LOCUS       NM_029624               1861 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus lipase maturation factor 1 (Lmf1), transcript variant
            1, mRNA.
ACCESSION   NM_029624
VERSION     NM_029624.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1861)
  AUTHORS   Sha H, Sun S, Francisco AB, Ehrhardt N, Xue Z, Liu L, Lawrence P,
            Mattijssen F, Guber RD, Panhwar MS, Brenna JT, Shi H, Xue B,
            Kersten S, Bensadoun A, Peterfy M, Long Q and Qi L.
  TITLE     The ER-associated degradation adaptor protein Sel1L regulates LPL
            secretion and lipid metabolism
  JOURNAL   Cell Metab 20 (3), 458-470 (2014)
   PUBMED   25066055
REFERENCE   2  (bases 1 to 1861)
  AUTHORS   Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue
            IN, Kaufman RJ, Rutkowski DT and Peterfy M.
  TITLE     Lipase maturation factor 1 (lmf1) is induced by endoplasmic
            reticulum stress through activating transcription factor 6alpha
            (Atf6alpha) signaling
  JOURNAL   J Biol Chem 289 (35), 24417-24427 (2014)
   PUBMED   25035425
  REMARK    GeneRIF: determined the alpha-synuclein-binding domain of beta-III
            tubulin and demonstrated that a short fragment containing this
            domain can suppress alpha-synuclein accumulation in the primary
            cultured cells
REFERENCE   3  (bases 1 to 1861)
  AUTHORS   Ehrhardt N, Bedoya C and Peterfy M.
  TITLE     Embryonic viability, lipase deficiency, hypertriglyceridemia and
            neonatal lethality in a novel LMF1-deficient mouse model
  JOURNAL   Nutr Metab (Lond) 11, 37 (2014)
   PUBMED   25302068
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1861)
  AUTHORS   Hosseini M, Ehrhardt N, Weissglas-Volkov D, Lai CM, Mao HZ, Liao
            JL, Nikkola E, Bensadoun A, Taskinen MR, Doolittle MH, Pajukanta P
            and Peterfy M.
  TITLE     Transgenic expression and genetic variation of Lmf1 affect LPL
            activity in mice and humans
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (5), 1204-1210 (2012)
   PUBMED   22345169
  REMARK    GeneRIF: variation in Lmf1 expression is a posttranslational
            determinant of LPL activity.
REFERENCE   5  (bases 1 to 1861)
  AUTHORS   Yin F, Doolittle MH and Peterfy M.
  TITLE     A quantitative assay measuring the function of lipase maturation
            factor 1
  JOURNAL   J Lipid Res 50 (11), 2265-2269 (2009)
   PUBMED   19471043
  REMARK    GeneRIF: Results show that cotransfection of LPL with wild-type
            Lmf1 restores its ability to support normal lipase maturation.
REFERENCE   6  (bases 1 to 1861)
  AUTHORS   Ebersole T, Lai F and Artzt K.
  TITLE     New molecular markers for the distal end of the t-complex and their
            relationships to mutations affecting mouse development
  JOURNAL   Genetics 131 (1), 175-182 (1992)
   PUBMED   1350556
REFERENCE   7  (bases 1 to 1861)
  AUTHORS   Lai F and Artzt K.
  TITLE     Map positions of four dinucleotide repeats in the mouse t complex
  JOURNAL   Mamm Genome 3 (8), 476-477 (1992)
   PUBMED   1643311
REFERENCE   8  (bases 1 to 1861)
  AUTHORS   Oka K, Nakano T, Tkalcevic GT, Scow RO and Brown WV.
  TITLE     Molecular cloning of mouse hepatic triacylglycerol lipase: gene
            expression in combined lipase-deficient (cld/cld) mice
  JOURNAL   Biochim Biophys Acta 1089 (1), 13-20 (1991)
   PUBMED   2025643
REFERENCE   9  (bases 1 to 1861)
  AUTHORS   Davis RC, Ben-Zeev O, Martin D and Doolittle MH.
  TITLE     Combined lipase deficiency in the mouse. Evidence of impaired
            lipase processing and secretion
  JOURNAL   J Biol Chem 265 (29), 17960-17966 (1990)
   PUBMED   2211673
REFERENCE   10 (bases 1 to 1861)
  AUTHORS   Oka K, Yuan JG, Senda M, Masibay AS, Qasba PK, Masuno H, Scow RO,
            Paterniti JR Jr and Brown WV.
  TITLE     Expression of lipoprotein lipase gene in combined lipase deficiency
  JOURNAL   Biochim Biophys Acta 1008 (3), 351-354 (1989)
   PUBMED   2474325
  REMARK    Erratum:[Biochim Biophys Acta 1989 Nov 2;1009(2):199. Oasba PK
            [corrected to Qasba PK]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY229784.1, AK010312.1 and BQ031829.1.
            
