LOCUS       NM_026067               5067 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus exoribonuclease 1 (Eri1), mRNA.
ACCESSION   NM_026067
VERSION     NM_026067.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5067)
  AUTHORS   Pirouz M, Munafo M, Ebrahimi AG, Choe J and Gregory RI.
  TITLE     Exonuclease requirements for mammalian ribosomal RNA biogenesis and
            surveillance
  JOURNAL   Nat Struct Mol Biol 26 (6), 490-500 (2019)
   PUBMED   31160785
  REMARK    GeneRIF: 7SB ribosomal RNA can be oligoadenylated by an unknown
            enzyme and/or oligouridylated by TUT4/7 and subsequently processed
            by Dis3l2 and Eri1.
REFERENCE   2  (bases 1 to 5067)
  AUTHORS   Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer
            E, Ansel KM and Heissmeyer V.
  TITLE     Eri1 degrades the stem-loop of oligouridylated histone mRNAs to
            induce replication-dependent decay
  JOURNAL   Nat Struct Mol Biol 20 (1), 73-81 (2013)
   PUBMED   23202588
  REMARK    GeneRIF: data demonstrate how degradation of histone mRNAs is
            initiated when 3' oligouridylation creates a cis element that
            enables Eri1 to process the double-stranded stem-loop structure
REFERENCE   3  (bases 1 to 5067)
  AUTHORS   Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M,
            Woodruff P, Lanier LL, Heissmeyer V and Ansel KM.
  TITLE     Eri1 regulates microRNA homeostasis and mouse lymphocyte
            development and antiviral function
  JOURNAL   Blood 120 (1), 130-142 (2012)
   PUBMED   22613798
  REMARK    GeneRIF: Mouse Eri1 regulates miRNA homeostasis in lymphocytes and
            is required for normal NK-cell development and antiviral immunity.
REFERENCE   4  (bases 1 to 5067)
  AUTHORS   Bian Y, Zhou W, Zhao Y, Li X, Geng W, Hao R, Yang Q and Huang W.
  TITLE     High-dose siRNAs upregulate mouse Eri-1 at both transcription and
            posttranscription levels
  JOURNAL   PLoS One 6 (10), e26466 (2011)
   PUBMED   22039495
REFERENCE   5  (bases 1 to 5067)
  AUTHORS   Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND and Robson P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 5067)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 5067)
  AUTHORS   Yang XC, Torres MP, Marzluff WF and Dominski Z.
  TITLE     Three proteins of the U7-specific Sm ring function as the molecular
            ruler to determine the site of 3'-end processing in mammalian
            histone pre-mRNA
  JOURNAL   Mol Cell Biol 29 (15), 4045-4056 (2009)
   PUBMED   19470752
REFERENCE   8  (bases 1 to 5067)
  AUTHORS   Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith
            LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y,
            Kremmer E, Rao A and Heissmeyer V.
  TITLE     Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA
            processing
  JOURNAL   Nat Struct Mol Biol 15 (5), 523-530 (2008)
   PUBMED   18438418
  REMARK    GeneRIF: Findings indicate that Eri1 catalyzes the final trimming
            step in 5.8S rRNA processing, functionally and spatially connecting
            this regulator of RNAi with the basal translation machinery.
REFERENCE   9  (bases 1 to 5067)
  AUTHORS   Hong J, Qian Z, Shen S, Min T, Tan C, Xu J, Zhao Y and Huang W.
  TITLE     High doses of siRNAs induce eri-1 and adar-1 gene expression and
            reduce the efficiency of RNA interference in the mouse
  JOURNAL   Biochem J 390 (Pt 3), 675-679 (2005)
   PUBMED   16004606
  REMARK    GeneRIF: The roles of meri-1 (mouse enhanced RNAi) and adar1 in the
            regulation of RNA interference are reported.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014410.1, AK165026.1, AK161031.1 and AK050230.1.
            
            On Jan 17, 2008 this sequence version replaced NM_026067.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.248668.1, AK144223.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AK014410.1         3-74
            73-1850             AK165026.1         2-1779
            1851-3997           AK161031.1         716-2862
            3998-5067           AK050230.1         3063-4132
FEATURES             Location/Qualifiers
     source          1..5067
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 21.16 cM"
     gene            1..5067
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="exoribonuclease 1"
                     /db_xref="GeneID:67276"
                     /db_xref="MGI:MGI:1914526"
     exon            1..262
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    128..130
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="upstream in-frame stop codon"
     CDS             167..1204
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="three prime histone mRNA exonuclease 1; histone
                     mRNA 3' end-specific exonuclease; enhanced RNAi protein 1;
                     eri-1 homolog; 3'-5' exonuclease ERI1; histone mRNA
                     3'-exonuclease 1"
                     /codon_start=1
                     /product="3'-5' exoribonuclease 1"
                     /protein_id="NP_080343.4"
                     /db_xref="CCDS:CCDS22244.1"
                     /db_xref="GeneID:67276"
                     /db_xref="MGI:MGI:1914526"
                     /translation="

