LOCUS       NM_011068               2291 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus peroxisomal biogenesis factor 11 alpha (Pex11a),
            transcript variant 1, mRNA.
ACCESSION   NM_011068
VERSION     NM_011068.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Weng H, Ji X, Endo K and Iwai N.
  TITLE     Pex11a deficiency is associated with a reduced abundance of
            functional peroxisomes and aggravated renal interstitial lesions
  JOURNAL   Hypertension 64 (5), 1054-1060 (2014)
   PUBMED   25113963
  REMARK    GeneRIF: Pex11a deficiency is associated with a reduced abundance
            of functional peroxisomes and aggravated renal interstitial
            lesions.
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Weng H, Ji X, Naito Y, Endo K, Ma X, Takahashi R, Shen C, Hirokawa
            G, Fukushima Y and Iwai N.
  TITLE     Pex11alpha deficiency impairs peroxisome elongation and division
            and contributes to nonalcoholic fatty liver in mice
  JOURNAL   Am J Physiol Endocrinol Metab 304 (2), E187-E196 (2013)
   PUBMED   23169785
  REMARK    GeneRIF: Pex11alpha deficiency impairs peroxisome elongation and
            abundance and peroxisomal fatty acid oxidation, which contributes
            to increased lipid accumulation in the liver.
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Wu Y and Smas CM.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Li X, Baumgart E, Dong GX, Morrell JC, Jimenez-Sanchez G, Valle D,
            Smith KD and Gould SJ.
  TITLE     PEX11alpha is required for peroxisome proliferation in response to
            4-phenylbutyrate but is dispensable for peroxisome
            proliferator-activated receptor alpha-mediated peroxisome
            proliferation
  JOURNAL   Mol Cell Biol 22 (23), 8226-8240 (2002)
   PUBMED   12417726
  REMARK    GeneRIF: required for peroxisome proliferation in response to
            4-phenylbutyrate but dispensable for peroxisome
            proliferator-activated receptor alpha-mediated peroxisome
            proliferation
REFERENCE   5  (bases 1 to 2291)
  AUTHORS   Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh
            TA, Valle D, Schroer TA and Gould SJ.
  TITLE     Expression of PEX11beta mediates peroxisome proliferation in the
            absence of extracellular stimuli
  JOURNAL   J Biol Chem 273 (45), 29607-29614 (1998)
   PUBMED   9792670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076776.1 and AK149387.1.
            
            On Jan 26, 2018 this sequence version replaced NM_011068.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149387.1, AF093669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AK076776.1         1-109
            110-892             AK149387.1         2-784
            893-2291            AK149387.1         786-2184
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.12 cM"
     gene            1..2291
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /note="peroxisomal biogenesis factor 11 alpha"
                     /db_xref="GeneID:18631"
                     /db_xref="MGI:MGI:1338788"
     exon            1..222
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..907
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /note="PEX11-alpha; peroxin-11A; protein PEX11 homolog
                     alpha; peroxisomal biogenesis factor 11a"
                     /codon_start=1
                     /product="peroxisomal membrane protein 11A"
                     /protein_id="NP_035198.1"
                     /db_xref="CCDS:CCDS21386.1"
                     /db_xref="GeneID:18631"
                     /db_xref="MGI:MGI:1338788"
                     /translation="

MDAFIRVANQSQGRDRLFRATQHACMLLRYLLESKADKEAVVLKLKRLETSVSTGRKWFRLGNVFHAIQATEQSIQAADLAPRLCLTLANLNRVVYYICDTVLWAKSVGLTSGVNREKWQRWAARHYYYFLLLSLVRDLYEILLQMGQVARDRAKREKSSRDPPKYSVANEETEWLQSFLLLLFQSLKRHPPLLLDTVKNFCDILIPLNQLGIYKSNLGVVGLGGLISSLAGLLTVVYPQLKLKAR"

