LOCUS       NM_009123               1903 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus NK1 homeobox 2 (Nkx1-2), mRNA.
ACCESSION   NM_009123
VERSION     NM_009123.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Galea GL, Maniou E, Edwards TJ, Marshall AR, Ampartzidis I, Greene
            NDE and Copp AJ.
  TITLE     Cell non-autonomy amplifies disruption of neurulation by mosaic
            Vangl2 deletion in mice
  JOURNAL   Nat Commun 12 (1), 1159 (2021)
   PUBMED   33608529
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3301. PMID: 34050195]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral
            D, Martins GG, Wilson V and Mallo M.
  TITLE     A Tgfbr1/Snai1-dependent developmental module at the core of
            vertebrate axial elongation
  JOURNAL   Elife 9, e56615 (2020)
   PUBMED   32597756
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Chen N, Schill RL, O'Donnell M, Xu K, Bagchi DP, MacDougald OA,
            Koenig RJ and Xu B.
  TITLE     The transcription factor NKX1-2 promotes adipogenesis and may
            contribute to a balance between adipocyte and osteoblast
            differentiation
  JOURNAL   J Biol Chem 294 (48), 18408-18420 (2019)
   PUBMED   31615896
  REMARK    GeneRIF: Results suggest a role for NK1 homeobox 2 (NKX1-2) in
            promoting adipogenesis and possibly in regulating the balance
            between adipocyte and osteoblast differentiation of bone marrow
            mesenchymal precursor cells.
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Tahara N, Kawakami H, Chen KQ, Anderson A, Yamashita Peterson M,
            Gong W, Shah P, Hayashi S, Nishinakamura R, Nakagawa Y, Garry DJ
            and Kawakami Y.
  TITLE     Sall4 regulates neuromesodermal progenitors and their descendants
            during body elongation in mouse embryos
  JOURNAL   Development 146 (14) (2019)
   PUBMED   31235634
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Sandberg M, Taher L, Hu J, Black BL, Nord AS and Rubenstein JLR.
  TITLE     Genomic analysis of transcriptional networks directing progression
            of cell states during MGE development
  JOURNAL   Neural Dev 13 (1), 21 (2018)
   PUBMED   30217225
  REMARK    GeneRIF: In this study use a combination of genomics, CRISPR/Cas9
            engineering and TF motif analysis to investigate the
            transcriptional networks guiding development of the MGE and its
            descendants. Whereas NKX2-1 is required for initiating MGE
            characteristics in the VZ.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Rovescalli AC, Cinquanta M, Ferrante J, Kozak CA and Nirenberg M.
  TITLE     The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at
            canonical and noncanonical splice sites
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 1982-1987 (2000)
   PUBMED   10681422
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Kim YH, Choi CY, Lee SJ, Conti MA and Kim Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL and
            Buchwald M.
  TITLE     The Tlx-2 homeobox gene is a downstream target of BMP signalling
            and is required for mouse mesoderm development
  JOURNAL   Development 125 (10), 1877-1887 (1998)
   PUBMED   9550720
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Gavalas A, Davenne M, Lumsden A, Chambon P and Rijli FM.
  TITLE     Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
  JOURNAL   Development 124 (19), 3693-3702 (1997)
   PUBMED   9367425
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Schubert FR, Fainsod A, Gruenbaum Y and Gruss P.
  TITLE     Expression of the novel murine homeobox gene Sax-1 in the
            developing nervous system
  JOURNAL   Mech Dev 51 (1), 99-114 (1995)
   PUBMED   7669696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF222444.1.
            
