2024-11-01 08:24:51, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_025588 4277 bp mRNA linear ROD 30-APR-2024 DEFINITION Mus musculus exocyst complex component 2 (Exoc2), transcript variant 1, mRNA. ACCESSION NM_025588 VERSION NM_025588.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 4277) AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A., Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R., Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J., Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z., Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J., Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L., Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J., Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B., Jackson,S.P. and Balmus,G. CONSRTM Sanger Mouse Genetics Project TITLE Genetic determinants of micronucleus formation in vivo JOURNAL Nature 627 (8002), 130-136 (2024) PUBMED 38355793 REFERENCE 2 (bases 1 to 4277) AUTHORS Xu,J., Liu,H., Lan,Y. and Jiang,R. TITLE Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development JOURNAL Front Cell Dev Biol 9, 665109 (2021) PUBMED 33898467 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 4277) AUTHORS Xu,J., Liu,H., Lan,Y., Park,J.S. and Jiang,R. TITLE Genome-wide Identification of Foxf2 Target Genes in Palate Development JOURNAL J Dent Res 99 (4), 463-471 (2020) PUBMED 32040930 REFERENCE 4 (bases 1 to 4277) AUTHORS Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X., Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B., Caspary,T., Lipschutz,J.H. and Barral,D.C. TITLE Arl13b and the exocyst interact synergistically in ciliogenesis JOURNAL Mol Biol Cell 27 (2), 308-320 (2016) PUBMED 26582389 REFERENCE 5 (bases 1 to 4277) AUTHORS Xie,L., Zhu,D., Kang,Y., Liang,T., He,Y. and Gaisano,H.Y. TITLE Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion JOURNAL PLoS One 8 (7), e67561 (2013) PUBMED 23844030 REMARK GeneRIF: Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. Publication Status: Online-Only REFERENCE 6 (bases 1 to 4277) AUTHORS Nichols,C.D. and Casanova,J.E. TITLE Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex JOURNAL Curr Biol 20 (14), 1316-1320 (2010) PUBMED 20579884 REFERENCE 7 (bases 1 to 4277) AUTHORS Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and Robson,P. TITLE Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst JOURNAL Dev Cell 18 (4), 675-685 (2010) PUBMED 20412781 REFERENCE 8 (bases 1 to 4277) AUTHORS Saito,T., Shibasaki,T. and Seino,S. TITLE Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion JOURNAL Biomed Res 29 (2), 85-91 (2008) PUBMED 18480549 REFERENCE 9 (bases 1 to 4277) AUTHORS Mott,H.R., Nietlispach,D., Hopkins,L.J., Mirey,G., Camonis,J.H. and Owen,D. TITLE Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site JOURNAL J Biol Chem 278 (19), 17053-17059 (2003) PUBMED 12624092 REMARK GeneRIF: the structure of the Ral-binding domain of Sec5 REFERENCE 10 (bases 1 to 4277) AUTHORS Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A., Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L., Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E. TITLE BayGenomics: a resource of insertional mutations in mouse embryonic stem cells JOURNAL Nucleic Acids Res 31 (1), 278-281 (2003) PUBMED 12520002 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC049102.1. On Jun 9, 2003 this sequence version replaced NM_025588.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048154.1, SRR1660815.201104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..4277 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="13" /map="13" gene 1..4277 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="exocyst complex component 2" /db_xref="GeneID:66482" /db_xref="MGI:MGI:1913732" exon 1..52 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 53..213 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" misc_feature 63..65 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="upstream in-frame stop codon" CDS 96..2870 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="isoform 1 is encoded by transcript variant 1; exocyst complex component Sec5; SEC5-like 1; SEC5 homolog" /codon_start=1 /product="exocyst complex component 2 isoform 1" /protein_id="NP_079864.1" /db_xref="CCDS:CCDS26420.1" /db_xref="GeneID:66482" /db_xref="MGI:MGI:1913732" /translation="
MSRSRQPPLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTICGHNCLLTAEWMSASKIVCRVGQAKNDKGDIIVTTKSGGKGTSTVSFKLLKPEKIGILDQSAVWVDEMNYYDMRTDRNKGIPPLSLRPANPLGIEIEKCKLPQKNLEVLFHGMSADFTSENFSAAWYLIENHSTTSFEQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDALSAIHQKLEADGTEKVEGSMTQKLENVLNRASNTADTLFQEVLGRKDKADSTRNALNVLQRFKFLFNLPLNIKRNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKYYAEVEAGIEDLRELLLKKLLETPSTLHDQKRYIRYLSDLHAPGDPAWQCIGAQHKWTLKLMQDCKEGHMKSLKGHPGPHSPMLDLDNDVRPSVLGHLSQTASLKRGSSFQSGRDDTWRYKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQSERSKNVRQRQNDFKKMIQEVMHSLVKLIRGALLPLSLREGDGRQYGGWEVQAELSGQWLAHVIQTIRLTYESLTALEIPNDMLQIIQDLILDLRIRCIMVTLQHTAEEIKRLAEKEDWVVDNEGLTSLPCQFEQSIVHSLQSLKGVVDCKPGEASVFQQPKTQEEVCQLCINIMQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPAGVRNYLKEALVNIIAVHAEVFTISKELVPRVLARVVEAVSEELSRLMQCVSSFSRNGALQARLEICALRDTVAIYLTSESRSSFKQALEALPQLASGADKKSLEELLNKFKSSMHLQLTCFQAASPAVMKT"
misc_feature 117..368 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="IPT/TIG domain; Region: TIG; pfam01833" /db_xref="CDD:460355" misc_feature 489..2837 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="Exocyst complex component Sec5; Region: Sec5; pfam15469" /db_xref="CDD:464733" misc_feature 1386..1388 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from UniProtKB/Swiss-Prot (Q9D4H1.1); phosphorylation site" misc_feature 1389..1391 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from UniProtKB/Swiss-Prot (Q9D4H1.1); phosphorylation site" misc_feature 1398..1400 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from UniProtKB/Swiss-Prot (Q9D4H1.1); phosphorylation site" misc_feature 1413..1415 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="Phosphothreonine. /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from UniProtKB/Swiss-Prot (Q9D4H1.1); phosphorylation site" misc_feature 1455..1457 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from UniProtKB/Swiss-Prot (Q9D4H1.1); acetylation site" exon 214..390 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 391..517 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 518..631 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 632..756 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 757..837 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 838..983 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 984..1065 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1066..1168 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1169..1287 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1288..1413 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1414..1538 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1539..1604 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1605..1762 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1763..1884 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1885..1946 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 1947..2027 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2028..2087 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2088..2149 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2150..2216 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2217..2333 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2334..2475 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2476..2531 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2532..2654 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2655..2716 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2717..2776 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" exon 2777..4250 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /inference="alignment:Splign:2.1.0" regulatory 3044..3049 /regulatory_class="polyA_signal_sequence" /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="hexamer: AATAAA" polyA_site 3067 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" regulatory 4113..4118 /regulatory_class="polyA_signal_sequence" /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="hexamer: AATAAA" polyA_site 4135 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" regulatory 4225..4230 /regulatory_class="polyA_signal_sequence" /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="hexamer: AATAAA" polyA_site 4250 /gene="Exoc2" /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1" /note="major polyA site" ORIGIN
