LOCUS       NM_007524               1437 bp    mRNA    linear   ROD 02-MAY-2023
DEFINITION  Mus musculus NK3 homeobox 2 (Nkx3-2), mRNA.
ACCESSION   NM_007524
VERSION     NM_007524.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1437)
  AUTHORS   Melzer MK, Schirge S, Gout J, Arnold F, Srinivasan D, Burtscher I,
            Allgower C, Mulaw M, Zengerling F, Gunes C, Lickert H, Christoffels
            VM, Liebau S, Wagner M, Seufferlein T, Bolenz C, Moon AM, Perkhofer
            L and Kleger A.
  TITLE     TBX3 is dynamically expressed in pancreatic organogenesis and
            fine-tunes regeneration
  JOURNAL   BMC Biol 21 (1), 55 (2023)
   PUBMED   36941669
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1437)
  AUTHORS   Burganova G, Schonblum A, Sakhneny L, Epshtein A, Wald T, Tzaig M
            and Landsman L.
  TITLE     Pericytes modulate islet immune cells and insulin secretion through
            Interleukin-33 production in mice
  JOURNAL   Front Endocrinol (Lausanne) 14, 1142988 (2023)
   PUBMED   36967785
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1437)
  AUTHORS   Sakhneny L, Mueller L, Schonblum A, Azaria S, Burganova G, Epshtein
            A, Isaacson A, Wilson H, Spagnoli FM and Landsman L.
  TITLE     The postnatal pancreatic microenvironment guides beta cell
            maturation through BMP4 production
  JOURNAL   Dev Cell 56 (19), 2703-2711 (2021)
   PUBMED   34499867
REFERENCE   4  (bases 1 to 1437)
  AUTHORS   Oh HK, Park M, Choi SW, Jeong DU, Kim BJ, Kim JA, Choi HJ, Lee J,
            Cho Y, Kim JH, Seong JK, Choi BH, Min BH and Kim DW.
  TITLE     Suppression of Osteoarthritis progression by post-natal Induction
            of Nkx3.2
  JOURNAL   Biochem Biophys Res Commun 571, 188-194 (2021)
   PUBMED   34330063
  REMARK    GeneRIF: Suppression of Osteoarthritis progression by post-natal
            Induction of Nkx3.2.
REFERENCE   5  (bases 1 to 1437)
  AUTHORS   Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE,
            Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN,
            Vidal-Puig A, Ozanne SE, Medina-Gomez G and Constancia M.
  TITLE     Mesenchyme-derived IGF2 is a major paracrine regulator of
            pancreatic growth and function
  JOURNAL   PLoS Genet 16 (10), e1009069 (2020)
   PUBMED   33057429
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1437)
  AUTHORS   Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H,
            Lee Y, Lyons GE and Izumo S.
  TITLE     Vertebrate homologs of tinman and bagpipe: roles of the homeobox
            genes in cardiovascular development
  JOURNAL   Dev Genet 22 (3), 239-249 (1998)
   PUBMED   9621431
REFERENCE   7  (bases 1 to 1437)
  AUTHORS   Yoshiura KI and Murray JC.
  TITLE     Sequence and chromosomal assignment of human BAPX1, a
            bagpipe-related gene, to 4p16.1: a candidate gene for skeletal
            dysplasia
  JOURNAL   Genomics 45 (2), 425-428 (1997)
   PUBMED   9344671
REFERENCE   8  (bases 1 to 1437)
  AUTHORS   Wightman PJ, Hayward BE and Bonthron DT.
  TITLE     The genes encoding glucokinase regulatory protein and
            ketohexokinase co-localize to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 700-701 (1997)
   PUBMED   9271679
REFERENCE   9  (bases 1 to 1437)
  AUTHORS   Chen X and Lufkin T.
  TITLE     Linkage mapping of Sax2 to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 697-698 (1997)
   PUBMED   9271676
REFERENCE   10 (bases 1 to 1437)
  AUTHORS   Tribioli C, Frasch M and Lufkin T.
  TITLE     Bapx1: an evolutionary conserved homologue of the Drosophila
            bagpipe homeobox gene is expressed in splanchnic mesoderm and the
            embryonic skeleton
  JOURNAL   Mech Dev 65 (1-2), 145-162 (1997)
   PUBMED   9256352
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U87957.1 and BC145874.1.
            
