2024-04-29 10:08:30, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_031877 2572 bp mRNA linear ROD 21-DEC-2022 DEFINITION Mus musculus WASP family, member 1 (Wasf1), transcript variant 1, mRNA. ACCESSION NM_031877 VERSION NM_031877.3 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 2572) AUTHORS Longatti A, Ponzoni L, Moretto E, Giansante G, Lattuada N, Colombo MN, Francolini M, Sala M, Murru L and Passafaro M. TITLE Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice JOURNAL Mol Neurobiol 58 (12), 6092-6110 (2021) PUBMED 34455539 REFERENCE 2 (bases 1 to 2572) AUTHORS Zhang Y, Kang H, Lee Y, Kim Y, Lee B, Kim JY, Jin C, Kim S, Kim H and Han K. TITLE Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice JOURNAL Front Mol Neurosci 11, 482 (2019) PUBMED 30687000 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 2572) AUTHORS Chen Y, Milenkovic M, Horsfall W, Salahpour A, Soderling SH and Ramsey AJ. TITLE Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice JOURNAL PLoS One 13 (10), e0199341 (2018) PUBMED 30352064 REMARK GeneRIF: WAVE-1 restoration improves maze exploration performance of GluN1 knockdown mice Publication Status: Online-Only REFERENCE 4 (bases 1 to 2572) AUTHORS Fan L, Lu Y, Shen X, Shao H, Suo L and Wu Q. TITLE Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice JOURNAL Elife 7, e35242 (2018) PUBMED 29911975 REMARK GeneRIF: Data indicate a molecular protocadherin alpha (Pcdhalpha)/Wiskott-Aldrich syndrome potein Family (WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from protocadherin cell-surface receptors to actin cytoskeletal dynamics in cortical neuron migration and dendrite morphogenesis in mouse brain. Publication Status: Online-Only REFERENCE 5 (bases 1 to 2572) AUTHORS Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P and Kim Y. TITLE WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine JOURNAL Proc Natl Acad Sci U S A 114 (6), 1395-1400 (2017) PUBMED 28115704 REMARK GeneRIF: Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine. REFERENCE 6 (bases 1 to 2572) AUTHORS Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J and Scott JD. TITLE Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice JOURNAL Proc Natl Acad Sci U S A 100 (4), 1723-1728 (2003) PUBMED 12578964 REMARK GeneRIF: role in causing sensorimotor retardation and reduced learning and memory in mice REFERENCE 7 (bases 1 to 2572) AUTHORS Benachenhou N, Massy I and Vacher J. TITLE Characterization and expression analyses of the mouse Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar JOURNAL Gene 290 (1-2), 131-140 (2002) PUBMED 12062808 REFERENCE 8 (bases 1 to 2572) AUTHORS Chalhoub N, Benachenhou N and Vacher J. TITLE Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21 JOURNAL Mamm Genome 12 (12), 887-892 (2001) PUBMED 11707774 REFERENCE 9 (bases 1 to 2572) AUTHORS Westphal RS, Soderling SH, Alto NM, Langeberg LK and Scott JD. TITLE Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold JOURNAL EMBO J 19 (17), 4589-4600 (2000) PUBMED 10970852 REFERENCE 10 (bases 1 to 2572) AUTHORS Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M and Yamamura K. TITLE Exchangeable gene trap using the Cre/mutated lox system JOURNAL Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999) PUBMED 10512203 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY332208.1, BC053423.1 and AF290877.1. On Apr 23, 2009 this sequence version replaced NM_031877.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016896.1, SRR7974084.2897.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-39 BY332208.1 1-39 40-2173 BC053423.1 1-2134 2174-2548 BC053423.1 2136-2510 2549-2572 AF290877.1 2446-2469 FEATURES Location/Qualifiers source 1..2572 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" /chromosome="10" /map="10 22.07 cM" gene 1..2572 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="WASP family, member 1" /db_xref="GeneID:83767" /db_xref="MGI:MGI:1890563" exon 1..76 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 77..237 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" misc_feature 78..80 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="upstream in-frame stop codon" CDS 105..1784 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="isoform 1 is encoded by transcript variant 1; wiskott-Aldrich syndrome protein family member 1; protein WAVE-1; WASP family protein member 1; WASP family 1; WAS protein family, member 1; actin-binding protein WASF1" /codon_start=1 /product="actin-binding protein WASF1 isoform 1" /protein_id="NP_114083.1" /db_xref="CCDS:CCDS23801.1" /db_xref="GeneID:83767" /db_xref="MGI:MGI:1890563" /translation="
