LOCUS       NM_177884               3360 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus GC-rich sequence DNA binding factor 2 (Gcfc2),
            transcript variant 1, mRNA.
ACCESSION   NM_177884
VERSION     NM_177884.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3360)
  AUTHORS   Ma Y, Ren Y and Guan J.
  TITLE     Knockdown of GC binding factor 2 by RNA interference inhibits
            invasion and migration of vascular smooth muscle cells
  JOURNAL   Mol Med Rep 20 (2), 1781-1789 (2019)
   PUBMED   31257544
  REMARK    GeneRIF: The inhibition of vascular smooth muscle cells
            proliferation and migration by knockdown of GCF2 by RNA
            interference was mediated by the PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 3360)
  AUTHORS   Maga AM, Navarro N, Cunningham ML and Cox TC.
  TITLE     Quantitative trait loci affecting the 3D skull shape and size in
            mouse and prioritization of candidate genes in-silico
  JOURNAL   Front Physiol 6, 92 (2015)
   PUBMED   25859222
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3360)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 3360)
  AUTHORS   Ballif BA, Villen J, Beausoleil SA, Schwartz D and Gygi SP.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129024.4.
            
            On Sep 1, 2022 this sequence version replaced NM_177884.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078171.1, AK050789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC129024.4         86410-86669         c
            261-389             AC129024.4         84454-84582         c
            390-614             AC129024.4         79456-79680         c
            615-712             AC129024.4         77437-77534         c
            713-828             AC129024.4         74327-74442         c
            829-1015            AC129024.4         70782-70968         c
            1016-1139           AC129024.4         68907-69030         c
            1140-1221           AC129024.4         67338-67419         c
            1222-1334           AC129024.4         66807-66919         c
            1335-1534           AC129024.4         65828-66027         c
            1535-1685           AC129024.4         63735-63885         c
            1686-1804           AC129024.4         61967-62085         c
            1805-1881           AC129024.4         60363-60439         c
            1882-1948           AC129024.4         58562-58628         c
            1949-2095           AC129024.4         56928-57074         c
            2096-2220           AC129024.4         53393-53517         c
            2221-3360           AC129024.4         51255-52394         c
FEATURES             Location/Qualifiers
     source          1..3360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.81 cM"
     gene            1..3360
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="GC-rich sequence DNA binding factor 2"
                     /db_xref="GeneID:330361"
                     /db_xref="MGI:MGI:2141656"
     exon            1..260
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2338
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="GCF; TCF-9; transcription factor 9"
                     /codon_start=1
                     /product="intron Large complex component GCFC2"
                     /protein_id="NP_808552.2"
                     /db_xref="CCDS:CCDS20260.1"
                     /db_xref="GeneID:330361"
                     /db_xref="MGI:MGI:2141656"
                     /translation="

MALRPQRTFRRRQVESSDSDSDSDGAKEQSAEEPASAGGRTEGAERPRGARSARGRGRVWASSRRSPGAAPRGDGGAECRTAELSTDEEEGTHTLTGSKGDRSPSSDSSCSLEERDVSPIVEIPDAAFIQAARRKRELARTPGDYISLDVNHSCSTSDCKRSNEEDPESDPDDHEKRILFTPKPQTLRQRMAEETSIRSEESSEESQEDENQDIWEQQQMRKAVRIPAGQNTDLSHSSKSQTLKKFDTSISFPPVNLEIIKKQLNNRLTLLQESHRSHQREYEKYEQDIKSSKTAIQNLESASDHAQNYRFYRGMKSYVENIIDCLNEKIVSIVELESSMYTLLLKRSEALLKRRQDELKCESSYLQQLSRKDETSANGSLAVDEKDQRILEEIEARRMQRRQARELSGSCDHQEGMSSDDELSPAEMTNFHKCQGDILQDCKKVFEDVHDDFCNVQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRVQLLDWNPLKMDSIGLDKMPWFTAITEFMESSMDDIGKEDGSDKKILAAVINKTVVPRLTDFVETIWDPLSTSQTRSLTVHCRVAFEQFASENEVSKNKQDLLKSIVARMKKSIEDDIFIPLYPKSSEEGKMSPHSKFQERQFWGALKLFRNILLWNGLLPDDTLQDLGLGKLLNRYLIISLTNAVPGPDVVKKCSQIAACLPERWFENSAMRTSIPQLENFIKFLLQSAQKLSSSEFRNEVSEIILILVKVKALTQAESLREERPLEPLPAQSTGV"

