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Previous release (v1)
2024-11-01 08:06:11, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001424889 5224 bp mRNA linear ROD 17-JUL-2024
DEFINITION Mus musculus transforming growth factor, beta receptor I (Tgfbr1),
transcript variant 7, mRNA.
ACCESSION NM_001424889
VERSION NM_001424889.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 5224)
AUTHORS Bedolla,A., Wegman,E., Weed,M., Stevens,M.K., Ware,K., Paranjpe,A.,
Alkhimovitch,A., Ifergan,I., Taranov,A., Peter,J.D.,
Gonzalez,R.M.S., Robinson,J.E., McClain,L., Roskin,K.M., Greig,N.H.
and Luo,Y.
TITLE Adult microglial TGFbeta1 is required for microglia homeostasis via
an autocrine mechanism to maintain cognitive function in mice
JOURNAL Nat Commun 15 (1), 5306 (2024)
PUBMED 38906887
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 5224)
AUTHORS Zhang,M., Guo,T., Pei,F., Feng,J., Jing,J., Xu,J., Yamada,T.,
Ho,T.V., Du,J., Sehgal,P. and Chai,Y.
TITLE ARID1B maintains mesenchymal stem cell quiescence via inhibition of
BCL11B-mediated non-canonical Activin signaling
JOURNAL Nat Commun 15 (1), 4614 (2024)
PUBMED 38816354
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 5224)
AUTHORS Cai,Y., Zhou,Y., Yang,Q., Xu,J., Da,Q., Ma,Q., Zhao,D., Lu,T.,
Kim,H.W., Fulton,D., Jiang,X., Weintraub,N.L., Dong,K., Xu,S.,
Hong,M., Liu,Z. and Huo,Y.
TITLE Blockade of endothelial adenosine receptor 2A suppresses
atherosclerosis in vivo through inhibiting CREB-ALK5-mediated
endothelial to mesenchymal transition
JOURNAL Pharmacol Res 203, 107156 (2024)
PUBMED 38522762
REMARK GeneRIF: Blockade of endothelial adenosine receptor 2 A suppresses
atherosclerosis in vivo through inhibiting CREB-ALK5-mediated
endothelial to mesenchymal transition.
REFERENCE 4 (bases 1 to 5224)
AUTHORS Mohamed,F.E.Z.A., Dewidar,B., Lin,T., Ebert,M.P., Dooley,S.,
Meindl-Beinker,N.M. and Hammad,S.
TITLE TGFbetaR1 inhibition drives hepatocellular carcinoma proliferation
through induction of toll-like-receptor signalling
JOURNAL Int J Exp Pathol 105 (2), 64-74 (2024)
PUBMED 38328944
REMARK GeneRIF: TGFbetaR1 inhibition drives hepatocellular carcinoma
proliferation through induction of toll-like-receptor signalling.
REFERENCE 5 (bases 1 to 5224)
AUTHORS Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
Martins,G.G., Novoa,A. and Mallo,M.
TITLE Tgfbr1 controls developmental plasticity between the hindlimb and
external genitalia by remodeling their regulatory landscape
JOURNAL Nat Commun 15 (1), 2509 (2024)
PUBMED 38509075
REMARK GeneRIF: Tgfbr1 controls developmental plasticity between the
hindlimb and external genitalia by remodeling their regulatory
landscape.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 5224)
AUTHORS Iseki,S., Osumi-Yamashita,N., Miyazono,K., Franzen,P., Ichijo,H.,
Ohtani,H., Hayashi,Y. and Eto,K.
TITLE Localization of transforming growth factor-beta type I and type II
receptors in mouse development
JOURNAL Exp Cell Res 219 (2), 339-347 (1995)
PUBMED 7641785
REFERENCE 7 (bases 1 to 5224)
AUTHORS Roelen,B.A., Lin,H.Y., Knezevic,V., Freund,E. and Mummery,C.L.
TITLE Expression of TGF-beta s and their receptors during implantation
and organogenesis of the mouse embryo
JOURNAL Dev Biol 166 (2), 716-728 (1994)
PUBMED 7813789
REFERENCE 8 (bases 1 to 5224)
AUTHORS ten Dijke,P., Yamashita,H., Ichijo,H., Franzen,P., Laiho,M.,
Miyazono,K. and Heldin,C.H.
