LOCUS       NM_008257               1372 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus H6 homeobox 3 (Hmx3), mRNA.
ACCESSION   NM_008257
VERSION     NM_008257.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Kaiser M, Wojahn I, Rudat C, Ludtke TH, Christoffels VM, Moon A,
            Kispert A and Trowe MO.
  TITLE     Regulation of otocyst patterning by Tbx2 and Tbx3 is required for
            inner ear morphogenesis in the mouse
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33795231
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   Corman TS, Bergendahl SE and Epstein DJ.
  TITLE     Distinct temporal requirements for Sonic hedgehog signaling in
            development of the tuberal hypothalamus
  JOURNAL   Development 145 (21) (2018)
   PUBMED   30291164
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1372)
  AUTHORS   Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C,
            Hjerling-Leffler J, Sundstrom E, Pachnis V and Marklund U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (bases 1 to 1372)
  AUTHORS   Espinosa-Medina I, Saha O, Boismoreau F, Chettouh Z, Rossi F,
            Richardson WD and Brunet JF.
  TITLE     The sacral autonomic outflow is sympathetic
  JOURNAL   Science 354 (6314), 893-897 (2016)
   PUBMED   27856909
REFERENCE   6  (bases 1 to 1372)
  AUTHORS   Hadrys T, Braun T, Rinkwitz-Brandt S, Arnold HH and Bober E.
  TITLE     Nkx5-1 controls semicircular canal formation in the mouse inner ear
  JOURNAL   Development 125 (1), 33-39 (1998)
   PUBMED   9389661
REFERENCE   7  (bases 1 to 1372)
  AUTHORS   Rinkwitz-Brandt S, Arnold HH and Bober E.
  TITLE     Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes
            during mouse inner ear development
  JOURNAL   Hear Res 99 (1-2), 129-138 (1996)
   PUBMED   8970821
REFERENCE   8  (bases 1 to 1372)
  AUTHORS   Rinkwitz-Brandt S, Justus M, Oldenettel I, Arnold HH and Bober E.
  TITLE     Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox
            genes during brain and ear development
  JOURNAL   Mech Dev 52 (2-3), 371-381 (1995)
   PUBMED   8541222
REFERENCE   9  (bases 1 to 1372)
  AUTHORS   Stadler HS, Murray JC, Leysens NJ, Goodfellow PJ and Solursh M.
  TITLE     Phylogenetic conservation and physical mapping of members of the H6
            homeobox gene family
  JOURNAL   Mamm Genome 6 (6), 383-388 (1995)
   PUBMED   7647458
REFERENCE   10 (bases 1 to 1372)
  AUTHORS   Bober E, Baum C, Braun T and Arnold HH.
  TITLE     A novel NK-related mouse homeobox gene: expression in central and
            peripheral nervous structures during embryonic development
  JOURNAL   Dev Biol 162 (1), 288-303 (1994)
   PUBMED   7510254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159994.7, BE956569.1, BE649795.1 and AI326757.1.
            
            On Oct 2, 2007 this sequence version replaced NM_008257.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139482.1, AI528548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC159994.7         92560-92764
            206-486             BE956569.1         1-281
            487-787             AC159994.7         93648-93948
            788-1286            BE649795.1         1-499               c
            1287-1372           AI326757.1         1-86                c
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 74.32 cM"
     gene            1..1372
                     /gene="Hmx3"
                     /gene_synonym="Nkx-5.1; Nkx5-1; Nkx5.1"
                     /note="H6 homeobox 3"
                     /db_xref="GeneID:15373"
                     /db_xref="MGI:MGI:107160"
     CDS             1..1071
                     /gene="Hmx3"
                     /gene_synonym="Nkx-5.1; Nkx5-1; Nkx5.1"
                     /note="homeobox protein Nkx-5.1; homeobox protein H6
                     family member 3; H6 homeo box 3"
                     /codon_start=1
                     /product="homeobox protein HMX3"
                     /protein_id="NP_032283.3"
                     /db_xref="CCDS:CCDS21917.1"
                     /db_xref="GeneID:15373"
                     /db_xref="MGI:MGI:107160"
                     /translation="

