LOCUS       XM_011243147            8620 bp    mRNA    linear   ROD 10-APR-2023
DEFINITION  PREDICTED: Mus musculus Ros1 proto-oncogene (Ros1), transcript
            variant X1, mRNA.
ACCESSION   XM_011243147
VERSION     XM_011243147.2
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000076.7) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 22, 2016 this sequence version replaced XM_011243147.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2023_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/05/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="10"
     gene            1..8620
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Ros1 proto-oncogene; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     Protein, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 1 sample with
                     support for all annotated introns"
                     /db_xref="GeneID:19886"
                     /db_xref="MGI:MGI:97999"
     CDS             443..7468
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase ROS
                     isoform X1"
                     /protein_id="XP_011241449.1"
                     /db_xref="GeneID:19886"
                     /db_xref="MGI:MGI:97999"
                     /translation="

MKNICWLTLKLVKFVVLGCIIWISVAQSTVLSSCLTSCVTNLGRQLDSGTRYNLSEACIHGCQFWNSVDQETCALKCNDTYATICERESCEVGCSNAEGSYEEEVLESTELPTAPFASSIGSHGVTLRWNPANISGVKYIIQWKYAQLPGSWTFTETVSKLSYTVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPYGVPETAPLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKNQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIHHNITGISVYAQQQVVYFSEGTVIWMKGAANMSDVSDLRIFYQGSGLVSSISIDWLYQRMYFIMDKLVYVCELKNCSNLEEITPFSLIAPQKVVVDSYNGYLFYLLRDGIYRVNLPLPSGRDTKAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRVLPWVPLVTVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWTPPALAIGASPSAWQNWTYEVKVYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKGPGPWSAPSVGTTLVPATEPPFIMAVKEDGLWSKPLCSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHIPSIVGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGGDATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPKVIPDPVQESSFRIEGHTSSFQILWNEPPAVDWGIVFYSVEFSTHSKFLIIEQQSLPIFTVEGLEPYTLFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSSGRYTKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQVRVFTSKGPGPFSDIVMSKTSEIKPCPYLISLLGNKIVFLDMDQNQVLWTFSLEGDVSTVGYTTDDEMGYFAQGDTLFLLNLRNHSSSKLFQDALVSDIRVIAVDWIARHLYFALKASQNGTQIFNVDLEHKVKSPREVKTCKAHTTIISFSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQHGRSQCSCNVTESELSGAMTVDTSDPDRPWIYFTKRQEIWAMDLEGCQCWKVIMVPTIPAGKRIISLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDKAYLSLASDMVEATILYATNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSSDRRHKMLESQENVARIEGLQPFSMYMIQIAVKNYYSEPLEHLPLGKEIQGQTKSGVPGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAKLSLLITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFDTPEKPSALVPENTSLQLDWKARSNVNLTGFWFELQKWKYNEFYHVKASCSQGPVYVCNITDLQPYTSYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKGTFQFRAVAANEIGLGEYSEISEDITLVEDGVWITETSFILTIIVGIFLVATVPLTFVWHRSLKSHKASKEGLSVLNDNDKELAELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPREKLSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNVSHCGEAAPTGGVINKGFEGEDDEMVTLNSDDTMPVALMETKNQEGLNYMVLATKCSQGEGSYEGPLGPKELGSCDLKKDKKQPQADKDFCQEPQVAYGSPGLSEGLNYACLAHSEHGDVSE"

     misc_feature    776..979
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    order(1007..1012,1016..1021)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1061..1315
