2024-05-07 04:55:21, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001405239 4872 bp mRNA linear ROD 02-OCT-2023 DEFINITION Mus musculus histone deacetylase 5 (Hdac5), transcript variant 14, mRNA. ACCESSION NM_001405239 VERSION NM_001405239.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 4872) AUTHORS Zhu C, Piao Z and Jin L. TITLE HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction JOURNAL Orphanet J Rare Dis 18 (1), 266 (2023) PUBMED 37667300 REMARK GeneRIF: HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction. Publication Status: Online-Only REFERENCE 2 (bases 1 to 4872) AUTHORS Wang J, Wu S, Liu L, Pang Y, Li Z and Mu H. TITLE HDAC5-Mediated Acetylation of p100 Suppresses Its Processing JOURNAL Int Dent J 73 (3), 387-394 (2023) PUBMED 36156247 REMARK GeneRIF: HDAC5-Mediated Acetylation of p100 Suppresses Its Processing. REFERENCE 3 (bases 1 to 4872) AUTHORS Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S, Miyazaki S, Tsuneoka Y, Sugiyama F, Takahashi S, Hayashi Y, Muratani M, Liu Q, Miyoshi C, Yanagisawa M and Funato H. TITLE Kinase signalling in excitatory neurons regulates sleep quantity and depth JOURNAL Nature 612 (7940), 512-518 (2022) PUBMED 36477539 REFERENCE 4 (bases 1 to 4872) AUTHORS Huang S, Zheng X, Zhang X, Jin Z, Liu S, Fu L and Niu Y. TITLE Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle JOURNAL Appl Physiol Nutr Metab 47 (11), 1062-1074 (2022) PUBMED 35998371 REMARK GeneRIF: Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle. REFERENCE 5 (bases 1 to 4872) AUTHORS Sharma P, Karnam K, Mahale A, Sedmaki K, Krishna Venuganti V and Kulkarni OP. TITLE HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy JOURNAL Int Immunopharmacol 112, 109264 (2022) PUBMED 36183679 REMARK GeneRIF: HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy. REFERENCE 6 (bases 1 to 4872) AUTHORS Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP and Khochbin S. TITLE mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity JOURNAL J Biol Chem 275 (20), 15594-15599 (2000) PUBMED 10748098 REFERENCE 7 (bases 1 to 4872) AUTHORS Zhou X, Richon VM, Rifkind RA and Marks PA. TITLE Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5 JOURNAL Proc Natl Acad Sci U S A 97 (3), 1056-1061 (2000) PUBMED 10655483 REFERENCE 8 (bases 1 to 4872) AUTHORS Kao HY, Downes M, Ordentlich P and Evans RM. TITLE Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression JOURNAL Genes Dev 14 (1), 55-66 (2000) PUBMED 10640276 REFERENCE 9 (bases 1 to 4872) AUTHORS Grozinger CM, Hassig CA and Schreiber SL. TITLE Three proteins define a class of human histone deacetylases related to yeast Hda1p JOURNAL Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999) PUBMED 10220385 REFERENCE 10 (bases 1 to 4872) AUTHORS Verdel A and Khochbin S. TITLE Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers JOURNAL J Biol Chem 274 (4), 2440-2445 (1999) PUBMED 9891014 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL954730.15. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR17784643.1329693.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375 [ECO:0006172] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-138 AL954730.15 63571-63708 c 139-210 AL954730.15 51982-52053 c 211-470 AL954730.15 40473-40732 c 471-615 AL954730.15 40196-40340 c 616-730 AL954730.15 39988-40102 c 731-861 AL954730.15 39356-39486 c 862-1008 AL954730.15 39051-39197 c 1009-1121 AL954730.15 38850-38962 c 1122-1253 AL954730.15 38398-38529 c 1254-1476 AL954730.15 37997-38219 c 1477-1688 AL954730.15 36110-36321 c 1689-1970 AL954730.15 35619-35900 c 1971-2142 AL954730.15 34799-34970 c 2143-2276 AL954730.15 33966-34099 c 2277-2397 AL954730.15 33535-33655 c 2398-2447 AL954730.15 33202-33251 c 2448-2555 AL954730.15 32932-33039 c 2556-2611 AL954730.15 32571-32626 c 2612-2699 AL954730.15 32363-32450 c 2700-2819 AL954730.15 31232-31351 c 2820-2917 AL954730.15 30905-31002 c 2918-3036 AL954730.15 30625-30743 c 3037-3170 AL954730.15 30105-30238 c 3171-3255 AL954730.15 29804-29888 c 3256-3421 AL954730.15 29518-29683 c 3422-4872 AL954730.15 27984-29434 c FEATURES Location/Qualifiers source 1..4872 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="11" /map="11 65.82 cM" gene 1..4872 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /note="histone deacetylase 5" /db_xref="GeneID:15184" /db_xref="MGI:MGI:1333784" exon 1..138 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 139..210 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" CDS 144..3461 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /EC_number="3.5.1.98" /note="isoform 11 is encoded by transcript variant 14; histone deacetylase mHDA1; histone deacetylase 4" /codon_start=1 /product="histone deacetylase 5 isoform 11" /protein_id="NP_001392168.1" /db_xref="GeneID:15184" /db_xref="MGI:MGI:1333784" /translation="