MPEPGPDASGTASAPPPQPPPQPPAPKESPFSIRNLLNGDHHRPPPKPQPPPRTLFAPASAAAAAAAAAAAAAKGALEGAAGFALSQVGDLAFPRFEIPAQRFALPAHYLERSPAWWYPYTLTPAGGHLPRPEASEKALLRDSSPASGTDRDSPEPLLKADPDHKELDSKSPDEIILEESDSEEGKKEGEAVPGAAGTTVGATTATPGSEDWKAGAESPEKKPACRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAAQRIVRVPILYHENSAAEGAAAAAGAPVPVSQPLLTFPHPVYYSHPVVSSVPLLRPV"

     misc_feature    order(682..696,700..702,751..753,769..771,808..810,
                     814..819,826..831,835..843,847..852)
                     /gene="Hmx3"
                     /gene_synonym="Nkx-5.1; Nkx5-1; Nkx5.1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    688..849
                     /gene="Hmx3"
                     /gene_synonym="Nkx-5.1; Nkx5-1; Nkx5.1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(688..690,697..699,817..819,826..831,838..840)
                     /gene="Hmx3"
                     /gene_synonym="Nkx-5.1; Nkx5-1; Nkx5.1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            1..400
                     /gene="Hmx3"
                     /gene_synonym="Nkx-5.1; Nkx5-1; Nkx5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..1372
                     /gene="Hmx3"
                     /gene_synonym="Nkx-5.1; Nkx5-1; Nkx5.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgccggagcccgggccggacgcctcgggcactgccagcgcgccgcccccgcagccaccgccccaacctcccgcgcccaaggaatccccgttctccatcaggaacctgctcaacggagaccatcaccggccgcccccgaagcctcagccgcccccacgaacgctctttgctccggcctcggctgctgccgccgccgccgccgctgcggccgccgcagccaaaggtgccctggagggcgccgcgggcttcgcgctctcgcaggtgggcgacctggctttcccccgctttgagatcccagcgcagaggtttgccctgcccgcgcactacctggagcgctccccggcctggtggtacccctacaccctgacccccgccggcggtcacctcccgcgaccagaagcctcggaaaaggccctcctgcgagactcctcccctgcgtccggcaccgatcgagactccccggagcctctgctcaaggctgaccccgaccacaaggagctggactccaagagcccggacgagatcattctggaagagagcgactcggaggaaggcaaaaaagaaggcgaggcggtgcctggcgcggccgggacgaccgtaggggcgactacggcgacaccgggctcagaggactggaaggcgggcgccgagagtcccgagaagaagccggcgtgccgcaaaaagaagacgcgcaccgtcttctcgcgcagccaggtcttccagctcgagtccacattcgacatgaaacgctacctgagcagctcggagcgcgctggcctggccgcgtcgcttcacctcaccgagacgcaggtcaagatctggttccagaatcgccgcaacaagtggaagcgacagctggcggccgagctggaggcggccaacctgagccacgccgctgcgcagcgcatcgtacgcgtgcccatcctctaccacgagaactctgcggccgagggggcggcagcggctgcgggggcaccggtgccagtcagccagccgctgctcaccttcccgcacccagtctactactcgcacccggtggtctcgtccgtgcccctactaaggccggtgtgagatgggacaggggacagggagtgagcacccggccaccttttggggaccccggaggagactgggccgggccgagggtgccgggctgtggccagcgaccttgggctcactgccttgcctcccaccccccaatagcattttgtaagtatttgcaatgcattttcgtgcaattaattcctatgaatttgaggcgcttctcctcttatttttggttttgcttaccattgagagaaaacggggtggggcaggggggaacgacaaaattaccaggtcaaaacttccaattgaaagttctttaaaaaaa

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