2024-11-01 08:19:32, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001424888 5571 bp mRNA linear ROD 17-JUL-2024 DEFINITION Mus musculus transforming growth factor, beta receptor I (Tgfbr1), transcript variant 6, mRNA. ACCESSION NM_001424888 VERSION NM_001424888.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 5571) AUTHORS Bedolla,A., Wegman,E., Weed,M., Stevens,M.K., Ware,K., Paranjpe,A., Alkhimovitch,A., Ifergan,I., Taranov,A., Peter,J.D., Gonzalez,R.M.S., Robinson,J.E., McClain,L., Roskin,K.M., Greig,N.H. and Luo,Y. TITLE Adult microglial TGFbeta1 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice JOURNAL Nat Commun 15 (1), 5306 (2024) PUBMED 38906887 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5571) AUTHORS Zhang,M., Guo,T., Pei,F., Feng,J., Jing,J., Xu,J., Yamada,T., Ho,T.V., Du,J., Sehgal,P. and Chai,Y. TITLE ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling JOURNAL Nat Commun 15 (1), 4614 (2024) PUBMED 38816354 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5571) AUTHORS Cai,Y., Zhou,Y., Yang,Q., Xu,J., Da,Q., Ma,Q., Zhao,D., Lu,T., Kim,H.W., Fulton,D., Jiang,X., Weintraub,N.L., Dong,K., Xu,S., Hong,M., Liu,Z. and Huo,Y. TITLE Blockade of endothelial adenosine receptor 2A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition JOURNAL Pharmacol Res 203, 107156 (2024) PUBMED 38522762 REMARK GeneRIF: Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition. REFERENCE 4 (bases 1 to 5571) AUTHORS Mohamed,F.E.Z.A., Dewidar,B., Lin,T., Ebert,M.P., Dooley,S., Meindl-Beinker,N.M. and Hammad,S. TITLE TGFbetaR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll-like-receptor signalling JOURNAL Int J Exp Pathol 105 (2), 64-74 (2024) PUBMED 38328944 REMARK GeneRIF: TGFbetaR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll-like-receptor signalling. REFERENCE 5 (bases 1 to 5571) AUTHORS Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A., Martins,G.G., Novoa,A. and Mallo,M. TITLE Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape JOURNAL Nat Commun 15 (1), 2509 (2024) PUBMED 38509075 REMARK GeneRIF: Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape. Publication Status: Online-Only REFERENCE 6 (bases 1 to 5571) AUTHORS Iseki,S., Osumi-Yamashita,N., Miyazono,K., Franzen,P., Ichijo,H., Ohtani,H., Hayashi,Y. and Eto,K. TITLE Localization of transforming growth factor-beta type I and type II receptors in mouse development JOURNAL Exp Cell Res 219 (2), 339-347 (1995) PUBMED 7641785 REFERENCE 7 (bases 1 to 5571) AUTHORS Roelen,B.A., Lin,H.Y., Knezevic,V., Freund,E. and Mummery,C.L. TITLE Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo JOURNAL Dev Biol 166 (2), 716-728 (1994) PUBMED 7813789 REFERENCE 8 (bases 1 to 5571) AUTHORS ten Dijke,P., Yamashita,H., Ichijo,H., Franzen,P., Laiho,M., Miyazono,K. and Heldin,C.H. TITLE Characterization of type I receptors for transforming growth factor-beta and activin JOURNAL Science 264 (5155), 101-104 (1994) PUBMED 8140412 REFERENCE 9 (bases 1 to 5571) AUTHORS Suzuki,A., Shioda,N., Maeda,T., Tada,M. and Ueno,N. TITLE A mouse TGF-beta type I receptor that requires type