LOCUS       NM_008264               1318 bp    mRNA    linear   ROD 17-SEP-2023
DEFINITION  Mus musculus homeobox A13 (Hoxa13), mRNA.
ACCESSION   NM_008264 XM_906397
VERSION     NM_008264.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1318)
  AUTHORS   Fuiten AM, Yoshimoto Y, Shukunami C and Stadler HS.
  TITLE     Digits in a dish: An in vitro system to assess the molecular
            genetics of hand/foot development at single-cell resolution
  JOURNAL   Front Cell Dev Biol 11, 1135025 (2023)
   PUBMED   36994104
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1318)
  AUTHORS   Chen X, Tang AT, Tober J, Yang J, Leu NA, Sterling S, Chen M, Yang
            Y, Mericko-Ishizuka P, Speck NA and Kahn ML.
  TITLE     Mouse placenta fetal macrophages arise from endothelial cells
            outside the placenta
  JOURNAL   Dev Cell 57 (23), 2652-2660 (2022)
   PUBMED   36473461
REFERENCE   3  (bases 1 to 1318)
  AUTHORS   Zhu J, Patel R, Trofka A, Harfe BD and Mackem S.
  TITLE     Sonic hedgehog is not a limb morphogen but acts as a trigger to
            specify all digits in mice
  JOURNAL   Dev Cell 57 (17), 2048-2062 (2022)
   PUBMED   35977544
REFERENCE   4  (bases 1 to 1318)
  AUTHORS   Bolt CC, Lopez-Delisle L, Hintermann A, Mascrez B, Rauseo A, Andrey
            G and Duboule D.
  TITLE     Context-dependent enhancer function revealed by targeted inter-TAD
            relocation
  JOURNAL   Nat Commun 13 (1), 3488 (2022)
   PUBMED   35715427
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1318)
  AUTHORS   Duboc V, Sulaiman FA, Feneck E, Kucharska A, Bell D,
            Holder-Espinasse M and Logan MPO.
  TITLE     Tbx4 function during hindlimb development reveals a mechanism that
            explains the origins of proximal limb defects
  JOURNAL   Development 148 (19) (2021)
   PUBMED   34423345
REFERENCE   6  (bases 1 to 1318)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1318)
  AUTHORS   Mock,B.A., D'Hoostelaere,L.A., Matthai,R. and Huppi,K.
  TITLE     A mouse homeo box gene, Hox-1.5, and the morphological locus, Hd,
            map to within 1 cM on chromosome 6
  JOURNAL   Genetics 116 (4), 607-612 (1987)
   PUBMED   2887485
REFERENCE   8  (bases 1 to 1318)
  AUTHORS   Gibson,D.M. and MacLean,S.J.
  TITLE     Ef2: a new LY-3-linked light-chain marker expressed in normal mouse
            serum immunoglobulin
  JOURNAL   J Exp Med 149 (6), 1477-1486 (1979)
   PUBMED   109570
REFERENCE   9  (bases 1 to 1318)
  AUTHORS   Eicher,E.M. and Beamer,W.G.
  TITLE     Inherited ateliotic dwarfism in mice. Characteristics of the
            mutation, little, on chromosome 6
  JOURNAL   J Hered 67 (2), 87-91 (1976)
   PUBMED   1270792
REFERENCE   10 (bases 1 to 1318)
  AUTHORS   Green,M.C. and Shultz,L.D.
  TITLE     Motheaten, an immunodeficient mutant of the mouse. I. Genetics and
            pathology
  JOURNAL   J Hered 66 (5), 250-258 (1975)
   PUBMED   1184950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U59322.1.
            
