2024-04-23 19:50:09, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_053212 918 bp mRNA linear ROD 22-DEC-2022 DEFINITION Mus musculus taste receptor, type 2, member 116 (Tas2r116), mRNA. ACCESSION NM_053212 VERSION NM_053212.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 918) AUTHORS Kim D, Pauer SH, Yong HM, An SS and Liggett SB. TITLE beta2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function JOURNAL J Biol Chem 291 (34), 17616-17628 (2016) PUBMED 27342779 REMARK GeneRIF: Thus the beta2AR acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function. REFERENCE 2 (bases 1 to 918) AUTHORS Nelson TM, Munger SD and Boughter JD Jr. TITLE Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice JOURNAL BMC Genet 6, 32 (2005) PUBMED 15938754 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 918) AUTHORS Conte C, Ebeling M, Marcuz A, Nef P and Andres-Barquin PJ. TITLE Evolutionary relationships of the Tas2r receptor gene families in mouse and human JOURNAL Physiol Genomics 14 (1), 73-82 (2003) PUBMED 12734386 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 918) AUTHORS Shi P, Zhang J, Yang H and Zhang YP. TITLE Adaptive diversification of bitter taste receptor genes in Mammalian evolution JOURNAL Mol Biol Evol 20 (5), 805-814 (2003) PUBMED 12679530 REFERENCE 5 (bases 1 to 918) AUTHORS Matsunami H, Montmayeur JP and Buck LB. TITLE A family of candidate taste receptors in human and mouse JOURNAL Nature 404 (6778), 601-604 (2000) PUBMED 10766242 REFERENCE 6 (bases 1 to 918) AUTHORS Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ and Zuker CS. TITLE A novel family of mammalian taste receptors JOURNAL Cell 100 (6), 693-702 (2000) PUBMED 10761934 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BK001084.1. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..918 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" /chromosome="6" /map="6 64.03 cM" gene 1..918 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="taste receptor, type 2, member 116" /db_xref="GeneID:112408" /db_xref="MGI:MGI:1890258" CDS 1..918 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="candidate taste receptor mt2r56; T2R116; taste receptor, type 2, member 7; taste receptor, type 2, member 14" /codon_start=1 /product="taste receptor type 2 member 116" /protein_id="NP_444442.1" /db_xref="CCDS:CCDS20625.1" /db_xref="GeneID:112408" /db_xref="MGI:MGI:1890258" /translation="
MNGVLQVTFIVILSVEFIIGIFGNGFIAVVNIKDLVKGRKISSVDQILTALAISRIALLWLILVSWWIFVLYPGQWMTDRRVSIMHSIWTTFNQSSLWFATSLSIFYFFKIANFSNPIFLYLKVRLKKVMIGTLIMSLILFCLNIIIMNAPENILITEYNVSMSYSLILNNTQLSMLFPFANTMFGFIPFAVSLVTFVLLVFSLWKHQRKMQHSAHGCRDASTKAHIRALQTLIASLLLYSIFFLSHVMKVWSALLLERTLLLLITQVARTAFPSVHSWVLILGNAKMRKASLYVFLWLRCRHKE"
misc_feature 22..888 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="mammalian taste receptor 2, subtype 14, member of the seven-transmembrane G protein-coupled receptor superfamily; Region: 7tm_TAS2R14-like; cd15019" /db_xref="CDD:320147" misc_feature 22..99 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="TM helix 1 [structural motif]; Region: TM helix 1" /db_xref="CDD:320147" misc_feature 25..87 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="propagated from UniProtKB/Swiss-Prot (Q7M713.1); transmembrane region" misc_feature 133..207 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="TM helix 2 [structural motif]; Region: TM helix 2" /db_xref="CDD:320147" misc_feature 166..228 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="propagated from UniProtKB/Swiss-Prot (Q7M713.1); transmembrane region" misc_feature 247..315 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="TM helix 3 [structural motif]; Region: TM helix 3" /db_xref="CDD:320147" misc_feature 277..279 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q7M713.1); glycosylation site" misc_feature 304..366 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="propagated from UniProtKB/Swiss-Prot (Q7M713.1); transmembrane region" misc_feature 385..447 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="propagated from UniProtKB/Swiss-Prot (Q7M713.1); transmembrane region" misc_feature 394..444 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="TM helix 4 [structural motif]; Region: TM helix 4" /db_xref="CDD:320147" misc_feature 478..480 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q7M713.1); glycosylation site" misc_feature 508..510 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q7M713.1); glycosylation site" misc_feature 523..594 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="TM helix 5 [structural motif]; Region: TM helix 5" /db_xref="CDD:320147" misc_feature 553..615 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="propagated from UniProtKB/Swiss-Prot (Q7M713.1); transmembrane region" misc_feature 667..744 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="TM helix 6 [structural motif]; Region: TM helix 6" /db_xref="CDD:320147" misc_feature 709..771 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="propagated from UniProtKB/Swiss-Prot (Q7M713.1); transmembrane region" misc_feature 778..855 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="TM helix 7 [structural motif]; Region: TM helix 7" /db_xref="CDD:320147" misc_feature 784..846 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /note="propagated from UniProtKB/Swiss-Prot (Q7M713.1); transmembrane region" exon 1..918 /gene="Tas2r116" /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16; Tas2r7; TRB1; TRB4" /inference="alignment:Splign:2.1.0" ORIGIN
atgaatggtgtcctacaggttacatttatagtcattttgagtgtggaatttataattggcatctttggcaatggattcatagcggtggtgaacataaaggacttggtcaagggaaggaagatctcttcagtggatcagatcctcactgctctggccatctccagaattgcactgctgtggttaatattagtaagttggtggatatttgtgctttacccaggacaatggatgactgatagaagagttagcataatgcacagtatatggacaacattcaaccagagtagtctctggtttgctacaagtctcagcatcttttattttttcaagatagcaaatttttccaaccctatttttctttatttaaaggtcagacttaaaaaagtcatgatagggacattgataatgtctttgattctcttttgtttaaatattatcattatgaatgcacctgagaacattttaatcactgaatataatgtatctatgtcttacagcttgattttgaataacacacagctttctatgctgtttccatttgccaacaccatgtttgggttcataccttttgctgtgtcactggtcacttttgtccttcttgttttctccctgtggaaacatcagagaaagatgcaacacagtgcccatggatgcagagatgccagcactaaggcccacatcagagccttgcagacattgattgcctccctcctcctgtattccattttcttcctgtctcatgttatgaaggtttggagtgctctgcttctggagaggacactcctgcttttgatcacacaggttgcaagaacagcttttccgtcagtgcactcctgggtcctgattctgggcaatgctaagatgagaaaggcttctctctatgtattcctgtggctgaggtgcaggcacaaagaatga
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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