MEDERGRERGGDAAQQKTPRPECEESRPLSVEKKQRCRLDGKETDGSKFISSNGSDFSDPVYKEIAMTNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNYYKKQKLMLKESSAGDSYYDYICIIDFEATCEEGNPAEFLHEIIEFPVVLLNTHTLEIEDTFQQYVRPEVNDQLSEFCIGLTGITQDQVDRADAFPQVLKKVIEWMKSKELGTKYKYCILTDGSWDMSKFLSIQCRLSRLKHPAFAKKWINIRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPHSGLDDSKNIARIAIRMLQDGCELRINEKILGGQLMSVSSSLPVEGAPAPQMPHSRK"

     misc_feature    167..316
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMF2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    329..331
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV48; propagated from
                     UniProtKB/Swiss-Prot (Q7TMF2.2); phosphorylation site"
     misc_feature    338..340
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV48; propagated from
                     UniProtKB/Swiss-Prot (Q7TMF2.2); phosphorylation site"
     misc_feature    380..484
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="SAP domain; Region: SAP; pfam02037"
                     /db_xref="CDD:426575"
     misc_feature    542..1084
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="DEDDh 3'-5' exonuclease domain of Caenorhabditis
                     elegans ERI-1, human 3' exonuclease, and similar proteins;
                     Region: ERI-1_3'hExo_like; cd06133"
                     /db_xref="CDD:99836"
     misc_feature    order(554..565,569..571,707..709,842..856,866..868,
                     1031..1033,1046..1048)
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="active site"
                     /db_xref="CDD:99836"
     misc_feature    order(554..565,569..571,707..709,842..856,866..868,
                     1031..1033,1046..1048)
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:99836"
     misc_feature    order(554..556,560..562,854..856,1031..1033,1046..1048)
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99836"
     exon            263..441
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..652
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..736
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..846
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..961
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..5067
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3981..3986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="putative"
     polyA_site      3997
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="putative"
     regulatory      5047..5052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="putative"
     polyA_site      5067
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="putative"
ORIGIN      