            On Jun 19, 2003 this sequence version replaced NM_009123.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF222444.1, BC139757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.3 cM"
     gene            1..1903
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="NK1 homeobox 2"
                     /db_xref="GeneID:20231"
                     /db_xref="MGI:MGI:104806"
     exon            1..325
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="upstream in-frame stop codon"
     CDS             112..1029
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="homeobox protein SAX-1; homeobox protein
                     Nkx1.2E427; spinal cord axial homeobox gene 1; NK1
                     transcription factor related, locus 2"
                     /codon_start=1
                     /product="NK1 transcription factor-related protein 2"
                     /protein_id="NP_033149.1"
                     /db_xref="CCDS:CCDS21924.1"
                     /db_xref="GeneID:20231"
                     /db_xref="MGI:MGI:104806"
                     /translation="

MLAWQDVGAKAAPSHHKISFSVLDILDPQKFTRAALPPVRLAALEAKKSLEEVEAGQDACSGNPIGSQETPDAVGRGIDPGSPVEGSEAEEEEEAEDAGRAHQPERWQGVHEGSPEARAVAVGTEESGAEGLPASPGSPGSPRPRRRRAESSCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAVQAGGGAPQPGTPGAVAGGGGSATGSSPGPPVPGALPYQTFPTYPATNVLFPAASFPLTTAANGSPFTPFLGPSYLTPFYAPHL"

     misc_feature    262..585
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="propagated from UniProtKB/Swiss-Prot (P42580.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(580..594,598..600,649..651,667..669,706..708,
                     712..717,724..729,733..741,745..750)
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(586..588,595..597,715..717,724..729,736..738)
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    589..747
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    739..882
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="propagated from UniProtKB/Swiss-Prot (P42580.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            326..1903
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aattccagttcgcggctggagagctgtggccaaaccactgcagaagacagcggctgagcgcatccagccccgaccccagtacggctggcctcgggcccgcgggaggcgggcatgttggcatggcaggacgtcggggccaaggcggccccctctcaccacaagatctccttctctgtcttggacatcttggatccgcaaaaattcacgcgagctgccctcccgccggtgcgtctcgctgccctggaagccaagaaaagtttagaagaggtggaagcagggcaagatgcttgttcggggaatccaatcgggtcacaggagacccctgatgcggtgggccgaggcattgaccccgggtctccggtggagggctccgaggcagaggaggaggaggaagctgaggatgcggggcgcgcgcaccagccagagcgctggcagggggtccatgagggctcaccagaggcccgggcagtagcggtgggaacggaagagagcggcgcggaaggcctcccggcgtccccgggctctcccggttccccgcggccccgacgccggcgagccgagtccagctgcgccaagccaaggcgcgcgcgcactgccttcacttacgagcagctggtggccctagagaacaagtttcgagccacgcgctatctgtcggtgtgcgaacgcctgaacctggcgctgtcgctcagcctcacggagacgcaggtcaaaatttggttccagaaccgcaggaccaagtggaagaagcagaacccaggggccgacggcgccgtgcaggcgggaggcggtgcgcctcagcctgggacaccgggcgcggtagcggggggcggtggcagtgccactgggagtagtcctggccctccggttcctggcgctctgccctatcagactttccccacctatcctgccaccaacgtcctcttccctgccgcctccttcccgctgacgaccgccgccaacgggagtcccttcactccattccttgggccctcctacttgacccctttctatgctccacacctatgaatccggtactgctgctcagtcagaattcacgagtgatcagtatgatgacgcgggtccccgcttcacagaggggcactgaccgccccctcctggtgtgccccttccctccgactgctggtgacgccaccagagggcgaggagaagtcacctgcagactacaaccacacaagccactgaggggtcgaggcgatgtccgtccagaccaggctgttttaaacgtttccagcttctggacctcattcttccctttgatttacttcgagggctctgttctttaccgtgtctggctaataagggttcccaggatggagaccagagggagccaagatgccctgggcaccagttgctagcaccaaggactgaatctttaaaggtggcaggacttatgaagaggaagaaacttttcttcctggcgttggaagtggctcagcacggaactcccaaatcctgaacaaagctggagcacgaggaacccaaagcagatgcagttgttgagtgggctggtttcaagatgcacgaccttagtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtagactccattgttgagtgggctggtttcaagatgcacgaccttagtgtgtgtgtgtgtgtgtgtgtagactccatttgtggcccgaagttgttcagcgctgtacctatattcacccagagaagacacggggcaactctgttacctcacaggttttgagaacagcttggacagaccacagcggtgtcctaaaatgcacaaaaaggacagaaaagggagcgatgacccaaaggctctcctgaagtctgtgtgtgagtctttgtgatgtacagtgcttggcgcccatctgtccgttctgctacactttcacggacttca

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