LOCUS       NM_028797                740 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus gametocyte specific factor 1 (Gtsf1), mRNA.
ACCESSION   NM_028797 XM_895110 XM_917380
VERSION     NM_028797.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 740)
  AUTHORS   Arif A, Bailey S, Izumi N, Anzelon TA, Ozata DM, Andersson C,
            Gainetdinov I, MacRae IJ, Tomari Y and Zamore PD.
  TITLE     GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute
            proteins
  JOURNAL   Nature 608 (7923), 618-625 (2022)
   PUBMED   35772669
  REMARK    GeneRIF: GTSF1 accelerates target RNA cleavage by PIWI-clade
            Argonaute proteins.
REFERENCE   2  (bases 1 to 740)
  AUTHORS   He Y, Chen Q, Dai J, Cui Y, Zhang C, Wen X, Li J, Xiao Y, Peng X,
            Liu M, Shen B, Sha J, Hu Z, Li J and Shu W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   3  (bases 1 to 740)
  AUTHORS   Ipsaro JJ, O'Brien PA, Bhattacharya S, Palmer AG 3rd and Joshua-Tor
            L.
  TITLE     Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons
  JOURNAL   Cell Rep 34 (13), 108914 (2021)
   PUBMED   33789107
  REMARK    GeneRIF: Asterix/Gtsf1 links tRNAs and piRNA silencing of
            retrotransposons.
REFERENCE   4  (bases 1 to 740)
  AUTHORS   Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N,
            Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya
            A, Chuma S and Miyazaki JI.
  TITLE     Mouse GTSF1 is an essential factor for secondary piRNA biogenesis
  JOURNAL   EMBO Rep 19 (4) (2018)
   PUBMED   29437694
  REMARK    GeneRIF: Our findings indicate that GTSF1 is a crucial factor for
            the slicing of target RNAs by PIWI-piRNAs and thus affects
            secondary piRNA biogenesis in prospermatogonia.
REFERENCE   5  (bases 1 to 740)
  AUTHORS   Yoshimura T, Toyoda S, Kuramochi-Miyagawa S, Miyazaki T, Miyazaki
            S, Tashiro F, Yamato E, Nakano T and Miyazaki J.
  TITLE     Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC
            Zn-finger motif, is involved in spermatogenesis and retrotransposon
            suppression in murine testes
  JOURNAL   Dev Biol 335 (1), 216-227 (2009)
   PUBMED   19735653
  REMARK    GeneRIF: Results indicate that Gtsf1/Cue110 is required for
            spermatogenesis and involved in retrotransposon suppression in male
            germ cells.
REFERENCE   6  (bases 1 to 740)
  AUTHORS   Krotz SP, Ballow DJ, Choi Y and Rajkovic A.
  TITLE     Expression and localization of the novel and highly conserved
            gametocyte-specific factor 1 during oogenesis and spermatogenesis
  JOURNAL   Fertil Steril 91 (5 Suppl), 2020-2024 (2009)
   PUBMED   18706558
  REMARK    GeneRIF: Expression pattern of Gtsf1 and its high conservation
            suggests that it may play an important role in germ cell
            development.
REFERENCE   7  (bases 1 to 740)
  AUTHORS   Yoshimura T, Miyazaki T, Toyoda S, Miyazaki S, Tashiro F, Yamato E
            and Miyazaki J.
  TITLE     Gene expression pattern of Cue110: a member of the uncharacterized
            UPF0224 gene family preferentially expressed in germ cells
  JOURNAL   Gene Expr Patterns 8 (1), 27-35 (2007)
   PUBMED   17919994
  REMARK    GeneRIF: the Cue110 gene is expressed predominantly in male germ
            cells at stages from the pachytene spermatocytes to round
            spermatids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU945975.1, AK005675.1 and CO812705.1.
            
            On or before Nov 1, 2008 this sequence version replaced
            XM_917380.3, XM_895110.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU939747.1, DV661953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BU945975.1         4-26
            24-718              AK005675.1         2-696
            719-740             CO812705.1         737-758
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.93 cM"
     gene            1..740
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /note="gametocyte specific factor 1"
                     /db_xref="GeneID:74174"
                     /db_xref="MGI:MGI:1921424"
     exon            1..72
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    69..71
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /note="upstream in-frame stop codon"
     exon            73..117
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..605
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /codon_start=1
                     /product="gametocyte-specific factor 1"
                     /protein_id="NP_083073.1"
                     /db_xref="CCDS:CCDS49744.1"
                     /db_xref="GeneID:74174"
                     /db_xref="MGI:MGI:1921424"
                     /translation="

MEDTYIDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRNLGQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTASFCGNNSPANNIVMEHKSNLASGMRVPKSLPYVLPWKNNGNAQ"

     misc_feature    123..125
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8WW33; propagated from
                     UniProtKB/Swiss-Prot (Q9DAN6.1); phosphorylation site"
     misc_feature    141..215
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /note="U11-48K-like CHHC zinc finger; Region: zf-U11-48K;
                     pfam05253"
                     /db_xref="CDD:428393"
     misc_feature    243..314
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /note="U11-48K-like CHHC zinc finger; Region: zf-U11-48K;
                     pfam05253"
                     /db_xref="CDD:428393"
     exon            118..218
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            219..345
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            346..429
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            430..493
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            494..588
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            589..622
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
     exon            623..723
                     /gene="Gtsf1"
                     /gene_synonym="1700006H03Rik; Cue110"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aggccggaagtgggcgttgccggggcctggctgtgaggcgaagtcggcggtggggagagcttctggactgagcacttgaacaggactcctttgccatcagcatggaagacacttacatcgactccctggaccctgaaaagttattacagtgcccctatgataaaaatcaccagatcagggcctgcaggtttccttatcatcttatcaagtgcagaaagaatcatcctgatgtcgcaaacaaattggctacttgtcccttcaatgctcggcatcaggttccccgggctgagatcagtcatcacatctcgagctgtgatgacaagagctgtattgagcaggatgtggtcaaccaaaccaggaaccttggacaagagactctggctgagagcacatggcagtgccctccttgtgatgaagactgggataaagatttgtgggaacagactagcaccccatttgtctggggcacagccagtttctgtggcaacaacagtcctgcaaataacatagttatggaacataagagtaaccttgcttcaggcatgcgagttcccaagtctctgccctatgttttgccatggaaaaacaatggaaatgcacagtaactgaacatctttttcaaatgccagactgtggaagactcttgcttattcctgctaccaagggttcttcttttttctctttatctaattatagaacagtaaactgtctgtgactttcaaaaaaaaaaaaaaaaaaaa

//