            On Nov 16, 2011 this sequence version replaced NM_029624.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154622.1, BC020104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY229784.1         2-26
            26-30               BY229784.1         28-32
            31-1758             AK010312.1         2-1729
            1759-1861           BQ031829.1         17-119              c
FEATURES             Location/Qualifiers
     source          1..1861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.7 cM"
     gene            1..1861
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="lipase maturation factor 1"
                     /db_xref="GeneID:76483"
                     /db_xref="MGI:MGI:1923733"
     exon            1..206
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1738
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="transmembrane protein 112"
                     /codon_start=1
                     /product="lipase maturation factor 1"
                     /protein_id="NP_083900.3"
                     /db_xref="CCDS:CCDS37502.2"
                     /db_xref="GeneID:76483"
                     /db_xref="MGI:MGI:1923733"
                     /translation="

MRPDSLVMAAPEGSLRKRKVGGAEHSPASQPSLARDPADSPARLHTGTFWLTRIVLLRALAFIYFVAFLVAFNQNKALIGDRGLLPCKLYLKNVQEYFQGSTGWAAWTYAPTIMWLLDWSDMNFNLDLIALLGLGISSFVLVTGCANMILMTALWALYMSLVNVGQIWYSFGWESQLLETGFLGIFLSPLWTLSRLPKNTPTSQIVLWGFRWLIFRIMLGAGLIKVRGDKCWLDLTCMDFHYETQPVPNPIAYYLHRSPWWFHRFETLSNHFVELLVPFFLFLGRRMRILHGVLQILFQVILIISGNLSFLNWLTIVPSLACFDDAALGFLFPSGPQGLKKQVLEIQREDTQRVQPKPRDRGCLVRQVVNISLGILVAWLSVPVVINLLSSRQIMNTSFNPLRIVNTYGAFGSVTKERTEVILQGTVSPNASAPDAVWEDYEFKCKPGDPWRQPCLISPYHYRLDWLMWFAAFQTYEQNEWILHLAGKLLAGDSEALALLAVNPFEGRTPPRWIRGEHYRYKFSLPGGQHATQGKWWIRKRIGPYFPPLRLEDLKEYFKTREWPLPEPPSRHTR"

     misc_feature    14..130
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    161..229
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
                     transmembrane region"
     misc_feature    395..466
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
                     transmembrane region"
     misc_feature    518..1654
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="Lipase maturation factor; Region: LMF1; pfam06762"
                     /db_xref="CDD:429107"
     misc_feature    635..676
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
                     transmembrane region"
     misc_feature    890..976
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
                     transmembrane region"
     misc_feature    1115..1177
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
                     transmembrane region"
     exon            207..516
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            517..527
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            528..676
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            677..742
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            743..910
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1097
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1251
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1435
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1548
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1861
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gccctttgtgctcatgcgcccagacagcctagtaatggctgcgcccgaggggtcgctgagaaaacggaaggtcgggggtgcggagcacagtccagcgtcgcaaccttctctggctagagatcccgcagattctccagctcggctgcacacgggcaccttctggctgactagaatcgtgctcctgcgggccctcgctttcatttactttgtggcctttttggtggcattcaatcagaacaaggccctcatcggtgaccggggcctgctgccctgcaaactgtacctgaagaatgtccaggagtacttccagggcagcactggctgggctgcctggacctatgcaccaaccattatgtggttgttggactggtcagacatgaacttcaacctggacctcattgctcttcttgggctgggcatctcgtcctttgtcctggtgaccggctgtgccaacatgatactcatgactgccctctgggccctctacatgtccctggtcaacgtagggcagatctggtattcttttggatgggagtcacagctgctggaaacaggattcctggggatctttctgagccctctctggacactgtcccgcctgcccaagaacacccccacatcccagattgtcctgtggggcttccgctggctgatcttcagaatcatgcttggagcgggcctcatcaaggtccgcggggacaagtgctggctggatctgacctgcatggacttccactatgagactcagcccgtgcccaacccgatagcctactacctgcacaggtcaccatggtggttccaccgctttgagaccctcagcaaccacttcgtggagcttcttgtgcctttcttcctgttccttggacggcggatgcgcattcttcatggagtgctgcagatccttttccaggtgatcctcatcatcagtgggaacctgagcttcctgaactggctcaccatcgtgcccagccttgcctgcttcgacgatgcagctctgggattcctgtttccctcaggacctcaaggcctaaagaagcaagtcctggagattcagagggaagatacacaaagggtccagcccaagccaagagacagaggctgcttggtgcggcaagtggtcaacatctccctgggcatcctggtggcctggctcagcgtacccgtggttatcaatctgctaagctccaggcagatcatgaacacctccttcaacccgctcaggatcgtcaacacctatggggcctttggaagtgtcaccaaagagcggactgaggtgatcctgcagggcacagtgagccccaacgccagcgcacctgatgcagtgtgggaagactatgagttcaagtgcaaaccgggcgacccctggaggcagccatgcctcatctcgccataccactaccgcctggactggctgatgtggttcgcagctttccagacctatgagcagaacgagtggatccttcatctggcgggtaagctcctagctggtgactctgaagccctggccctacttgctgttaacccctttgagggcaggactccccccaggtggatccgaggagaacactaccggtacaagttcagcctccccgggggccagcacgccacccagggcaagtggtggatccgcaagcgaattggtccttacttccccccactccgccttgaggatctgaaggaatactttaagactcgggagtggccactaccagaacccccatctagacacacacgctgaaataaagaccagagaccaaccgcttctctacctatactgtgctgcggccacgggacccgcacagggacccggcagcccatggatcctgccaagaagagattggaaaaggatgtgcttcctagc

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