            On Nov 24, 2007 this sequence version replaced NM_007524.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145872.1, BC021014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 U87957.1           1-5
            6-1437              BC145874.1         1-1432
FEATURES             Location/Qualifiers
     source          1..1437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 22.58 cM"
     gene            1..1437
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /note="NK3 homeobox 2"
                     /db_xref="GeneID:12020"
                     /db_xref="MGI:MGI:108015"
     exon            1..742
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    82..84
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /note="upstream in-frame stop codon"
     CDS             277..1278
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /note="homeodomain protein Nkx-3.2; homeobox protein NK-3
                     homolog B; bagpipe homeobox protein homolog 1; bagpipe
                     homeobox gene 1 homolog"
                     /codon_start=1
                     /product="homeobox protein Nkx-3.2"
                     /protein_id="NP_031550.2"
                     /db_xref="CCDS:CCDS19259.1"
                     /db_xref="GeneID:12020"
                     /db_xref="MGI:MGI:108015"
                     /translation="

MAVRGSGTLTPFSIQAILNKKEERGGLATPEGRPAPGGTEVAVTAAPAVCCWRIFGETEAGALGGAEDSLLASPARTRTAVGQSAESPGGWDSDSALSEENEGRRRCADVPGASGTGRARVTLGLDQPGCELHAAKDLEEEAPVRSDSEMSASVSGDHSPRGEDDSVSPGGARVPGLRGAAGSGASGGQAGGVEEEEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVAVKVLVRDDQRQYLPGEVLRPPSLLPLQPSYYYPYYCLPGWALSTCAAAAGTQ"

     misc_feature    496..639
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /note="propagated from UniProtKB/Swiss-Prot (P97503.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    685..912
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /note="propagated from UniProtKB/Swiss-Prot (P97503.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(895..909,913..915,964..966,982..984,1021..1023,
                     1027..1032,1039..1044,1048..1056,1060..1065)
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    901..1065
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:395001"
     misc_feature    order(901..903,910..912,1030..1032,1039..1044,1051..1053)
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            743..1437
                     /gene="Nkx3-2"
                     /gene_synonym="Bapx1; Nkx-3.2; NKX3.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaagagataatcggccgggctgtaggagaagagcatctggcgctggattccaggggagggggtcctggcgaggtgggcctgtgaggtggggtgagggtcggcgcggatcctggaactgaggggggcgggggctgctgtgctgcgcaggagtgggttgcgggggcctggcgcgcccctctcactcgcgctgaggtcgcccagagctccgtgtcaggctcgaagctgtccccgcgccccagttgccctcctggctgccggctccgatctgcggcgcagatggctgtgcgcggcagcggcaccttgacgcccttctccatccaggcgatcctcaacaagaaagaggagcgcggcgggttggctacgccggaggggcgcccggcaccagggggcacagaggtggcggtgaccgcggcgcccgccgtctgctgctggcggatcttcggggagaccgaggccggtgcgctggggggcgccgaggactctcttctggcatctcccgcccgaaccagaacagccgtggggcagagcgcagagagtccgggaggttgggactcagactcagccctgagcgaagagaacgagggcaggaggcgctgcgccgatgtcccgggagccagtggaaccggccgcgccagggtgaccctgggcctggaccagccaggctgcgagctgcacgccgccaaggacctggaggaggaagccccggtccgcagcgacagcgagatgtcagccagcgtttcaggcgaccacagcccgagaggcgaggatgacagcgttagccctggaggtgcacgcgtgcctgggttgcgcggcgccgcgggcagcggggctagcggcgggcaggcgggcggcgtggaggaggaggaagagcccgcagcccctaaaccgcgaaagaagcgctcccgggccgccttctcgcacgcccaggtcttcgagctggagcgccgctttaaccatcagcgctacctgtccgggccggagcgcgcagacctggcagcttcgctgaagctcacagagacgcaagtgaagatctggtttcagaaccgtcgctacaagaccaaacgccggcagatggccgccgacctgctcgcctctgcacccgccgccaagaaagtggccgtaaaggtgctggtgcgtgacgaccaaagacagtatttgcccggagaggtgctgaggccaccttcccttctgccactgcagccctcctactactacccttactactgtctcccgggctgggcgctgtccacgtgcgcggccgctgctggtacccagtgaagcccttgggacgaggcaaagaaggattcctgcgtcccccgtatgcaccgccacggacaggtgtactctgtgcaggcgagttctgctcaactggggatgaggcaggtggggaatgaaatcctgctgggacttgacacacctatccagggtgacagggcc

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