LOCUS       NM_010002               1760 bp    mRNA    linear   ROD 23-NOV-2023
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 38
            (Cyp2c38), transcript variant 1, mRNA.
ACCESSION   NM_010002 XM_911996
VERSION     NM_010002.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Meng XY, Zheng QC and Zhang HX.
  TITLE     A comparative analysis of binding sites between mouse CYP2C38 and
            CYP2C39 based on homology modeling, molecular dynamics simulation
            and docking studies
  JOURNAL   Biochim Biophys Acta 1794 (7), 1066-1072 (2009)
   PUBMED   19358898
  REMARK    GeneRIF: By comparison of active site architectures between CYP2C38
            and CYP2C39, the possible reasons affecting their substrate binding
            were proposed
REFERENCE   2  (bases 1 to 1760)
  AUTHORS   Kasai F, Yoshihara M, Matsukuma S, O'Brien P and Ferguson-Smith MA.
  TITLE     Emergence of complex rearrangements at translocation breakpoints in
            a transgenic mouse; implications for mechanisms involved in the
            formation of chromosome rearrangements
  JOURNAL   Cytogenet Genome Res 119 (1-2), 83-90 (2007)
   PUBMED   18160786
REFERENCE   3  (bases 1 to 1760)
  AUTHORS   Luo G, Zeldin DC, Blaisdell JA, Hodgson E and Goldstein JA.
  TITLE     Cloning and expression of murine CYP2Cs and their ability to
            metabolize arachidonic acid
  JOURNAL   Arch Biochem Biophys 357 (1), 45-57 (1998)
   PUBMED   9721182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139233.10.
            
            On Jul 29, 2022 this sequence version replaced NM_010002.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050051.1, AF047725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC139233.10        49463-49651
            190-352             AC139233.10        51799-51961
            353-502             AC139233.10        52126-52275
            503-663             AC139233.10        74164-74324
            664-840             AC139233.10        76308-76484
            841-982             AC139233.10        107736-107877
            983-1170            AC139233.10        110745-110932
            1171-1312           AC139233.10        120248-120389
            1313-1760           AC139233.10        121426-121873
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.03 cM"
     gene            1..1760
                     /gene="Cyp2c38"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     38"
                     /db_xref="GeneID:13097"
                     /db_xref="MGI:MGI:1306819"
     exon            1..189
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    4..6
                     /gene="Cyp2c38"
                     /note="upstream in-frame stop codon"
     CDS             22..1494
                     /gene="Cyp2c38"
                     /EC_number="1.14.14.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytochrome P450 2C38; CYPIIC38; cytochrome
                     P450, 2c38"
                     /codon_start=1
                     /product="cytochrome P450 2C38 isoform 1 precursor"
                     /protein_id="NP_034132.2"
                     /db_xref="CCDS:CCDS29794.1"
                     /db_xref="GeneID:13097"
                     /db_xref="MGI:MGI:1306819"
                     /translation="

MDLVTFLVLTLSSLILLSLWRQRSRRGRLPPGPTPFPIIGNFLQIDVKNFNQSLTNFSKTYGPVFTLYLGSRPIVVLHGYEAVKEALIDHGEEFSGRENIPMSEKINNGLGITFSNGNSWKETRRFTLMTLRNLGMGKRNIEDRVREEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMKKLNENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNFKYIRSYLLEKVKEHQESLDVTNPRDFIDYFLIKQKQANHIEQAEYSLENLVCTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVVGRHRSPCMQDRSRMPYTDAMIHEVQRFINLVPNNLPHAVTCDIKFRNYIIPKGTTVVTSLTSVLHDSKEFPNPEMFDPGHFLDANGNFKKSDYFMTFSAGKRVCAGEGLARMELFLILTTILQNFKLKSLVHPKDIDMIPFVNGLITLPPHYQLCFIPL"