     misc_feature    29..394
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKT3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    74..76
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    77..79
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    83..85
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    281..283
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    284..286
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    380..382
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    428..664
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKT3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    533..535
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    635..637
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    644..646
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    1394..2038
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="GC-rich sequence DNA-binding factor-like protein;
                     Region: GCFC; pfam07842"
                     /db_xref="CDD:400273"
     exon            261..389
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            390..614
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            615..712
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            713..828
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1015
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1139
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1221
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1334
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1534
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1685
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1804
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1881
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1948
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2095
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2220
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..3360
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aaggagacgcgccaatcctacttggaacatggctctcaggccccagaggactttcaggcggcgccaggtcgagtccagcgatagcgatagcgatagcgacggcgcgaaggagcagagtgcggaggagccggcgtctgccggcggccgaacagagggagcggagcggccgcgcggggcccgcagcgcccggggccgaggtcgggtctgggcgagttcccgccgcagcccgggagctgctccccgcggggacggcggagcagaatgcagaacagctgagctctcaacggatgaagaggaaggaacacataccttgacaggaagtaagggtgatcggagtccgtcctctgatagctcttgctctctggaagaaagagacgtttcacccatagttgagatccccgatgcagcttttattcaggcagcccgcagaaaacgggagttggccaggaccccaggggactacatttcattggatgtaaaccactcctgctccacttctgactgtaagagaagcaatgaagaggacccagagagcgatcctgatgaccacgaaaagagaatactgtttaccccaaagcctcaaacactccggcaaagaatggctgaagaaacgtcaatcaggagtgaggaatcaagtgaagagagtcaggaagatgaaaaccaagacatctgggagcagcagcagatgaggaaagcagtcaggatcccggcgggacaaaatacagacctttcccacagcagtaagtctcaaaccctgaagaagtttgatacttccatttcatttccaccggtaaatttggaaattataaagaaacagttaaataatagattaacattactacaggagtctcatcgctcacaccagagagaatatgaaaaatatgaacaagacatcaagagttcaaagacggctatccagaatcttgagagtgcatcagaccatgctcaaaactacagattctacaggggcatgaaaagttatgtggaaaatataattgattgtctaaatgaaaagattgtcagcattgtggaactagaatcatccatgtacacgttgcttttaaaacggtcagaagcacttttgaaacgcaggcaagatgaattaaaatgcgaatcatcatatttgcagcagttatcacgcaaagatgagacatcggcaaatggaagcttggctgtggatgaaaaggatcaacggattttagaagagattgaagctcggaggatgcagagaagacaggccagggagctctcgggcagctgtgaccatcaggaagggatgtctagtgatgatgagctgtctcctgcagagatgactaacttccacaagtgccaaggtgacattttacaggattgtaagaaagtttttgaagatgtgcatgatgatttttgtaacgtccagaatattttattgaaatttcagcagtggcgagaaaagtttcctgattcctactatgaagccttcgttggtttctgcttaccaaagcttttaagtcccctgatacgagttcagttgcttgactggaatcctcttaagatggactccataggtctagacaagatgccctggttcacagctataacagagtttatggagagcagcatggacgatatagggaaggaagatggttctgataaaaaaatcttggctgctgtcatcaacaaaacagttgttcctcgacttacagattttgtagagaccatttgggatcccctgtcaacctcacagacaagaagtttaacagtgcactgcagagtggcttttgaacagttcgcttctgaaaatgaagttagtaaaaataaacaggatttacttaaatctattgttgcaagaatgaagaagtcaatagaagatgatatttttattcctctatacccaaagagctctgaagaaggaaaaatgtcaccacactccaagttccaagaaagacagttctggggagctctaaagctcttccgaaatattcttctttggaatggccttctcccagatgacaccttgcaagatctgggactggggaagctgctgaatcgctaccttatcatctctcttactaatgccgtccctggaccagatgtggttaaaaagtgcagccagatagcagcatgtctaccagaaagatggtttgagaactctgctatgaggacatcaattccccagctagaaaacttcattaagtttttgttgcagtctgcacagaaattatcctcaagtgaattcaggaatgaagtcagtgaaataattcttatcctggtgaaggtaaaagctctgactcaagccgaatccctcagagaagagcgtcccctggagcccctcccagcccagagtacaggtgtttgagtgcgccgtgtgggagtgcccagagtcaagatgaccgtgtcacagccgatgccgcctttgctgggtgcccacttggggtgtggccaggcctcctgatgcttcgtagctgagggaagtaatgcacagcagcagccgagctcagtgtgctgctcttttactctctcaatccggaaggaaatgaagcaatctgacacacagaagcatgcctgaatcaaaaccatcttcagcaaactccaatgtttgcagatcagctaatgaggaagctctatctctggatggtttcttttatcttattctttggtggggactcggtctcattctgaagtgtaaggaattacttattaaatagctaacacatttttatacaaactgtcctttcaaaatctgtactgacttactgtgtgaaatcagtgcaagagagtgccagtgatctccagattttgattcattgtcaatttgttaaaaaaaaaaaaactttgaaaaaagatttatttttatatgtgtggtcatgtatgtacctgggtgggtttagcactacctccatgtaggggccagagggcatcaggtcccctggaactggaatccaggaggttgtgggccatctaatgtgcttggaaccaaacccaggtcctcagaagagatcttcaccctccctgtgaagaatgaagctgtggtctgagtcatctgtaagtccttaagtgaggcttttttgctatgttttgtgtaactcatggtaggactaaaaaggccattgctcttttaaatacagaaatgtaaagtatttctctaattaaggtagtctgaggcaaggtgattaagaaattatgaacttttctcaaaatgactgtattaatgttcttaagtatatttgttaagcaactcaatgatgatcctgtatttatttttccgtgttgtcactttagacatttgctcgttacaaaagcatgtgtatatgtgtgcagaaagttttgtatataaatggcagagactttatttttgctgttaaagggcacttttggaaa

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