LOCUS       NM_183201               5989 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus schlafen 5 (Slfn5), mRNA.
ACCESSION   NM_183201
VERSION     NM_183201.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5989)
  AUTHORS   Nakagawa K, Matsuki T, Zhao L, Kuniyoshi K, Tanaka H, Ebina I,
            Yoshida KJ, Nabeshima H, Fukushima K, Kanemaru H, Yamane F,
            Kawasaki T, Machida T, Naito H, Takakura N, Satoh T and Akira S.
  TITLE     Schlafen-8 is essential for lymphatic endothelial cell activation
            in experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 30 (2), 69-78 (2018)
   PUBMED   29528433
REFERENCE   2  (bases 1 to 5989)
  AUTHORS   Mavrommatis E, Arslan AD, Sassano A, Hua Y, Kroczynska B and
            Platanias LC.
  TITLE     Expression and regulatory effects of murine Schlafen (Slfn) genes
            in malignant melanoma and renal cell carcinoma
  JOURNAL   J Biol Chem 288 (46), 33006-33015 (2013)
   PUBMED   24089532
  REMARK    GeneRIF: several mouse Slfn genes are up-regulated in response to
            IFN treatment of mouse melanoma and renal cell carcinoma cells,
            including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8.
REFERENCE   3  (bases 1 to 5989)
  AUTHORS   Bustos O, Naik S, Ayers G, Casola C, Perez-Lamigueiro MA,
            Chippindale PT, Pritham EJ and de la Casa-Esperon E.
  TITLE     Evolution of the Schlafen genes, a gene family associated with
            embryonic lethality, meiotic drive, immune processes and
            orthopoxvirus virulence
  JOURNAL   Gene 447 (1), 1-11 (2009)
   PUBMED   19619625
REFERENCE   4  (bases 1 to 5989)
  AUTHORS   Neumann B, Zhao L, Murphy K and Gonda TJ.
  TITLE     Subcellular localization of the Schlafen protein family
  JOURNAL   Biochem Biophys Res Commun 370 (1), 62-66 (2008)
   PUBMED   18355440
REFERENCE   5  (bases 1 to 5989)
  AUTHORS   Geserick P, Kaiser F, Klemm U, Kaufmann SH and Zerrahn J.
  TITLE     Modulation of T cell development and activation by novel members of
            the Schlafen (slfn) gene family harbouring an RNA helicase-like
            motif
  JOURNAL   Int Immunol 16 (10), 1535-1548 (2004)
   PUBMED   15351786
REFERENCE   6  (bases 1 to 5989)
  AUTHORS   Le Bras S, Cohen-Tannoudji M, Guyot V, Vandormael-Pournin S,
            Coumailleau F, Babinet C and Baldacci P.
  TITLE     Transcript map of the Ovum mutant (Om) locus: isolation by exon
            trapping of new candidate genes for the DDK syndrome
  JOURNAL   Gene 296 (1-2), 75-86 (2002)
   PUBMED   12383505
REFERENCE   7  (bases 1 to 5989)
  AUTHORS   Schwarz DA, Katayama CD and Hedrick SM.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036486.1, AK040359.1 and AL603745.16.