cacacgctcccggaagtaggaggcgtccggcggagtttgtgtggcggccgccgcgggaacgtgaagcgcggtagtttttcaagggagagagcgaggcggcttcccgcgggtctcggtggaccgacagtgagcgtccgcggccgtctcgcggcccgcgagaggcggcatggaggacgagcggggccgggagcgtggcggcgacgcggcgcagcagaagacgccgcggccggagtgtgaggagtcccggccgctgagcgtggagaaaaagcagcgatgcagacttgatggcaaagagacagatggatcgaagttcatttcctccaatggcagtgacttcagtgacccggtttacaaagagatcgcaatgacaaacggttgtatcaaccggatgagtaaggaggaactcagagctaaactttcagaatttaagcttgaaacaagaggagtcaaggatgttctaaagaagagactgaaaaactattacaagaagcagaagttgatgctgaaagagagctccgctggggacagttactatgactacatttgtatcattgactttgaggctacttgtgaagaggggaacccagctgagttcctacatgaaatcattgagtttcctgttgtcctgttgaatacacacaccttagaaatcgaagatacgtttcagcagtatgtgaggccagaagtcaatgatcagctttcagagttctgcatcggtcttactggaatcactcaggatcaggtagacagagccgatgctttccctcaggtcctgaaaaaagtgattgagtggatgaagtcaaaggagttgggaactaagtacaagtactgtatactaacagatggctcctgggatatgagtaagttcctgagcatccagtgccggctcagcagactcaaacacccggccttcgctaagaagtggatcaatatccggaagtcatacggaaacttctataaggttcccagaagccagaccaaactaacaataatgcttgaaaaattaggaatggattatgatggacggcctcacagcggtctcgatgactctaagaacattgctagaatagctattcggatgcttcaggatggatgtgaacttcgaatcaatgaaaaaatacttggagggcagttgatgagtgtgtcctcatccttaccagtagagggcgctccagctccacagatgccacatagtagaaagtaactgcagttttgtctgatcagttgctacaaaagtagcaggcgaatgaatctgagttaatgcaaccttcaagcaccttaaacatttaagatcttattacaattacagatagatgggtatgtatgcagacattttgtgggaggacacaccaaattctttgtcaccagcacttttgatctgagcagtatttgttacacacagtaaccagtctctgctcagaactgaattttataatgtaaggtgtccaagatgtgtcccttggcttttaagatggaagttttatcagaaaattctttacatgtcatgttcttattgatactggaatttaaaatgaatttctacattaccaccatgaaattaaatacattttttgaaaatgtggaaaggattgaaaggtagtgtttgcccattgagttttaagtaaaacgtggttcttttaactttgtaagtttgtaggtgaagtgagggctttgtcccaagaaggctgtgtgggtaccagattctgcaagtgttgaagttctatagttcaagtggcataatgtttctatataacctacacgttctcccacatattttaatcatctctgggtagcttatacttaataaactataaagaaatggttgtatcatttagggaataatgacaaggaaaaaaaaaagcctgcaagttgatgtagacacaaccatagtgggccttgctacatagctcatgagctaaaaaaaaaccaagatctgagatggtggaggcaacttcagctgtcccctgcgtcactctctggccagcagctgtccccccctgcgtcactcactctggtccactcagcaaagtgcttgctgagcagcaaattcaggtgtttcttcttggaacattttcggcatatctgtgtatagcctatattcaagccaggaagttgtttctaaaggtgtctactttgacagccctgaacacacatgacccccagaacacacgtgatagactaagagaatcaactcagctcaaggatgataaagtactgggaccagtttcatattataactggaaaccttgtaataggtcatagaatttagttaaaaatctagttactggaggctagcaagatggctcagtggttaaaagtacttgcttctcttgtagaagatccaagttcaattcccagaacccacatggtggctcacaaccatctgtaagtttcaaagaatccaacaggcaaaacattcataaacataaaataactaaatttagaatactgggctggagagatgcctcagaagttaagagtgctggctgctctttgagaggccctgaagttcaattcccagcacccacatagtggctcccaaccccctacaatgagactgctgtcctcttctggcatgcaggcagaatgttgtatatataatatatacatcctttttaaaagtctaattactggtgagactaatggaaagttagaaaaggcagcctggtagcacagatgtgtaatttcagtcctcaagagttaaggcataggtgaatctgaagccactctgagccatataatgagctcctgattccaaaatgtgtcagtagaaaatacaagtgaacttgtgagagctataacttacaaatcaatgggaaaatctgaagatttgctccttgccttccctcaccattgtgaatgtatattcgccctgcttttgagctcatggtaaacatttgtattcagtactgtgaggtgaaatgttttgttccatagtaaaaagtacctggcttgtcttggtgagtgaccagtatatattggaaagtaattcctgcttctaaagtcaagatgtgctctggagatgatgatgtcatactgtctggaggctaacagtgggagcttttggaattaaacccctctaatgctttcctggacccatctcattggcattgcctgttgttttgttttttcaactttccttaatgattgtgatcatattatgtccatcaccactataatcaagtagattgatcatgtttcctaactcggacataggaggaacgacagcgatgcgcttgggaccatgagaatttgctacccaggcttgcggtttcattccccagtgagctctgtcttgaagcaaagggacaggaaatggtcattgtgagggacagaagccagcaggctctctggactgacttactcttcattttctcacataagccatggtgacacaggcaggttcatgccctagaaaaataattgcttgtcacctgattgcatagttgctactgaatagggaaactaccattgggaagttagagaatagcaggacatactaatgccttcctctttgttttgtttttaaatcaggctgtttaaattttttcctaatcaagtgcttaacattttttttttaaagaacttaacactgcaagcttttaaaatgcttttggctctactaagtatttcgccatcttcactcactctgagtctctgtcaaaccatttgatttggctttctgctgatataacctgtctgtaagttatagagtgagtcataattcttgaaaggaaactactgcagcctgcctgcctacgttgtgtgtaaagatactggttcttgttactgctgggatggcttacactggtgctagtgtttgctgatacttacttaaagctttattttctcagtcgccatggtcatctccttgttttccttttacttgcttggacattgagactgatttttccccctgtattattttcaaatccacacaaactggtatatattctcagctacattttgtctgattttgtattaaatactgacattgactctggaaatttttctttctctccacttctccctctgactgggtcaagcaaaagcaggaagaagaggttttcttttttttcagcatgtgtttctgcgtgtatgtgtgcctgggagagtttatgtgcaccatgtacccttagattcctgtggacgcctcagaactggagttgcaggtggccatgagcacctaatgtgggtgctgggatcctgagtcaatgcctctgcaagagccgtcgcactcaactctggggccatctctccagcctcaaggccctttcttgtagcctttagagacctgcttgtcctgctgtagggataggttttctcagctgggttaacaggaaagaccatgggagtcatgctaaactggtcctattgctgacgagtcatttattaaatggtgatttgattacttgaaaggtgaaagaacttttagttcatcgtcccagatattaaagcactattgcgaaggataaggaagaaggggtgggtagtaagatttctggggaaggagggatcacaagtgatcaatacaaggagcaccagtcaagtcacccacctcgagtgagccatgtcctttgtgaagtctgtgagtatgtgtcctgttgcaaggaagactttgagctgctggaggagactgacttccttagtgatgagctgtgaactcctcctttattccagcggggcctgttgagatgctttccgtgtgtaatgattgcagtgttggtaaatgagtagtcccactaagtatcgtccttagtgttgaccctcatttcagctcttcctgcccccacacagcatcaatgcacacactgtagccacgaaccaaatctgatagccaagtggcaagttaaaatcaagagtgcttgtatgtatgcatgtgtgtatgtatgtatatatgtatgtatgtttttgacagggtatgtctgtgtagtctaatcaggtttcaaattcttcggtactggaattacaggtaagtgctacctaccatgccaatgatgtgacttgtagcataggaattttatgaaataaaattttgatgttgtaaataaagctttgtggaatagc

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