LOCUS       NM_001410199            1610 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 38
            (Cyp2c38), transcript variant 2, mRNA.
ACCESSION   NM_001410199 XM_017318054
VERSION     NM_001410199.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1610)
  AUTHORS   Kawamura,T., Ichikawa,M., Hatogai,J., Koyama,Y., Tachibana,M.,
            Kuwahara,M., Negishi,K., Matsumoto,M., Miyazaki,M. and Ochiai,W.
  TITLE     Mouse Cyp2c expression and zonation structure in the liver begins
            in the early neonatal stage
  JOURNAL   Biopharm Drug Dispos 43 (4), 130-139 (2022)
   PUBMED   35748067
REFERENCE   3  (bases 1 to 1610)
  AUTHORS   Meng,X.Y., Zheng,Q.C. and Zhang,H.X.
  TITLE     A comparative analysis of binding sites between mouse CYP2C38 and
            CYP2C39 based on homology modeling, molecular dynamics simulation
            and docking studies
  JOURNAL   Biochim Biophys Acta 1794 (7), 1066-1072 (2009)
   PUBMED   19358898
  REMARK    GeneRIF: By comparison of active site architectures between CYP2C38
            and CYP2C39, the possible reasons affecting their substrate binding
            were proposed
REFERENCE   4  (bases 1 to 1610)
  AUTHORS   Kasai,F., Yoshihara,M., Matsukuma,S., O'Brien,P. and
            Ferguson-Smith,M.A.
  TITLE     Emergence of complex rearrangements at translocation breakpoints in
            a transgenic mouse; implications for mechanisms involved in the
            formation of chromosome rearrangements
  JOURNAL   Cytogenet Genome Res 119 (1-2), 83-90 (2007)
   PUBMED   18160786
REFERENCE   5  (bases 1 to 1610)
  AUTHORS   Luo,G., Zeldin,D.C., Blaisdell,J.A., Hodgson,E. and Goldstein,J.A.
  TITLE     Cloning and expression of murine CYP2Cs and their ability to
            metabolize arachidonic acid
  JOURNAL   Arch Biochem Biophys 357 (1), 45-57 (1998)
   PUBMED   9721182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139233.10.
            
            On Jul 29, 2022 this sequence version replaced XM_017318054.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.101486.1,
                                           ERR2844020.1777906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC139233.10        49463-49651
            190-352             AC139233.10        51799-51961
            353-513             AC139233.10        74164-74324
            514-690             AC139233.10        76308-76484
            691-832             AC139233.10        107736-107877
            833-1020            AC139233.10        110745-110932
            1021-1162           AC139233.10        120248-120389
            1163-1610           AC139233.10        121426-121873
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.03 cM"
     gene            1..1610
                     /gene="Cyp2c38"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     38"
                     /db_xref="GeneID:13097"
                     /db_xref="MGI:MGI:1306819"
     exon            1..189
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    4..6
                     /gene="Cyp2c38"
                     /note="upstream in-frame stop codon"
     CDS             22..1344
                     /gene="Cyp2c38"
                     /EC_number="1.14.14.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cytochrome P450 2C38; CYPIIC38; cytochrome P450, 2c38"
                     /codon_start=1
                     /product="cytochrome P450 2C38 isoform 2"
                     /protein_id="NP_001397128.1"
                     /db_xref="GeneID:13097"
                     /db_xref="MGI:MGI:1306819"
                     /translation="