gcggcggcctggaaccggttggctgggacctgacaccgcctgcaagctgcaggttgcttctataactggatcacgagtttgctgcacaaagtaccatgtctcgatcccggcagcccccacttgtaacaggcatctctccaaatgaaggaataccttggaccaaagtcacaattagaggggagaacctgggtactggtcccactgacctcataggcttgacaatttgtggacataattgcctcctcacggcagaatggatgtctgcgagtaaaattgtctgtcgagtgggacaagccaaaaatgacaaaggagacattattgtcacaactaagtcagggggtaaaggaacctcaactgtctcttttaagctactcaagcctgaaaaaataggcattttagatcagtctgcagtgtgggtggatgaaatgaattattatgatatgcggactgacaggaacaaagggattcctcccttgtctctccgtcctgcgaatcctcttggcattgaaattgagaaatgtaaacttcctcagaagaacttagaagtgttattccatggcatgagtgctgattttacaagtgagaatttttcagcagcctggtatctcatagagaatcactccaccaccagttttgagcagctcaagatggcggtcaccaacctcaaaaggcaggccaacaagaagagtgagggtagtctggcatatgtgaagggcggcctcagtaccttctttgaagctcaagatgctctctcagctatccatcaaaaactagaagcagatggaactgaaaaagtagaaggatccatgacacagaaattggagaatgtcctcaatagagcaagtaacaccgctgacacattgttccaagaagtattaggtcggaaagacaaggcagattccactaggaacgccctcaacgtacttcagcgatttaaatttctcttcaaccttcctctcaatattaaacggaatattcaaaagggggattatgatgtagttattaatgattatgaaaaagccaaatcgctctttgggaaaacggaggtgcaagttttcaagaaatattatgctgaagtagaagcaggaattgaagatctaagagagttacttctaaagaaattgctcgagactccatcaaccttacatgaccagaagcgctacataaggtatctttccgacctccatgcacctggtgaccctgcttggcagtgtattggagctcagcacaagtggaccctcaagctcatgcaagactgcaaagaaggccacatgaagagcctaaaaggtcacccaggcccgcacagccccatgctcgacctagacaacgatgtgcgcccctcggtgttgggccacctcagtcagacagcgtcactgaagagggggagcagctttcagtctggccgagatgacacatggaggtataagactccccacagagtggcatttgttgaaaaattaaccaagcttgtgttaagtcagctgcctaacttctggaaactctggatttcatatgttaatggaagtcttttcagtgagacggctgagaagtcaggccagagtgaaagatcaaagaatgtgaggcagagacaaaacgatttcaagaaaatgattcaagaagtaatgcactccctggtgaagctgatccggggagccctgcttccactcagcctccgagaaggggatgggaggcagtatggcggctgggaggtgcaggcagagctttcggggcagtggctcgcacacgttatccagaccataaggctaacatatgaatcactgaccgccctggagattcccaatgacatgttacagattatccaggacctaattttggatctccgaatacgttgcataatggtgacattgcagcatacggccgaagagataaagagattagctgaaaaagaagactgggttgttgataatgaaggactgacttccctaccatgtcagtttgaacagagcattgttcactccctgcagtccttgaagggtgttgtcgattgcaaacctggagaagccagcgtctttcaacagcctaaaacgcaggaggaggtttgccagttatgcatcaatatcatgcaggtttttatatactgcctggaacaactgagcaccaagcctgatgcagacatagatactactcatctttctgttgatgtttcttctcctgatttgtttggaagcatccatgaagacttcagtttgacttcagagcagaggcttttgatagtcctgagtaattgctgctatttagaacgtcacaccttcctaaacatagcagaacattttgaaaaacacaacttccagggaatagagaaaataacacaggttagcatggcatcgctgaaagaactggatcaacgactctttgaaaattacattgagctaaaagcagatcccattgttggatccttagaacctgggatctacgcaggctactttgattggaaggactgcctgcctccggcaggtgtcagaaactatttaaaagaagcattggtgaatataattgctgtgcatgcagaggtattcactatttccaaggaactggtgccacgggtcttggccagagtggtagaagcagtctctgaagagctgagccggctgatgcagtgcgtctcatccttcagcagaaatggagcactgcaggccagacttgaaatctgtgctctgagggacactgtagccatttacctgacctcggaaagcaggtctagttttaaacaggccctggaggccctgcctcagcttgcaagtggtgcggacaaaaagtcactggaagagctgctcaacaagttcaagagcagcatgcacttgcagctcacctgcttccaagctgcgtctccagcagtcatgaaaacataggctctgcaagaagagcatcagacatggcggtggagactgtcctcgtgctgtgcagcagagattacacgtcaagcactgcatttaacgtctcttttccccagcatggtggtgcagaaagatgcccatggatatttaatttcaatctatttaaactaccatagtttaaacatccaaataaacagtttttgttattgctagctttggtcctgaaaggctgtgtagcatactcttcaaaatgctgtgagtctggggatttctccatcatggtccagagcggcccatggtgtgtgtgtgtgcccttctcagtgcccctcttctaggcctactgttggcagtttccagcccaggtgagacatttgagaagagatttgaagtcacagtttttagagctttgtcctaaactttaaaataaccatttcatacaagtggttctaagctccccaccctgtttctgtaaagaaaaatatacagtctacacataaaaatgttaatatttggataaatttgtgatccacaagtcctcgtatgaactctgaatttcatagtctgactttcatttctcccagtgctaaacactgaagcttgtggttctcactcagccttaagctgatggatcactgcagtggtgtggggagggttcacaaggacctgtatgtggaggccctgtcacacccacaaggcctggggaaggcttgtggtcttcaatgcagcctaaagatgaagccaggctcctcggcaaggcagcactccctccccctctgccacttcccacgcggtgaaatgtcttgctccatagctggaaagaggctgctctggcatgggctgtgttttgtaaagatttgaggtgccccaagtgaccaggcactgagctgtgactcagtggtgagtggcttgcgcagtagagtcaggtcattgtgacctgcaggcagctttcacctcactccatccttccgtcagcctctgttgcacttcactcttcagactgatctgtggataatgtaggctcctcttctagagttgacaaaactaattccagagcacagcatatgtaccctgtggattatttaaggtaaatgagtgtatgtttatttatcacagtgactggaagtagaaattgtaatcctttgttgcaaaataagtatgtaccgcattgtctcctccctgtgtgctgttattatatctgacataaacaaactaaattccaaagcagaagtacagaaccatttgttattttaaacacctaataaatacagtgcacaaagccagtagttgtccttctctgtaagacccctatctttatttcaccatttttattagctctgtaattgcttatattcctgattttaaaatccacaataaatagtggagttctctcttttaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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