            
            On May 30, 2009 this sequence version replaced NM_183201.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036486.1, AK040359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK036486.1         2-15
            15-2558             AK040359.1         2-2545
            2559-5989           AL603745.16        77598-81028
FEATURES             Location/Qualifiers
     source          1..5989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..5989
                     /gene="Slfn5"
                     /note="schlafen 5"
                     /db_xref="GeneID:327978"
                     /db_xref="MGI:MGI:1329004"
     exon            1..94
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     exon            95..160
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1188
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2843
                     /gene="Slfn5"
                     /note="expressesd sequence AI956840"
                     /codon_start=1
                     /product="schlafen family member 5"
                     /protein_id="NP_899024.3"
                     /db_xref="CCDS:CCDS25153.1"
                     /db_xref="GeneID:327978"
                     /db_xref="MGI:MGI:1329004"
                     /translation="

MSFLEDLELNFAECIQDGGKATLGVRQREEMDTTHCMKQNEIISQAVCALLNSGGGVVRVEIENGDYNFERDGVGLNLPPLFRNHLDEMLYGKLFLIYVSSWDVAASHVRLATLCSNLYHRCGTFTEVMDPEKALKFLKRVQDPRILGDSDSLNLQEAPVDDAQMILASDLFHSPQLQYLEKLNFTKSSHVEFQMFSADLSQGIRERLPKCVSALANSEGGYVFFGVHDETRHVIGCEKEKINCTNLKSTIDACIRKMPVYHFCGQNHKVQYELKFLEVYDKEALHGYVCAIKVERFCCAAFAKAPDSWEIKDNNKKPLTANDWASRMIEINPDLSSFPQMIPWKSMLNTTPCSKTVFTHKYLKCVEDLQKDYFPVSPNRITYTPESVYKDLFADYRGLRNLINMEMRCFSQGILIFSHSWAVDLGLQRRQDVICDALLISPNNVPILYTICNKWDLGNRHYSMKVARTLKQKLVNMGGYPGRLGIIPLVLPLGSHQRVRNDLEMPVYPESYNFITTQQVEALLQSLVIILFGFRPLLNEELNLESETVALLSDQQYGLLSTNLSKHREMFVHGLPGSGKTTLALMIVGKIRNVFNCQADNILYICENQSLKRFIVRKNVCQAVTRKTFMKNTFDNVQHIIVDEAQNFRTEDGNWYAKAKAITQRARDGPGVLYIFLDYFQINHLCCSGLPELQHQKPLLKLTRMLRSGDNITSYLQDIMHQIRENPPPNVPQEALMVGEELEWGPDVTGNLEITDNLNLEQMSVYVAEKCQSLWRSGYFTDVAVLFTRARDIEKCRDKLLLAMRRRSMSQLAEEPSLLVQVREGLDSLGSHVVLESVHRFSGMERSIVFGIIPMGSETAIFYNALLCLASRARTHLYIVKVVF"

     misc_feature    <315..1172
                     /gene="Slfn5"
                     /note="hypothetical protein; Provisional; Region:
                     PHA02782"
                     /db_xref="CDD:165147"
     misc_feature    1899..>2465
                     /gene="Slfn5"
                     /note="Uncharacterized conserved protein (DUF2075);
                     Region: DUF2075; pfam09848"
                     /db_xref="CDD:430875"
     misc_feature    1899..>2123
                     /gene="Slfn5"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; Region: DEAD-like_helicase_N; cl28899"
                     /db_xref="CDD:452890"
     misc_feature    order(1914..1934,2115..2117)
                     /gene="Slfn5"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:350670"
     exon            1189..1314
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..2038
