2024-11-01 08:53:53, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001410199 1610 bp mRNA linear ROD 02-MAY-2024 DEFINITION Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 38 (Cyp2c38), transcript variant 2, mRNA. ACCESSION NM_001410199 XM_017318054 VERSION NM_001410199.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 1610) AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A., Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R., Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J., Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z., Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J., Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L., Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J., Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B., Jackson,S.P. and Balmus,G. CONSRTM Sanger Mouse Genetics Project TITLE Genetic determinants of micronucleus formation in vivo JOURNAL Nature 627 (8002), 130-136 (2024) PUBMED 38355793 REFERENCE 2 (bases 1 to 1610) AUTHORS Kawamura,T., Ichikawa,M., Hatogai,J., Koyama,Y., Tachibana,M., Kuwahara,M., Negishi,K., Matsumoto,M., Miyazaki,M. and Ochiai,W. TITLE Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage JOURNAL Biopharm Drug Dispos 43 (4), 130-139 (2022) PUBMED 35748067 REFERENCE 3 (bases 1 to 1610) AUTHORS Meng,X.Y., Zheng,Q.C. and Zhang,H.X. TITLE A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies JOURNAL Biochim Biophys Acta 1794 (7), 1066-1072 (2009) PUBMED 19358898 REMARK GeneRIF: By comparison of active site architectures between CYP2C38 and CYP2C39, the possible reasons affecting their substrate binding were proposed REFERENCE 4 (bases 1 to 1610) AUTHORS Kasai,F., Yoshihara,M., Matsukuma,S., O'Brien,P. and Ferguson-Smith,M.A. TITLE Emergence of complex rearrangements at translocation breakpoints in a transgenic mouse; implications for mechanisms involved in the formation of chromosome rearrangements JOURNAL Cytogenet Genome Res 119 (1-2), 83-90 (2007) PUBMED 18160786 REFERENCE 5 (bases 1 to 1610) AUTHORS Luo,G., Zeldin,D.C., Blaisdell,J.A., Hodgson,E. and Goldstein,J.A. TITLE Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid JOURNAL Arch Biochem Biophys 357 (1), 45-57 (1998) PUBMED 9721182 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139233.10. On Jul 29, 2022 this sequence version replaced XM_017318054.2. ##Evidence-Data-START## Transcript exon combination :: SRR5189682.101486.1, ERR2844020.1777906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-189 AC139233.10 49463-49651 190-352 AC139233.10 51799-51961 353-513 AC139233.10 74164-74324 514-690 AC139233.10 76308-76484 691-832 AC139233.10 107736-107877 833-1020 AC139233.10 110745-110932 1021-1162 AC139233.10 120248-120389 1163-1610 AC139233.10 121426-121873 FEATURES Location/Qualifiers source 1..1610 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="19" /map="19 34.03 cM" gene 1..1610 /gene="Cyp2c38" /note="cytochrome P450, family 2, subfamily c, polypeptide 38" /db_xref="GeneID:13097" /db_xref="MGI:MGI:1306819" exon 1..189 /gene="Cyp2c38" /inference="alignment:Splign:2.1.0" misc_feature 4..6 /gene="Cyp2c38" /note="upstream in-frame stop codon" CDS 22..1344 /gene="Cyp2c38" /EC_number="1.14.14.1" /note="isoform 2 is encoded by transcript variant 2; cytochrome P450 2C38; CYPIIC38; cytochrome P450, 2c38" /codon_start=1 /product="cytochrome P450 2C38 isoform 2" /protein_id="NP_001397128.1" /db_xref="GeneID:13097" /db_xref="MGI:MGI:1306819" /translation="
