LOCUS       NM_025926               4839 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B4
            (Dnajb4), transcript variant 2, mRNA.
ACCESSION   NM_025926
VERSION     NM_025926.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4839)
  AUTHORS   Inoue M, Noguchi S, Inoue YU, Iida A, Ogawa M, Bengoechea R,
            Pittman SK, Hayashi S, Watanabe K, Hosoi Y, Sano T, Takao M, Oya Y,
            Takahashi Y, Miyajima H, Weihl CC, Inoue T and Nishino I.
  TITLE     Distinctive chaperonopathy in skeletal muscle associated with the
            dominant variant in DNAJB4
  JOURNAL   Acta Neuropathol 145 (2), 235-255 (2023)
   PUBMED   36512060
  REMARK    GeneRIF: Distinctive chaperonopathy in skeletal muscle associated
            with the dominant variant in DNAJB4.
REFERENCE   2  (bases 1 to 4839)
  AUTHORS   Weihl CC, Topf A, Bengoechea R, Duff J, Charlton R, Garcia SK,
            Dominguez-Gonzalez C, Alsaman A, Hernandez-Lain A, Franco LV,
            Sanchez MEP, Beecroft SJ, Goullee H, Daw J, Bhadra A, True H, Inoue
            M, Findlay AR, Laing N, Olive M, Ravenscroft G and Straub V.
  TITLE     Loss of function variants in DNAJB4 cause a myopathy with early
            respiratory failure
  JOURNAL   Acta Neuropathol 145 (1), 127-143 (2023)
   PUBMED   36264506
  REMARK    GeneRIF: Loss of function variants in DNAJB4 cause a myopathy with
            early respiratory failure.
REFERENCE   3  (bases 1 to 4839)
  AUTHORS   Luo WJ, Yu SL, Chang CC, Chien MH, Chang YL, Liao KM, Lin PC, Chung
            KP, Chuang YH, Chen JJW, Yang PC and Su KY.
  TITLE     HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12
            heterodimerization in macrophages
  JOURNAL   Elife 11, e76094 (2022)
   PUBMED   35983991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4839)
  AUTHORS   Hsu MC, Luo WJ, Guo BC, Chen CH, Hu PA, Tsai YH, Su KY and Lee TS.
  TITLE     Genetic Deletion of HLJ1 Does Not Affect Blood Coagulation in Mice
  JOURNAL   Int J Mol Sci 23 (4), 2064 (2022)
   PUBMED   35216179
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4839)
  AUTHORS   Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen
            HC, Chen HY, Wu R, Yang PC, Chen JJ and Yu SL.
  TITLE     HLJ1 is an endogenous Src inhibitor suppressing cancer progression
            through dual mechanisms
  JOURNAL   Oncogene 35 (43), 5674-5685 (2016)
   PUBMED   27065329
REFERENCE   6  (bases 1 to 4839)
  AUTHORS   Katoh M.
  TITLE     Functional proteomics, human genetics and cancer biology of GIPC
            family members
  JOURNAL   Exp Mol Med 45 (6), e26 (2013)
   PUBMED   23743496
  REMARK    Review article
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123075.5 and BC017161.1.
