2024-04-20 06:14:39, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_029861 1614 bp mRNA linear ROD 06-AUG-2023 DEFINITION Mus musculus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA. ACCESSION NM_029861 XM_354599 VERSION NM_029861.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 1614) AUTHORS Gu SM, Seo S, Park D, Kim S, Lamichhane S, Han KM, Kim YH, Lee S, Hong JT, Cha HJ and Yun J. TITLE Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription JOURNAL Int J Mol Sci 22 (19), 10486 (2021) PUBMED 34638827 REMARK GeneRIF: Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription. Publication Status: Online-Only REFERENCE 2 (bases 1 to 1614) AUTHORS Booth WT, Clodfelter JE, Leone-Kabler S, Hughes EK, Eldeeb K, Howlett AC and Lowther WT. TITLE Cannabinoid receptor interacting protein 1a interacts with myristoylated Galphai N terminus via a unique gapped beta-barrel structure JOURNAL J Biol Chem 297 (3), 101099 (2021) PUBMED 34418434 REMARK GeneRIF: Cannabinoid receptor interacting protein 1a interacts with myristoylated Galphai N terminus via a unique gapped beta-barrel structure. REFERENCE 3 (bases 1 to 1614) AUTHORS Terral G, Busquets-Garcia A, Varilh M, Achicallende S, Cannich A, Bellocchio L, Bonilla-Del Rio I, Massa F, Puente N, Soria-Gomez E, Grandes P, Ferreira G and Marsicano G. TITLE CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory JOURNAL Curr Biol 29 (15), 2455-2464 (2019) PUBMED 31327715 REMARK GeneRIF: Pharmacological blockade or genetic deletion of anterior piriform cortex (aPC)-CB1 receptors specifically impaired the retrieval of conditioned odor preference. Interestingly, expression of conditioned odor aversion was unaffected by local CB1 receptor blockade, indicating that the role of aPC endocannabinoid signaling is selective for retrieval of appetitive memory. REFERENCE 4 (bases 1 to 1614) AUTHORS Miranda K, Mehrpouya-Bahrami P, Nagarkatti PS and Nagarkatti M. TITLE Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells JOURNAL Front Immunol 10, 1049 (2019) PUBMED 31134094 REMARK GeneRIF: these data demonstrate that blocking CB1 receptors leads to upregulation of miR-30e-5p and down regulation of DLL4 in adipose tissue macrophages, which in turn suppress DLL4-Notch signaling-induced polarization of inflammatory Th1 cells and adipocyte energy storage. Publication Status: Online-Only REFERENCE 5 (bases 1 to 1614) AUTHORS Papilloud A, Guillot de Suduiraut I, Zanoletti O, Grosse J and Sandi C. TITLE Peripubertal stress increases play fighting at adolescence and modulates nucleus accumbens CB1 receptor expression and mitochondrial function in the amygdala JOURNAL Transl Psychiatry 8 (1), 156 (2018) PUBMED 30111823 REMARK GeneRIF: peripubertal stress affects CB1 gene expression in the nucleus accumbens shell Publication Status: Online-Only REFERENCE 6 (bases 1 to 1614) AUTHORS Smith TH, Blume LC, Straiker A, Cox JO, David BG, McVoy JR, Sayers KW, Poklis JL, Abdullah RA, Egertova M, Chen CK, Mackie K, Elphick MR, Howlett AC and Selley DE. TITLE Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation JOURNAL Mol Pharmacol 87 (4), 747-765 (2015) PUBMED 25657338 REMARK GeneRIF: CRIP1a appears to act as a broad negative regulator of CB1 receptor function REFERENCE 7 (bases 1 to 1614) AUTHORS Blume LC, Eldeeb K, Bass CE, Selley DE and Howlett AC. TITLE Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells JOURNAL Cell Signal 27 (3), 716-726 (2015) PUBMED 25446256 REMARK GeneRIF: Endogenous levels of CRIP1a modulate CB1R-mediated signal transduction by facilitating a Gi/o protein subtype preference for Gi1 and Gi2, accompanied by an overall suppression of G-protein-mediated signaling in neuronal cells. REFERENCE 8 (bases 1 to 1614) AUTHORS Keimpema E, Barabas K, Morozov YM, Tortoriello G, Torii M, Cameron G, Yanagawa Y, Watanabe M, Mackie K and Harkany T. TITLE Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding JOURNAL J Neurosci 30 (42), 13992-14007 (2010) PUBMED 20962221 REFERENCE 9 (bases 1 to 1614) AUTHORS Werner HB, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, Orfaniotou F, Dhaunchak A, Brinkmann BG, Mobius W, Guarente L, Casaccia-Bonnefil P, Jahn O and Nave KA. TITLE Proteolipid protein is required for transport of sirtuin 2 into CNS myelin JOURNAL J Neurosci 27 (29), 7717-7730 (2007) PUBMED 17634366 REFERENCE 10 (bases 1 to 1614) AUTHORS Wertz K and Herrmann BG. TITLE Large-scale screen for genes involved in gonad development JOURNAL Mech Dev 98 (1-2), 51-70 (2000) PUBMED 11044607 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL606466.12. On Aug 21, 2018 this sequence version replaced NM_029861.