LOCUS       NR_151663               1946 bp    RNA     linear   ROD 06-AUG-2023
DEFINITION  Mus musculus transmembrane protein 38A (Tmem38a), transcript
            variant 4, non-coding RNA.
ACCESSION   NR_151663
VERSION     NR_151663.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Murakami M, Toyama Y, Yonekura M, Ohba T, Matsuzaki Y, Sawamura D,
            Murakami AM, Nishi M, Itagaki S, Tomita H and Takeshima H.
  TITLE     Decreased cardiac pacemaking and attenuated beta-adrenergic
            response in TRIC-A knockout mice
  JOURNAL   PLoS One 15 (12), e0244254 (2020)
   PUBMED   33347504
  REMARK    GeneRIF: Decreased cardiac pacemaking and attenuated
            beta-adrenergic response in TRIC-A knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Zhou X, Park KH, Yamazaki D, Lin PH, Nishi M, Ma Z, Qiu L, Murayama
            T, Zou X, Takeshima H, Zhou J and Ma J.
  TITLE     TRIC-A Channel Maintains Store Calcium Handling by Interacting With
            Type 2 Ryanodine Receptor in Cardiac Muscle
  JOURNAL   Circ Res 126 (4), 417-435 (2020)
   PUBMED   31805819
  REMARK    GeneRIF: Data suggest a function for TRIC-A protein (TRIC-A) as an
            accessory protein that interacts with ryanodine receptor calcium
            release channel (RyR2) to modulate intracellular Ca2+ signaling.
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   O'Brien F, Eberhardt D, Witschas K, El-Ajouz S, Iida T, Nishi M,
            Takeshima H, Sitsapesan R and Venturi E.
  TITLE     Enhanced activity of multiple TRIC-B channels: an endoplasmic
            reticulum/sarcoplasmic reticulum mechanism to boost counterion
            currents
  JOURNAL   J Physiol 597 (10), 2691-2705 (2019)
   PUBMED   30907436
  REMARK    GeneRIF: The role of TRIC-A and TRIC-B channels in skeletal muscle
            sarcoplasmic reticulum channels is reported.
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Robson MI, de Las Heras JI, Czapiewski R, Le Thanh P, Booth DG,
            Kelly DA, Webb S, Kerr ARW and Schirmer EC.
  TITLE     Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane
            Proteins Enhances Repression of Critical Developmental Genes during
            Myogenesis
  JOURNAL   Mol Cell 62 (6), 834-847 (2016)
   PUBMED   27264872
  REMARK    GeneRIF: Three muscle-specific nuclear membrane proteins, NET39,
            Tmem38A, and WFS1, direct specific myogenic genes to the nuclear
            periphery to facilitate their repression during myogenesis.
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Zhou X, Lin P, Yamazaki D, Park KH, Komazaki S, Chen SR, Takeshima
            H and Ma J.
  TITLE     Trimeric intracellular cation channels and sarcoplasmic/endoplasmic
            reticulum calcium homeostasis
  JOURNAL   Circ Res 114 (4), 706-716 (2014)
   PUBMED   24526676
  REMARK    GeneRIF: TRIC-A and TRIC-B seem to have differential functions in
            Ca(2+) signaling in excitable and nonexcitable cells.
            Review article
            Erratum:[Circ Res. 2020 May 8;126(10):e119. PMID: 32379571]
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D,
            Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H,
            Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A,
            Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T and
            Takeshima H.
  TITLE     TRIC-A channels in vascular smooth muscle contribute to blood
            pressure maintenance
  JOURNAL   Cell Metab 14 (2), 231-241 (2011)
   PUBMED   21803293
  REMARK    GeneRIF: TRIC-A channels contribute to maintaining blood pressure,
            while TRIC-A SNPs could provide biomarkers for constitutional
            diagnosis and personalized medical treatment of essential
            hypertension.
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Zhao X, Yamazaki D, Park KH, Komazaki S, Tjondrokoesoemo A, Nishi
            M, Lin P, Hirata Y, Brotto M, Takeshima H and Ma J.
  TITLE     Ca2+ overload and sarcoplasmic reticulum instability in tric-a null
            skeletal muscle
  JOURNAL   J Biol Chem 285 (48), 37370-37376 (2010)
   PUBMED   20858894
  REMARK    GeneRIF: Absence of TRIC-A leads to instability of Ca(2+) movement
            across the sarcoplasmic reticulum membrane.
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Yamazaki D, Yamazaki T and Takeshima H.
  TITLE     New molecular components supporting ryanodine receptor-mediated
            Ca(2+) release: roles of junctophilin and TRIC channel in embryonic
            cardiomyocytes
  JOURNAL   Pharmacol Ther 121 (3), 265-272 (2009)
   PUBMED   19095005
  REMARK    Review article
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Bleunven C, Treves S, Jinyu X, Leo E, Ronjat M, De Waard M, Kern G,
            Flucher BE and Zorzato F.
  TITLE     SRP-27 is a novel component of the supramolecular signalling
            complex involved in skeletal muscle excitation-contraction coupling
  JOURNAL   Biochem J 411 (2), 343-349 (2008)
   PUBMED   18035970
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Yazawa M, Ferrante C, Feng J, Mio K, Ogura T, Zhang M, Lin PH, Pan
            Z, Komazaki S, Kato K, Nishi M, Zhao X, Weisleder N, Sato C, Ma J
            and Takeshima H.
  TITLE     TRIC channels are essential for Ca2+ handling in intracellular
            stores
  JOURNAL   Nature 448 (7149), 78-82 (2007)
   PUBMED   17611541
  REMARK    GeneRIF: TRIC channels are likely to act as counter-ion channels
            that function in synchronization with Ca2+ release from
            intracellular stores
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC172623.3 and AC182435.3.
            