            
            On Sep 30, 2017 this sequence version replaced NM_025926.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017161.1, AK136240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC123075.5         145312-145353
            43-2329             BC017161.1         1-2287
            2330-4839           AC123075.5         155068-157577
FEATURES             Location/Qualifiers
     source          1..4839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.03 cM"
     gene            1..4839
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="DnaJ heat shock protein family (Hsp40) member B4"
                     /db_xref="GeneID:67035"
                     /db_xref="MGI:MGI:1914285"
     exon            1..469
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    235..237
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="upstream in-frame stop codon"
     CDS             259..1272
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="isoform 1 is encoded by transcript variant 2; dnaJ
                     homolog subfamily B member 4; DnaJ (Hsp40) homolog,
                     subfamily B, member 4"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 4 isoform 1"
                     /protein_id="NP_080202.1"
                     /db_xref="CCDS:CCDS17915.1"
                     /db_xref="GeneID:67035"
                     /db_xref="MGI:MGI:1914285"
                     /translation="

MGKDYYHILGIDKGATDEDVKKAYRKQALKFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPIIHELKVSLEEIYSGCTKRMKISRKRLNPDGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPADIVFVIKDKEHPKFKRDGSNIVYTAKISLREALCGCSLNVPTMDGRNLPMSVTDIVKPGMRRRVIGYGLPFPKNPDQRGDLLIEFDVSFPDVISAASKEILRKHLPAS"

     misc_feature    259..1254
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="DnaJ-class molecular chaperone with C-terminal Zn
                     finger domain [Posttranslational modification, protein
                     turnover, chaperones]; Region: DnaJ; COG0484"
                     /db_xref="CDD:223560"
     misc_feature    622..624
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UDY4; propagated from
                     UniProtKB/Swiss-Prot (Q9D832.1); phosphorylation site"
     misc_feature    700..702
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UDY4; propagated from
                     UniProtKB/Swiss-Prot (Q9D832.1); phosphorylation site"
     exon            470..1038
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..4839
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gagacacgtagttgaagtgggagggtctagctgaggccgtctccgtgcggtgtctatttatctgtaagtgagctgccggggaggaattaaatagagacgctgcctgctgcctctggacagctgagccgagttgctgatttgctttaacttgtaagatacccagcttgctttattttctcaggatcattgtgttgctaagcctggggacgctgttttcttttacaaagggaaatctaagttcatttcaaggcattcgaaatggggaaagactattatcacattttgggaattgacaaaggagctacagatgaagatgttaaaaaggcttaccgaaagcaagccctcaaatttcacccggacaagaacaaatctcctcaagcagaggaaaaatttaaagaggtcgcagaagcgtatgaagtactgagtgatcctaaaaagagagaaatatatgatcagtttggcgaagaaggcttgaagggaggcgctggaggtactgatggacaaggaggtaccttcaggtacactttccacggagatcctcatgccacatttgcagcctttttcggaggttccaacccttttgaaatcttctttgggagacggatgggtggaggtcgagattctgaagaaatggaaatagatggagatccctttagtgcctttggattcagcatgaatggatatccaagagacaggaattctgtgggaccctcccgtctcaaacaagaccctcccattattcatgaacttaaagtatcgcttgaagaaatatatagtggctgcaccaaacggatgaagatttctcgaaaaagattaaatcctgacggaaggagttacagatctgaggacaaaattctcaccattgagatcaaaaaagggtggaaagaaggcaccaaaatcacttttccgagggaaggcgatgaaacaccaaatagtatcccagcagacattgtttttgttattaaagacaaagaacatcccaagtttaaaagagacggatcaaatatagtttatactgctaaaattagtttacgggaggcattgtgtggctgctcacttaatgtgccaacaatggacggaagaaacctacctatgtcagtcactgatattgtgaaacctgggatgaggagaagagttattggatatgggctgccatttccaaaaaaccctgaccagcgtggcgacctactgatagaatttgatgtgtccttcccagacgtcatatctgcagcatccaaagagatcctgaggaagcatctccctgcctcctaggatgagaagaaccttgctatccatagtttgataagacactgaaaatataaaagtaccggcagttgactgctgtgaattctgtgtaaagatgtgtaaactcttctgagggctcattaaactgcatgaatagacacagttcaaataggcaacgtgggtttttacagtagggatgaaaagtcattcactgtatttcatttctcccaaatcagaaatttttagtatttcatttacaagtaaaagttggttttgtggtctatggatatacttctagtaaatactagattatccaagtactgtgtgcatgtgcgtgtgtgtgtgtgtgtgtgtgtgtacgcgcgcgtgtgtgtctgtgtgtgctcgtgtctgtgtgtgtatctttaaatgatcagtgtgataggctcctttaataaaaattaaaattcttaagtgtatatgtaatatgtggagaataaaagccaaagtcatacagaaatgcagtctaggtgacattcagagatgctgtgttgggctggtaccagaatgcattgatgtgtgtgctttaccgttgtgacttctcaatattctgcagcgtttcttaagagcatggttgtaatgttcgtaaagcagacctcatcataagaagaaaatgaatgacattttctctcctgtggaagtcccaatagccagagctcctgatattttagaaacagatggtttttaagtggccacatgtaattttatgcagttgactatatatcttaaacttaataagctcattttgtggttcattagtttaaggtatttgtttactaacatgtttttagagaaaatactgttacttggcattaattgtccatttacagtgttctgttaagttcctcatgctatgcaccttacataatttccctaaagaacagtcatctatcactgtggtgttaaaccgcaatctggatataacaaacaccatcactgcttgtgggtaatgtgctgtcatcatataaatattctaccttttcatgtatatagattgcatttcttaggtgttttaatttttaaaatatatttacattctaaaaaattactgtcttctgttttatatctatcaaaagtgatgttatgaaaaattttttgtaaaacagttttcagaatgatatatatctatacataaatatatatggtatactgagtcctatagtctttttaatagaatgtgaagttatttagaaattctgtataaaattatagtaagcgtataccttgtggctttattgaaatagaattctcataagataaaattcacactaacctccctcatttttttggtactgttgactgacgtcagagctgcgtgcacactaagtgcctcccaccgtggagctgtgcccagcctccccctctctctctctttctttgtggtgtagttttgaatttcgtgtatccacagacctgtgcagtcaccatgaacagcttctgtgccccctctcccctcagcccctggagcactgatctgcttttcaagatggattctattgtagaatagaatcggtcggcatgcggctcctttatttgctgtcgttcacccagcacagcactgttctcaaggtccagtctggcctcattatcagtaacttcatcctttgtgtggcagatcatgtacttgggtagaatcccatttggtcagcttacctcttctttggtgttttgggcatctgggttctatctactcagtatgaataatgatgctatgagcatttgtaaacaaatttctgtgtggatagactgactgcattctctgaggtacatagttgagagtggaatggttaggaaaagctacatccattagttgcaaatagaaaatgttaaaaatgccagagagttgaggtaatcgcaccatctccttgaacatcatggaaattcacacagatataaagagctaaagtcttggagtgatggttgtagttcatattcgaaaccacatacccacagtattcaacttttgagttgtttgaggggggcagggtgtgtgtgtgtttgtgtctgcttgtttggaggtagggtcttactatgtagctctggctggtatgttgctccatgtgactcaagttcacgataaatttatgggaatttttctccctgcctcatagtggctggaatgaatggcatgtgccattcacaccacacaggctttgaaccaacaattattattgcagtcttattgagtaaacattttctctgagccaaaataaagggtttataaacacaaataatctttcagttagttcctttagtaataattattctaacaatcaatcaatcaatcaatcaatctgtactactcttagggctgagggtagggttcggtgacagtagtagaataaatgtacaaaatatataaatttagaggaaacatgcttccgagtgtagtaagtgcccattgttttgttaaatattgaattaatactgacagtaaaatgttaaaaattttcagatttaaactatgagagtacttttgacttctaagatgttccttttaggggctggaaagagggctcagaggcacttgcctctcgtgagtggacctgggttcagttcccaggacacacttggaggctcccagccgtctgaaactccagttccaaggacacctctttggtctccatgggcaccaggcatgcatgtggtgcacctacatacatgcagacaaacacagcatcctttttttttaaaattcttttaaagtgtttaatttactagtccttgcatagctcaaatgattttgcagcataatgagtccagtaaagcttcttattaaagatgtttgttaaaagaacacatatccacgggtcttatggctttccagggcaggtgttgtatttggtagctctgtagctgaggaacagttttcttaggacggttctaagcgagacgcactgttccatcacatctgccctccctgccacgtggtgcttcgtaacccatggccttgaaagcattgggctctgacatccacattagcttgtctctctggctattagtcggtcttggaggcaaggggttgaacaagcctcttgtttattcttaggaaactgtcattggaatgtttgtgattggatgaaatgaaattagtgcaagtgattggactcagtcaatggccttgatgaaacactcctctcacatttcaggaattacctgctcagtcttggggagtcaaggccaacatggctttcattcaataatagataatgtagtatggctgactatcttcacaatctctctctctgtatgtgtgtgtgtaggtgaacacgtgtgtttaagcaaatgtcttaacacgaactaatattaagataggaaagagtaatttatgctgtttataacaatgacaaatacacaaaatttagattcttggcttacaatatttatatttaaattatttatatttaatactgaagttttgtaaaattgattcagggaacaagactagaaagttactttgcctgggtttctaacgccctttaaccttttttgaaactcttttcttctagttttttctaaaaattaaatttgtcttttgacaataccataaatgaa

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