TITLE Characterization of type I receptors for transforming growth
factor-beta and activin
JOURNAL Science 264 (5155), 101-104 (1994)
PUBMED 8140412
REFERENCE 9 (bases 1 to 5224)
AUTHORS Suzuki,A., Shioda,N., Maeda,T., Tada,M. and Ueno,N.
TITLE A mouse TGF-beta type I receptor that requires type II receptor for
ligand binding
JOURNAL Biochem Biophys Res Commun 198 (3), 1063-1069 (1994)
PUBMED 8117262
REFERENCE 10 (bases 1 to 5224)
AUTHORS Tomoda,T., Kudoh,T., Noma,T., Nakazawa,A., Muramatsu,M. and Arai,K.
TITLE Molecular cloning of a mouse counterpart for human TGF-beta type I
receptor
JOURNAL Biochem Biophys Res Commun 198 (3), 1054-1062 (1994)
PUBMED 8117261
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL772232.18 and AL772150.11.
Summary: This gene encodes a member of the transforming growth
factor beta (TGF-beta) receptor family of proteins. These proteins
comprise one component of the TGF-beta signaling pathway, which
transduces extracellular signals into gene expression changes to
regulate a wide range of cellular responses, including
proliferation, migration, differentiation and apoptosis. Homozygous
knockout mice for this gene exhibit impaired angiogenesis and
embryonic lethality. Alternative splicing results in multiple
transcript variants. [provided by RefSeq, Aug 2015].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR10223971.4669.1,
SRR13422592.317802.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849388, SAMN01164134
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-139 AL772232.18 138526-138664
140-370 AL772150.11 26456-26686
371-538 AL772150.11 32904-33071
539-695 AL772150.11 33471-33627
696-820 AL772150.11 35630-35754
821-951 AL772150.11 37023-37153
952-5224 AL772150.11 40753-45025
FEATURES Location/Qualifiers
source 1..5224
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="4"
/map="4 26.02 cM"
gene 1..5224
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="transforming growth factor, beta receptor I"
/db_xref="GeneID:21812"
/db_xref="MGI:MGI:98728"
exon 1..139
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/inference="alignment:Splign:2.1.0"
CDS 55..1077
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/EC_number="2.7.11.30"
/note="isoform 7 precursor is encoded by transcript
variant 7; TGF-beta receptor type-1; TGF-beta receptor
type I; transforming growth factor-beta receptor type I"
/codon_start=1
/product="TGF-beta receptor type-1 isoform 7 precursor"
/protein_id="NP_001411818.1"
/db_xref="GeneID:21812"
/db_xref="MGI:MGI:98728"
/translation="
MEAAAAAPRRPQLLIVLVAAATLLPGAKGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
sig_peptide 55..141
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
misc_feature <139..174
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="Transforming growth factor beta type I GS-motif;
Region: TGF_beta_GS; pfam08515"
/db_xref="CDD:462503"
misc_feature 190..1053
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="Catalytic domain of the Serine/Threonine Kinases,
Transforming Growth Factor beta Type I Receptor and
Activin Type IB/IC Receptors; Region:
STKc_TGFbR1_ACVR1b_ACVR1c; cd14143"
/db_xref="CDD:271045"
misc_feature order(196..210,220..222,253..255,259..261,343..345,
403..414,424..426,430..432,562..564,568..570,574..579,
583..585,616..618,625..627,685..696)
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="active site"
/db_xref="CDD:271045"
