LOCUS       NM_028904               3552 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus RecQ mediated genome instability 1 (Rmi1), transcript
            variant 2, mRNA.
ACCESSION   NM_028904
VERSION     NM_028904.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3552)
  AUTHORS   Guiraldelli MF, Eyster C and Pezza RJ.
  TITLE     Genome instability and embryonic developmental defects in RMI1
            deficient mice
  JOURNAL   DNA Repair (Amst) 12 (10), 835-843 (2013)
   PUBMED   23900276
  REMARK    GeneRIF: results demonstrate the importance of RMI1 in maintaining
            genome integrity and normal embryonic development
REFERENCE   2  (bases 1 to 3552)
  AUTHORS   Xue X, Raynard S, Busygina V, Singh AK and Sung P.
  TITLE     Role of replication protein A in double holliday junction
            dissolution mediated by the BLM-Topo IIIalpha-RMI1-RMI2 protein
            complex
  JOURNAL   J Biol Chem 288 (20), 14221-14227 (2013)
   PUBMED   23543748
REFERENCE   3  (bases 1 to 3552)
  AUTHORS   Suwa A, Yoshino M, Kurama T, Shimokawa T and Aramori I.
  TITLE     Glucose regulates RMI1 expression through the E2F pathways in
            adipose cells
  JOURNAL   Endocrine 40 (1), 56-61 (2011)
   PUBMED   21432623
  REMARK    GeneRIF: Glucose regulates RMI1 expression through the E2F pathways
            in adipose cells.
REFERENCE   4  (bases 1 to 3552)
  AUTHORS   Chen H, You MJ, Jiang Y, Wang W and Li L.
  TITLE     RMI1 attenuates tumor development and is essential for early
            embryonic survival
  JOURNAL   Mol Carcinog 50 (2), 80-88 (2011)
   PUBMED   21229605
  REMARK    GeneRIF: These results demonstrated a dual-role of RMI1 in
            embryonic development and tumor suppression.
REFERENCE   5  (bases 1 to 3552)
  AUTHORS   Suwa A, Yoshino M, Yamazaki C, Naitou M, Fujikawa R, Matsumoto S,
            Kurama T, Shimokawa T and Aramori I.
  TITLE     RMI1 deficiency in mice protects from diet and genetic-induced
            obesity
  JOURNAL   FEBS J 277 (3), 677-686 (2010)
   PUBMED   20050919
  REMARK    GeneRIF: results suggest that the regulation of energy balance by
            RMI1 is attributable to the regulation of food intake and E2F8
            expression in adipose tissue.
REFERENCE   6  (bases 1 to 3552)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154437.2.
            
            On Jan 26, 2022 this sequence version replaced NM_028904.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032229.1, AK016542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AC154437.2         143779-144002
            225-313             AC154437.2         148215-148303
            314-3552            AC154437.2         149123-152361
FEATURES             Location/Qualifiers
     source          1..3552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 31.05 cM"
     gene            1..3552
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="RecQ mediated genome instability 1"
                     /db_xref="GeneID:74386"
                     /db_xref="MGI:MGI:1921636"
     exon            1..224
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            225..313
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    262..264
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="upstream in-frame stop codon"
     exon            314..3552
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..2193
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="RMI1, RecQ mediated genome instability 1, homolog"
                     /codon_start=1
                     /product="recQ-mediated genome instability protein 1"
                     /protein_id="NP_083180.3"
                     /db_xref="CCDS:CCDS26571.1"
                     /db_xref="GeneID:74386"
                     /db_xref="MGI:MGI:1921636"
                     /translation="

MSVASAVLRVETWLLATWHVKVPPMWLEACVNWIQEENNNATLSQAQINKQVLEQWLLTDLRDLEHPLLPDDILELPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVSAETQSTPKPWEVRPSRMLMLQLTDGVTHIQGMEYQSIPALHSGLPPGTKILVRGCILFRLGVLLLKPENVKVLGGEVDGLSEENAQEKVLARLIGELDPTVPVIPNNSIHNVPKVSGGLDAVLGPSDEELLASLDESEESAANNDVAMERSCFSTGTSSNTTPTNPSGFEPGCNISSRPKEKPPNQPTHFTDGEFDDFSLEEALLLEETVQKEQMETKASQPLTLKENTGKCMEIFSHKPSSLNHTALIHKQGNSNFDEKTSEQMIHEDKFFDCASTRNHHKRFSAHDFTNDSKISEVDDAAQQTLSSSNVHCLRNKILNRKLDLSEKSSQISKENGHPFQACSSRSFENNTYLSIGMDLHSPPFIYLSVLMARKPKEVTTVTVKAFIVTLTGNLSSSGGFWGVTAKVSDGTAYLDVDFIDEILTSMIGYSVPEMKQLRKDPLKYKTFLEGLQKCQRDLIDLCCLMTISYDPSSCKGVVLELQDVGMEHVENLKKRLNK"

     misc_feature    343..345
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9A7; propagated from
                     UniProtKB/Swiss-Prot (Q9D4G9.1); acetylation site"
     misc_feature    382..954
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="RecQ mediated genome instability protein; Region:
                     RMI1_N; pfam08585"
                     /db_xref="CDD:430090"
     misc_feature    1015..1017
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9A7; propagated from
                     UniProtKB/Swiss-Prot (Q9D4G9.1); phosphorylation site"
     misc_feature    1147..1275
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D4G9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1219..1221
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9A7; propagated from
                     UniProtKB/Swiss-Prot (Q9D4G9.1); phosphorylation site"
     misc_feature    1780..2172
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="Recq-mediated genome instability protein 1,
                     C-terminal OB-fold; Region: RMI1_C; pfam16099"
                     /db_xref="CDD:435136"
ORIGIN      