MDLVTFLVLTLSSLILLSLWRQRSRRGRLPPGPTPFPIIGNFLQIDVKNFNQSLTNFSKTYGPVFTLYLGSRPIVVLHGYEAVKEALIDHGEEFSGRENIPMSEKINNGLGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMKKLNENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNFKYIRSYLLEKVKEHQESLDVTNPRDFIDYFLIKQKQANHIEQAEYSLENLVCTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVVGRHRSPCMQDRSRMPYTDAMIHEVQRFINLVPNNLPHAVTCDIKFRNYIIPKGTTVVTSLTSVLHDSKEFPNPEMFDPGHFLDANGNFKKSDYFMTFSAGKRVCAGEGLARMELFLILTTILQNFKLKSLVHPKDIDMIPFVNGLITLPPHYQLCFIPL"

     misc_feature    202..1326
                     /gene="Cyp2c38"
                     /note="cytochrome P450 family 2, subfamily C, and similar
                     cytochrome P450s; Region: CYP2C-like; cd20665"
                     /db_xref="CDD:410758"
     misc_feature    order(310..312,751..753,760..765,772..777,784..786,
                     937..939,952..957,964..969,973..975,1150..1158,1168..1170,
                     1174..1182,1192..1194,1201..1203)
                     /gene="Cyp2c38"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:410758"
     misc_feature    order(343..345,481..486,493..495,511..513,568..570,
                     580..582,589..591,745..750,757..762,769..774,955..957,
                     967..969,1297..1302)
                     /gene="Cyp2c38"
                     /note="chemical substrate binding pocket [chemical
                     binding]; other site"
                     /db_xref="CDD:410758"
     exon            190..352
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            353..513
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            514..690
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            691..832
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1020
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1162
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1610
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1586..1591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c38"
                     /note="hexamer: AATAAA"
     polyA_site      1598
                     /gene="Cyp2c38"
                     /note="major polyA site"
     polyA_site      1610
                     /gene="Cyp2c38"
ORIGIN      

gtatgaataaggagggtttctatggatcttgtcacattcctggtgctcactctctcctctctcattctcctctcactatggagacagaggtctagaagagggaggctccctcctggccccactcctttcccgattattggtaatttccttcagattgatgtgaagaacttcaaccaatccttaaccaatttctcaaaaacctatggccccgttttcactctgtatttgggctcacggcccattgttgtattgcatgggtatgaagcagtgaaggaagctctgattgatcatggggaggagttttctggtagagaaaacatcccaatgtctgaaaagattaataatggccttggctcaccttgtgaccccacattcattctgagctgtgctccatgcaatgtcatctgctcaattatttttcaagatcgttttgattacaaggataaagattttcttatgctcatgaaaaaactaaatgagaatgtcaagattctgagctccccatggttgcaggtctgcaataatttccccttgctcattgactattgtccgggaagtcatcacaaagtactaaaaaacttcaaatatattagaagttacctgttggagaaagtaaaagaacaccaagaatcactggatgttacaaaccctcgtgactttatcgattatttcctgattaaacaaaaacaggcaaaccacatcgaacaagcagaatattcacttgaaaatctggtctgcactatcaataatctctttgctgcaggaacagagacaacaagcacaacactgagatatgctctcctactcctgatgaagtacccagatgtcacagctaaagtccaagaagagattgaccatgtggttggtagacaccgtagcccctgcatgcaggacaggagccgcatgccctatactgatgccatgattcatgaggtccagagattcatcaaccttgtccctaacaacctaccccatgcagtgacctgtgacattaaattcagaaactacatcatccccaagggaacaacagtagtaacgtcactgacatcagttctgcatgacagcaaggagttccccaacccagagatgtttgaccctggccactttctagacgctaatggaaactttaagaaaagtgactacttcatgactttctcagcaggaaaacgggtttgtgctggagagggcctggcccgcatggagctgtttctaatcctgaccaccattttacagaactttaaactgaaatctctggttcacccaaaagacattgatatgatcccatttgtgaatggattaatcactctgccaccccattaccagctctgcttcattcctctctaaagagatcacacattctgaaccctcctctgttgccttctgcaatcccccccccagggttttattcacctctttccttatcagggataaggcatcttccatcctggctcacagaacccccttttctgaagacctagcaaacacatgcggtttctggagttatagcacaaatgcacttgtattatctcttttatataacagttgtctgagcccttatgcttatgtttatccattcctgcgttagaataaaacttcactggcaaataata

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