misc_feature order(196..216,220..222,253..255,259..261,403..408,
412..414,424..426,574..579,583..585,616..618)
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:271045"
misc_feature order(208..210,424..426,430..432,562..564,568..570,
574..576,625..627,685..696)
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:271045"
misc_feature order(289..294,301..306,313..318,358..360,364..366)
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="FKBP12 binding site [polypeptide binding]; other
site"
/db_xref="CDD:271045"
misc_feature 613..696
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:271045"
exon 140..370
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/inference="alignment:Splign:2.1.0"
exon 371..538
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/inference="alignment:Splign:2.1.0"
exon 539..695
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/inference="alignment:Splign:2.1.0"
exon 696..820
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/inference="alignment:Splign:2.1.0"
exon 821..951
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/inference="alignment:Splign:2.1.0"
exon 952..5224
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/inference="alignment:Splign:2.1.0"
regulatory 5203..5208
/regulatory_class="polyA_signal_sequence"
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="hexamer: AATAAA"
polyA_site 5224
/gene="Tgfbr1"
/gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
TGFR-1"
/note="major polyA site"
ORIGIN
gaggagaagctgcggccggggccgggccgggccacaaacagtggcggcgggaccatggaggcggcggccgctgctccacgtcgtccgcagctcctcatcgtgttggtggcggcggcgacgctgctcccgggggcgaagggtttaccactgcttgttcaaagaacaattgccaggaccattgtgttacaagaaagcattggcaaaggtcggtttggagaagtttggcgaggcaaatggcggggagaagaagttgctgtgaagatattctcttctagagaagagcgttcatggttccgagaggcagagatttatcagactgtaatgttacgccatgaaaatatcctgggatttatagcagcagacaacaaagacaatgggacatggacgcagctgtggttggtgtcagattatcatgagcatggatcccttttcgattacttgaatagatacactgttactgtggaaggaatgatcaagcttgctctgtccacagcaagtggtcttgcccatcttcacatggagattgttggtacccaaggaaaaccagctattgcccatagagatttgaaatcaaagaatatcttggtgaagaaaaatggaacctgttgtattgcagacttgggacttgctgtgagacatgattctgccacagatacaattgatattgctccaaaccacagagtaggcactaaaaggtacatggcccctgaagttctagatgattccataaatatgaaacattttgaatccttcaaacgcgctgacatctatgcaatgggcttagtgttctgggaaattgctcgacgctgttctattggtggaatccatgaagactatcagttgccttattatgatcttgtaccttctgatccatcggttgaagaaatgagaaaagtagtttgcgaacagaagttaaggccaaatattccaaacagatggcagagctgtgaggccttgagagtgatggctaaaattatgagagaatgctggtatgccaatggagcagcaaggctgacagctttgcgaattaaaaaaacattgtcacaactcagccaacaggaaggcatcaaaatgtaactgaaacaccgtgggaactctgctctcttcatatctgctcctgggtgtttaggaggctggttgttctacctcactgagagaacagagggctctgcttcctcttgcagcagtggaatatggtcaactgaaagcttcccagggtttctctgggcccagaggcagccgtggggtcctttctgtgcactatggatacttcttccagacagttacagaatgttgtgtagtctacttttgtttttattaacaaagcttgtttttaaagacaactgccagcccttagggagctgctgtgctgttgaccttctgtaagggtgaaggagctggggtgtggcactaaatgaagcacttctgattttcactcctagtagtacattctcagaggactctgaaccactagtgtttccttggttcactttgaatgtactgttctataatttttcaagatcttaaactaacactttaaactctatagtctaaaaaatatgacctcgtggaggcgtgggggcacagttgctccgttgtatttgtgcacagctccttcacactctgaacacaacacaccttcacagtagggttgtgctacaccagtaagtgctacttttgcatctgtctaagtggaaacgaacagaactacttaaaggcggtgttaagtcctgtatcattttcattcaaaaagtttatttttctgagtaacctaaaccttttctgggtttgtttttgttttttgagggtttttgtgatagatgtcattcagtcttcatgcctttctcctacccagatgtgcttgaaccactgaggcaaggctgtagcattgataagcagtgactgccatgcgggaacaccccacaggagcactggagctctgcagttgagacgtttagcctgagtttattttaagaagtgaagtggcactccaaacatgtacagtgctttatggatgtaatcattatggtatacagactccttttgaaaggggaggcttgtctattgccgaaggaaaagttgtatgctgttctgtaagccatttctttttctttatttgatcaaagcagtgttttgttttgttttgatttttcttttttggaaaggaattgcatttaaaattcaaatgtggttaatgttaaataataggcctttttctaggaaggcagatatagttaatatgaatgtacaagtgtaggtgactttcacatgttatgtagctgtaagtatttgtggattctatcttgggaagggtagagttagtggagttttgaggtctcactaccctttgaggaaggcagcttttaattcagtctttttatctcatatgtgcagatcttgcaactgcttgatttacatggtagcaatgaattcagtgccacgttgatactaggagaagcagcaactaatagctattctgagtagaggctctcttcatatattcttggtcatattaaatgtcaaagtcagtccgttgggtcttctcactgctgctggagttaggtggttgagcctgggttttacttcagtgctgtcaaatctttgcagggcttgtgtggctttcaaagtcctttttatcactgtgatcatattctgggcggggaaatgttatcatcattgcttgagacgagatgttgaacatagtgataccaatccccagataaaaaggtcaaaataacctttagtgtttagccaagaagagattgtgactattgatctgaagcagctgggctctgttaatgtcttatttcaaacctagcatacatttgaagactatttggtcttaaaccaaagtaactgtaggacgaatgacatactacctagacattagtgtccgtttcatacgtcagaaacaccatgggaaaaagtacctagagattagtatctttaatacaaatctgagttttttctgtaattatcatgatttcatcaatgtaagtaagggtttgttgttacagttgtatcacctgcttaaataagctcttgtgctataatcaggtacttttggggcctttgttttcagttttttccatttctaacccttcgagatctgctttatagaaatccagggaccaatgtattttatcactaaaactgtttttatataattttaagaccataccaaaagttatctgagttaaagttgtaatacgtttcttactttcttgcaaggaaatgggtttttactgaagacacttctcatgatatctgaagttgaagaatcattatgtttttcttacctaagtggataaaatgtgctttgatgaatcagggaattttttaaagttcgaatttagttctaaattgagtttacatgtttacagctaattttttgtgtagggatagtttgattctctaggtggccaatactgaatataaaaataacttaaaaattgagataggtcatggttaatgtggctataactatatatacatctaattagagaaatatttctatgtaattttgtagtgcagtctgttgtttctattgccaatcaaagacttccccccagccccaaagtgtagtatggctaagacatatcttctgacaaattacatattatcttgtcaataccctggttaagctagcatgaaggaagtatgacttactgaggcttacacaacttgagtcccttatatcttcagctctgtttttcccactctgcctttctgctgccccctggctcagagacttagtgttcctgaccccacctccagcctttggacctaagagctgcttttgagacctaaaatgaagtgattgatggaagctgtgtgacatttttccacttccttgagtcactgggtgttatgagggagtgatctgcaaattggggtagggggtgcccctactggtagccctgctttgatgtcagctctgggcaaagattagggtgacagctaagtggcagtggaagttggcctcagaagtagtggccagctgtgtctctagtaggacagtaaaggcatgaagctcagcctgtaatcctgctactacagtagtactccagaagtgccttgaggccctgtgtggggctgtggccatcaagaattccagattttggttctcgctgcagacttaagtggccatgtagccatttttgtaatccatacatgtttgactcttccctctgcaaattgtcagatacgtaaaaccaatgacaaactactacttaacatgcacaccaaaatctgcccagaagacattgtgatttcattccatgcactgaaggaatgattgtaaatcatttctttgttccttggtcatgggagtgttctggttctacattgtggagattccagctgttgttctgttatagcccagcagaacaagtcgacgtgttgaaattctgaagaatagtttgggagtgcagtacagcttcatgtgttggatgttgaaactttcatgggccctctttagaaaagcagaggactgtcagcacattatttttaatcctgttatgcactcgtacttattgtcagtaacaataagtacgagtattgaaaatattgtcagtaacattcagtctctttcttaaagtgaatttgcttatttttcaatgagatttgtgagtttaatattatgaactgtgttttgataatccctttttcacattgtgccaatggaatggaatatttgatatttctttatatgtcaaggagatgcttcaatatgtcatttgctttaaacttaaattacctctcaagagaccaaggtacatttacctcattgtgtatataatgtttaatatttgtcagcatccaccaggtttgcaattttatttctataaagtgtgagtgttacgttgctaagttactcagatggtactgtattgtttatatctgtaccccaaatgacatcatctagactttgttttctgtgtcttattgtatttgtgcagtcctttaaccctgttggtgtgattgctgccctttcagatatgtgcaggtgtctatagaaattctcatttaaggtgaatggttttgagaaacctgtgaagagagaagcataaactgcatttccccatcagttttttaaatgtacattgtatgtgtagtaatattccagatgaattgtaaataaaagctagggagatgcttaaatttcatcctaacactacagtagaaaatggaagcaatgcaaataaacaactttttcccacca
//
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@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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