LOCUS       NM_025588               4277 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus exocyst complex component 2 (Exoc2), transcript
            variant 1, mRNA.
ACCESSION   NM_025588
VERSION     NM_025588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4277)
  AUTHORS   Xu J, Liu H, Lan Y and Jiang R.
  TITLE     Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene
            Expression in Palate Development
  JOURNAL   Front Cell Dev Biol 9, 665109 (2021)
   PUBMED   33898467
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4277)
  AUTHORS   Xu J, Liu H, Lan Y, Park JS and Jiang R.
  TITLE     Genome-wide Identification of Foxf2 Target Genes in Palate
            Development
  JOURNAL   J Dent Res 99 (4), 463-471 (2020)
   PUBMED   32040930
REFERENCE   3  (bases 1 to 4277)
  AUTHORS   Seixas C, Choi SY, Polgar N, Umberger NL, East MP, Zuo X, Moreiras
            H, Ghossoub R, Benmerah A, Kahn RA, Fogelgren B, Caspary T,
            Lipschutz JH and Barral DC.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   4  (bases 1 to 4277)
  AUTHORS   Xie L, Zhu D, Kang Y, Liang T, He Y and Gaisano HY.
  TITLE     Exocyst sec5 regulates exocytosis of newcomer insulin granules
            underlying biphasic insulin secretion
  JOURNAL   PLoS One 8 (7), e67561 (2013)
   PUBMED   23844030
  REMARK    GeneRIF: Exocyst sec5 regulates exocytosis of newcomer insulin
            granules underlying biphasic insulin secretion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4277)
  AUTHORS   Heider MR and Munson M.
  TITLE     Exorcising the exocyst complex
  JOURNAL   Traffic 13 (7), 898-907 (2012)
   PUBMED   22420621
  REMARK    Review article
REFERENCE   6  (bases 1 to 4277)
  AUTHORS   Nichols CD and Casanova JE.
  TITLE     Salmonella-directed recruitment of new membrane to invasion foci
            via the host exocyst complex
  JOURNAL   Curr Biol 20 (14), 1316-1320 (2010)
   PUBMED   20579884
REFERENCE   7  (bases 1 to 4277)
  AUTHORS   Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND and Robson P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 4277)
  AUTHORS   Saito T, Shibasaki T and Seino S.
  TITLE     Involvement of Exoc3l, a protein structurally related to the
            exocyst subunit Sec6, in insulin secretion
  JOURNAL   Biomed Res 29 (2), 85-91 (2008)
   PUBMED   18480549
REFERENCE   9  (bases 1 to 4277)
  AUTHORS   Mott HR, Nietlispach D, Hopkins LJ, Mirey G, Camonis JH and Owen D.
  TITLE     Structure of the GTPase-binding domain of Sec5 and elucidation of
            its Ral binding site
  JOURNAL   J Biol Chem 278 (19), 17053-17059 (2003)
   PUBMED   12624092
  REMARK    GeneRIF: the structure of the Ral-binding domain of Sec5
REFERENCE   10 (bases 1 to 4277)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049102.1.