            On Dec 7, 2005 this sequence version replaced XM_906397.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.41 cM"
     gene            1..1318
                     /gene="Hoxa13"
                     /gene_synonym="Hd; Hox-1.10"
                     /note="homeobox A13"
                     /db_xref="GeneID:15398"
                     /db_xref="MGI:MGI:96173"
     exon            1..1022
                     /gene="Hoxa13"
                     /gene_synonym="Hd; Hox-1.10"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1267
                     /gene="Hoxa13"
                     /gene_synonym="Hd; Hox-1.10"
                     /note="homeobox protein Hox-1.10; hypodactyly"
                     /codon_start=1
                     /product="homeobox protein Hox-A13"
                     /protein_id="NP_032290.1"
                     /db_xref="GeneID:15398"
                     /db_xref="MGI:MGI:96173"
                     /translation="

MTASVLLHPRWIEPTVMFLYDNGGGLVADELNKNMEGAAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPLAPGAAAAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYPCARMGPHPNAIKSCAQPASAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPYHHHQPVPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQTQPPHLWKSTLPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKKVINKLKTTS"

     misc_feature    <557..772
                     /gene="Hoxa13"
                     /gene_synonym="Hd; Hox-1.10"
                     /note="Hox protein A13 N terminal; Region: HoxA13_N;
                     pfam12284"
                     /db_xref="CDD:432453"
     misc_feature    order(1067..1081,1085..1087,1136..1138,1154..1156,
                     1193..1195,1199..1204,1211..1216,1220..1228,1232..1237)
                     /gene="Hoxa13"
                     /gene_synonym="Hd; Hox-1.10"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    1073..1234
                     /gene="Hoxa13"
                     /gene_synonym="Hd; Hox-1.10"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(1073..1075,1082..1084,1202..1204,1211..1216,
                     1223..1225)
                     /gene="Hoxa13"
                     /gene_synonym="Hd; Hox-1.10"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            1023..1318
                     /gene="Hoxa13"
                     /gene_synonym="Hd; Hox-1.10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgacccgcccccctcgctcgggccccggccccgcgcgccgcgctcttcacttcttgggggctttttaaaacagcgccactggggtcttctccatgcggctcgggctatgacagcctccgtgctcctccacccccgctggatcgagcccaccgtcatgtttctctacgacaacggcggcggcctggtggccgacgagctcaacaagaacatggaaggggcggcggcggcggcagcggcggcggccgcggcggcggcggcgggagctgggggcgggggcttcccccacccggctgccgcggccgcggggggcaacttctcggtggccgcagcggccgccgccgccgccgccgccgcggccaaccagtgccgcaacctgatggcgcatcccgcacccctggcgcccggcgccgcggccgcgtacagcagcgccccgggggaggcgcccccgtccgccgccgccgccgccgccgccgccgctgctgccgccgccgccgcggctgccgcgtcgtcgtcgggagggcccgggccggcggggcccgcgggtgccgaggccgccaagcagtgcagtccctgctcggcggcggcacagagctcgtcggggcccgcggcgctgccctacggctacttcggcagcggctactacccgtgcgcccgcatgggcccgcaccccaacgccatcaagtcgtgcgcgcagcctgcttcggccgccgccgccttcgccgacaagtacatggacaccgccggccccgcggccgaggagttcagctcccgcgccaaggagtttgctttctaccatcagggctacgcagccgggccttaccaccatcaccagcccgtgcccggctacctggatatgccagtagttccggggctcgggggtcctggcgagtcgcgccacgagcctctggggcttcccatggaaagctatcagccctgggctctgcccaacggctggaacggccaaatgtactgccccaaagagcagacgcagcctccccacctctggaagtccactctgcccgacgtcgtctcccatccttcagacgccagctcctataggagggggagaaagaagcgcgtgccttacactaaggtgcagttgaaagaactcgaacgggaatacgctacgaacaaattcattaccaaggacaaacggaggaggatatcagccacgacaaacctctctgagaggcaggtcacaatctggttccagaacaggagggtcaaagagaaaaaagtcatcaataaactcaagaccactagttaatggattaaaaggtggagcagagggcagcttgaagaaacgcttaaggatttg

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