II receptor for ligand binding JOURNAL Biochem Biophys Res Commun 198 (3), 1063-1069 (1994) PUBMED 8117262 REFERENCE 10 (bases 1 to 5571) AUTHORS Tomoda,T., Kudoh,T., Noma,T., Nakazawa,A., Muramatsu,M. and Arai,K. TITLE Molecular cloning of a mouse counterpart for human TGF-beta type I receptor JOURNAL Biochem Biophys Res Commun 198 (3), 1054-1062 (1994) PUBMED 8117261 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL772150.11. Summary: This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189685.148844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-255 AL772150.11 16336-16590 256-486 AL772150.11 23360-23590 487-717 AL772150.11 26456-26686 718-885 AL772150.11 32904-33071 886-1042 AL772150.11 33471-33627 1043-1167 AL772150.11 35630-35754 1168-1298 AL772150.11 37023-37153 1299-5571 AL772150.11 40753-45025 FEATURES Location/Qualifiers source 1..5571 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="4" /map="4 26.02 cM" gene 1..5571 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="transforming growth factor, beta receptor I" /db_xref="GeneID:21812" /db_xref="MGI:MGI:98728" exon 1..255 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" misc_feature 48..50 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="upstream in-frame stop codon" CDS 174..1424 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /EC_number="2.7.11.30" /note="isoform 6 is encoded by transcript variant 6; TGF-beta receptor type-1; TGF-beta receptor type I; transforming growth factor-beta receptor type I" /codon_start=1 /product="TGF-beta receptor type-1 isoform 6" /protein_id="NP_001411817.1" /db_xref="GeneID:21812" /db_xref="MGI:MGI:98728" /translation="
MDLKSLIMVMMEDYKDITPLKKLQENKEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
misc_feature 438..521 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="Transforming growth factor beta type I GS-motif; Region: TGF_beta_GS; pfam08515" /db_xref="CDD:462503" misc_feature 537..1400 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; Region: STKc_TGFbR1_ACVR1b_ACVR1c; cd14143" /db_xref="CDD:271045" misc_feature order(543..557,567..569,600..602,606..608,690..692, 750..761,771..773,777..779,909..911,915..917,921..926, 930..932,963..965,972..974,1032..1043) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="active site" /db_xref="CDD:271045" misc_feature order(543..563,567..569,600..602,606..608,750..755, 759..761,771..773,921..926,930..932,963..965) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:271045" misc_feature order(555..557,771..773,777..779,909..911,915..917, 921..923,972..974,1032..1043) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:271045" misc_feature order(636..641,648..653,660..665,705..707,711..713) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="FKBP12 binding site [polypeptide binding]; other site" /db_xref="CDD:271045" misc_feature 960..1043 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="activation loop (A-loop); other site" /db_xref="CDD:271045" exon 256..486 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 487..717 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 