            Transcript Variant: This variant (4) lacks three internal exons
            compared to variant 1. This variant is represented as non-coding
            because it lacks a large portion of the coding region found in
            variant 1.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.164220.1,
                                           SRR7345562.3830973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               AC172623.3         7322-7726           c
            406-523             AC182435.3         30926-31043
            524-1946            AC182435.3         32088-33510
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Mus musculus"
                     /mol_type="transcribed RNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.08 cM"
     gene            1..1946
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /note="transmembrane protein 38A"
                     /db_xref="GeneID:74166"
                     /db_xref="MGI:MGI:1921416"
     misc_RNA        1..1946
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /product="transmembrane protein 38A, transcript variant 4"
                     /db_xref="GeneID:74166"
                     /db_xref="MGI:MGI:1921416"
     exon            1..405
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    282..533
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_144534.2"
                     /note="predicted ORF does not meet quality criteria for
                     protein coding locus with longer protein data"
                     /db_xref="GeneID:74166"
     exon            406..523
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1946
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

attctaactacgcagatgtttaaggacaagattccctcttgtgtgtgctggatgcaggggacagatcgcctttttggctctgttgaacgagttctgacgtccctacggccccgcattttgggctcccggctgctaggagtcccccaccacccctcctctcccgaggggtgggggcaggcggggggcggtgcctggcagtggggcgggctcagtggcgagggagcattcgtcgggcagcggggcgcgggacgcacggggccggggaggcgccctccatcgccatggacctgatgtcagcgctgagcctgggcgagctagcgctcagcttctcgcgggtgccgctcttccctgttttcgacctcagctacttcatcgtctccatcatctacctgaagtatgagccagccccaccaaggccagtctgtatggagccatcctgttcaccttgcagcagactcgctggctcccagtgtccaaggccagcctcattttcgtcttcaccatgtttatggtgtcatgtaaggtgttcctgacagccacacactcccacagttctccatttgatatcctggagggttacatctgcccagtgctgtttggggcaacttggggaggcgaccatcaccatgacaaccatggagcaccacatggcatgggactaggcacccagcactccggcctgcctgccaaggccaaggaagagctgggcgaaggatccaggaagaagaagaccaagaaagcggattaggggttggccccaggaatccactgcgtgcttggtagaaggatgtggactcaaagaaactcagaacttaggggcattcagggctcagaccctcccctccccccgccctgctctctaccaccctcaacttccccatctgcagtttggagccatcagcaattccaagggctgatgtgggctaaattagtgtggaggaattcaacagatgtggaaaaccctgccctctgccagacccctcaaaaggtcacagcctttgggggcacacagtctaggcccaaagccctggctggtaggctcttggttttcattctgtgttctgtctaattatatcttgtaactaaaagaatttaaagccacatggagactcaattatctagatcctctcgagagccaggtgctggggtcccatgtccttccgcactcaggacctccctagaattttgtgactcctgctggacatctttaggcaaatggccttccttctctgagccttctgtttctgttctgtagcatggagaccccaggtcctcctgtgtacaaaagggtctttataatttcaagcagttgcttaagcagcgtgctagtgagaaggagactggagcagcatgaaggacagtggcaggctgcttggtatgtaggccatttgtgtttgaggccagaaggtctcaccagatactcagctgagcatgagcaggcacatttagggcagactgctaacaggaggggggcttgagttcctaggtgcccacaggtaagaggtgtgggtgcagagcagagggtccaagagccaacagccttggttactcacaattgggctctgggtgtatcaggtgtccctcatgcctgatcagcatagttcattcagtcattcaacaaacacacagatccacacatgctcgctatacagtgtcatgctgctcctcttaggagcgagccttatacaggggaagggccatggtcgccaaagtctccagggcacctgagagaggtgagcatggggtcctgctggtctcaggcttatgtgaggctcagatctagttgaagtacccagtgtagcccatttgttgagaaaatgctcctcataactttgcctggaggtagggtaggccctgaggctggaagctcccgagtttcatccccttgatgtcaatcaaagctcagtgtgagtgatcagccaataaatctggtgcgagtaaatcaa

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