            
            On Jun 9, 2003 this sequence version replaced NM_025588.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048154.1, SRR1660815.201104.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..4277
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="exocyst complex component 2"
                     /db_xref="GeneID:66482"
                     /db_xref="MGI:MGI:1913732"
     exon            1..52
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            53..213
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    63..65
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="upstream in-frame stop codon"
     CDS             96..2870
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exocyst complex component Sec5; SEC5-like 1; SEC5 homolog"
                     /codon_start=1
                     /product="exocyst complex component 2 isoform 1"
                     /protein_id="NP_079864.1"
                     /db_xref="CCDS:CCDS26420.1"
                     /db_xref="GeneID:66482"
                     /db_xref="MGI:MGI:1913732"
                     /translation="

MSRSRQPPLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTICGHNCLLTAEWMSASKIVCRVGQAKNDKGDIIVTTKSGGKGTSTVSFKLLKPEKIGILDQSAVWVDEMNYYDMRTDRNKGIPPLSLRPANPLGIEIEKCKLPQKNLEVLFHGMSADFTSENFSAAWYLIENHSTTSFEQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDALSAIHQKLEADGTEKVEGSMTQKLENVLNRASNTADTLFQEVLGRKDKADSTRNALNVLQRFKFLFNLPLNIKRNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKYYAEVEAGIEDLRELLLKKLLETPSTLHDQKRYIRYLSDLHAPGDPAWQCIGAQHKWTLKLMQDCKEGHMKSLKGHPGPHSPMLDLDNDVRPSVLGHLSQTASLKRGSSFQSGRDDTWRYKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQSERSKNVRQRQNDFKKMIQEVMHSLVKLIRGALLPLSLREGDGRQYGGWEVQAELSGQWLAHVIQTIRLTYESLTALEIPNDMLQIIQDLILDLRIRCIMVTLQHTAEEIKRLAEKEDWVVDNEGLTSLPCQFEQSIVHSLQSLKGVVDCKPGEASVFQQPKTQEEVCQLCINIMQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPAGVRNYLKEALVNIIAVHAEVFTISKELVPRVLARVVEAVSEELSRLMQCVSSFSRNGALQARLEICALRDTVAIYLTSESRSSFKQALEALPQLASGADKKSLEELLNKFKSSMHLQLTCFQAASPAVMKT"

     misc_feature    117..368
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="IPT/TIG domain; Region: TIG; pfam01833"
                     /db_xref="CDD:426462"
     misc_feature    489..2837
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="Exocyst complex component Sec5; Region: Sec5;
                     pfam15469"
                     /db_xref="CDD:434738"
     misc_feature    1386..1388
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1); phosphorylation site"
     misc_feature    1389..1391
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1); phosphorylation site"
     misc_feature    1398..1400
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1); phosphorylation site"
     misc_feature    1413..1415
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1); phosphorylation site"
     misc_feature    1455..1457
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1); acetylation site"
     exon            214..390
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..517
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..631
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..756
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..837
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..983
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1065
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1168
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1287
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1413
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1538
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1604
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1762
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1884
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1946
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2027
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2087
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2149
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2216
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2333
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2475
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2531
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2654
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2716
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2776
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..4250