     misc_feature    167..877
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /note="Peroxisomal biogenesis factor 11 (PEX11); Region:
                     PEX11; pfam05648"
                     /db_xref="CDD:398979"
     misc_feature    446..508
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z211.1);
                     transmembrane region"
     misc_feature    818..880
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z211.1);
                     Region: Required for homodimerization, interaction with
                     PEX11G, and peroxisomal localization.
                     /evidence=ECO:0000250|UniProtKB:O75192"
     misc_feature    818..880
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z211.1);
                     transmembrane region"
     exon            223..338
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            339..2291
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaactccaaaagccgcgtttccgaaggtgtgcccacccccgtgtgggcggagagacgaagtcccacccacctggcaactaatctgttcccgctgtcccccgggaccggcgacgtcccaggggacccacgagggagcgggcgcaacgcgtggctgtgggtgggagccatggacgccttcatccgagtcgccaaccaaagccagggccgggaccgacttttcagagccactcagcacgcatgcatgttgcttagatatttgttagagtctaaagctgacaaagaggccgtggtactgaagctcaagaggctggagaccagtgtgagcactggccgtaaatggttcagactgggcaacgtgttccatgccatccaggcaactgagcagagcatccaagccgctgacctcgcgccccgcttatgcctgacattagccaacctcaaccgcgtggtttattacatctgtgacactgtcctctgggcgaagagtgtgggtcttacctctggagtcaacagagagaaatggcaaaggtgggcggctcgccattactactacttcctcttgctgagcctggtccgggatctgtatgagatcttgctgcagatgggacaagttgcacgtgacagagcaaagagagagaaatcctctcgggaccctcctaagtacagcgtggctaatgaagagactgaatggctccagtccttcctcctcctcctattccagtctctaaagcgacatcctcccttgctcctggacaccgtgaagaacttctgtgacatcctgatccctctgaaccagcttgggatctacaagtccaatctcggcgtggtaggacttggaggtctcatatcctctttggctggtctcctcacggtagtgtatcctcagctgaaactgaaggcccgctagggtgtttggaggctttaaggctagcagttcagtggaacaaacatttggttttgtcccaatgtttactgtgcttaatttaaaaaaaaaaaaaaaatcatgtgagcaccttaccatcctatgagcagaggtaggaccagcagtggcgcatgctacagtaacttcatttctgttcaggtaacattactgagcatcttttatgtacatagtaagagcctagtgttgctggacaaataaagatgaaaaggagagaaaccatgaaagacccaaagaaactagaattacagatcaggttgcacaggtccctgattccacacaagcacaccagggctgaagcacagcactcccagctctgcttaagttttcccttttctcccatctgttattatcccccactcccacgggtgtcaggagtgagatggaggggagctgggctcagcgcctgttaacctgctggtcccggtcattgctgcagtcgtgtcctgaccatgtccagtagcctcagaagaacatcagtgcctctggggcggaggctgtgtccacaggtagaaggctctcggtaatgctaggagcaagcaagagccacagaagggaccagaggtgaaagcaggtgggaggtcaccgcggcctgttatgtcatccgtcacagataaggactatgacagtacaaaacaaagctgatagcacagattcattgggagactttccaggatgatccgcgtgatctcgttaccttcagcggtcttcccgggctcagagcccttagccccttaacatgcccccgagtcctggagcttcagttgatggtttctgtcccagtctatgaaatgcaaagcaatctagactcacccaggttggtttgatttagctacataacagtttatgcaattccacagtaatttttatcaaaataagagaattaaattttttctgtctatagatgtaggaacgtcagttttctgtgacaaatctggttttctcaggacaactgagagggacaggaaagagcaatagggccagtggaggggtcgtggggacaccgggtcagtgcatttgcccgtgttcacacttcacggttcagtcttcctgtcttgagtttggttggtttaggtgtgtggtgtgggagacactggccagcaggcgggtcatgtctactaagtggaaatgagaactatgcactaagcaattgtttcccataaatgtgaaggtgattcttgaaaagtggactcaggcccttggcattctctacttttaaaatgataatgtgctttgagaagactttgggggcgggggttgagattaaagtggctaaaacaagacaaataccagcaaatgcctatttgcactgtaactttaattatgtctaataaatttctagataaaattg

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