LOCUS       NM_027287               4861 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B4
            (Dnajb4), transcript variant 1, mRNA.
ACCESSION   NM_027287
VERSION     NM_027287.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4861)
  AUTHORS   Inoue M, Noguchi S, Inoue YU, Iida A, Ogawa M, Bengoechea R,
            Pittman SK, Hayashi S, Watanabe K, Hosoi Y, Sano T, Takao M, Oya Y,
            Takahashi Y, Miyajima H, Weihl CC, Inoue T and Nishino I.
  TITLE     Distinctive chaperonopathy in skeletal muscle associated with the
            dominant variant in DNAJB4
  JOURNAL   Acta Neuropathol 145 (2), 235-255 (2023)
   PUBMED   36512060
  REMARK    GeneRIF: Distinctive chaperonopathy in skeletal muscle associated
            with the dominant variant in DNAJB4.
REFERENCE   2  (bases 1 to 4861)
  AUTHORS   Weihl CC, Topf A, Bengoechea R, Duff J, Charlton R, Garcia SK,
            Dominguez-Gonzalez C, Alsaman A, Hernandez-Lain A, Franco LV,
            Sanchez MEP, Beecroft SJ, Goullee H, Daw J, Bhadra A, True H, Inoue
            M, Findlay AR, Laing N, Olive M, Ravenscroft G and Straub V.
  TITLE     Loss of function variants in DNAJB4 cause a myopathy with early
            respiratory failure
  JOURNAL   Acta Neuropathol 145 (1), 127-143 (2023)
   PUBMED   36264506
  REMARK    GeneRIF: Loss of function variants in DNAJB4 cause a myopathy with
            early respiratory failure.
REFERENCE   3  (bases 1 to 4861)
  AUTHORS   Luo WJ, Yu SL, Chang CC, Chien MH, Chang YL, Liao KM, Lin PC, Chung
            KP, Chuang YH, Chen JJW, Yang PC and Su KY.
  TITLE     HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12
            heterodimerization in macrophages
  JOURNAL   Elife 11, e76094 (2022)
   PUBMED   35983991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4861)
  AUTHORS   Hsu MC, Luo WJ, Guo BC, Chen CH, Hu PA, Tsai YH, Su KY and Lee TS.
  TITLE     Genetic Deletion of HLJ1 Does Not Affect Blood Coagulation in Mice
  JOURNAL   Int J Mol Sci 23 (4), 2064 (2022)
   PUBMED   35216179
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4861)
  AUTHORS   Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen
            HC, Chen HY, Wu R, Yang PC, Chen JJ and Yu SL.
  TITLE     HLJ1 is an endogenous Src inhibitor suppressing cancer progression
            through dual mechanisms
  JOURNAL   Oncogene 35 (43), 5674-5685 (2016)
   PUBMED   27065329
REFERENCE   6  (bases 1 to 4861)
  AUTHORS   Katoh M.
  TITLE     Functional proteomics, human genetics and cancer biology of GIPC
            family members
  JOURNAL   Exp Mol Med 45 (6), e26 (2013)
   PUBMED   23743496
  REMARK    Review article
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006478.1 and AC123075.5.
