2024-04-27 06:08:46, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_008098 4042 bp mRNA linear ROD 05-AUG-2023 DEFINITION Mus musculus myotrophin (Mtpn), mRNA. ACCESSION NM_008098 VERSION NM_008098.4 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 4042) AUTHORS Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP and Harten SK. TITLE Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse JOURNAL Differentiation 94, 8-20 (2017) PUBMED 27930960 REFERENCE 2 (bases 1 to 4042) AUTHORS Fujiwara I, Remmert K, Piszczek G and Hammer JA. TITLE Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges JOURNAL Proc Natl Acad Sci U S A 111 (19), E1970-E1979 (2014) PUBMED 24778263 REMARK GeneRIF: Our data argue that a large pool of freely diffusing, inactive capping protein (CP:V-1) feeds, via CARMIL-driven complex exchange, the formation of weak-capping complexes (CP:CARMIL) at the plasma membrane of protruding edges. REFERENCE 3 (bases 1 to 4042) AUTHORS Campbell GR, Baudhuin A, Vranizan K and Ngai J. TITLE Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling JOURNAL Mol Cell Neurosci 46 (2), 548-561 (2011) PUBMED 21194568 REFERENCE 4 (bases 1 to 4042) AUTHORS Li Y, Xu X, Liang Y, Liu S, Xiao H, Li F, Cheng H and Fu Z. TITLE miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression JOURNAL Int J Clin Exp Pathol 3 (3), 254-264 (2010) PUBMED 20224724 REMARK GeneRIF: miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells (a NOD-derived beta-cell line) by repressing myotrophin (V1) protein expression. Publication Status: Online-Only REFERENCE 5 (bases 1 to 4042) AUTHORS Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M and Asahara H. TITLE A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58 JOURNAL Dev Cell 17 (6), 836-848 (2009) PUBMED 20059953 REFERENCE 6 (bases 1 to 4042) AUTHORS Piao Y, Ko NT, Lim MK and Ko MS. TITLE Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method JOURNAL Genome Res 11 (9), 1553-1558 (2001) PUBMED 11544199 REFERENCE 7 (bases 1 to 4042) AUTHORS Fujigasaki H, Song SY, Kobayashi T and Yamakuni T. TITLE Murine central neurons express a novel member of the cdc10/SWI6 motif-containing protein superfamily JOURNAL Brain Res Mol Brain Res 40 (2), 203-213 (1996) PUBMED 8872304 REFERENCE 8 (bases 1 to 4042) AUTHORS Pennica D, Shaw KJ, Luoh SM and Wood WI. TITLE Isolation of cDNA clones encoding the mouse protein V-1 JOURNAL Gene 158 (2), 305-306 (1995) PUBMED 7607560 REFERENCE 9 (bases 1 to 4042) AUTHORS Taoka M, Isobe T, Okuyama T, Watanabe M, Kondo H, Yamakawa Y, Ozawa F, Hishinuma F, Kubota M, Minegishi A et al. TITLE Murine cerebellar neurons express a novel gene encoding a protein related to cell cycle control and cell fate determination proteins JOURNAL J Biol Chem 269 (13), 9946-9951 (1994) PUBMED 8144589 REFERENCE 10 (bases 1 to 4042) AUTHORS Mukherjee DP, McTiernan CF and Sen S. TITLE Myotrophin induces early response genes and enhances cardiac gene expression JOURNAL Hypertension 21 (2), 142-148 (1993) PUBMED 8428777 REMARK GeneRIF: Rat neonatal cardiac myocytes incubated with myotrophin showed an increase in c-myc, c-fos, and c-jun RNA levels and an increase in connexin 43, atrial natriuretic factor, skeletal alpha-actin, and total myosin transcript levels. COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA559569.1, BC054811.1, AK049398.1 and AC166251.6. On May 7, 2009 this sequence version replaced NM_008098.