     sig_peptide     22..81
                     /gene="Cyp2c38"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     82..1491
                     /gene="Cyp2c38"
                     /product="Cytochrome P450 2C38. /evidence=ECO:0000255.
                     /id=PRO_0000051721"
                     /note="propagated from UniProtKB/Swiss-Prot (P56655.2)"
     misc_feature    202..1476
                     /gene="Cyp2c38"
                     /note="cytochrome P450 family 2, subfamily C, and similar
                     cytochrome P450s; Region: CYP2C-like; cd20665"
                     /db_xref="CDD:410758"
     misc_feature    order(310..312,355..360,379..381,391..393,901..903,
                     910..915,922..927,934..936,1087..1089,1102..1107,
                     1114..1119,1123..1125,1300..1308,1318..1320,1324..1332,
                     1342..1344,1351..1353)
                     /gene="Cyp2c38"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:410758"
     misc_feature    order(343..345,358..363,631..636,643..645,661..663,
                     718..720,730..732,739..741,895..900,907..912,919..924,
                     1105..1107,1117..1119,1447..1452)
                     /gene="Cyp2c38"
                     /note="chemical substrate binding pocket [chemical
                     binding]; other site"
                     /db_xref="CDD:410758"
     exon            190..352
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            353..502
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            503..663
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            664..840
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            841..982
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1170
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1312
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1760
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtatgaataaggagggtttctatggatcttgtcacattcctggtgctcactctctcctctctcattctcctctcactatggagacagaggtctagaagagggaggctccctcctggccccactcctttcccgattattggtaatttccttcagattgatgtgaagaacttcaaccaatccttaaccaatttctcaaaaacctatggccccgttttcactctgtatttgggctcacggcccattgttgtattgcatgggtatgaagcagtgaaggaagctctgattgatcatggggaggagttttctggtagagaaaacatcccaatgtctgaaaagattaataatggccttggcattacttttagcaatggaaacagttggaaagagacaagacgtttcacactcatgaccctaaggaatttgggcatggggaaaaggaacattgaggatcgtgttcgagaagaagcacagtgtcttgtggaagaactaaggaaaaccaagggctcaccttgtgaccccacattcattctgagctgtgctccatgcaatgtcatctgctcaattatttttcaagatcgttttgattacaaggataaagattttcttatgctcatgaaaaaactaaatgagaatgtcaagattctgagctccccatggttgcaggtctgcaataatttccccttgctcattgactattgtccgggaagtcatcacaaagtactaaaaaacttcaaatatattagaagttacctgttggagaaagtaaaagaacaccaagaatcactggatgttacaaaccctcgtgactttatcgattatttcctgattaaacaaaaacaggcaaaccacatcgaacaagcagaatattcacttgaaaatctggtctgcactatcaataatctctttgctgcaggaacagagacaacaagcacaacactgagatatgctctcctactcctgatgaagtacccagatgtcacagctaaagtccaagaagagattgaccatgtggttggtagacaccgtagcccctgcatgcaggacaggagccgcatgccctatactgatgccatgattcatgaggtccagagattcatcaaccttgtccctaacaacctaccccatgcagtgacctgtgacattaaattcagaaactacatcatccccaagggaacaacagtagtaacgtcactgacatcagttctgcatgacagcaaggagttccccaacccagagatgtttgaccctggccactttctagacgctaatggaaactttaagaaaagtgactacttcatgactttctcagcaggaaaacgggtttgtgctggagagggcctggcccgcatggagctgtttctaatcctgaccaccattttacagaactttaaactgaaatctctggttcacccaaaagacattgatatgatcccatttgtgaatggattaatcactctgccaccccattaccagctctgcttcattcctctctaaagagatcacacattctgaaccctcctctgttgccttctgcaatcccccccccagggttttattcacctctttccttatcagggataaggcatcttccatcctggctcacagaacccccttttctgaagacctagcaaacacatgcggtttctggagttatagcacaaatgcacttgtattatctcttttatataacagttgtctgagcccttatgcttatgtttatccattcctgcgttagaataaaacttcactggcaaataata

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