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1283..1288,1292..1297)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2144..2434
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(2144..2146,2351..2353,2396..2398)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(2399..2404,2408..2413)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    3551..3871
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(3551..3553,3788..3790,3833..3835)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(3836..3841,3845..3850)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    5096..5335
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    5393..5668
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(5633..5638,5642..5647)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    5681..5962
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(5936..5941,5945..5950)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    6287..7072
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     C-ros; Region: PTKc_c-ros; cd05044"
                     /db_xref="CDD:270640"
     misc_feature    order(6287..6289,6299..6301,6356..6358,6362..6364,
                     6500..6511,6518..6523,6659..6661,6671..6676,6680..6682,
                     6728..6730,6782..6796,6821..6823,6923..6925)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="active site"
                     /db_xref="CDD:270640"
     misc_feature    order(6287..6289,6299..6301,6356..6358,6362..6364,
                     6500..6511,6518..6523,6671..6676,6680..6682,6728..6730)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270640"
     misc_feature    order(6659..6661,6671..6673,6782..6796,6821..6823,
                     6923..6925)
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270640"
     misc_feature    6725..6802
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270640"
ORIGIN      

gcatagtcaaaacccaatttcctgcatagctcagtcaacctcaaagaagtgcggtggctgaccgacctaagtgtcctgtgtcaggattgtgtggcctggctcgctggaaagcaatctaagtttctcctgtttatttagcatgtgtagagctcttcctggatctaacttttagccagggaatgtcttttgttatgggagcaaaaggaagctaaactataaaatagccttgctgcgatgttctgggctatctaagatccaaaggtctaaactaatccaaaggcctcaatattctttttaaagagagaatgatattctaacattgcgaaagaaaacagaaaacctacttgtcacacttgcaactgaagtatgaagcctaaagagttcttaaagcaaggtggagctatgaggaccccagctgtgtaggaagccagccctcctgaggatgaagaacatctgctggctcaccctgaaacttgtgaagtttgtggtccttgggtgcatcatatggatttctgtggcacagagtacagttctgagcagctgcctaacgtcctgtgtaactaacctgggcaggcagcttgacagtggcacacggtacaatctgagtgaggcgtgcatccatggatgtcagttttggaactctgtagatcaggaaacgtgtgctttaaagtgtaatgacacctacgccaccatttgtgagagggagtcctgtgaggtcggctgcagcaatgcggagggtagctacgaagaggaagtgctggaaagcacagaacttcctacagcaccctttgcatcttccattggaagtcatggtgtgacattacgctggaaccctgccaacatctctggagtcaaatacataattcaatggaaatatgcccaacttccaggaagctggactttcacggagaccgtgtccaagctctcatacacggtggaacccctgcatccattcacagaatatatttttcgagtggtttggatcttcacagcccaactgcatctttattccccaccaagtcccagttacaggactcatccttatggagttccagaaactgcacctctcatcctgaacatggaaagctggagccctgatactgtggaggtcagctgggctccacctcatttcccaggtggacctattttgggttataatttaaggctcatcagtaaaaatcaaaaattagattcagggacacagagaaccagtttccagttttattctactctaccaaacaccacctacaggttttctatcgcagcagtcaatgaagttggtgaggggccagaagcagaatctacagttaccactccatccccatcagttcaagaagaagaacaatggctctttttatccagaaaaacttctctaagaaagaggtctttgaagtacttagtagatgaagcacattgcctttggtcagatgctatacaccataatattacaggaatatcagtctatgctcagcagcaagtggtttatttttcagaaggaactgtcatctggatgaagggggctgccaacatgtctgatgtgtctgacctgagaattttttaccaaggctcaggtctagtgtcttctatctccatagactggctgtaccaaaggatgtatttcatcatggataaactggtatatgtctgtgaattaaagaattgctcaaatttagaggaaatcactcccttctctcttattgcacctcagaaagttgtggttgactcctacaatgggtacctcttttatctcctgagagacggcatctacagagtcaatctccctttgccatctggcagggacaccaaagctgtgcgtattgtggagagtggcacattaaaggactttgcagtaaagccccaatccaagcgaatcatttacttcaatgacaccatgcaactcttcatgtcaacgtttctggatggctctgccttccaccgggtcctgccttgggtcccccttgtgactgtgaagagctttgcttgtgaaaacaatgacttcctcatcacagatggcaaggccatttttcagcaggactccctgtctttcaatgaattcatcgtgggatgtgacctgagtcacatagaagagtttgggtttggtaacttggtcatctttggctcctctgtccagtcataccctctgccaggacatccacaggaggtctcagtgctgtttggttctcgagaggcccttattcagtggacgcctcctgctctcgccataggagccagtccttccgcctggcagaactggacttatgaagtcaaagtttattcccaggacatccttgaaatcactcaagttttctcgaacataagcgggaccatgcttaatgtacccgaactgcagagttctacaaagtacactgtctctgtgagagcaagttctcctaaaggcccaggcccctggtcagcaccatcagtgggtaccaccttggtaccagctactgaaccaccattcatcatggctgtgaaagaagatgggctctggagcaaaccactctgtagttttggtccaggagaattcctgtcctctgatgtaggaaacgtgtcagatatggattggtacaacaacagcctctactacagtgacacaaaaggcaacgtttatgtgcggcctctgaatgggatggatatctcagagaattatcacatacccagcattgtaggagctggggctttggcctttgaatggctgggtcactttctctactgggctgggaagacatatgtgatccaaaggcagtctgtgttgacgggacacacggacattgtgactcatgtgaagctgttggtgaatgacatggctgtggattcagttggtggctatctctattggacaacactctactcagttgaaagcaccagactcaatggagaaagttctcttgtactacaggctcagccctggctctctggaaaaaaggttattgctctaacactagacctcagtgatgggctcctgtattggctggtgcaggacaatcagtgtattcatctgtacacagctgttcttcgaggatggagtggtggggatgctaccatcacagagtttgcagcctggagtacttctgaaatctcccagaatgcactgatgtactacagtggtagactcttctggatcaatggatttaggatcattacagcacaggaaataggtcagagaaccagtgtgtctgtttcggagccagcgaaattcaatcagttcacaattatacagacatctctcaagcctctgccaggaaacttttcctctactcccaaggttatcccagatcctgttcaggagtcttcatttcgaattgaaggacacacttcaagtttccaaatcctgtggaatgagccccctgcggtggactggggcatcgttttctacagtgtggaatttagcactcattccaagttcctgattattgaacaacagtctttacctatttttactgtggaaggactggagccctataccttatttaatctttctgtcactccttatacctactggggaaagggccaaaaaacatctctatcatttcgtgcacctgaatcagttccatcagcaccagaaaaccccagaatatttatattgtcaagcggaagatacaccaagaagaatgaagttgtggtagagttcaggtggaataaacctaagcatgaaaatggagtgctaaccaaatttgaaatcttctatcacatatctaaacaaagtggcacaaatagatcaactgaagactggatgtctgccagtgttatacccccagtgatgtcttttcaacttgaggctgtgagtcctgagtatactgttgccttccaggttagagtcttcacatccaaagggccagggccattttctgatatagtgatgtctaaaacatcagaaatcaagccatgtccgtatctcatatctcttctcggcaataagatcgtgtttctagacatggatcaaaatcaagttttgtggacattttccctggagggagacgtcagcacagtggggtacacaacagacgatgaaatggggtatttcgctcaaggagacacgctcttccttctgaatttgcgtaatcattccagttccaagcttttccaggatgcactggtttctgacattagagttattgctgttgattggattgcaaggcacctctactttgctctgaaagcatcacaaaacggaacacagatattcaatgttgaccttgaacacaaggtgaaatcccccagggaggtgaagacttgcaaagcacatacaacaataatttctttctctatatatcccctcttgagtcgcttgtattggacagaagtttcagatctgggccatcagatgttctactgcaatattagcaatcacacctcgcaacatgttctacaacccaaggcttcaaaccaacatggaaggagtcaatgttcttgtaatgtgacagaatctgagttaagtggggcaatgactgtggatacctctgacccagacagaccatggatatactttaccaaaaggcaagagatctgggccatggatctggaaggatgtcagtgttggaaagtcatcatggtacctactatccctgcaggaaaaagaatcattagcttaacagtggatggggagtttatatattggatcatgaaaacaaaggatgatgcccaaatttatcaagcaaagaagggaagcggggccatcctttcccaagtgaaggcctccaggagtaagcatatcttggcttacagttctgctctgcagccttttccagataaagcatatctgtctctagcttcagatatggtagaagcaactatattatatgccaccaacaccagcctcacactcaaattacctccagtcaagacaaacctcacgtggcatggtattacccaccccacgtcaacatacctgatttactatatggaagctaatagggcaaacagctctgacaggagacacaaaatgctggaatcacaggagaatgtagcccggattgaaggtctgcagccattttcaatgt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