2024-11-01 07:56:31, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NR_039559 64 bp RNA linear ROD 21-AUG-2023 DEFINITION Mus musculus microRNA 5100 (Mir5100), microRNA. ACCESSION NR_039559 VERSION NR_039559.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 64) AUTHORS Mierzejewski B, Grabowska I, Michalska Z, Zdunczyk K, Zareba F, Irhashava A, Chrzaszcz M, Patrycy M, Streminska W, Janczyk-Ilach K, Koblowska M, Iwanicka-Nowicka R, Gromadka A, Kowalski K, Ciemerych MA and Brzoska E. TITLE SDF-1 and NOTCH signaling in myogenic cell differentiation: the role of miRNA10a, 425, and 5100 JOURNAL Stem Cell Res Ther 14 (1), 204 (2023) PUBMED 37582765 REMARK GeneRIF: SDF-1 and NOTCH signaling in myogenic cell differentiation: the role of miRNA10a, 425, and 5100. Publication Status: Online-Only REFERENCE 2 (bases 1 to 64) AUTHORS Aomatsu A, Kaneko S, Yanai K, Ishii H, Ito K, Hirai K, Ookawara S, Kobayashi Y, Sanui M and Morishita Y. TITLE MicroRNA expression profiling in acute kidney injury JOURNAL Transl Res 244, 1-31 (2022) PUBMED 34871811 REMARK GeneRIF: MicroRNA expression profiling in acute kidney injury. REFERENCE 3 (bases 1 to 64) AUTHORS Wang H, Cui Y, Luan J, Zhou X, Li C, Li H, Shi L and Han J. TITLE MiR-5100 promotes osteogenic differentiation by targeting Tob2 JOURNAL J Bone Miner Metab 35 (6), 608-615 (2017) PUBMED 27873073 REMARK GeneRIF: These results revealed a new molecular mechanism that fine-tunes osteoblast differentiation through miR-5100/Tob2/osterix networks. REFERENCE 4 (bases 1 to 64) AUTHORS Li,C.J., Cheng,P., Liang,M.K., Chen,Y.S., Lu,Q., Wang,J.Y., Xia,Z.Y., Zhou,H.D., Cao,X., Xie,H., Liao,E.Y. and Luo,X.H. TITLE MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation JOURNAL J Clin Invest 125 (4), 1509-1522 (2015) PUBMED 25751060 REFERENCE 5 (bases 1 to 64) AUTHORS Polikepahad S and Corry DB. TITLE Profiling of T helper cell-derived small RNAs reveals unique antisense transcripts and differential association of miRNAs with argonaute proteins 1 and 2 JOURNAL Nucleic Acids Res 41 (2), 1164-1177 (2013) PUBMED 23185045 REFERENCE 6 (bases 1 to 64) AUTHORS Spierings DC, McGoldrick D, Hamilton-Easton AM, Neale G, Murchison EP, Hannon GJ, Green DR and Withoff S. TITLE Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage JOURNAL Blood 117 (20), 5340-5349 (2011) PUBMED 21403133 REFERENCE 7 (bases 1 to 64) AUTHORS Kozomara A and Griffiths-Jones S. TITLE miRBase: integrating microRNA annotation and deep-sequencing data JOURNAL Nucleic Acids Res 39 (Database issue), D152-D157 (2011) PUBMED 21037258 REFERENCE 8 (bases 1 to 64) AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ. TITLE miRBase: microRNA sequences, targets and gene nomenclature JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006) PUBMED 16381832 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AL596215.7. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611515.1, JF446399.1 [ECO:0000345] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-64 AL596215.7 157986-158049 c FEATURES Location/Qualifiers source 1..64 /organism="Mus musculus" /mol_type="transcribed RNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="11" /map="11 37.81 cM" gene 1..64 /gene="Mir5100" /gene_synonym="mir-5100; mmu-mir-5100; mu-mir-5100" /note="microRNA 5100" /db_xref="GeneID:100628625" /db_xref="MGI:MGI:4950420" /db_xref="miRBase:MI0018008" precursor_RNA 1..64 /gene="Mir5100" /gene_synonym="mir-5100; mmu-mir-5100; mu-mir-5100" /product="microRNA 5100" /db_xref="GeneID:100628625" /db_xref="MGI:MGI:4950420" /db_xref="miRBase:MI0018008" exon 1..64 /gene="Mir5100" /gene_synonym="mir-5100; mmu-mir-5100; mu-mir-5100" /inference="alignment:Splign:2.1.0" ncRNA 36..56 /ncRNA_class="miRNA" /gene="Mir5100" /gene_synonym="mir-5100; mmu-mir-5100; mu-mir-5100" /product="mmu-miR-5100" /db_xref="miRBase:MIMAT0020607" /db_xref="GeneID:100628625" /db_xref="MGI:MGI:4950420" /db_xref="miRBase:MI0018008" ORIGIN
gtgggagggaggacttgggaactgaagagcagagttcgaatcccagcggtgcctcttcccgact
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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