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054811.1, AK083888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-87 CA559569.1 1-87 88-3806 BC054811.1 1-3719 3807-3960 AK049398.1 3710-3863 3961-4042 AC166251.6 33851-33932 FEATURES Location/Qualifiers source 1..4042 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="6" /map="6 15.27 cM" gene 1..4042 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="myotrophin" /db_xref="GeneID:14489" /db_xref="MGI:MGI:99445" exon 1..350 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /inference="alignment:Splign:2.1.0" misc_feature 234..236 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="upstream in-frame stop codon" CDS 279..635 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="protein V-1; granule cell differentiation protein" /codon_start=1 /product="myotrophin" /protein_id="NP_032124.1" /db_xref="CCDS:CCDS20002.1" /db_xref="GeneID:14489" /db_xref="MGI:MGI:99445" /translation="
MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEATDNQAIKALLQ"
misc_feature 282..368 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="propagated from UniProtKB/Swiss-Prot (P62774.2); Region: ANK 1" misc_feature 282..284 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="N-acetylcysteine. /evidence=ECO:0007744|PubMed:23806337; propagated from UniProtKB/Swiss-Prot (P62774.2); acetylation site" misc_feature 288..290 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="N6-acetyllysine. /evidence=ECO:0007744|PubMed:23806337; propagated from UniProtKB/Swiss-Prot (P62774.2); acetylation site" misc_feature 294..569 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="Ankyrin repeats (3 copies); Region: Ank_2; pfam12796" /db_xref="CDD:432791" misc_feature 294..374 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="ANK repeat [structural motif]; Region: ANK repeat" /db_xref="CDD:293786" misc_feature order(297..302,309..317,321..326,336..338,345..347, 372..374,378..380,384..386,396..401,408..416,420..425, 435..437,444..446,471..473,477..479,483..485,495..500, 507..515,519..524,534..536,543..545) /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="oligomer interface [polypeptide binding]; other site" /db_xref="CDD:293786" misc_feature 309..311 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P58546; propagated from UniProtKB/Swiss-Prot (P62774.2); acetylation site" misc_feature 348..350 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P58546; propagated from UniProtKB/Swiss-Prot (P62774.2); acetylation site" misc_feature 369..371 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="Phosphothreonine. /evidence=ECO:0000250|UniProtKB:P58546; propagated from UniProtKB/Swiss-Prot (P62774.2); phosphorylation site" misc_feature 378..476 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="propagated from UniProtKB/Swiss-Prot (P62774.2); Region: ANK 2" misc_feature 378..473 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="ANK repeat [structural motif]; Region: ANK repeat" /db_xref="CDD:293786" misc_feature 477..575 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="propagated from UniProtKB/Swiss-Prot (P62774.2); Region: ANK 3" misc_feature 477..569 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /note="ANK repeat [structural motif]; Region: ANK repeat" /db_xref="CDD:293786" exon 351..464 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /inference="alignment:Splign:2.1.0" exon 465..548 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /inference="alignment:Splign:2.1.0" exon 549..4042 /gene="Mtpn" /gene_synonym="5033418D15Rik; Gcdp; V1" /inference="alignment:Splign:2.1.0" ORIGIN