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..5989
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cacagggtagaggtctccactctggacccaggacatcagctctgattccaggagacggggcgccctgcgggctgcggaggacagactccggcggtttcctggaggttccagcaagacaccatctcaccacttgccgctctagagctcaacctttggccaggaaaagatttcagctaaaggcggagaagatgagtttcctggaggatttggaactgaactttgcggaatgtatacaagatggaggaaaagcgacccttggggttaggcaaagggaggaaatggataccacacactgcatgaaacagaacgaaatcatctcgcaagccgtgtgcgctctgctgaattccggtggcggagtggtcagggttgagattgagaacggagactataattttgagagggatggagttggcttgaatctgccaccattgttcagaaaccatttagacgagatgctgtatggaaagctctttttaatatatgtgagttcgtgggacgtggcagcctctcacgtgaggctcgctaccctgtgctccaatttgtaccacagatgtggaacatttactgaggtcatggatcctgaaaaagccctgaaattcctcaaaagggtccaggatcctaggattcttggtgactctgactcgctaaatctacaggaagctcctgtagatgacgctcagatgatcttagcttctgatttgtttcatagcccgcagctccagtacctggaaaaactcaacttcacaaagtcctcacacgttgaatttcaaatgttctcggcagacctttcccagggcattagagagagacttcccaagtgtgtttctgcacttgccaattctgaagggggctatgtgttttttggtgtgcatgatgagacccgtcatgtcattggatgtgaaaaggaaaagataaattgtaccaacttgaaatctactatcgatgcctgtatcaggaagatgcctgtctaccacttctgtggacaaaaccacaaagtgcaatatgagcttaaattccttgaagtgtatgataaggaggccctccatgggtatgtctgtgcaatcaaggtcgaacgattctgctgtgcagcatttgccaaagcgcccgattcctgggagataaaggacaataataagaagccgctaactgcgaatgactgggcctctcggatgatagaaatcaacccagacctttccagtttccctcagatgatcccctggaagagtatgttaaacaccacaccctgcagcaagaccgtgttcacacataaatatttgaaatgtgtggaagacctgcagaaggattactttccagtgtcacccaacaggattacatatactccagagagcgtctacaaggacctcttcgcagattacagaggactaagaaacttaataaatatggaaatgcgctgtttctctcaagggatattgatcttctcccacagctgggctgtagatctaggtcttcagaggaggcaagatgtcatctgtgacgctcttctgatttccccgaacaacgttccaatcctgtacaccatttgcaacaagtgggatctggggaacaggcactattccatgaaagttgcccgtaccctgaagcagaagctggtgaacatgggtggctaccctggaagattaggcatcattcccttggtcttaccactgggttctcaccaaagagtaaggaatgacttagaaatgccagtgtaccccgaatcctataacttcataaccacacagcaggtggaagctctgttgcaatctcttgtgatcatcttgtttgggttcagacccctgttaaatgaagagttaaacttggagtctgagactgtggccctgctctcagaccaacagtacgggttgctttcaactaacctgagcaagcacagagagatgtttgttcacggcttacctggatcagggaagaccactctagctctcatgatcgtggggaagatcaggaatgtgttcaactgtcaagctgacaacattctttacatctgtgagaaccagtccttgaagaggttcattgtgaggaaaaacgtttgccaggcagtgacacggaaaaccttcatgaaaaatacctttgataatgtgcaacatatcatcgtggacgaagctcagaatttccgaacggaggacgggaactggtacgcaaaggccaaagccatcactcagagagcgagagatggcccaggagttctctacatttttctggattactttcagatcaatcacttgtgttgcagtggcctccctgagctccaacaccagaagccgttattgaagctcaccagaatgctccgcagcggagacaacataaccagctaccttcaggatataatgcatcaaatcagagaaaatcctcccccaaatgtcccccaagaagccttgatggtgggtgaagaacttgaatggggtccagatgtcacaggcaacttagagattactgataacttgaatttggagcagatgtcagtctatgtagcagagaaatgccagagtctttggaggtctggctatttcacggatgttgctgttcttttcactagagccagagatatagaaaaatgtagagacaagcttctgctagcaatgaggaggaggtccatgtctcagctcgctgaggagcccagtttactagtgcaggtcagggaggggttggatagtctgggtagtcacgtcgtgttggagagtgttcaccgattttcaggcatggaaagaagtattgtgtttgggatcattccaatgggatctgagacggccattttctacaatgctctgctctgtctggcttccagggcaaggacacatctgtatattgtaaaggttgtgttttgataggaagatgccagttttcagttagcttgggttggtctctagctgtctttgaagctctttgatctaaacatttaagcaccaaaaacatttcatgtacaatcagccacactcagggcaagcaaatatgagtatgggggatgtagacagtaggaagagacagcagagcaattagctggcactgagatatcctttctctctctctctctctctctctctctctctctctgtgtgtgtgtgtgtatgtgtgtgtgtgtatcaggaaggactggttgtttgaggtaggcaggaaagagctaattatgagatgactgctgacttctcgtagactcagatattttccttgtttttaacacagccaccggcagaaatgcttgatcttggtgtgtggagggagcatgaaggggagagggggagagagtgtgtccatctttagcaggacatagtttgaaatgtaagttcacaaactgcaagctatgatttcagggtgagtccagttcagtttagcttgtcgagttgcttcctgttttgcctttcatcggcattgctgtttctgatctttgccttctacatgacttatttattcagaatctttgactccgccttaatactattcctgtggggacccagagttactaccgtcaaagtgccaaagtgtgggtgcagtggtttggaaggtagagggccgaagaggaagaatgtacagagtctaagcctggcatcactccacacttaatttagtaaccacagtatgcaaacataagtcaaatatctctgctctctgtgcgctccccagttcaaacagcctttcgaaggccgttgctgaaaaaatactcatttgtcatttgctttaggtctctgtatagccctggctgtcctggaactcactctgtagaccaggctggcctcgaactcagaaatccacctgcctctgcctcccgagtgctgggattaaaggcatgtgccaccacgctcggcttctctgaaactcaatatttagagccaaacagagcaaacttttctgggagacacaaacaaacaaaaatccagagttcatttccagggatgatttgcaggagcaaatcatgaaaacttaaggaaaatgaataaacatagagagtatgatataaattgaataacttagagaaaaaaaatcacacattctaatgggtggatcggaacctaccatgtttatcagagagtgtgtgggtatgggtgagtgtgggtgtggataataatcagaaaaaaaagacaaagaagcttggggaaatggagggctggagagtagggcatcaggacacatgtgctatgaagcagaaaggatgctgtggggagatggaagtggagtcacaagggaaggctcagggaggggaggggcacagatattagcaaaatactgtaaaaaaataaacttgaacatagaatcggtttgctttaggcatctagttacattcttagagaatttatatcaaagaaatttacttctagccaggaagtgatggcacacacctttaaccccagaactcagaaggcagaggcaggtggatctctgagttggaggccagcctggtttacagagtgagttctaggacatctaaggttatacagaaaacccctgtctcaaaaagcaaagctgagccaagccaagccaagccaaaccaaaccaaaccaaaccaaaccaaatcaaacccaaaaaccaccatcaacaaaaaaactccaaacaaatgacaaagagccaggtagtggtggtgcatagctttaatctcagcactatggagacagagacagaaggatctcttaagtttgagctagcctggtctacagagtgagtgtcaggatagccagaaaggtcaagaaacaatatgctggggaaatgctggcagcaaatgtcataaatattttttccctaaagtttctattcatggtagtttaatcccagcactcaggaggcagaggcaagtggatctccgtgagtttgagtccaacctggtccacatagtgagtttcgggctaaccagggttacatactgagaccttgtctcaaaatttttttttatacataaaagaaaaatttccgggctggtgagatggctcagtgggtaagagcacccgactgctcttccgaaggtcaggagttcaaatcccagcaaccacatggtggctcacaaccatctgtaacgagatctgactccctcttctggagtgtctgaggacagctacagtgtacttacatataataaataaataaataaataaatcttaaaaaaaaaaaaatataaaaaaaaaaaaaaaaaaaaaagaaaaatttccaagattaaaggaaaactggacaaagaatttgacaggaagagcacagaaggagtttaaaaagctcctacacatgggggagacatcccttacggtggcatgagtgtcacataaccaggtgtgtgacaacatgctgtttggagagaaagacctggcaatggccatgatatgcttggatgtttgtaaccttttaccctgagattcattcctaaggaacttattctgcacagacagcttgcacacatgtaaaaagcttctgggtcgacgtatagagttttgcttctagtagcagaaagcacagcagtagtaaacacaatacagatgagttgaagggagtaatttacagaaaatcacaacacaccatcatatcacgaagccataaaaagtgagatcgcccttgtatttatgtggggccatctctaagatgttctgtattgtgaccaaagtctacctatcctgtgcctctagggccgacacacatgcttgcagatgctttcaggattttttttttttaaataaaccttaaaatctctggagcaggggcatcggtgcccagggagaaagacagcttctgctcttttggactctaggttctctaccatgtggcacttgatgaagttttgctttgcatatgtttttacttataaatgtaatggatttataaatgactttctcagtttttatcaacctgtatcctggtaaacatttcataatcatagtgggtattaatagtgggtagtgaatggggaatttgaaaactatacaatgtaggatgtagaagtgctgacacactgttcaagctttttttaaaaaataaaataaaggacataagatattgcaac

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