LOCUS       NM_010461               2645 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus homeobox B8 (Hoxb8), mRNA.
ACCESSION   NM_010461
VERSION     NM_010461.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Bohic M, Upadhyay A, Eisdorfer JT, Keating J, Simon RC, Briones BA,
            Azadegan C, Nacht HD, Oputa O, Martinez AM, Bethell BN, Gradwell
            MA, Romanienko P, Ramer MS, Stuber GD and Abraira VE.
  TITLE     A new Hoxb8FlpO mouse line for intersectional approaches to dissect
            developmentally defined adult sensorimotor circuits
  JOURNAL   Front Mol Neurosci 16, 1176823 (2023)
   PUBMED   37603775
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu
            F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G, Suo
            S and Peng G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Kumar S, Alam SS, Bareke E, Beauchamp MC, Dong Y, Chan W, Majewski
            J and Jerome-Majewska LA.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, Qiu X, Yang J, Xu J,
            Hao S, Wang X, Lu H, Chen X, Liu X, Huang X, Li Z, Hong Y, Jiang Y,
            Peng J, Liu S, Shen M, Liu C, Li Q, Yuan Y, Wei X, Zheng H, Feng W,
            Wang Z, Liu Y, Wang Z, Yang Y, Xiang H, Han L, Qin B, Guo P, Lai G,
            Munoz-Canoves P, Maxwell PH, Thiery JP, Wu QF, Zhao F, Chen B, Li
            M, Dai X, Wang S, Kuang H, Hui J, Wang L, Fei JF, Wang O, Wei X, Lu
            H, Wang B, Liu S, Gu Y, Ni M, Zhang W, Mu F, Yin Y, Yang H, Lisby
            M, Cornall RJ, Mulder J, Uhlen M, Esteban MA, Li Y, Liu L, Xu X and
            Wang J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Van Deren DA, De S, Xu B, Eschenbacher KM, Zhang S and Capecchi MR.
  TITLE     Defining the Hoxb8 cell lineage during murine definitive
            hematopoiesis
  JOURNAL   Development 149 (8) (2022)
   PUBMED   35452096
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Zwartkruis F, Hoeijmakers T, Deschamps J and Meijlink F.
  TITLE     The murine Hox-2.4 promoter contains a functional octamer motif
  JOURNAL   Nucleic Acids Res 20 (7), 1599-1606 (1992)
   PUBMED   1349742
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Jones FS, Prediger EA, Bittner DA, De Robertis EM and Edelman GM.
  TITLE     Cell adhesion molecules as targets for Hox genes: neural cell
            adhesion molecule promoter activity is modulated by cotransfection
            with Hox-2.5 and -2.4
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2086-2090 (1992)
   PUBMED   1347944
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Ben-David L, Aberdam D, Sachs L and Blatt C.
  TITLE     A deletion and a rearrangement distinguish between the
            intracisternal A-particle of Hox-2.4 and that of interleukin-3 in
            the same leukemic cells
  JOURNAL   Virology 182 (1), 382-387 (1991)
   PUBMED   1673811
REFERENCE   10 (bases 1 to 2645)
  AUTHORS   Aberdam D, Negreanu V, Sachs L and Blatt C.
  TITLE     The oncogenic potential of an activated Hox-2.4 homeobox gene in
            mouse fibroblasts
  JOURNAL   Mol Cell Biol 11 (1), 554-557 (1991)
   PUBMED   1670897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645478.15, AK083980.1 and AK131612.1.
            
            On Dec 21, 2006 this sequence version replaced NM_010461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13721.1, BC139209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AL645478.15        96505-96970
            467-729             AK083980.1         2-264
            730-1482            AL645478.15        97234-97986
            1483-1585           AL645478.15        98763-98865
            1586-2635           AK131612.1         461-1510
            2636-2645           AL645478.15        99916-99925
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.82 cM"
     gene            1..2645
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="homeobox B8"
                     /db_xref="GeneID:15416"
                     /db_xref="MGI:MGI:96189"
     exon            1..1482
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    666..668
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="upstream in-frame stop codon"
     CDS             1059..1790
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="homeobox protein Hox-2.4; homeo box B8"
                     /codon_start=1
                     /product="homeobox protein Hox-B8"
                     /protein_id="NP_034591.1"
                     /db_xref="CCDS:CCDS25293.1"
                     /db_xref="GeneID:15416"
                     /db_xref="MGI:MGI:96189"
                     /translation="

MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKEKLERAPETAEQGDAQKGDKK"

     misc_feature    1458..1475
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="propagated from UniProtKB/Swiss-Prot (P09632.2);
                     Region: Antp-type hexapeptide"
     misc_feature    order(1497..1511,1515..1517,1566..1568,1584..1586,
                     1623..1625,1629..1634,1641..1646,1650..1658,1662..1667)
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1503..1505,1512..1514,1632..1634,1641..1646,
                     1653..1655)
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1506..1664
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    1665..1787
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="propagated from UniProtKB/Swiss-Prot (P09632.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1483..2645
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aagctttaaatatgactacctcgtttgtttgaaaatatgtttaggagaggaagctgtatgatttgataacttgtattaaaataccaattacatttataggaccttttaaaactcggtgcaattaaaccgtgttcttttacatttttccgaagcgaccctgacatttagaaagactccaattgcctcgttaaaatcgcgaaattaacagcgtgcctacgccaggctcagcgttgtggatgtgtgtgtatggtgtttttccgtgactcccccacatcagtctttgggggtggtctgcgaaggtatttgatttgttgtgaggcaagagatatctcattaatgtaggtagttaaacagatttaatccgtattcgttctctctctctcccccctccctctccccccctctccccctctttctccctgggtgtttttttctcttcccctcctttttttctgccctctcctcactccctggcgctctctcgctctagctctctctcgcactcgctctctctcgctctcaccctcgctctgcgttctgtccgggaggagtacccagaagccaataggatgcggggtctctaatggatgcaaatgatggtgaaaagacggggcaaaatatgaaacaactcatttggagggaagtaaatcaccgaaaactgtttatgaactggcatcccttcttcgaaatgtaaagcgaggacctctttaagtggcggtatatttttgtttggggggtggggggtggggggagggcgagcgagccgcggctgccatgcaggcttagacttttgcaggcttcgctcttctattcctggaaatcacaaaaagtgtggcggctttgagatcttcttcgtcttttctttcttttccttccttccttcttttttttcccctcctcccttttcctctcctttcctggcgagggtgactaggagccggcgaatccgcgtttttttttctctctctctccctcccttttccccctccccaccccctccccaacagcccccaactacagcctgcgccgccgccgccgccgcctcaaaattcaataaaatgagctcttatttcgtcaactcactgttctccaaatacaaaaccggggagtccctgcgccccaattattatgactgcggcttcgcccaggacctgggcggccgacccaccgtggtgtacggtcccagcagcggcggcagcttccagcacccttcgcaaatccaggagttctaccacgggccatcgtcgctgtccacagctccctaccagcagaacccgtgcgccgtggcgtgccacggcgaccccggcaacttctacggctacgaccctctgcagcgccagagcctgttcggtgcgcaggatccagacctggtgcagtacgcagactgcaagctcgcggcagccagcggcctgggcgaggaggccgaggggtctgagcagagcccgtcgcccacacagctctttccctggatgcgccctcaagcagccgccggacgcaggcgaggccgccagacctacagtcgctaccagaccctggagctggagaaggagttcctatttaatccctatctgactcgcaagcggaggatcgaggtatcgcacgcgctgggactgacagagagacaggtcaaaatctggttccagaatcggagaatgaagtggaaaaaggagaacaacaaagacaagtttcccagcagtaaatgcgagcaggaggagctggagaaagagaagctggagcgggcaccagagaccgccgagcagggcgatgcgcagaagggtgacaagaagtaggctccagctgggactgctcgggcccggactagcccgcacgtccgccggtcccccccgcgaccacgccgccgccgcccgccccccgcctccgagagctccggccccgcgagcggagccaggagctgggcctcccacagcagcgtcccccgccgcgccagtccccgctagtggtagtatctcgtaatagcttctgtgtgtgagctaccgtggatctccttcccttctcttgggggtccggggggaaaaaaagaaaaggattttaagcaaggactccctcgtcctgcgagggtgatcgactgcggcctggcagaaccccctcgcccccgccccatgtaaaaaagcctccttgtgcaatggtctgtttcctttgaacgtgcttctttgtaatgaccgaggtaccgatttctgctaagttttcccaacaacatgaaactgcctattcacgccgtaattctttctgtctcccgctcactttctctctttctctcgctctctttctctcaccgcgtccccatctttcctcgcaaccccctctccccgctgccctccctagctggctttctctcttgcttctctcttttcctcctgtccccccacccccaccccctttggtttgacaattttgtcttaagtgtttctcaaaagagattactttagttagcatgcgcgctgtgagcattgttaaaagtgttcttaggtttactgtgaagagaatgtatcctgtatctgtgaattgctttatgggggggagggagggctaattatatattttgttgttcctctatactttgttctgttgtctgcgcctgaaaagggcggaagagttacaataaagtttacaagcgagaacccgag

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