LOCUS       NM_178598               1382 bp    mRNA    linear   ROD 06-MAR-2023
DEFINITION  Mus musculus transgelin 2 (Tagln2), mRNA.
ACCESSION   NM_178598
VERSION     NM_178598.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR,
            Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O
            and Maynard C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   2  (bases 1 to 1382)
  AUTHORS   Catela C, Chen Y, Weng Y, Wen K and Kratsios P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1382)
  AUTHORS   Li Z, Ye Z, Ma J, Gu Q, Teng J and Gong X.
  TITLE     MicroRNA-133b alleviates doxorubicin-induced cardiomyocyte
            apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2
  JOURNAL   Int J Mol Med 48 (1) (2021)
   PUBMED   33982775
  REMARK    GeneRIF: MicroRNA133b alleviates doxorubicininduced cardiomyocyte
            apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
REFERENCE   4  (bases 1 to 1382)
  AUTHORS   Kim HR, Park JS, Park JH, Yasmin F, Kim CH, Oh SK, Chung IJ and Jun
            CD.
  TITLE     Cell-permeable transgelin-2 as a potent therapeutic for dendritic
            cell-based cancer immunotherapy
  JOURNAL   J Hematol Oncol 14 (1), 43 (2021)
   PUBMED   33731208
  REMARK    GeneRIF: Cell-permeable transgelin-2 as a potent therapeutic for
            dendritic cell-based cancer immunotherapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1382)
  AUTHORS   Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gomez-Serrano M,
            Garcia-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes
            E, Guzman R, Macias-Gonzalez M, Buxo M, Girones J, Vilallonga R,
            Naon D, Botas P, Delgado E, Corella D, Burcelin R, Fruhbeck G,
            Ricart W, Simo R, Castrillon-Rodriguez I, Tinahones FJ, Bosch F,
            Vidal-Puig A, Malagon MM, Peral B, Zorzano A and Fernandez-Real JM.
  TITLE     Cytoskeletal transgelin 2 contributes to gender-dependent adipose
            tissue expandability and immune function
  JOURNAL   FASEB J 33 (8), 9656-9671 (2019)
   PUBMED   31145872
  REMARK    GeneRIF: Current findings highlight the contribution of
            cytoskeletal TAGLN2 to the obese phenotype in a gender-dependent
            manner
REFERENCE   6  (bases 1 to 1382)
  AUTHORS   Gu WK, Li XM, Edderkaoui B, Strong DD, Lau KH, Beamer WG, Donahue
            LR, Mohan S and Baylink DJ.
  TITLE     Construction of a BAC contig for a 3 cM biologically significant
            region of mouse chromosome 1
  JOURNAL   Genetica 114 (1), 1-9 (2002)
   PUBMED   11990753
REFERENCE   7  (bases 1 to 1382)
  AUTHORS   Kibar Z, Vogan KJ, Groulx N, Justice MJ, Underhill DA and Gros P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
REFERENCE   8  (bases 1 to 1382)
  AUTHORS   Doudney K, Murdoch JN, Paternotte C, Bentley L, Gregory S, Copp AJ
            and Stanier P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
REFERENCE   9  (bases 1 to 1382)
  AUTHORS   Eddleston J, Murdoch JN, Copp AJ and Stanier P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   10 (bases 1 to 1382)
  AUTHORS   Stanier P, Abu-Hayyeh S, Murdoch JN, Eddleston J and Copp AJ.
  TITLE     Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and
            9: further evidence for a paralogous relationship
  JOURNAL   Genomics 51 (1), 144-147 (1998)
   PUBMED   9693045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151576.1.
            