718..885 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 886..1042 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 1043..1167 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 1168..1298 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 1299..5571 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" regulatory 5550..5555 /regulatory_class="polyA_signal_sequence" /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="hexamer: AATAAA" polyA_site 5571 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="major polyA site" ORIGIN
attacaggaaggacaggctccaatgagagggaagggagcacttgagataatcagatggcggaggcaatcataagaacagaaacaacagaaaccaaggttacttggcatcatcagaacccaattctcccaccacagcaagtcctggatacaccatcacaccagaaaagcaagatatggatctaaagtcacttatcatggtgatgatggaagactataaggatataactcccttaaagaaattacaggagaataaagaaaagcagtcagctggccttggtcctgtggagctggcagctgtcattgctggtccagtctgcttcgtctgcattgcacttatgctgatggtctatatctgccataaccgcactgtcattcaccaccgtgtgccaaatgaagaggatccatcactagatcgccctttcatttcagagggcaccaccttaaaagatttaatttatgatatgacaacatcagggtctggatcaggtttaccactgcttgttcaaagaacaattgccaggaccattgtgttacaagaaagcattggcaaaggtcggtttggagaagtttggcgaggcaaatggcggggagaagaagttgctgtgaagatattctcttctagagaagagcgttcatggttccgagaggcagagatttatcagactgtaatgttacgccatgaaaatatcctgggatttatagcagcagacaacaaagacaatgggacatggacgcagctgtggttggtgtcagattatcatgagcatggatcccttttcgattacttgaatagatacactgttactgtggaaggaatgatcaagcttgctctgtccacagcaagtggtcttgcccatcttcacatggagattgttggtacccaaggaaaaccagctattgcccatagagatttgaaatcaaagaatatcttggtgaagaaaaatggaacctgttgtattgcagacttgggacttgctgtgagacatgattctgccacagatacaattgatattgctccaaaccacagagtaggcactaaaaggtacatggcccctgaagttctagatgattccataaatatgaaacattttgaatccttcaaacgcgctgacatctatgcaatgggcttagtgttctgggaaattgctcgacgctgttctattggtggaatccatgaagactatcagttgccttattatgatcttgtaccttctgatccatcggttgaagaaatgagaaaagtagtttgcgaacagaagttaaggccaaatattccaaacagatggcagagctgtgaggccttgagagtgatggctaaaattatgagagaatgctggtatgccaatggagcagcaaggctgacagctttgcgaattaaaaaaacattgtcacaactcagccaacaggaaggcatcaaaatgtaactgaaacaccgtgggaactctgctctcttcatatctgctcctgggtgtttaggaggctggttgttctacctcactgagagaacagagggctctgcttcctcttgcagcagtggaatatggtcaactgaaagcttcccagggtttctctgggcccagaggcagccgtggggtcctttctgtgcactatggatacttcttccagacagttacagaatgttgtgtagtctacttttgtttttattaacaaagcttgtttttaaagacaactgccagcccttagggagctgctgtgctgttgaccttctgtaagggtgaaggagctggggtgtggcactaaatgaagcacttctgattttcactcctagtagtacattctcagaggactctgaaccactagtgtttccttggttcactttgaatgtactgttctataatttttcaagatcttaaactaacactttaaactctatagtctaaaaaatatgacctcgtggaggcgtgggggcacagttgctccgttgtatttgtgcacagctccttcacactctgaacacaacacaccttcacagtagggttgtgctacaccagtaagtgctacttttgcatctgtctaagtggaaacgaacagaactacttaaaggcggtgttaagtcctgtatcattttcattcaaaaagtttatttttctgagtaacctaaaccttttctgggtttgtttttgttttttgagggtttttgtgatagatgtcattcagtcttcatgcctttctcctacccagatgtgcttgaaccactgaggcaaggctgtagcattgataagcagtgactgccatgcgggaacaccccacaggagcactggagctctgcagttgagacgtttagcctgagtttattttaagaagtgaagtggcactccaaacatgtacagtgctttatggatgtaatcattatggtatacagactccttttgaaaggggaggcttgtctattgccgaaggaaaagttgtatgctgttctgtaagccatttctttttctttatttgatcaaagcagtgttttgttttgttttgatttttcttttttggaaaggaattgcatttaaaattcaaatgtggttaatgttaaataataggcctttttctaggaaggcagatatagttaatatgaatgtacaagtgtaggtgactttcacatgttatgtagctgtaagtatttgtggattctatcttgggaagggtagagttagtggagttttgaggtctcactaccctttgaggaaggcagcttttaattcagtctttttatctcatatgtgcagatcttgcaactgcttgatttacatggtagcaatgaattcagtgccacgttgatactaggagaagcagcaactaatagctattctgagtagaggctctcttcatatattcttggtcatattaaatgtcaaagtcagtccgttgggtcttctcactgctgctggagttaggtggttgagcctgggttttacttcagtgctgtcaaatctttgcagggcttgtgtggctttcaaagtcctttttatcactgtgatcatattctgggcggggaaatgttatcatcattgcttgagacgagatgttgaacatagtgataccaatccccagataaaaaggtcaaaataacctttagtgtttagccaagaagagattgtgactattgatctgaagcagctgggctctgttaatgtcttatttcaaacctagcatacatttgaagactatttggtcttaaaccaaagtaactgtaggacgaatgacatactacctagacattagtgtccgtttcatacgtcagaaacaccatgggaaaaagtacctagagattagtatctttaatacaaatctgagttttttctgtaattatcatgatttcatcaatgtaagtaagggtttgttgttacagttgtatcacctgcttaaataagctcttgtgctataatcaggtacttttggggcctttgttttcagttttttccatttctaacccttcgagatctgctttatagaaatccagggaccaatgtattttatcactaaaactgtttttatataattttaagaccataccaaaagttatctgagttaaagttgtaatacgtttcttactttcttgcaaggaaatgggtttttactgaagacacttctcatgatatctgaagttgaagaatcattatgtttttcttacctaagtggataaaatgtgctttgatgaatcagggaattttttaaagttcgaatttagttctaaattgagtttacatgtttacagctaattttttgtgtagggatagtttgattctctaggtggccaatactgaatataaaaataacttaaaaattgagataggtcatggttaatgtggctataactatatatacatctaattagagaaatatttctatgtaattttgtagtgcagtctgttgtttctattgccaatcaaagacttccccccagccccaaagtgtagtatggctaagacatatcttctgacaaattacatattatcttgtcaataccctggttaagctagcatgaaggaagtatgacttactgaggcttacacaacttgagtcccttatatcttcagctctgtttttcccactctgcctttctgctgccccctggctcagagacttagtgttcctgaccccacctccagcctttggacctaagagctgcttttgagacctaaaatgaagtgattgatggaagctgtgtgacatttttccacttccttgagtcactgggtgttatgagggagtgatctgcaaattggggtagggggtgcccctactggtagccctgctttgatgtcagctctgggcaaagattagggtgacagctaagtggcagtggaagttggcctcagaagtagtggccagctgtgtctctagtaggacagtaaaggcatgaagctcagcctgtaatcctgctactacagtagtactccagaagtgccttgaggccctgtgtggggctgtggccatcaagaattccagattttggttctcgctgcagacttaagtggccatgtagccatttttgtaatccatacatgtttgactcttccctctgcaaattgtcagatacgtaaaaccaatgacaaactactacttaacatgcacaccaaaatctgcccagaagacattgtgatttcattccatgcactgaaggaatgattgtaaatcatttctttgttccttggtcatgggagtgttctggttctacattgtggagattccagctgttgttctgttatagcccagcagaacaagtcgacgtgttgaaattctgaagaatagtttgggagtgcagtacagcttcatgtgttggatgttgaaactttcatgggccctctttagaaaagcagaggactgtcagcacattatttttaatcctgttatgcactcgtacttattgtcagtaacaataagtacgagtattgaaaatattgtcagtaacattcagtctctttcttaaagtgaatttgcttatttttcaatgagatttgtgagtttaatattatgaactgtgttttgataatccctttttcacattgtgccaatggaatggaatatttgatatttctttatatgtcaaggagatgcttcaatatgtcatttgctttaaacttaaattacctctcaagagaccaaggtacatttacctcattgtgtatataatgtttaatatttgtcagcatccaccaggtttgcaattttatttctataaagtgtgagtgttacgttgctaagttactcagatggtactgtattgtttatatctgtaccccaaatgacatcatctagactttgttttctgtgtcttattgtatttgtgcagtcctttaaccctgttggtgtgattgctgccctttcagatatgtgcaggtgtctatagaaattctcatttaaggtgaatggttttgagaaacctgtgaagagagaagcataaactgcatttccccatcagttttttaaatgtacattgtatgtgtagtaatattccagatgaattgtaaataaaagctagggagatgcttaaatttcatcctaacactacagtagaaaatggaagcaatgcaaataaacaactttttcccacca
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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