MDLVTFLVLTLSSLILLSLWRQRSRRGRLPPGPTPFPIIGNFLQIDVKNFNQSLTNFSKTYGPVFTLYLGSRPIVVLHGYEAVKEALIDHGEEFSGRENIPMSEKINNGLGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMKKLNENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNFKYIRSYLLEKVKEHQESLDVTNPRDFIDYFLIKQKQANHIEQAEYSLENLVCTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVVGRHRSPCMQDRSRMPYTDAMIHEVQRFINLVPNNLPHAVTCDIKFRNYIIPKGTTVVTSLTSVLHDSKEFPNPEMFDPGHFLDANGNFKKSDYFMTFSAGKRVCAGEGLARMELFLILTTILQNFKLKSLVHPKDIDMIPFVNGLITLPPHYQLCFIPL"
misc_feature 202..1326 /gene="Cyp2c38" /note="cytochrome P450 family 2, subfamily C, and similar cytochrome P450s; Region: CYP2C-like; cd20665" /db_xref="CDD:410758" misc_feature order(310..312,751..753,760..765,772..777,784..786, 937..939,952..957,964..969,973..975,1150..1158,1168..1170, 1174..1182,1192..1194,1201..1203) /gene="Cyp2c38" /note="heme binding site [chemical binding]; other site" /db_xref="CDD:410758" misc_feature order(343..345,481..486,493..495,511..513,568..570, 580..582,589..591,745..750,757..762,769..774,955..957, 967..969,1297..1302) /gene="Cyp2c38" /note="chemical substrate binding pocket [chemical binding]; other site" /db_xref="CDD:410758" exon 190..352 /gene="Cyp2c38" /inference="alignment:Splign:2.1.0" exon 353..513 /gene="Cyp2c38" /inference="alignment:Splign:2.1.0" exon 514..690 /gene="Cyp2c38" /inference="alignment:Splign:2.1.0" exon 691..832 /gene="Cyp2c38" /inference="alignment:Splign:2.1.0" exon 833..1020 /gene="Cyp2c38" /inference="alignment:Splign:2.1.0" exon 1021..1162 /gene="Cyp2c38" /inference="alignment:Splign:2.1.0" exon 1163..1610 /gene="Cyp2c38" /inference="alignment:Splign:2.1.0" regulatory 1586..1591 /regulatory_class="polyA_signal_sequence" /gene="Cyp2c38" /note="hexamer: AATAAA" polyA_site 1598 /gene="Cyp2c38" /note="major polyA site" polyA_site 1610 /gene="Cyp2c38" ORIGIN
gtatgaataaggagggtttctatggatcttgtcacattcctggtgctcactctctcctctctcattctcctctcactatggagacagaggtctagaagagggaggctccctcctggccccactcctttcccgattattggtaatttccttcagattgatgtgaagaacttcaaccaatccttaaccaatttctcaaaaacctatggccccgttttcactctgtatttgggctcacggcccattgttgtattgcatgggtatgaagcagtgaaggaagctctgattgatcatggggaggagttttctggtagagaaaacatcccaatgtctgaaaagattaataatggccttggctcaccttgtgaccccacattcattctgagctgtgctccatgcaatgtcatctgctcaattatttttcaagatcgttttgattacaaggataaagattttcttatgctcatgaaaaaactaaatgagaatgtcaagattctgagctccccatggttgcaggtctgcaataatttccccttgctcattgactattgtccgggaagtcatcacaaagtactaaaaaacttcaaatatattagaagttacctgttggagaaagtaaaagaacaccaagaatcactggatgttacaaaccctcgtgactttatcgattatttcctgattaaacaaaaacaggcaaaccacatcgaacaagcagaatattcacttgaaaatctggtctgcactatcaataatctctttgctgcaggaacagagacaacaagcacaacactgagatatgctctcctactcctgatgaagtacccagatgtcacagctaaagtccaagaagagattgaccatgtggttggtagacaccgtagcccctgcatgcaggacaggagccgcatgccctatactgatgccatgattcatgaggtccagagattcatcaaccttgtccctaacaacctaccccatgcagtgacctgtgacattaaattcagaaactacatcatccccaagggaacaacagtagtaacgtcactgacatcagttctgcatgacagcaaggagttccccaacccagagatgtttgaccctggccactttctagacgctaatggaaactttaagaaaagtgactacttcatgactttctcagcaggaaaacgggtttgtgctggagagggcctggcccgcatggagctgtttctaatcctgaccaccattttacagaactttaaactgaaatctctggttcacccaaaagacattgatatgatcccatttgtgaatggattaatcactctgccaccccattaccagctctgcttcattcctctctaaagagatcacacattctgaaccctcctctgttgccttctgcaatcccccccccagggttttattcacctctttccttatcagggataaggcatcttccatcctggctcacagaacccccttttctgaagacctagcaaacacatgcggtttctggagttatagcacaaatgcacttgtattatctcttttatataacagttgtctgagcccttatgcttatgtttatccattcctgcgttagaataaaacttcactggcaaataata
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]