LOCUS       XM_011240478            3006 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus argonaute RISC catalytic subunit 3 (Ago3),
            transcript variant X1, mRNA.
ACCESSION   XM_011240478
VERSION     XM_011240478.4
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000070.7) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 21, 2020 this sequence version replaced XM_011240478.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="4"
     gene            1..3006
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="argonaute RISC catalytic subunit 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 15 ESTs, 138 long SRA reads, 1 Protein, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 14 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:214150"
                     /db_xref="MGI:MGI:2446634"
     CDS             282..2804
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X1"
                     /protein_id="XP_011238780.1"
                     /db_xref="GeneID:214150"
                     /db_xref="MGI:MGI:2446634"
                     /translation="

MEIGSAGPIGAQPLFIVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSVKFVSRVSWHLLHEALAGGTLPEPLELDKPVSTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNFFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSALPDGSVSRRLAKQA"

     misc_feature    498..782
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    810..962
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    963..1325
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1119..1121,1164..1166,1206..1208,1218..1220,
                     1272..1274,1293..1295,1299..1301)
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1458..2735
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1869..1871,1881..1883,1917..1928,1935..1937,
                     1959..1961,1968..1970,1980..1982,1992..1994)
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2073..2075,2079..2081,2289..2291,2703..2705)
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gtgacgcgagcgggcttccgggggcgaccgggaaaagcgagcggctgcggcggcggggcggctggcgggtcgggaagctgcacgcgtcagcatctgtgggcgacgcaagttccggacctggttccagcgtcctcactcaggactgtcgccgctcttacctcgctgcaggctgtctgtctctcccgactgtgcctcttgtgcccggagctttccgagggcgtccgctcctcgcctctgtggtggcacccttctctcgtgaagcactccccccagctccatgaatggaaatcggctccgcaggacccattggggcccagcccctattcatcgtgcccagaagacctgggtatggcactatgggcaaacccattaaactgttggctaactgttttcaagttgaaatcccaaagattgatgtctacctctatgaagttgacatcaaaccagacaagtgtcctcgaagagtgaacagagaagtagttgattcaatggttcagcattttaaagtgactatatttggagaccgtagaccagtttatgatggaaaaagaagcctttatacagccaatccacttcctgtggcaaccactggggtagatttagatgttacattacctggggaaggtggaaaagatcgacctttcaaggtgtcagtcaaatttgtgtctcgagtcagctggcacctactacatgaagcactggctggagggactttgcctgagccactggaattagacaagcctgtcagcactaaccccgtccatgccgttgacgtggtgctccgacatctgccctctatgaaatatacgcctgtggggcgttcctttttctcagctccagaaggatatgaccaccctctgggagggggcagggaagtatggtttggattccatcagtctgttcggcctgccatgtggaaaatgatgctaaatattgatgtttctgccactgccttttacaaagcacaacctgtaattcagttcatgtgtgaagttcttgacattcacaacattgatgaacaacccagacccctgactgattctcatcgggtaaaattcactaaggagataaaaggtctgaaagttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacgagaaggcctgccagccaccaaacctttcctttacagctagaaaatggccaaactgtggagaggactgtggctcagtatttcagagaaaagtacacgctgcagctgaagtacccacaccttccctgcctgcaagtggggcaggagcagaagcatacatacctgccactagaagtctgtaatattgtggctgggcaaaggtgtatcaagaaactaacggacaatcagacttctacaatgataaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcagtttaaagtgcgggatgaaatggcccatgtgacaggacgtgtacttccagcacctatgctccagtacggaggacggaaccggacagtagccacacccagccacggagtatgggacatgcgaggaaaacagttccacacaggagtcgaaatcaaaatgtgggctattgcttgctttgccacacagaggcagtgcagagaagaaatactaaaaggtttcacagaccagcttcggaagatttccaaggatgcagggatgcccatccagggtcagccatgcttctgcaaatacgcacagggggcagacagcgtggagcccatgttccggcatctcaagaacacctactcaggactgcagctcattatcgtcatcctgcccgggaagacaccagtgtatgcggaagtgaaacgtgtgggagatacacttttgggtatggccacacagtgtgtacaagtcaagaatgtaataaaaacatctcctcaaactctttcaaacttgtgcctaaagatcaatgttaaacttggaggaatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatcttcctgggcgcagatgtcacacacccgcctgctggtgacggaaaaaagccctccattgctgctgttgtaggtagtatggatgcccatccaagcagatactgtgccacagtaagagttcagagaccccgacaggaaatcatccaggacttggcctccatggtccgggaactgctcatccaattttataaatcaacccgattcaaacctactcgtataatcttctatcgggatggtgtttcagaaggacagttcagacaggtattatattatgagctactggcaattcgagaagcctgtatcagtttggaaaaagactatcaacctggaataacctacattgttgttcagaagagacatcatacacggttgttctgtgctgataggacagaaagggttggaagaagcggcaacatcccagctggaaccacggtggataccgacattactcacccatatgaattcgacttttatctctgtagccatgctggaatacagggtaccagccgtccttcacactatcatgttttatgggatgacaacttctttactgcagatgaacttcagctgctcacttaccagctctgtcacacttacgtacgctgtacaagatctgtttctatccctgcaccagcatattacgctcacctggtggcattcagagccagatatcatcttgtggacaaggaacatgacagtgccctgccagatggctcagtcagtagaagacttgccaaacaagcctgacagcctgacctaggctcagtcatcagaactcaggatggaactagagaactgactcctgatggttgtcctcagacctctctgtgggcaccatggcataaatggaccaacaaacacaagacaacaacagcaattgtaataataaataacttttcatgagcatgacttcatttataataaagataattcaccattctgcatcctg

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