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcggcggcctggaaccggttggctgggacctgacaccgcctgcaagctgcaggttgcttctataactggatcacgagtttgctgcacaaagtaccatgtctcgatcccggcagcccccacttgtaacaggcatctctccaaatgaaggaataccttggaccaaagtcacaattagaggggagaacctgggtactggtcccactgacctcataggcttgacaatttgtggacataattgcctcctcacggcagaatggatgtctgcgagtaaaattgtctgtcgagtgggacaagccaaaaatgacaaaggagacattattgtcacaactaagtcagggggtaaaggaacctcaactgtctcttttaagctactcaagcctgaaaaaataggcattttagatcagtctgcagtgtgggtggatgaaatgaattattatgatatgcggactgacaggaacaaagggattcctcccttgtctctccgtcctgcgaatcctcttggcattgaaattgagaaatgtaaacttcctcagaagaacttagaagtgttattccatggcatgagtgctgattttacaagtgagaatttttcagcagcctggtatctcatagagaatcactccaccaccagttttgagcagctcaagatggcggtcaccaacctcaaaaggcaggccaacaagaagagtgagggtagtctggcatatgtgaagggcggcctcagtaccttctttgaagctcaagatgctctctcagctatccatcaaaaactagaagcagatggaactgaaaaagtagaaggatccatgacacagaaattggagaatgtcctcaatagagcaagtaacaccgctgacacattgttccaagaagtattaggtcggaaagacaaggcagattccactaggaacgccctcaacgtacttcagcgatttaaatttctcttcaaccttcctctcaatattaaacggaatattcaaaagggggattatgatgtagttattaatgattatgaaaaagccaaatcgctctttgggaaaacggaggtgcaagttttcaagaaatattatgctgaagtagaagcaggaattgaagatctaagagagttacttctaaagaaattgctcgagactccatcaaccttacatgaccagaagcgctacataaggtatctttccgacctccatgcacctggtgaccctgcttggcagtgtattggagctcagcacaagtggaccctcaagctcatgcaagactgcaaagaaggccacatgaagagcctaaaaggtcacccaggcccgcacagccccatgctcgacctagacaacgatgtgcgcccctcggtgttgggccacctcagtcagacagcgtcactgaagagggggagcagctttcagtctggccgagatgacacatggaggtataagactccccacagagtggcatttgttgaaaaattaaccaagcttgtgttaagtcagctgcctaacttctggaaactctggatttcatatgttaatggaagtcttttcagtgagacggctgagaagtcaggccagagtgaaagatcaaagaatgtgaggcagagacaaaacgatttcaagaaaatgattcaagaagtaatgcactccctggtgaagctgatccggggagccctgcttccactcagcctccgagaaggggatgggaggcagtatggcggctgggaggtgcaggcagagctttcggggcagtggctcgcacacgttatccagaccataaggctaacatatgaatcactgaccgccctggagattcccaatgacatgttacagattatccaggacctaattttggatctccgaatacgttgcataatggtgacattgcagcatacggccgaagagataaagagattagctgaaaaagaagactgggttgttgataatgaaggactgacttccctaccatgtcagtttgaacagagcattgttcactccctgcagtccttgaagggtgttgtcgattgcaaacctggagaagccagcgtctttcaacagcctaaaacgcaggaggaggtttgccagttatgcatcaatatcatgcaggtttttatatactgcctggaacaactgagcaccaagcctgatgcagacatagatactactcatctttctgttgatgtttcttctcctgatttgtttggaagcatccatgaagacttcagtttgacttcagagcagaggcttttgatagtcctgagtaattgctgctatttagaacgtcacaccttcctaaacatagcagaacattttgaaaaacacaacttccagggaatagagaaaataacacaggttagcatggcatcgctgaaagaactggatcaacgactctttgaaaattacattgagctaaaagcagatcccattgttggatccttagaacctgggatctacgcaggctactttgattggaaggactgcctgcctccggcaggtgtcagaaactatttaaaagaagcattggtgaatataattgctgtgcatgcagaggtattcactatttccaaggaactggtgccacgggtcttggccagagtggtagaagcagtctctgaagagctgagccggctgatgcagtgcgtctcatccttcagcagaaatggagcactgcaggccagacttgaaatctgtgctctgagggacactgtagccatttacctgacctcggaaagcaggtctagttttaaacaggccctggaggccctgcctcagcttgcaagtggtgcggacaaaaagtcactggaagagctgctcaacaagttcaagagcagcatgcacttgcagctcacctgcttccaagctgcgtctccagcagtcatgaaaacataggctctgcaagaagagcatcagacatggcggtggagactgtcctcgtgctgtgcagcagagattacacgtcaagcactgcatttaacgtctcttttccccagcatggtggtgcagaaagatgcccatggatatttaatttcaatctatttaaactaccatagtttaaacatccaaataaacagtttttgttattgctagctttggtcctgaaaggctgtgtagcatactcttcaaaatgctgtgagtctggggatttctccatcatggtccagagcggcccatggtgtgtgtgtgtgcccttctcagtgcccctcttctaggcctactgttggcagtttccagcccaggtgagacatttgagaagagatttgaagtcacagtttttagagctttgtcctaaactttaaaataaccatttcatacaagtggttctaagctccccaccctgtttctgtaaagaaaaatatacagtctacacataaaaatgttaatatttggataaatttgtgatccacaagtcctcgtatgaactctgaatttcatagtctgactttcatttctcccagtgctaaacactgaagcttgtggttctcactcagccttaagctgatggatcactgcagtggtgtggggagggttcacaaggacctgtatgtggaggccctgtcacacccacaaggcctggggaaggcttgtggtcttcaatgcagcctaaagatgaagccaggctcctcggcaaggcagcactccctccccctctgccacttcccacgcggtgaaatgtcttgctccatagctggaaagaggctgctctggcatgggctgtgttttgtaaagatttgaggtgccccaagtgaccaggcactgagctgtgactcagtggtgagtggcttgcgcagtagagtcaggtcattgtgacctgcaggcagctttcacctcactccatccttccgtcagcctctgttgcacttcactcttcagactgatctgtggataatgtaggctcctcttctagagttgacaaaactaattccagagcacagcatatgtaccctgtggattatttaaggtaaatgagtgtatgtttatttatcacagtgactggaagtagaaattgtaatcctttgttgcaaaataagtatgtaccgcattgtctcctccctgtgtgctgttattatatctgacataaacaaactaaattccaaagcagaagtacagaaccatttgttattttaaacacctaataaatacagtgcacaaagccagtagttgtccttctctgtaagacccctatctttatttcaccatttttattagctctgtaattgcttatattcctgattttaaaatccacaataaatagtggagttctctcttttaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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