LOCUS       NM_011409               1834 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus schlafen 3 (Slfn3), mRNA.
ACCESSION   NM_011409
VERSION     NM_011409.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Vomhof-DeKrey EE, Stover AD, Labuhn M, Osman MR and Basson MD.
  TITLE     Vil-Cre specific Schlafen 3 knockout mice exhibit sex-specific
            differences in intestinal differentiation markers and Schlafen
            family members expression levels
  JOURNAL   PLoS One 16 (10), e0259195 (2021)
   PUBMED   34710177
  REMARK    GeneRIF: Vil-Cre specific Schlafen 3 knockout mice exhibit
            sex-specific differences in intestinal differentiation markers and
            Schlafen family members expression levels.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Vomhof-DeKrey EE, Lansing JT, Darland DC, Umthun J, Stover AD,
            Brown C and Basson MD.
  TITLE     Loss of Slfn3 induces a sex-dependent repair vulnerability after
            50% bowel resection
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 320 (2), G136-G152 (2021)
   PUBMED   33237796
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Vomhof-DeKrey EE, Lee J, Lansing J, Brown C, Darland D and Basson
            MD.
  TITLE     Schlafen 3 knockout mice display gender-specific differences in
            weight gain, food efficiency, and expression of markers of
            intestinal epithelial differentiation, metabolism, and immune cell
            function
  JOURNAL   PLoS One 14 (7), e0219267 (2019)
   PUBMED   31260507
  REMARK    GeneRIF: Study characterized the role of Slfn3 in the intestinal
            homeostasis. Slfn3KO mice have a phenotype of decreased weight gain
            that is unlikely caused by a single gene but instead multiple
            genes/pathways. This includes the metabolic pathways of
            glycerolipid, linoleic and arachidonic acid metabolism,
            sex-dependent disregulation of glucose transporters, Glut2 and
            SGLT1, and intestinal differentiation genes, Notch2 and Cdx2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Nakagawa K, Matsuki T, Zhao L, Kuniyoshi K, Tanaka H, Ebina I,
            Yoshida KJ, Nabeshima H, Fukushima K, Kanemaru H, Yamane F,
            Kawasaki T, Machida T, Naito H, Takakura N, Satoh T and Akira S.
  TITLE     Schlafen-8 is essential for lymphatic endothelial cell activation
            in experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 30 (2), 69-78 (2018)
   PUBMED   29528433
REFERENCE   5  (bases 1 to 1834)
  AUTHORS   Berger M, Krebs P, Crozat K, Li X, Croker BA, Siggs OM, Popkin D,
            Du X, Lawson BR, Theofilopoulos AN, Xia Y, Khovananth K, Moresco
            EM, Satoh T, Takeuchi O, Akira S and Beutler B.
  TITLE     An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due
            to loss of immune cell quiescence
  JOURNAL   Nat Immunol 11 (4), 335-343 (2010)
   PUBMED   20190759
REFERENCE   6  (bases 1 to 1834)
  AUTHORS   Bustos O, Naik S, Ayers G, Casola C, Perez-Lamigueiro MA,
            Chippindale PT, Pritham EJ and de la Casa-Esperon E.
  TITLE     Evolution of the Schlafen genes, a gene family associated with
            embryonic lethality, meiotic drive, immune processes and
            orthopoxvirus virulence
  JOURNAL   Gene 447 (1), 1-11 (2009)
   PUBMED   19619625
REFERENCE   7  (bases 1 to 1834)
  AUTHORS   Schwarz DA, Katayama CD and Hedrick SM.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF099974.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF099974.1, SRR7345562.1531951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..1834
                     /gene="Slfn3"
                     /note="schlafen 3"
                     /db_xref="GeneID:20557"
                     /db_xref="MGI:MGI:1329005"
     exon            1..79
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    27..29
                     /gene="Slfn3"
                     /note="upstream in-frame stop codon"
     exon            80..1149
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1763
                     /gene="Slfn3"
                     /codon_start=1
                     /product="schlafen 3"
                     /protein_id="NP_035539.1"
                     /db_xref="CCDS:CCDS25159.1"
                     /db_xref="GeneID:20557"
                     /db_xref="MGI:MGI:1329005"
                     /translation="

MKDIQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNSLPGIMHLPHDYLDFMQHKDYFFVFVKPLKPNQKGPGITTLKTNLYRRINSISDEVKVANAVQLLKSRTDPEEKAESRPSSPGKIVCNETLNECLSLFNRDWLAYEETFCFTKSIHAEVKLTPKEKIFPKEKILELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFEAEKSNLVLLESEIEKCIQQLPVTHFCGEKEKIKYTCKFIEVRKSGAVCAYVCALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKRQMDATAVMPGKVICCPEALYMKPFSQHEGYEHLVRTELGSLLKGTLVISKSWALDLGLQEKQEVIWDVLHISQGSLLTLYVFVQGDENLEGNSSLLGELGAELKGYYKQIALTLKQMLLNHCGYTAEIGIIVKITYLGHKTMCLYDTSTKIRYPQKYYLSAKAVKDLEKALVEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVPVLRNV"

     misc_feature    <219..1124
                     /gene="Slfn3"
                     /note="hypothetical protein; Provisional; Region:
                     PHA02782"
                     /db_xref="CDD:165147"
     exon            1150..1816
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gccaaaaatgcctggggcctcggagatgaaagacggacctgaacaggagcagagacacagagctggccacacatggaaggaaaggacttcatctgggaaacagaggcagtgattggaaaacaaacatcattgttgatcaggacacagactatgctgaactggttctgtttattggagaaatcacacttggagagaaaaataggaattcaatgaaagatattcaactgagaagaaaagaagccaaaagtatattacaggctgtgtgcaccctgctgaattctggagggggcgtggtcaaggctcacattaaaaatcaaaactacagcttcaccagagatggaatgggactggatttggtaaattccttacccggtatcatgcaccttcctcatgactatctagacttcatgcagcacaaagactactttttcgtttttgtgaaaccattgaagccgaatcagaaagggccggggatcaccaccttgaaaacgaacttgtacagaagaatcaactcaatctcagatgaagtgaaagtagcgaatgcagtgcagctcctcaaatccaggacagatcccgaagagaaagcagaatccagaccaagttcacctgggaaaatcgtctgtaatgaaacactaaatgaatgtctttccttatttaacagagactggcttgcctatgaggagacattctgtttcactaaatccatacatgctgaagtaaaattgactcctaaggaaaagatttttcctaaggaaaagattttagagctcctccctcaaactgtttctgcatttgcaaacactgatgggggatttttgttcattggcttggatggcaaaacgcagcaaattattggttttgaagcagagaagagcaatctcgtgcttctagagagtgaaatagaaaagtgcatccaacagctgcctgtcactcacttctgtggggagaaggagaagatcaagtacacgtgcaaattcatcgaagtgcgcaaatccggagctgtgtgtgcatatgtgtgtgcgctcagagtggagaggttctgctgtgcagtgttcgctgcagagcccgagtcctggcacgtggaaggtggctgtgtgaagaggtttaccacagaggaatgggtgaagcgccagatggatgccactgcagtgatgcctggaaaggtgatatgctgtccagaagccctctatatgaaaccattctcacaacatgaaggctatgagcacttagtccggacagaattgggctccctgcttaaaggaacactggttatctccaagagctgggctttggatctgggcttgcaagagaagcaggaagttatctgggatgtgcttcatatttcccagggcagtctcctgaccctgtatgtctttgtccagggagatgagaacctggaaggcaacagcagtcttcttggggaactaggcgccgagttaaagggctattataaacaaattgccctaacattaaagcagatgttgttaaaccattgtggttacactgcggaaataggtattatagtaaagataacatacttgggtcataagacaatgtgtctttatgacacaagcacaaaaatacgttacccccaaaaatattatctgtcggccaaggcagtaaaggacttagaaaaagctctcgttgaaatcttaggaagttatgagtctttctacagtttacccaggagaaactgggattcttttatgtctgcatttttaaatgtgggaagttatatagtccctgttttgagaaatgtatgagaaatgtcttaactcatattcgaatctgacaagacataaaaaaaacaaatggaaaaaaaaaaaaaaaaaaa

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