LOCUS       NM_001401199            4494 bp    mRNA    linear   ROD 31-DEC-2022
DEFINITION  Mus musculus myotubularin related protein 6 (Mtmr6), transcript
            variant 3, mRNA.
ACCESSION   NM_001401199
VERSION     NM_001401199.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4494)
  AUTHORS   Maekawa M, Terasaka S, Mochizuki Y, Kawai K, Ikeda Y, Araki N,
            Skolnik EY, Taguchi T and Arai H.
  TITLE     Sequential breakdown of 3-phosphorylated phosphoinositides is
            essential for the completion of macropinocytosis
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), E978-E987 (2014)
   PUBMED   24591580
REFERENCE   2  (bases 1 to 4494)
  AUTHORS   Mochizuki Y, Ohashi R, Kawamura T, Iwanari H, Kodama T, Naito M and
            Hamakubo T.
  TITLE     Phosphatidylinositol 3-phosphatase myotubularin-related protein 6
            (MTMR6) is regulated by small GTPase Rab1B in the early secretory
            and autophagic pathways
  JOURNAL   J Biol Chem 288 (2), 1009-1021 (2013)
   PUBMED   23188820
REFERENCE   3  (bases 1 to 4494)
  AUTHORS   Mochizuki Y and Majerus PW.
  TITLE     Characterization of myotubularin-related protein 7 and its binding
            partner, myotubularin-related protein 9
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9768-9773 (2003)
   PUBMED   12890864
REFERENCE   4  (bases 1 to 4494)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166113.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660813.184543.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC166113.3         43789-43850
            63-206              AC166113.3         45783-45926
            207-527             AC166113.3         54402-54722
            528-623             AC166113.3         55968-56063
            624-814             AC166113.3         62656-62846
            815-931             AC166113.3         69426-69542
            932-1094            AC166113.3         72380-72542
            1095-1252           AC166113.3         74234-74391
            1253-1381           AC166113.3         77214-77342
            1382-1516           AC166113.3         81840-81974
            1517-1649           AC166113.3         84291-84423
            1650-1759           AC166113.3         85215-85324
            1760-1885           AC166113.3         85681-85806
            1886-1935           AC166113.3         88417-88466
            1936-2136           AC166113.3         88871-89071
            2137-2268           AC166113.3         90360-90491
            2269-2395           AC166113.3         91212-91338
            2396-4494           AC166113.3         92570-94668
FEATURES             Location/Qualifiers
     source          1..4494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..4494
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="myotubularin related protein 6"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
     exon            1..62
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            63..206
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            207..527
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            528..623
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            624..814
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    776..778
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="upstream in-frame stop codon"
     CDS             809..2644
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /EC_number="3.1.3.64"
                     /EC_number="3.1.3.95"
                     /note="isoform 2 is encoded by transcript variant 3;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase"
                     /codon_start=1
                     /product="myotubularin-related protein 6 isoform 2"
                     /protein_id="NP_001388128.1"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
                     /translation="

MQVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAQQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRIVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDTERRNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYPRELYVPRTASRPVIVGSSNFRSKGRLPVLSYCRQGTEAAICRCSQPLSGFSARCLEDEHLLQAISKANPGNRYMYVVDTRPKLNAIANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGSKGLSVNDFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDPREVSPVFTQFLECVWHLTQQFPQAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLDDKKKYLNPLYSSKSQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLSIIMNMNEQSKQLEEDIKDLEAKIKQCKNGILTKELLHAVHPESPALKTSLCLKEPSLLPVKDTLRAIEGSSPADNRYCDYAEEFSKSEPTVVSLEYGVARMTC"

     misc_feature    812..1093
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:450165"
     misc_feature    1178..2083
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:452893"
     exon            815..931
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1094
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1252
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1381