gctgctcacgtgtgccgggaggggcgactgcggggggattttcgagccccgagggagtttggcgcgattggaggagggacggtcgccccgtgagcgcccgattgggcgggaagaagtgaaagagggaaaagagaacccagctgggaacgggagagggagagcggcgcgcggccctgggatcacgctgcggtgcgaggcgaggcgaggcgaggcgggaaggccagggtcatttctctgcagaggaggctctgagtactgtactgaccatctagcttgaaatccctcgttagctcacaggctggcctgctaagtggtagatgtggatcctcttacttaaaagaaatgagtgtagctagtgctgtattaagagttgaaacctggcttttggcaacatggcatgttaaggtacctccaatgtggctggaagcttgtgttaactggatccaagaagaaaataataatgctactttgagtcaggcacaaataaataaacaagtgttggagcaatggcttcttactgacctgagagacttggaacatcctctcttacctgatgacattttagaactgccaaagggagaactgaatgggttttatgctctacagatcaattctttggttgatgtgagtcagcctgcttattcacagatacagaagctgagaggaaagaatacaaccaatgatctcgtctcagctgaaacgcagagtactccaaaaccatgggaagtgaggccttctcggatgctgatgctacagctcactgatggtgtcacacacattcagggaatggagtatcagtctatcccagctctccatagtggtcttcctccaggtacaaaaattttagttcgtggatgcattttgttccgtcttggtgttctcttactgaaaccagaaaatgtgaaggtgctagggggtgaggtagatggtctttcagaagaaaatgcccaagaaaaagtacttgcaagattaattggggaacttgatcctacagttccagtcattccaaataattccattcacaacgtgcccaaagtttcagggggcttagatgctgttttggggccctcggatgaagaactcttggcaagtcttgatgaaagtgaagagtctgcagcaaataatgacgtggctatggaaagaagctgtttcagcacaggcacttcctcaaatactactccgacaaatccgtctggttttgagccaggatgtaacatttcttcaaggccaaaggagaaaccaccaaaccagcccacgcatttcactgatggagaatttgatgacttttcactggaagaggccttgcttttggaagagactgtccagaaagaacagatggaaacaaaagcatcgcagccactaactttgaaggaaaacactggtaaatgtatggagattttttcacataaacctagtagtctgaaccacacagctttgattcataaacaaggaaacagcaattttgatgaaaaaacatctgaacaaatgattcatgaagacaaattttttgattgtgcatctactagaaaccatcataagagattctcagctcatgattttacaaatgacagtaagatttcagaagtagatgatgcagcacaacagaccctcagcagttcaaatgtacattgcttacgtaataaaatattaaacagaaagctggacctatcagaaaagagttcacaaatttctaaagaaaatggccaccctttccaggcttgttcttcaagatcatttgagaataatacttatctatctattggcatggacttacattctccaccctttatctatttgtctgttctaatggccagaaagccaaaggaagttactactgtgacagtcaaagcgtttattgtcactttaactggaaatctctcaagttctggtggcttttggggtgtaactgcaaaagtttctgatggtactgcatatctagatgtagattttatagacgaaatacttaccagtatgatagggtattcagtaccagaaatgaaacaattaagaaaggaccctcttaaatataaaacattcctagaagggttacagaaatgtcagcgagatctgatcgatttgtgttgcctgatgactatttcatacgatccttcttcatgtaaaggggtggtgctggaattgcaagatgttggtatggaacacgtggagaacctaaagaaacggttgaataaataatttgccagaatgctattggagcacactttaaaacaggcaaatatttggaatcaaatttgtgtattctcagttttggaattctgtaagaaaaagcttcagagcttaaagctggggcagctccgcggttgacagacacagtgtctgccaagtgtggtaactggagtttaaccatctggtctctcgaggcaaaaggcgagaccctgcttccagaatccgttggtagtcctctacacaggtggcagaggacacacacacacacacacgtactaaataaatgacatttaaaaataaagatatttaatcaaaatatgtgaaagaatgtttatattttggtgatactggcccagagtcttgtaatgctagcaagtttctaccatagttacatctctagatccttgggatgtttgtttgttttgtttatttttttgttttccctccctggaaactggatctcatacacaggctgtcctcaaactctcttgtatagctgagagtgacctcgagtttctggtctcttgccttcaccacccaagtgctagatttagggttgtacatttttacctgtgcgtgctaggcaaatgctctaccaactgagccatatccccagtccttgttgaagggtttagctgacccactctggctgagaaacttgttttccacttgtcattggataaacctaaaattgataaagaatagtgatggactgacagcagtttgttgggtaaaggtgcttgctgctgagcctgacaacctgatgctattcctggtaccacatgctggaaagcgaaaactctcccacaagatggcctctgatttccacctgcatgccaaaacgtgtgtgctccctcccatacataaaggtacacacaatgaaataaaatttaataaagagttgatgttccccagtgagatattactgaaagttaggaattgaaaattagtaattttacctctaataagttgaatattaaaaaaaattgtactgtgatttagatatcttccatttactgtgtgtataggtcagagggcagcctgggacacttggctttctcctgctgtgtggattcatggggtaaaatcctcaggctctgcacgcaccttgtacctgctgagctgtgaggatggctctggcttttgagatagtatcctgatacgtttccaggatcctgcgaattggctttgcatatgagttatttgtgttattgttttaaagagactagactatttccttttgctgtactagattatgtttgggagatgtacttttaaaattgtaaaagtgtgtgtgtgtgtagagattgatgaatggaatgaacctctgaacctgtaagccatccccaattaaatgtccttagaaga

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