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2024-04-29 22:07:23, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_001424888            5571 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Mus musculus transforming growth factor, beta receptor I (Tgfbr1),
            transcript variant 6, mRNA.
ACCESSION   NM_001424888
VERSION     NM_001424888.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5571)
  AUTHORS   Xu X, Guo Y, Luo X, Shen Z, Sun Z, Shen B, Zhou C, Wang J, Lu J,
            Zhang Q, Ye Y, Luo Y, Qu Y, Cai X, Dong H and Lu L.
  TITLE     Hydronidone ameliorates liver fibrosis by inhibiting activation of
            hepatic stellate cells via Smad7-mediated degradation of TGFbetaRI
  JOURNAL   Liver Int 43 (11), 2523-2537 (2023)
   PUBMED   37641479
  REMARK    GeneRIF: Hydronidone ameliorates liver fibrosis by inhibiting
            activation of hepatic stellate cells via Smad7-mediated degradation
            of TGFbetaRI.
REFERENCE   2  (bases 1 to 5571)
  AUTHORS   Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y and
            Zhou B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   3  (bases 1 to 5571)
  AUTHORS   Wei H, Du S, Parksong J, Pasolli HA, Matte-Martone C, Regot S,
            Gonzalez LE, Xin T and Greco V.
  TITLE     Organ function is preserved despite reorganization of niche
            architecture in the hair follicle
  JOURNAL   Cell Stem Cell 30 (7), 962-972 (2023)
   PUBMED   37419106
REFERENCE   4  (bases 1 to 5571)
  AUTHORS   Zhou J, Tian G, Quan Y, Kong Q, Huang F, Li J, Wu W, Tang Y, Zhou Z
            and Liu X.
  TITLE     The long noncoding RNA THBS1-AS1 promotes cardiac fibroblast
            activation in cardiac fibrosis by regulating TGFBR1
  JOURNAL   JCI Insight 8 (6), e160745 (2023)
   PUBMED   36787190
  REMARK    GeneRIF: The long noncoding RNA THBS1-AS1 promotes cardiac
            fibroblast activation in cardiac fibrosis by regulating TGFBR1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5571)
  AUTHORS   McCoy AM, Lakhdari O, Shome S, Caoili K, Hernandez GE, Aghaeepour
            N, Butcher LD, Fisch K and Prince LS.
  TITLE     Sp3 is essential for normal lung morphogenesis and cell cycle
            progression during mouse embryonic development
  JOURNAL   Development 150 (5) (2023)
   PUBMED   36762637
REFERENCE   6  (bases 1 to 5571)
  AUTHORS   Iseki S, Osumi-Yamashita N, Miyazono K, Franzen P, Ichijo H, Ohtani
            H, Hayashi Y and Eto K.
  TITLE     Localization of transforming growth factor-beta type I and type II
            receptors in mouse development
  JOURNAL   Exp Cell Res 219 (2), 339-347 (1995)
   PUBMED   7641785
REFERENCE   7  (bases 1 to 5571)
  AUTHORS   Roelen BA, Lin HY, Knezevic V, Freund E and Mummery CL.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   8  (bases 1 to 5571)
  AUTHORS   ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K
            and Heldin CH.
  TITLE     Characterization of type I receptors for transforming growth
            factor-beta and activin
  JOURNAL   Science 264 (5155), 101-104 (1994)
   PUBMED   8140412
REFERENCE   9  (bases 1 to 5571)
  AUTHORS   Suzuki A, Shioda N, Maeda T, Tada M and Ueno N.
  TITLE     A mouse TGF-beta type I receptor that requires type II receptor for
            ligand binding
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1063-1069 (1994)
   PUBMED   8117262
REFERENCE   10 (bases 1 to 5571)
  AUTHORS   Tomoda T, Kudoh T, Noma T, Nakazawa A, Muramatsu M and Arai K.
  TITLE     Molecular cloning of a mouse counterpart for human TGF-beta type I
            receptor
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1054-1062 (1994)
   PUBMED   8117261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772150.11.