ccgagcagagctttctggagagaggaagaggaagaggaagtgggaggcgggccctagcggggcgtgaaccggaagtgtaagcgtcctgcttctcctcagctaggcggaacctgctctgctgggcccaacggctgcagaagaactttctcccgcccgaaccgtagccgcgacccgcagtctcgcccgctcagcggcctgaggcgcgtcgctttctcgtgtcccctcgtcgggcctaatcgccgctcctgcccggcccgccggcccaccccgctgcagtcatgtgcgacaaggagttcatgtgggccctgaaaaacggagacttggatgaggtgaaggactatgtggctaagggagaagatgtcaaccggacactagagggtggaaggaagcctcttcattatgctgcagattgtggacagcttgaaatcctggaatttctgctgctgaaaggagcagatattaatgctccagataaacatcatattacccctcttctgtctgctgtctatgagggtcatgtttcctgcgtgaaattgcttctgtcaaagggtgctgataagactgtgaaaggcccagatggactgaccgcccttgaagccactgacaaccaggcaatcaaagctcttctccagtgatagatggatggacggactgataacttgggaaggatgactctcctgtggcctcacactgctgcctgtctgtctgtcactttctatctgccagcttcttcagctaaatactttaagagggtgaagggagagagaaattcataacaaatcagactgccaggggaggggaataaaacatgttttggaggagcagtggggaatgtgatgagacttttactgggattcctgatcaaaccagcctgtttttcatttccagtaaaatatacagcttattcccaagggagagcaaaaatacagtctattggaatcattggaccttctcagctccctagctaatttattaattagtttattgaaggtctgactatacaaggccaactctacttatttggtagccctagctgtgagcagtagtggctgctgttatgtcaacatagggtgctgagataagcaattagctatagccttctgccttaagaatgcactctcctgggggctcctggctagttaagagcggttagtgaccaaaatctctctagaatgacgttaatctttacataagagcttagataaggtaaggagcagcgcactcctgaattgctggatgactaaactttggattttctctcccctttcacatcaatttcatgtctctttagataaaactgactagttttatttataaaatgttaaattctaggagcctaaaggaggaatcattccagtaggcttatttctttttttctcctttagactcagacatttatataacattgaaacactttgagactccttctggtagtaaaggagatttaaaaataaaatcatagccataagcgtgttagtatcttataaagagagaacagttgtcttagtacctatggagtttcttcatttgctatttgagtgagccagccttcgttgtgtttggagaatgaagaatattctttggaatgcctctcaaaaacccaccatggatgctgattttatagtgcaccaaaggtatcactggggtgagatgtactgtatttggacagatgggacctcatcccttcaaaaacattcttgttaccatgttctcctgagctggtaatagactcttgctgggccagtaccaccccacctgcatggtgtttttatcttaacaatcattctttgcatacatgtgacaacttcaaaatgcattctgtgttcttataatacagtgccctaaaacggtattcctaggacctgcagataagagaaacttatctctaactttttctttcatgaacaataaaatgaattaaaacatacaaccttaaatttgatggcctacactttaagtattaagatgtcttttgcttttaatttgccatctatacaggattacaaaaactattagaatctttccatagccaatcatgcaataattgaatgtacctcaaatttttaaagggtaggtgatgggatagggacttataatcacattagggataataatattaaaaacctaactgattttttttaaggcattgtagcattatatagcagggttaaactattactaagaacaatcagcctggctaataactattaatcagttgataattggttggggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgttctcccatgaactcttttttatcctgtggctttttcactttcaactagcctgcccctgtagtttttctatgtccaagaaaacaatcacaaaacagtagtttaaatactttgatatatttggctagctctgctgttttaatgcagcctactagagttggatatcctacacttaatcttaaccaaaaggccaagcagctatagagttggacattctgctaggaagtggaaggcacatgatcagtctatgagtcaatataatgcaacagggtgttttgagacctttgttttcacctcttggcatactattttaaaggcttgaattttaccctttacacaattttcaatttttctttcaaagtcttctgttatagttggctattgcagagtgtatattgtcttatcattccagaacttgggtctgctttctacagtcattatggtaccaaaaccatatgattctttgtacagtttatcccagtgttccttgtaatgcagtagaggctattttgccttccccctttgttggccattttgtaaacccatagctatgaagtgattgcttgagaaaatagcatataaacatagactaggatagactgaccaggatggtttacagtttctttaaaaaaataataaacaaaaataaacaaaaaaaaaactaggttatttataatgtatttctgaaccacttggcagagaaattcatgacacttaatgttaatatttttgaataaatgaagctaaaatgtctgcttttggtacaacacgcattaataaaaggttaagttttgttttccactgaagtactatttaacatctcagaaaaaaaccctgcatgttctatagttttatattaaaatccatcatttcatatgcactgtatcaaaaacaggttacttgcctgaacatggttagtgtactaacaggtctgcccacccctaccctcacccccagcttcatgccagcatatgtagatttgagttctaacacagcacttgcatatcccatgtgcacaagctcacctttccagaaccagctgggcgcagaagaaaggcagtaactgcagcatgtgaaagctaaaacaagtagccttctagtcatttctttctttccccagccagataaaaggagcttcaatatatgtgtacttgatttttattcacttcagctgagctgctgtttccttcatgtaatattgtatactgggttgtgtatagaagaagctggtaagagtgccctccttcataaataagcaattgcagtgttttgcatgcaaatttaaaaaaatttaaattgtcctgattctattttgtaaatggagaaacaatctttctaagcagtatggaggaagactagtgctttgtgcacttttggtatatttgagttcatgtttccacaatgtcattcccttgacacagttgggtttctcataagtatcctagttcatgtacatccgaatgctaactaatactgtgtttaagtttcgtgttgcaagaacaaatggaataaacttgaattgtgctatagataacatgttagcaacatatttatccccagtcactgttgccttcctttccagacgtccttaacgatatgaaaatcttgactaacttgagattttaataccattttatcctacttctagaagaaatgaagaaaccaattattaaagagctaacgatactagatgctgctcatagaaaagcttttttttttaacttcaatataagttttctgatacacattgttgctgtatatgggtccagg
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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