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087946.1, AK171947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-490 AL606466.12 108077-108566 c 491-641 AL606466.12 105644-105794 c 642-1614 AL606466.12 81053-82025 c FEATURES Location/Qualifiers source 1..1614 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="11" /map="11 9.5 cM" gene 1..1614 /gene="Cnrip1" /gene_synonym="1500041B16Rik; 3110054C06Rik; 5330437A18Rik; C2orf32" /note="cannabinoid receptor interacting protein 1" /db_xref="GeneID:380686" /db_xref="MGI:MGI:1917505" exon 1..490 /gene="Cnrip1" /gene_synonym="1500041B16Rik; 3110054C06Rik; 5330437A18Rik; C2orf32" /inference="alignment:Splign:2.1.0" misc_feature 138..140 /gene="Cnrip1" /gene_synonym="1500041B16Rik; 3110054C06Rik; 5330437A18Rik; C2orf32" /note="upstream in-frame stop codon" CDS 312..806 /gene="Cnrip1" /gene_synonym="1500041B16Rik; 3110054C06Rik; 5330437A18Rik; C2orf32" /note="CRIP-1" /codon_start=1 /product="CB1 cannabinoid receptor-interacting protein 1" /protein_id="NP_084137.1" /db_xref="CCDS:CCDS24447.1" /db_xref="GeneID:380686" /db_xref="MGI:MGI:1917505" /translation="
MGDLPGLVRLSIALRIQPNDGPVFFKVDGQRFGQNRTIKLLTGSSYKVEVKIKPTTLQVENISIGGVLVPLELKGKEPDGERVVYTGIYDTEGVAPTKSGERQPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKESFL"
misc_feature 321..785 /gene="Cnrip1" /gene_synonym="1500041B16Rik; 3110054C06Rik; 5330437A18Rik; C2orf32" /note="CB1 cannabinoid receptor-interacting protein 1; Region: CNRIP1; pfam15043" /db_xref="CDD:405692" exon 491..641 /gene="Cnrip1" /gene_synonym="1500041B16Rik; 3110054C06Rik; 5330437A18Rik; C2orf32" /inference="alignment:Splign:2.1.0" exon 642..1614 /gene="Cnrip1" /gene_synonym="1500041B16Rik; 3110054C06Rik; 5330437A18Rik; C2orf32" /inference="alignment:Splign:2.1.0" ORIGIN
agtgctgatttgcggggcagcctgccagtccagtcactgcgagccctcgcgtgcgtgcagggccctgcgtggggagcgggggatggggcagcctgctgcctccatgctgtctcttgggccggctccttttctgagtgtagtggagggccacagctgcttctcaaaatctggggtggacagaggcgaccgctcctagctgtggcctgcatccatccgctctctcttcctccctgcttgtcccctccgcccaaagcgccgcagcagctctctccagccttcactgtccaccactccagtctcggttgccaactatgggggacctacccggactcgtgcgcctttccatcgcgctgcgcatccagcccaacgacggccctgttttcttcaaggtggacgggcagcgttttggccagaaccgcacaatcaagctgctcaccggctcctcctacaaggtggaggtgaagattaagcccacaacactgcaggtcgagaacatttccattggtggtgtccttgtcccactggagctgaagggtaaagagcctgacggggagagagttgtctacaccggcatctatgacacagaaggtgtagccccaaccaaaagtggagagcgacaacccatccagatcaccatgcctttcacagacattgggaccttcgagacagtgtggcaagtcaaattctacaattaccacaagcgagaccattgccagtggggaagtcctttctctgtcattgagtatgaatgcaagcccaatgagacccgcagcctcatgtgggtgaataaggagtccttcctctgaaaatgattccttctgatgttgcaagacaatctccagaaactgacctttagacaaaccagcacaagccttaaccaaggcacaccacaccatggctgtttcccaatgacctcctacccccagttactgtgaaagtgtgactcccctctgatgcagtacccatgacatcacatgtaatgtcacattcctgaaagctctccttttgctattgtatgctggtgttcctgcatctatcctgtctgccagtgtgacaggagctcagtggaagtagcaggtttgtcctacaccaaagttccacagagagaccgtggtgttttgttttcaagataaataatttctcccttttgtgttcattgttaaattaagataacaatgtgctggagtccctcatgtgtgacttgtaacatgtagcatgcaatgtgtgtgagcatccaaaggtgactttgtgaaaaaaaatgtaacaacatggtctgcagtaaatgggacccaaatgttgtgcttcctattaacagctcggctgtttcagagaaaggaagataatgaaggaataaaaagatgaatatataagtaagtatttataatgtattaatagtatttcaagtagcaaggcattttgctgtggtctagtagaaatagggaaaagacattgttgtggaattggacctgtggctcatccctttggcaagctaccatagactttaaacaaacataaaggtggcactaatacataccctttaacttgaactttgtacaaccgtgtatggaatggtaatcaacttttgatatttcttaataaagacattggaaatga
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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