MSGREPSLEILPRTPLHSIPVAVEVKPVLPGAMPSSMGGGGGGSPSPVELRGALAGPMDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLLGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGTGPGVSSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMIPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDTSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPEETEEELTEQQEALLGEGALTIPREGSTESESTQEDLEEEEEEEEEEEEDCIQVKDEDGESGPDEGPDLEESSAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKSPTDQPTVVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLGKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAQEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPSVNAVATLEKVIEIQSKHWSCVQRFAAGLGCSLREAQTGEKEEAETVSAMALLSVGAEQAQAVATQEHSPRPAEEPMEQEPAL"
misc_feature 318..581 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /note="Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9); Region: ClassIIa_HDAC_Gln-rich-N; cl25407" /db_xref="CDD:421006" misc_feature order(321..326,330..335,342..344,354..356,363..368, 375..380,384..389,396..401,405..410,417..425,429..437, 441..446,483..488,495..503) /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /note="tetramer interface [polypeptide binding]; other site" /db_xref="CDD:197397" misc_feature order(321..326,330..335,342..344,354..356,363..365, 375..377,384..386,396..401,405..410,417..422,429..431, 441..443,483..485,495..497) /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /note="dimer interface A, C [polypeptide binding]; other site" /db_xref="CDD:197397" misc_feature order(354..356,366..368,378..380,387..389,399..401, 408..410,420..425,432..437,444..446) /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /note="dimer interface A, D [polypeptide binding]; other site" /db_xref="CDD:197397" misc_feature 2127..3386 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /note="Histone deacetylase 5; Region: HDAC5; cd10007" /db_xref="CDD:212531" misc_feature order(2586..2591,2613..2618,2700..2702,2706..2708, 2982..2984,3102..3104) /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /note="putative active site [active]" /db_xref="CDD:212531" exon 211..470 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 471..615 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 616..730 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 731..861 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 862..1008 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 1009..1121 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 1122..1253 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 1254..1476 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 1477..1688 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 1689..1970 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 1971..2142 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2143..2276 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2277..2397 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2398..2447 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2448..2555 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2556..2611 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2612..2699 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2700..2819 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2820..2917 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 2918..3036 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 3037..3170 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 3171..3255 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 3256..3421 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" exon 3422..4872 /gene="Hdac5" /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600" /inference="alignment:Splign:2.1.0" ORIGIN
gttgttgttggtggcggcggcgagcggagccggaggagccgccgcaaagatggaggagccgtcgaggaggcgctgccgctgctgttgccgccgctgctgccgccgccgcccgcgaagccggagctcgagccgcagcggatggcatgtcaggccgggaaccatccttggaaatcctgccacggactcctctgcacagcatccctgtggcagtggaggtgaagccggtgctgccaggagccatgcccagctccatggggggtggaggtggaggtagccccagccccgtggagcttcggggggctctggcgggccccatggaccctgcgctacgggagcagcaactgcagcaggagctcctggtcctcaagcagcagcagcagctccagaagcagctcctgttcgccgagttccagaagcagcacgaccacttgacgcggcagcacgaggtccagctgcagaagcacctcaagcagcagcaggagatgctggcggctaagaggcagcaggagctggagcagcagcggcagcgggagcagcagcggcaggaggagctggagaaacagcggctggagcagcagctgctcatcctgcgcaacaaggagaagagcaaagagagtgccatcgccagcaccgaggtaaagctgaggctccaggaattcctgttgtccaagtcaaaggagcccacgccaggcggcctcaaccattccctcccacagcaccccaaatgctggggagcccaccacgcttctttggaccagagttcccctccccagagcggccctcctgggacgcctccctcctacaaattgcctttgcttgggccctatgacagccgtgatgactttcccctccgtaaaacggcctcggaacccaacttaaaagtacgttcgaggctaaaacagaaggtagccgagaggagaagcagtcccctcctgcgtcgaaaggatggcactgttattagtacttttaagaagagagcagttgagatcaccggcacggggcctggggtgtcgtccgtgtgtaacagtgcgcccggctctggccccagctctcccaacagttcccacagcaccatcgctgagaacggctttactggctcagtccccaacatccccactgagatgatcccccagcaccgggccctccctctggacagttccccaaaccagttcagcctctatacgtctccttctctgcccaacatctccctagggctgcaggccactgtcactgtcaccaactcgcacctcaccgcctccccgaagctgtcaacacagcaggaggctgagaggcaggcccttcagtccctgcggcagggcggcacactgaccggcaagttcatgagcacatcctccatccctggctgcctgttgggagtggcactggagggtgacacaagcccccacgggcacgcttccctgctgcagcacgttttgctcctggagcaggcccggcaacagagcacgctcatagcagtgccgctccatgggcagtccccactggtgacgggtgaacgtgtggccaccagcatgaggacggtgggtaagctcccgaggcaccgacctctgagccgcactcagtcctccccgctgccgcagagtccccaggccctgcagcagctggtcatgcagcagcagcaccagcagttcctggagaagcagaagcagcagcagatgcagctgggcaagatccttaccaaaactggggagctgtcaaggcagcccaccactcacccggaggagacagaagaggagctgacggagcagcaggaggccttgctgggagagggggccctgaccattccccgggaaggctctacagaaagtgagagcacccaggaagacctagaagaggaggaggaggaggaggaggaggaagaggaggactgcattcaggtcaaggatgaggatggcgagagtggtcctgatgaaggccctgacttagaagagtccagtgctggttacaaaaagttgttcgcagatgcccagcagttacagcccctccaggtgtaccaggcacccctcagcctggccactgtgcctcatcaggccctgggccgcacccagtcctcacctgctgctcctgggagcatgaagagccccacagaccaacccactgtggtgaagcacctcttcaccacaggtgtggtctatgacacgttcatgctgaagcaccagtgtatgtgcggaaacacacacgtgcacccagagcacgccggccgcatccagagcatctggtcccggctgcaggaaactggtctgctcggcaagtgtgagcggatccggggtcgtaaagccacactggatgaaatccagaccgtgcactctgagtaccacaccctgctctatgggaccagcccccttaaccggcagaagctggacagcaagaagctgcttggccccatcagccagaagatgtacgccatgctgccctgtgggggcattggggtggacagtgacacggtgtggaatgagatgcactcctcaagtgccgtgcgaatggcagtgggctgcctggtggagctggccttcaaggtggctgcaggagagctcaagaatggatttgctatcatccggcccccaggacaccatgctgaggagtccacagccatgggattctgcttcttcaactccgtagccatcacagctaaactcctgcagcagaagctgagcgtgggcaaggtcctcatcgtggactgggatattcaccatggcaacggcacccagcaagcattctacaacgatccctctgtgctctacatctccctgcatcgctacgacaacgggaacttctttccaggctctggggctcctgaagaggttggtggagggccaggtgtggggtacaacgtaaatgtggcgtggacaggaggtgtggatccccccattggagatgtggaatacctgacagccttcaggacagtggtgatgcccattgcccaggagttctcacctgacgtcgtcctagtctccgctgggtttgatgctgttgaaggacatctgtctccactgggtggctattctgtcaccgccagatgttttggccacttgaccaggcagctcatgacactggctgggggccgggtggtgctggccctggagggaggccatgacttgaccgccatctgtgatgcctctgaggcctgtgtctcggctctgctcagcgtggagctgcagcccttggatgaagcagtcttgcagcaaaagcccagcgtcaatgcggttgccacactagagaaagtcatcgagatccagagcaaacactggagctgtgtacagaggtttgccgctggtctgggctgctcgctgcgggaggctcagacaggtgagaaagaggaggccgagactgtgagcgccatggccctgctttccgtgggggctgagcaggcccaggctgttgccactcaagagcacagccccaggccagcagaggagcccatggagcaggagcctgccctgtgacaccctggcccccatccctctgggcttcatcattgtgattttgtttattttttctattaaaaacaaaaagtcacacattcaacaacgtgtgccgtgtgggtctctcagcctcgcccgcctccaagctgtttcagaaccccctcccactacaagggccctgggtcagctttcgaatccattccttctatggggcattgggtgcagtacccactttgcccatgttgtatcccatacccaattccccgtactcttctaccgtggacagtgctccaggcagtactgccaactctggagctgcctgagatgggaacagtgattggtgcctggacttcagttggcttttggggaatgccttaatttgaaatctgcccctctccaccctcaggatgatgtactaccatttaagatgcagaatcgagggaaggtaggcgtccaccccaaactttcccttcctctctatctccctcaccattctgcagactctcctctttggcctcagcactgaagactcgtgcccaggatgtaggccttagacttgtggccaggcttcttgtctcttactcctgagtatcccaggagctcaaagggtaccgggtggtgtgcagcggggttagaaggggccaggaggacctgcgtatgcaggcaggttctccactttttttctattaaactctccgtcttgtgctggaccagtataaggaggggagaaggtagaccctgcatgggggcttcaggttcatgcaagcccctctgatgttctgggccagattttctccatccatcagcctgctgcaagcagaagggtcaagatccagctcccttctggagcctttttgctttgaaacctggggatcgtgaaagacagggtagatatagttctagaatagacagggccagaaccctgtctagaagccacccctgtcccccagaggtgttgggggggggggagtccagctctcagcaggaggttgttaggagctatccatcttttccagtagccttgtgtccagaggctggagcccacagacttccagtgaatgtggtctagcctgtaggaaaccaaagatgggaaatggctcctaaggggccaatttttcttcccctataccacatccccagggctcagctatctgtttccatattgtccgtatggggcctgagcagggctgagggagctggggagtcccaccactattagttttctgtgtgtttgcgtgctgtctgtatcatccttgcactgaaccagaggctgctcacctcccactctctccccgtaggctgatcttatcctgtgccaacccactcctgctttgtctccctggacatggattttagttcagtagtttgtatcccaacacatggtttttgtcttcgtgtaaataaacttatttgtggcagtgctttctgggaa
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@meso_cacase at
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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