LOCUS       NM_001410199            1610 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 38
            (Cyp2c38), transcript variant 2, mRNA.
ACCESSION   NM_001410199 XM_017318054
VERSION     NM_001410199.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Meng XY, Zheng QC and Zhang HX.
  TITLE     A comparative analysis of binding sites between mouse CYP2C38 and
            CYP2C39 based on homology modeling, molecular dynamics simulation
            and docking studies
  JOURNAL   Biochim Biophys Acta 1794 (7), 1066-1072 (2009)
   PUBMED   19358898
  REMARK    GeneRIF: By comparison of active site architectures between CYP2C38
            and CYP2C39, the possible reasons affecting their substrate binding
            were proposed
REFERENCE   2  (bases 1 to 1610)
  AUTHORS   Kasai F, Yoshihara M, Matsukuma S, O'Brien P and Ferguson-Smith MA.
  TITLE     Emergence of complex rearrangements at translocation breakpoints in
            a transgenic mouse; implications for mechanisms involved in the
            formation of chromosome rearrangements
  JOURNAL   Cytogenet Genome Res 119 (1-2), 83-90 (2007)
   PUBMED   18160786
REFERENCE   3  (bases 1 to 1610)
  AUTHORS   Luo G, Zeldin DC, Blaisdell JA, Hodgson E and Goldstein JA.
  TITLE     Cloning and expression of murine CYP2Cs and their ability to
            metabolize arachidonic acid
  JOURNAL   Arch Biochem Biophys 357 (1), 45-57 (1998)
   PUBMED   9721182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139233.10.
            
            On Jul 29, 2022 this sequence version replaced XM_017318054.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.101486.1,
                                           ERR2844020.1777906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC139233.10        49463-49651
            190-352             AC139233.10        51799-51961
            353-513             AC139233.10        74164-74324
            514-690             AC139233.10        76308-76484
            691-832             AC139233.10        107736-107877
            833-1020            AC139233.10        110745-110932
            1021-1162           AC139233.10        120248-120389
            1163-1610           AC139233.10        121426-121873
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.03 cM"
     gene            1..1610
                     /gene="Cyp2c38"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     38"
                     /db_xref="GeneID:13097"
                     /db_xref="MGI:MGI:1306819"
     exon            1..189
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    4..6
                     /gene="Cyp2c38"
                     /note="upstream in-frame stop codon"
     CDS             22..1344
                     /gene="Cyp2c38"
                     /EC_number="1.14.14.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; cytochrome P450 2C38; CYPIIC38; cytochrome
                     P450, 2c38"
                     /codon_start=1
                     /product="cytochrome P450 2C38 isoform 2 precursor"
                     /protein_id="NP_001397128.1"
                     /db_xref="GeneID:13097"
                     /db_xref="MGI:MGI:1306819"
                     /translation="

MDLVTFLVLTLSSLILLSLWRQRSRRGRLPPGPTPFPIIGNFLQIDVKNFNQSLTNFSKTYGPVFTLYLGSRPIVVLHGYEAVKEALIDHGEEFSGRENIPMSEKINNGLGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMKKLNENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNFKYIRSYLLEKVKEHQESLDVTNPRDFIDYFLIKQKQANHIEQAEYSLENLVCTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVVGRHRSPCMQDRSRMPYTDAMIHEVQRFINLVPNNLPHAVTCDIKFRNYIIPKGTTVVTSLTSVLHDSKEFPNPEMFDPGHFLDANGNFKKSDYFMTFSAGKRVCAGEGLARMELFLILTTILQNFKLKSLVHPKDIDMIPFVNGLITLPPHYQLCFIPL"

     sig_peptide     22..81
                     /gene="Cyp2c38"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    202..1326
                     /gene="Cyp2c38"
                     /note="cytochrome P450 family 2, subfamily C, and similar
                     cytochrome P450s; Region: CYP2C-like; cd20665"
                     /db_xref="CDD:410758"
     misc_feature    order(310..312,751..753,760..765,772..777,784..786,
                     937..939,952..957,964..969,973..975,1150..1158,1168..1170,
                     1174..1182,1192..1194,1201..1203)
                     /gene="Cyp2c38"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:410758"
     misc_feature    order(343..345,481..486,493..495,511..513,568..570,
                     580..582,589..591,745..750,757..762,769..774,955..957,
                     967..969,1297..1302)
                     /gene="Cyp2c38"
                     /note="chemical substrate binding pocket [chemical
                     binding]; other site"
                     /db_xref="CDD:410758"
     exon            190..352
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            353..513
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            514..690
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            691..832
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1020
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1162
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1610
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtatgaataaggagggtttctatggatcttgtcacattcctggtgctcactctctcctctctcattctcctctcactatggagacagaggtctagaagagggaggctccctcctggccccactcctttcccgattattggtaatttccttcagattgatgtgaagaacttcaaccaatccttaaccaatttctcaaaaacctatggccccgttttcactctgtatttgggctcacggcccattgttgtattgcatgggtatgaagcagtgaaggaagctctgattgatcatggggaggagttttctggtagagaaaacatcccaatgtctgaaaagattaataatggccttggctcaccttgtgaccccacattcattctgagctgtgctccatgcaatgtcatctgctcaattatttttcaagatcgttttgattacaaggataaagattttcttatgctcatgaaaaaactaaatgagaatgtcaagattctgagctccccatggttgcaggtctgcaataatttccccttgctcattgactattgtccgggaagtcatcacaaagtactaaaaaacttcaaatatattagaagttacctgttggagaaagtaaaagaacaccaagaatcactggatgttacaaaccctcgtgactttatcgattatttcctgattaaacaaaaacaggcaaaccacatcgaacaagcagaatattcacttgaaaatctggtctgcactatcaataatctctttgctgcaggaacagagacaacaagcacaacactgagatatgctctcctactcctgatgaagtacccagatgtcacagctaaagtccaagaagagattgaccatgtggttggtagacaccgtagcccctgcatgcaggacaggagccgcatgccctatactgatgccatgattcatgaggtccagagattcatcaaccttgtccctaacaacctaccccatgcagtgacctgtgacattaaattcagaaactacatcatccccaagggaacaacagtagtaacgtcactgacatcagttctgcatgacagcaaggagttccccaacccagagatgtttgaccctggccactttctagacgctaatggaaactttaagaaaagtgactacttcatgactttctcagcaggaaaacgggtttgtgctggagagggcctggcccgcatggagctgtttctaatcctgaccaccattttacagaactttaaactgaaatctctggttcacccaaaagacattgatatgatcccatttgtgaatggattaatcactctgccaccccattaccagctctgcttcattcctctctaaagagatcacacattctgaaccctcctctgttgccttctgcaatcccccccccagggttttattcacctctttccttatcagggataaggcatcttccatcctggctcacagaacccccttttctgaagacctagcaaacacatgcggtttctggagttatagcacaaatgcacttgtattatctcttttatataacagttgtctgagcccttatgcttatgtttatccattcctgcgttagaataaaacttcactggcaaataata

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