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDADLLHKHIEVANGPASHYETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPTPTCISSATGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVAVAALAHPPSGLHPAPSTAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE"
misc_feature 612..710 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 921..1304 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1125..1127 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="Asymmetric dimethylarginine, alternate. /evidence=ECO:0007744|PubMed:24129315; Omega-N-methylarginine, alternate. /evidence=ECO:0007744|PubMed:24129315; propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); methylation site" misc_feature 1338..1577 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1557..1781 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1); Region: WH2_WAVE-1; cd22071" /db_xref="CDD:409214" misc_feature 1569..1571 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q92558; propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); phosphorylation site" misc_feature order(1593..1598,1602..1610,1614..1622,1635..1646) /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="actin-binding motif [polypeptide binding]; other site" /db_xref="CDD:409214" misc_feature order(1596..1601,1605..1610,1617..1622,1638..1643, 1695..1700,1707..1712,1719..1721,1731..1733) /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="Nap1 binding interface [polypeptide binding]; other site" /db_xref="CDD:409214" misc_feature 1635..1646 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="actin-binding sequence [structural motif]; Region: actin-binding sequence" /db_xref="CDD:409214" exon 238..372 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 373..526 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 527..644 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 645..817 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 818..997 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 998..1626 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 1627..2550 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" ORIGIN
tcccccaaagtgcggatcgggcaataccacagagcctcaggacagggggaagcgccgtcctcttgcccacggacgggtgagctggttcagtggctgagctcaagatgccgttggtgaaaagaaacatcgaccctcggcacttgtgccacacagcactgcccaggggcattaagaacgaactggaatgtgtaaccaacatttccctggcaaatataattagacaactgagtagcctaagtaagtatgctgaagacatatttggagaattattcaatgaagcacacagtttttccttcagagttaactcgttgcaagagcgcgtggaccgattgtctgttagtgtcacacagcttgatcctaaggaggaagaactgtctttgcaagatataacgatgagaaaggctttccggagctccacaattcaagatcagcagcttttcgaccgcaagacgttgcctattccattgcaagaaacatacgatgtgtgtgagcaacctccgcctctcaatatcctcaccccttacagggatgatggtaaggaagggctgaagttttataccaatccttcatatttctttgatctgtggaaagaaaagatgttgcaagatacagaggacaagaggaaggaaaagagaaagcagaagcagaaaaatctagaccgtcctcatgaaccagagaaagtgccaagagcacctcatgacaggcggcgggaatggcagaagctggcccaaggtccagagctggctgaggatgacgctgacctcctacacaagcatattgaagttgccaatggcccagcctctcattatgagacaaggccacagacatacgtggatcatatggacggatcgtactcactctctgccttgccattcagtcagatgagtgaacttctgaccagagctgaggagagggtcttagtcagaccccatgaacctcctccgcctccaccaatgcatggagcaggagatgcaaagcccacacccacctgtatcagttctgctacaggtttgatagagaatcgcccccagtccccagctgcaggcagaacacctgtgtttgtgagccccactcccccacctcctcccccacctcttccgtctgccttgtccacttcttcactaagagcttcaatgacctcaactcctcccccaccagtccctcctccgcctcctcccccagccactgctttgcaggccccagcagtgcccccacctccggctcctcttcagattgcccctggtgttcttcacccagctcctcctccaattgctcctcctctagtgcagccctctcccccagtagctcgagctgccccagtatgcgagactgtgccagttcacccactcccgcaaggtgaagtgcaggggctgcctccacccccaccaccgcctcctctacctccgcctggcatccggccatcatctcctgtcgcagttgcagctcttgctcatcctccctctgggctccatccagcaccatctactgccccgggtccccatgctccattaatgcctccatctcctccatcacaagttctacctgcctctgagccaaagcgccatccatccaccctgcctgtaatcagtgacgcaaggagtgtgctgctggaagccatccgaaaaggtattcagcttcgcaaagtggaagagcagcgtgaacaggaagcaaaacacgagcggattgaaaacgacgtggccaccatcctgtctcgccgcattgctgtggagtatagcgactcggaagatgactcggagttcgatgaagtagactggctggagtaagaaagccacagtgacttggaagatgactcggagttcgatgaagtagactggatggagtaagacagccgccttgctctgtattgcaaggctgaatgcacatgtccctcgtggcgcttgttctttgaaaatgttcggtcattctagtgttttgcttcctattcctcataatgaataacccttttcctccattatttttgatttctatgaaaagtattagcatatatttcaaactaaatattttgtggcttaccttaatttttccccctggaaaaatataatttggtccaataaactactaagtattaagcatggaaagccgttattagagtagcagattcagtttttgatattccttaattgtgcactttgtgatttttttttttttttttaaatttgaagaacgcaactgagactggaatcttgaaggcagctgtgtctgggaacgagccttattccgtttcttgatgttttaaatgaagaaacactgcctcgattatatgaatacactcagaaggaacatgtagcttgtagtgttgaattctcttaaaggaatggttagctttggttatcattttgttgtttttgaatacttgccttatttgaacgtttagcagaaccccttcccacttatatattgtgtggtacagttttgcttgcctatagaagtttaaatttttccatgtgaaatactcagaataagcatatgtgtgacttacataatgtgagaattacaatctgatgtaataaacggttcattttaaaggctaaaaaaaaaaaaaaaaaaaaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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