            
            On Sep 30, 2017 this sequence version replaced NM_027287.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006478.1, SRR7345562.3935428.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AK006478.1         2-50
            50-68               AC123075.5         129123-129141
            69-476              AK006478.1         69-476
            477-477             AC123075.5         145766-145766
            478-672             AK006478.1         478-672
            673-731             AC123075.5         152355-152413
            732-1265            AK006478.1         732-1265
            1266-1410           AC123075.5         153982-154126
            1411-1422           AK006478.1         1411-1422
            1423-4861           AC123075.5         154139-157577
FEATURES             Location/Qualifiers
     source          1..4861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.03 cM"
     gene            1..4861
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="DnaJ heat shock protein family (Hsp40) member B4"
                     /db_xref="GeneID:67035"
                     /db_xref="MGI:MGI:1914285"
     exon            1..249
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            250..491
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    257..259
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="upstream in-frame stop codon"
     CDS             281..1294
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="isoform 1 is encoded by transcript variant 1; dnaJ
                     homolog subfamily B member 4; DnaJ (Hsp40) homolog,
                     subfamily B, member 4"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 4 isoform 1"
                     /protein_id="NP_081563.2"
                     /db_xref="CCDS:CCDS17915.1"
                     /db_xref="GeneID:67035"
                     /db_xref="MGI:MGI:1914285"
                     /translation="

MGKDYYHILGIDKGATDEDVKKAYRKQALKFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPIIHELKVSLEEIYSGCTKRMKISRKRLNPDGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPADIVFVIKDKEHPKFKRDGSNIVYTAKISLREALCGCSLNVPTMDGRNLPMSVTDIVKPGMRRRVIGYGLPFPKNPDQRGDLLIEFDVSFPDVISAASKEILRKHLPAS"

     misc_feature    281..1276
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="DnaJ-class molecular chaperone with C-terminal Zn
                     finger domain [Posttranslational modification, protein
                     turnover, chaperones]; Region: DnaJ; COG0484"
                     /db_xref="CDD:223560"
     misc_feature    644..646
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UDY4; propagated from
                     UniProtKB/Swiss-Prot (Q9D832.1); phosphorylation site"
     misc_feature    722..724
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UDY4; propagated from
                     UniProtKB/Swiss-Prot (Q9D832.1); phosphorylation site"
     exon            492..1060
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..4861
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcgcacggggcgtgcggggcgtccgcggcgacgctgcggaaccgtctgcggcccggcggcgggagcccaccatgctccggggcgccgagctgcctctgcccatgtctccacccgggccggtcacaagcggggaggaactcagaccaccgggcccttagttctcgagccgattgcctactgagtctcttatgtaaaatagtgtgggcgagcggatggtgaaagtatgaccgccctttgtcctttaaaaacggaaatctaagttcatttcaaggcattcgaaatggggaaagactattatcacattttgggaattgacaaaggagctacagatgaagatgttaaaaaggcttaccgaaagcaagccctcaaatttcacccggacaagaacaaatctcctcaagcagaggaaaaatttaaagaggtcgcagaagcgtatgaagtactgagtgatcctaaaaagagagaaatatatgatcagtttggcgaagaaggcttgaagggaggcgctggaggtactgatggacaaggaggtaccttcaggtacactttccacggagatcctcatgccacatttgcagcctttttcggaggttccaacccttttgaaatcttctttgggagacggatgggtggaggtcgagattctgaagaaatggaaatagatggagatccctttagtgcctttggattcagcatgaatggatatccaagagacaggaattctgtgggaccctcccgtctcaaacaagaccctcccattattcatgaacttaaagtatcgcttgaagaaatatatagtggctgcaccaaacggatgaagatttctcgaaaaagattaaatcctgacggaaggagttacagatctgaggacaaaattctcaccattgagatcaaaaaagggtggaaagaaggcaccaaaatcacttttccgagggaaggcgatgaaacaccaaatagtatcccagcagacattgtttttgttattaaagacaaagaacatcccaagtttaaaagagacggatcaaatatagtttatactgctaaaattagtttacgggaggcattgtgtggctgctcacttaatgtgccaacaatggacggaagaaacctacctatgtcagtcactgatattgtgaaacctgggatgaggagaagagttattggatatgggctgccatttccaaaaaaccctgaccagcgtggcgacctactgatagaatttgatgtgtccttcccagacgtcatatctgcagcatccaaagagatcctgaggaagcatctccctgcctcctaggatgagaagaaccttgctatccatagtttgataagacactgaaaatataaaagtaccggcagttgactgctgtgaattctgtgtaaagatgtgtaaactcttctgagggctcattaaactgcatgaatagacacagttcaaataggcaacgtgggtttttacagtagggatgaaaagtcattcactgtatttcatttctcccaaatcagaaatttttagtatttcatttacaagtaaaagttggttttgtggtctatggatatacttctagtaaatactagattatccaagtactgtgtgcatgtgcgtgtgtgtgtgtgtgtgtgtgtgtacgcgcgcgtgtgtgtctgtgtgtgctcgtgtctgtgtgtgtatctttaaatgatcagtgtgataggctcctttaataaaaattaaaattcttaagtgtatatgtaatatgtggagaataaaagccaaagtcatacagaaatgcagtctaggtgacattcagagatgctgtgttgggctggtaccagaatgcattgatgtgtgtgctttaccgttgtgacttctcaatattctgcagcgtttcttaagagcatggttgtaatgttcgtaaagcagacctcatcataagaagaaaatgaatgacattttctctcctgtggaagtcccaatagccagagctcctgatattttagaaacagatggtttttaagtggccacatgtaattttatgcagttgactatatatcttaaacttaataagctcattttgtggttcattagtttaaggtatttgtttactaacatgtttttagagaaaatactgttacttggcattaattgtccatttacagtgttctgttaagttcctcatgctatgcaccttacataatttccctaaagaacagtcatctatcactgtggtgttaaaccgcaatctggatataacaaacaccatcactgcttgtgggtaatgtgctgtcatcatataaatattctaccttttcatgtatatagattgcatttcttaggtgttttaatttttaaaatatatttacattctaaaaaattactgtcttctgttttatatctatcaaaagtgatgttatgaaaaattttttgtaaaacagttttcagaatgatatatatctatacataaatatatatggtatactgagtcctatagtctttttaatagaatgtgaagttatttagaaattctgtataaaattatagtaagcgtataccttgtggctttattgaaatagaattctcataagataaaattcacactaacctccctcatttttttggtactgttgactgacgtcagagctgcgtgcacactaagtgcctcccaccgtggagctgtgcccagcctccccctctctctctctttctttgtggtgtagttttgaatttcgtgtatccacagacctgtgcagtcaccatgaacagcttctgtgccccctctcccctcagcccctggagcactgatctgcttttcaagatggattctattgtagaatagaatcggtcggcatgcggctcctttatttgctgtcgttcacccagcacagcactgttctcaaggtccagtctggcctcattatcagtaacttcatcctttgtgtggcagatcatgtacttgggtagaatcccatttggtcagcttacctcttctttggtgttttgggcatctgggttctatctactcagtatgaataatgatgctatgagcatttgtaaacaaatttctgtgtggatagactgactgcattctctgaggtacatagttgagagtggaatggttaggaaaagctacatccattagttgcaaatagaaaatgttaaaaatgccagagagttgaggtaatcgcaccatctccttgaacatcatggaaattcacacagatataaagagctaaagtcttggagtgatggttgtagttcatattcgaaaccacatacccacagtattcaacttttgagttgtttgaggggggcagggtgtgtgtgtgtttgtgtctgcttgtttggaggtagggtcttactatgtagctctggctggtatgttgctccatgtgactcaagttcacgataaatttatgggaatttttctccctgcctcatagtggctggaatgaatggcatgtgccattcacaccacacaggctttgaaccaacaattattattgcagtcttattgagtaaacattttctctgagccaaaataaagggtttataaacacaaataatctttcagttagttcctttagtaataattattctaacaatcaatcaatcaatcaatcaatctgtactactcttagggctgagggtagggttcggtgacagtagtagaataaatgtacaaaatatataaatttagaggaaacatgcttccgagtgtagtaagtgcccattgttttgttaaatattgaattaatactgacagtaaaatgttaaaaattttcagatttaaactatgagagtacttttgacttctaagatgttccttttaggggctggaaagagggctcagaggcacttgcctctcgtgagtggacctgggttcagttcccaggacacacttggaggctcccagccgtctgaaactccagttccaaggacacctctttggtctccatgggcaccaggcatgcatgtggtgcacctacatacatgcagacaaacacagcatcctttttttttaaaattcttttaaagtgtttaatttactagtccttgcatagctcaaatgattttgcagcataatgagtccagtaaagcttcttattaaagatgtttgttaaaagaacacatatccacgggtcttatggctttccagggcaggtgttgtatttggtagctctgtagctgaggaacagttttcttaggacggttctaagcgagacgcactgttccatcacatctgccctccctgccacgtggtgcttcgtaacccatggccttgaaagcattgggctctgacatccacattagcttgtctctctggctattagtcggtcttggaggcaaggggttgaacaagcctcttgtttattcttaggaaactgtcattggaatgtttgtgattggatgaaatgaaattagtgcaagtgattggactcagtcaatggccttgatgaaacactcctctcacatttcaggaattacctgctcagtcttggggagtcaaggccaacatggctttcattcaataatagataatgtagtatggctgactatcttcacaatctctctctctgtatgtgtgtgtgtaggtgaacacgtgtgtttaagcaaatgtcttaacacgaactaatattaagataggaaagagtaatttatgctgtttataacaatgacaaatacacaaaatttagattcttggcttacaatatttatatttaaattatttatatttaatactgaagttttgtaaaattgattcagggaacaagactagaaagttactttgcctgggtttctaacgccctttaaccttttttgaaactcttttcttctagttttttctaaaaattaaatttgtcttttgacaataccataaatgaa

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