            
            Summary: This gene encodes a member of the transforming growth
            factor beta (TGF-beta) receptor family of proteins. These proteins
            comprise one component of the TGF-beta signaling pathway, which
            transduces extracellular signals into gene expression changes to
            regulate a wide range of cellular responses, including
            proliferation, migration, differentiation and apoptosis. Homozygous
            knockout mice for this gene exhibit impaired angiogenesis and
            embryonic lethality. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.148844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AL772150.11        16336-16590
            256-486             AL772150.11        23360-23590
            487-717             AL772150.11        26456-26686
            718-885             AL772150.11        32904-33071
            886-1042            AL772150.11        33471-33627
            1043-1167           AL772150.11        35630-35754
            1168-1298           AL772150.11        37023-37153
            1299-5571           AL772150.11        40753-45025
FEATURES             Location/Qualifiers
     source          1..5571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.02 cM"
     gene            1..5571
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /note="transforming growth factor, beta receptor I"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
     exon            1..255
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    48..50
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /note="upstream in-frame stop codon"
     CDS             174..1424
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /EC_number="2.7.11.30"
                     /note="isoform 6 is encoded by transcript variant 6;
                     TGF-beta receptor type-1; TGF-beta receptor type I;
                     transforming growth factor-beta receptor type I"
                     /codon_start=1
                     /product="TGF-beta receptor type-1 isoform 6"
                     /protein_id="NP_001411817.1"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
                     /translation="
MDLKSLIMVMMEDYKDITPLKKLQENKEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
     exon            256..486
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..717
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..885
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1042
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1167
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1298
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..5571
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
attacaggaaggacaggctccaatgagagggaagggagcacttgagataatcagatggcggaggcaatcataagaacagaaacaacagaaaccaaggttacttggcatcatcagaacccaattctcccaccacagcaagtcctggatacaccatcacaccagaaaagcaagatatggatctaaagtcacttatcatggtgatgatggaagactataaggatataactcccttaaagaaattacaggagaataaagaaaagcagtcagctggccttggtcctgtggagctggcagctgtcattgctggtccagtctgcttcgtctgcattgcacttatgctgatggtctatatctgccataaccgcactgtcattcaccaccgtgtgccaaatgaagaggatccatcactagatcgccctttcatttcagagggcaccaccttaaaagatttaatttatgatatgacaacatcagggtctggatcaggtttaccactgcttgttcaaagaacaattgccaggaccattgtgttacaagaaagcattggcaaaggtcggtttggagaagtttggcgaggcaaatggcggggagaagaagttgctgtgaagatattctcttctagagaagagcgttcatggttccgagaggcagagatttatcagactgtaatgttacgccatgaaaatatcctgggatttatagcagcagacaacaaagacaatgggacatggacgcagctgtggttggtgtcagattatcatgagcatggatcccttttcgattacttgaatagatacactgttactgtggaaggaatgatcaagcttgctctgtccacagcaagtggtcttgcccatcttcacatggagattgttggtacccaaggaaaaccagctattgcccatagagatttgaaatcaaagaatatcttggtgaagaaaaatggaacctgttgtattgcagacttgggacttgctgtgagacatgattctgccacagatacaattgatattgctccaaaccacagagtaggcactaaaaggtacatggcccctgaagttctagatgattccataaatatgaaacattttgaatccttcaaacgcgctgacatctatgcaatgggcttagtgttctgggaaattgctcgacgctgttctattggtggaatccatgaagactatcagttgccttattatgatcttgtaccttctgatccatcggttgaagaaatgagaaaagtagtttgcgaacagaagttaaggccaaatattccaaacagatggcagagctgtgaggccttgagagtgatggctaaaattatgagagaatgctggtatgccaatggagcagcaaggctgacagctttgcgaattaaaaaaacattgtcacaactcagccaacaggaaggcatcaaaatgtaactgaaacaccgtgggaactctgctctcttcatatctgctcctgggtgtttaggaggctggttgttctacctcactgagagaacagagggctctgcttcctcttgcagcagtggaatatggtcaactgaaagcttcccagggtttctctgggcccagaggcagccgtggggtcctttctgtgcactatggatacttcttccagacagttacagaatgttgtgtagtctacttttgtttttattaacaaagcttgtttttaaagacaactgccagcccttagggagctgctgtgctgttgaccttctgtaagggtgaaggagctggggtgtggcactaaatgaagcacttctgattttcactcctagtagtacattctcagaggactctgaaccactagtgtttccttggttcactttgaatgtactgttctataatttttcaagatcttaaactaacactttaaactctatagtctaaaaaatatgacctcgtggaggcgtgggggcacagttgctccgttgtatttgtgcacagctccttcacactctgaacacaacacaccttcacagtagggttgtgctacaccagtaagtgctacttttgcatctgtctaagtggaaacgaacagaactacttaaaggcggtgttaagtcctgtatcattttcattcaaaaagtttatttttctgagtaacctaaaccttttctgggtttgtttttgttttttgagggtttttgtgatagatgtcattcagtcttcatgcctttctcctacccagatgtgcttgaaccactgaggcaaggctgtagcattgataagcagtgactgccatgcgggaacaccccacaggagcactggagctctgcagttgagacgtttagcctgagtttattttaagaagtgaagtggcactccaaacatgtacagtgctttatggatgtaatcattatggtatacagactccttttgaaaggggaggcttgtctattgccgaaggaaaagttgtatgctgttctgtaagccatttctttttctttatttgatcaaagcagtgttttgttttgttttgatttttcttttttggaaaggaattgcatttaaaattcaaatgtggttaatgttaaataataggcctttttctaggaaggcagatatagttaatatgaatgtacaagtgtaggtgactttcacatgttatgtagctgtaagtatttgtggattctatcttgggaagggtagagttagtggagttttgaggtctcactaccctttgaggaaggcagcttttaattcagtctttttatctcatatgtgcagatcttgcaactgcttgatttacatggtagcaatgaattcagtgccacgttgatactaggagaagcagcaactaatagctattctgagtagaggctctcttcatatattcttggtcatattaaatgtcaaagtcagtccgttgggtcttctcactgctgctggagttaggtggttgagcctgggttttacttcagtgctgtcaaatctttgcagggcttgtgtggctttcaaagtcctttttatcactgtgatcatattctgggcggggaaatgttatcatcattgcttgagacgagatgttgaacatagtgataccaatccccagataaaaaggtcaaaataacctttagtgtttagccaagaagagattgtgactattgatctgaagcagctgggctctgttaatgtcttatttcaaacctagcatacatttgaagactatttggtcttaaaccaaagtaactgtaggacgaatgacatactacctagacattagtgtccgtttcatacgtcagaaacaccatgggaaaaagtacctagagattagtatctttaatacaaatctgagttttttctgtaattatcatgatttcatcaatgtaagtaagggtttgttgttacagttgtatcacctgcttaaataagctcttgtgctataatcaggtacttttggggcctttgttttcagttttttccatttctaacccttcgagatctgctttatagaaatccagggaccaatgtattttatcactaaaactgtttttatataattttaagaccataccaaaagttatctgagttaaagttgtaatacgtttcttactttcttgcaaggaaatgggtttttactgaagacacttctcatgatatctgaagttgaagaatcattatgtttttcttacctaagtggataaaatgtgctttgatgaatcagggaattttttaaagttcgaatttagttctaaattgagtttacatgtttacagctaattttttgtgtagggatagtttgattctctaggtggccaatactgaatataaaaataacttaaaaattgagataggtcatggttaatgtggctataactatatatacatctaattagagaaatatttctatgtaattttgtagtgcagtctgttgtttctattgccaatcaaagacttccccccagccccaaagtgtagtatggctaagacatatcttctgacaaattacatattatcttgtcaataccctggttaagctagcatgaaggaagtatgacttactgaggcttacacaacttgagtcccttatatcttcagctctgtttttcccactctgcctttctgctgccccctggctcagagacttagtgttcctgaccccacctccagcctttggacctaagagctgcttttgagacctaaaatgaagtgattgatggaagctgtgtgacatttttccacttccttgagtcactgggtgttatgagggagtgatctgcaaattggggtagggggtgcccctactggtagccctgctttgatgtcagctctgggcaaagattagggtgacagctaagtggcagtggaagttggcctcagaagtagtggccagctgtgtctctagtaggacagtaaaggcatgaagctcagcctgtaatcctgctactacagtagtactccagaagtgccttgaggccctgtgtggggctgtggccatcaagaattccagattttggttctcgctgcagacttaagtggccatgtagccatttttgtaatccatacatgtttgactcttccctctgcaaattgtcagatacgtaaaaccaatgacaaactactacttaacatgcacaccaaaatctgcccagaagacattgtgatttcattccatgcactgaaggaatgattgtaaatcatttctttgttccttggtcatgggagtgttctggttctacattgtggagattccagctgttgttctgttatagcccagcagaacaagtcgacgtgttgaaattctgaagaatagtttgggagtgcagtacagcttcatgtgttggatgttgaaactttcatgggccctctttagaaaagcagaggactgtcagcacattatttttaatcctgttatgcactcgtacttattgtcagtaacaataagtacgagtattgaaaatattgtcagtaacattcagtctctttcttaaagtgaatttgcttatttttcaatgagatttgtgagtttaatattatgaactgtgttttgataatccctttttcacattgtgccaatggaatggaatatttgatatttctttatatgtcaaggagatgcttcaatatgtcatttgctttaaacttaaattacctctcaagagaccaaggtacatttacctcattgtgtatataatgtttaatatttgtcagcatccaccaggtttgcaattttatttctataaagtgtgagtgttacgttgctaagttactcagatggtactgtattgtttatatctgtaccccaaatgacatcatctagactttgttttctgtgtcttattgtatttgtgcagtcctttaaccctgttggtgtgattgctgccctttcagatatgtgcaggtgtctatagaaattctcatttaaggtgaatggttttgagaaacctgtgaagagagaagcataaactgcatttccccatcagttttttaaatgtacattgtatgtgtagtaatattccagatgaattgtaaataaaagctagggagatgcttaaatttcatcctaacactacagtagaaaatggaagcaatgcaaataaacaactttttcccacca
//

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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]