LOCUS       NM_025410                760 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus L antigen family, member 3 (Lage3), mRNA.
ACCESSION   NM_025410
VERSION     NM_025410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 760)
  AUTHORS   Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W,
            Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson
            JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N,
            Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC,
            Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult
            S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY,
            Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T,
            Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A,
            Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM,
            Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre
            E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F,
            Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE,
            Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH,
            Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N,
            Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G,
            Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P,
            Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M,
            Antignac C and Hildebrandt F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   2  (bases 1 to 760)
  AUTHORS   Cruz-Soto ME, Scheiber MD, Gregerson KA, Boivin GP and Horseman ND.
  TITLE     Pituitary tumorigenesis in prolactin gene-disrupted mice
  JOURNAL   Endocrinology 143 (11), 4429-4436 (2002)
   PUBMED   12399440
REFERENCE   3  (bases 1 to 760)
  AUTHORS   Alpen B, Gure AO, Scanlan MJ, Old LJ and Chen YT.
  TITLE     A new member of the NY-ESO-1 gene family is ubiquitously expressed
            in somatic tissues and evolutionarily conserved
  JOURNAL   Gene 297 (1-2), 141-149 (2002)
   PUBMED   12384295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK002539.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025410.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002539.1, DV065816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-760               AK002539.1         2-761
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.0 cM"
     gene            1..760
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="L antigen family, member 3"
                     /db_xref="GeneID:66192"
                     /db_xref="MGI:MGI:1913442"
     exon            1..294
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    53..55
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="upstream in-frame stop codon"
     CDS             92..538
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="ITBA2 protein homolog"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit Lage3"
                     /protein_id="NP_079686.1"
                     /db_xref="CCDS:CCDS30229.1"
                     /db_xref="GeneID:66192"
                     /db_xref="MGI:MGI:1913442"
                     /translation="

MQTAHTGLSHTADGADGQTSRCCPGNAGTKAVIPSGAHPVARALEASRNSSKSMVPLTQRPGTRHHRFSLFVPFPTSLEAEIACGSLVPDVEPHRGLVGKELKVSGCMLEVRWIAEDSRLLRLSIINFLDQLSLVVNTIQLFGPPVSC"

     misc_feature    92..154
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CR70.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    290..511
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="Transcription factor Pcc1; Region: Pcc1; pfam09341"
                     /db_xref="CDD:430541"
     exon            295..423
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..760
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cggaggataaggcgggttctgggccgcagcaatggcagaggcggcgggctggtaacgcgaaggtgggttgaaaggaggaacagcagcagacatgcagacagcacacacaggtttaagccacactgcagatggcgccgatggtcagactagccgctgttgtcctggtaatgcaggcacaaaggcagttattcccagtggagctcaccctgttgcaagagcactggaagcctcccgaaattccagcaaaagcatggtgcctttaacccaaaggcctggaacccgacatcacagattctccctcttcgtgcctttcccgacctctttggaggcagaaatcgcctgtgggtccctagttccagatgtcgaaccacatcgaggactggtagggaaggagcttaaagtgagcggctgcatgctggaggtacgctggatcgcggaagattctcgcctcctccgactttccatcatcaactttcttgaccagctttccctagtggtgaacaccatacagctctttgggcccccagtttcctgttaagcctggctggggacccatgtctgaccttatctccgtctcctcctaagcaatacaattttccctagggaaaagattctagaaatagtaactactacataaatgtgggggcctaatatttttttcctgatttggtcctcaggcacttaggagccatttggtctggtgcttcaatgtttgttgctgaagaaaataaagctatgttgctaatctgcatttgagctt

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