            On Jul 15, 2006 this sequence version replaced NM_178598.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151576.1, BC049861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.89 cM"
     gene            1..1382
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="transgelin 2"
                     /db_xref="GeneID:21346"
                     /db_xref="MGI:MGI:1312985"
     exon            1..87
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    26..28
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="upstream in-frame stop codon"
     exon            88..295
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..715
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="putative; transgelin 2 (MGD|MGI:1312985
                     GB|BC049861, evidence: BLASTN, 99%, match=1379);
                     SM22-beta"
                     /codon_start=1
                     /product="transgelin-2"
                     /protein_id="NP_848713.1"
                     /db_xref="CCDS:CCDS35784.1"
                     /db_xref="GeneID:21346"
                     /db_xref="MGI:MGI:1312985"
                     /translation="

MANRGPSYGLSREVQQKIEKQYDADLEQILIQWITTQCREDVGQPQPGRENFQKWLKDGTVLCKLINSLYPEGQAPVKKIQASSMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL"

     misc_feature    119..121
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4); acetylation site"
     misc_feature    146..148
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4); phosphorylation site"
     misc_feature    164..166
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4); acetylation site"
     misc_feature    167..577
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="calponin homology (CH) domain found in
                     transgelin-2; Region: CH_TAGLN2; cd21280"
                     /db_xref="CDD:409129"
     misc_feature    173..175
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4); acetylation site"
     misc_feature    order(191..193,203..205,377..379,383..388,395..400,
                     404..406,434..460,476..478,482..487,491..496,503..508,
                     515..517)
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409129"
     misc_feature    602..604
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4); phosphorylation site"
     misc_feature    635..712
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVA4.4);
                     Region: Calponin-like"
     misc_feature    635..709
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="Calponin family repeat; Region: Calponin;
                     pfam00402"
                     /db_xref="CDD:425664"
     misc_feature    653..655
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4); phosphorylation site"
     misc_feature    659..661
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4); methylation site"
     misc_feature    701..703
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4); methylation site"
     exon            296..470
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     exon            471..573
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1382
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="putative"
     polyA_site      1382
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="putative"
ORIGIN      

gaaaactccaagcccggccgggtcttgagctccactcgccgctgcagcccctgtcgtgcgtgcgctctcatccagccctcttggacgctctttgccatcaccacagctgctcagaatggccaacaggggaccttcctacggcctgagccgagaggtgcagcagaagattgagaagcagtacgacgcggatctggagcagatcctcatccagtggatcaccactcagtgccgtgaggacgtgggccagccccagcctggccgtgagaacttccagaagtggctcaaggacggcacggttctgtgcaagcttattaattcactgtatcctgaggggcaggccccagtaaagaagatccaggcctcttcgatggccttcaagcagatggagcagatctcccagttcctgcaggcagccgagcgctatggcattaacaccacggacatcttccagactgtggatctctgggaaggaaagaacatggcttgtgtgcagcggacactaatgaacctgggtgggctggcagtagccagggacgatgggctcttctctggggatcccaactggtttcctaagaaatccaaggagaaccctcggaacttctcggacaaccagttgcaagagggcaagaacgtgattgggttgcagatgggcaccaaccgtggagcatctcaggccggcatgaccggctatgggatgccacggcagatcctctgatcatactctctctccttcccctgccctccatgaatggttaatatatatgtatatatatgttttagcagacattccctgagagcccctggattgctgaactcccctctgccagggtccaggccagcctatcttgtcaccactggcagggcctgataattgcctctctctctctctctctttctctctctctctctctctctctctctctctctctctctctgggcttactaatgcattccttcccccacaaccatcaaaactggaccaacaaaaaccctgggaccaaagttgcctccccacagcatctttcctgctttcctgatctcttcttttagtccatcccttggctaggagtcagagattctgccccatggcctgatgctgcaccgacccttccttctacaaggaggcctctcctacagctgtggctgcagggacttaatttatagggaggggcctgtggctgtcactccagccacagctgggctgtacttaccacacgtctgggcagctttccctagcagaggctctttggcttctttctttccattcctctctcactgtggctaaggggtggagcagaggtaggacggctgcccaccatgctctggggcttgacgaacacgagtttgctgattttaaataaaaagatctcattttgttttgc

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