagtcatcatggtacctactatccctgcaggaaaaagaatcattagcttaacagtggatggggagtttatatattggatcatgaaaacaaaggatgatgcccaaatttatcaagcaaagaagggaagcggggccatcctttcccaagtgaaggcctccaggagtaagcatatcttggcttacagttctgctctgcagccttttccagataaagcatatctgtctctagcttcagatatggtagaagcaactatattatatgccaccaacaccagcctcacactcaaattacctccagtcaagacaaacctcacgtggcatggtattacccaccccacgtcaacatacctgatttactatatggaagctaatagggcaaacagctctgacaggagacacaaaatgctggaatcacaggagaatgtagcccggattgaaggtctgcagccattttcaatgtacatgattcagatagctgtgaagaactattattcagagcctttagaacatttacctcttggaaaagagattcaaggacaaactaaaagtggagtgcctggggcagtttgtcatatcaacgcaactgtgttgtcggacaccagtctccatgtattctggacagaatcccataagccaaacggaccaaaagagtcagtccgctatcagctggttatgtcatacctggctcccattcctgagactcctctaagacagggtgaatttccaagtgccaagctttctctgctcatcactaaactatctggtggacagctctatgtgatgaaggttctggcgtgccaccctgaggaaatgtggtgtactgagagtcatcctgtcagtgtcaacatgtttgacacaccagagaaaccctctgccttggttccagagaacactagtctgcagttagattggaaggctcgatcaaacgttaacctcaccggattttggtttgaactccagaagtggaaatataatgagttttaccatgtcaaagcttcatgcagccaaggtccagtttatgtctgtaacatcacagatctacaaccttacacctcctataacattcgagtggtggtggtctatacgacaggagaaaatagctcctccattccagagagtttcaagacaaaagccggagtcccaagcaaaccaggtattcctaaattactagaagggagtaaaaattccatccagtgggaaaaagctgaagataatgggagcagattgatgtactacacccttgaggtcagaaaaggcatttcaaatgactcacagaaccagagttcaaggtggaaggtggtgtttaatgggtcctgcagtagcatttgcacatggagatcaaaaaacctaaaaggaacatttcagttcagagcagttgctgcaaatgaaattggacttggagaatatagtgaaatcagtgaagacattacattagtggaagatggtgtttggataacagaaacaagttttatacttactatcatagttgggatatttctggttgctacagtcccactgacctttgtctggcatagaagcttgaaaagtcacaaagcttccaaggaaggcctctcggttctcaacgacaacgacaaagagttggctgagcttcgaggtctggcggctggagtgggactggccaatgcctgctacgcagtacatactgttccaacccaagaagagattgaaaatcttcctgccttccctcgggagaagctgagcctgcgtcttttgttgggaagtggagcttttggagaagtgtatgaaggcacagctatagacatcctaggcgtgggaagtggagaaatcaaagtggcagtgaagaccttgaagaaaggttcaacagaccaggagaagattgagttcctgaaggaggcgcacctgatgagcaagtttaatcaccccaacattctgaagcagctgggagtctgtctgttaggcgaaccccagtacattattctggaactgatggaagggggagaccttctaagctatctgcgcaaagctcgggggacaacgtttcatggtccttcactcaccttgcttgaccttgtagagctgtgtgtagatatttcaaaaggctgcgtctacttggagcagatgcacttcattcacagggatctggcagctcggaattgccttgtatcagtgaaagactacaccagtcctcgggtagtcaagattggtgactttggattggcaagagaaatctataaaaatgattattatagaaagagaggggaaggcctgcttcctgttcggtggatggctcctgaaaacttgatggacggaatcttcacttctcagtctgatgtatggtcctttggaattttggtgtgggagattttaactctcggtcatcaaccttatccagcgcattccaaccttgatgttttaaactatgtgcaagcaggagggagactggagccaccaagaaattgtcctgatgatctgtgaagatgatgaaatggtcactttgaactcagatgacacgatgccagttgcctt

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