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1516
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1649
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1759
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1885
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1935
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2136
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2268
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2395
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..4494
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gccgcgcagggaaccctgggatcggagtggaagcggtactcgtgtgaggccgggcggatgagcatgtggtgttgagaggtgctacaatttacagagtgtggaaagttaactgaagaggggactccatctatacacttctggagaagccccctccatgctgagataagatttcatatgcagctgttttgtactcctaacccactcctctccaggttgcctcccaggcttgaacccggacatgtgagccgctagccggctcgcaacaatttggcatcccacgcggggcctgggaaaggcagaagatactggaagaaacactgctggtttagagctccatggaagaataaaagaattaaagaaaatttgtaccggggcacgaagcaacgggtaaaaggttgctaagggtgtggtactaagctggaacagcgtgctgacccgtgcgctggattcgcttaggttcagcagtgatatcagaatctaggaatgcagcaggcagtcggccgcagctttcagaagctgctttttagtctcactatgtggaacagcatgctctgaaatttacaggcaacaacttgcctctgtctctgaagtgctgggattaaagtcatgccccagcatacaagctttactattagacaacatgggcttcctctctgcgtgcttcctccaggctccatcatctcccaaccacgcctccactgtttccttactcctcggtggttccacctgcccagccgaattttctctgggttgatactgtcagtactactgcacttaaaggcctgtttgtgttccttcatcagataaaatgcaggttgaacaagtaaagttacttgaccggtttagtaccaacaacaagtcactgacaggaacactgtatcttacggccacacacctattatttattgacgctcagcaaaaagaaacctggatactacaccaccatattgcctctgtggagaaacttgctctgaccacttctggatgcccacttgtgattcagtgcaagaacttcaggattgtgcatttcattgttcccagggaaagagattgccacgatatttataactctctcctgcagctatcaaaacaagcaaaatatgaagatctctatgccttctcttataatcccaagcaaaatgatactgaacgacggaatggttggcagcttattgaccttgctgcggagtatgagaggatgggagtgcccaatgcaaactggcaactgtcggatgccaaccgagagtacaaggtctgtgagacttatcccagagagctgtatgttcctcggacagctagccggccggtgatcgtgggcagttccaacttccggagcaagggcagacttccggtcctatcctactgccggcagggcactgaggctgccatttgtcgatgtagtcagccattgtcaggcttcagtgccaggtgcctagaggatgagcatttgcttcaagccattagtaaagccaacccaggaaaccgctacatgtatgttgtggataccaggcccaagctcaatgcaatagctaacagagcagctggaaaaggttatgaaaatgaagacaactattctaatattagatttcagttcgttggaatagaaaatattcatgtcatgagatccagccttcagaaattactggaagtgaatggtagcaaggggctttctgtcaatgatttctactctggtttggaaagttcaggatggcttcgccatatcaaggctgttttggatgctgcaatcttcttagccaaagcaatagtggttgaaaatgcaagtgtgttggtccactgttccgatgggtgggacaggacctcccaagtgtgctccctcggctcactgttgttggattcctactacaggacaatgaaaggattcatggttttaatagaaaaagattggatatcatttgggcataaattttcagagaggtgtggccatttggatggagacccgagggaggtctcaccagtgttcactcagttcttggagtgtgtctggcacctgactcagcagttcccacaagccttcgagttcaacgaagcgtttcttcttcagatccatgagcacattcattcatgccaatttgggaacttccttggcaactgtcagaaggagagagaggaactcaggttaaaggagaaaacttactccctgtggccttttcttttggatgacaaaaagaagtacttaaatcctctctacagttccaaatctcagagactgacagtcttggagccaaatacagcctctttcaattttaagttttggagaaacatgtaccaccagtttgatcggacgctccatcctcggcagtctgtgctgagcataattatgaatatgaatgagcaaagcaagcagttagaggaagacattaaagacctcgaggctaaaattaagcaatgcaaaaatggcatcctaacgaaggagttgctgcatgctgtccaccctgaatcacctgccctgaaaacctcgctgtgtctcaaagagccgagtctgcttcccgtgaaggacacactccgagctatagagggcagcagcccagcagataatcgctactgtgactatgccgaggaattttctaagtcggagcctaccgtggtcagcttggagtacggggtggccagaatgacttgttagcctccttccgtgatccctggatgactgtagtgtaagaaatgtatagttgtgaggatggtctgtacacatgggcaggaggggttgttgagtgactttggggcttagcagtaagtgagaaagtaggtagctgagaaaaggatcatagcaactcttgagaggagtgagtcagctaagtgccatttgtaacaagaacatactcatttctgtaggaagtgagtgctagtgtgtgtatgtactggaaaggggttacacaggactggtgagctgacagtctgttgattcagatgttaattccagccacgctcagtagctttcctctaactctgagaaaacagacctgacaacctgaaccctcagtgactgatgtggcatgtgctttcagttctggagctgtgtgactgtggattttgcagtcacaaaaatccaaatatatagtcaaaaatatagtgacgttttaacattaaagtgccatgaaaagtacttatgggacagccttaaagtagactctcagtttattctgtgggttttatagccgaggacaggatgtttgatctctcctttaatcagccttatttcatatgaagaactaactgcactctgattacttgggggccgcacactgcagtgctccaccatggaaagttgtagacatactctgctagtttgtaattagccagctccacccgtatttaaaatcagtgttaccgaaggctttgttctcgttgtcatttgttccaagctgcagctgacagttcattattcacagcttagaggactcatttcttaggctagtataagcacatttggcatttactttcggcttactgcagtctattaattcttactctgtggttggctttaatcctttgataactgtacatttaaagtggcaaagctctaaagcgttctgagtactaaatacatttttaacttgactgtagctgcctataaactttcaggtaaaggaaaaagggaagtgcgggtagtggagattttgcttggttacgaattctaaagcaatcatttttgtgtggagcatatttccttactcttaatataggaggggcagagaagggagcactgggggagccagctaatgtccaacagaagcagctttgacgcaggaaaaggtttattttgctttataggctcattgttattctgtgcactggggcatacatatcttttctaaaaaatcacttacaactgtcagtattaccagctggctctcaaagtttaatatcattgatggtgtgtgaggtacagttcaggggcactacaaaatctgtgtacattgtcttatatacctcctgaccacacctatatctgtagtatttcttgtgttagttttgaacatatgtatcttttttttttttttgggaaaaaaaaggaaagctttatcgtatatgattttatctagtccttatttttccaattcacttctgtaagaccttatgtaataaaaacactgcattttaaaaagtaacagaaatatactaaaaattacaatgtataatgaacagtgtttagacattgagaaaggaaacttaatctctgtgtccacaacaggagggttttgtgccttggttccagtcaagttgtggttttagacttctgtggcagacttcctagtcatcttctgggttccttatgctaattttcaacttcacatgtatatatgtgtttacatgctcacacagaaaacatcctgagtgacgtacaggacatacgttggcaaaagtctgtgtaaatgtctcataaaattagatttatgttcattgtgttttgggatgtatagcatgtaaattatttcatgtattatttaaaggcaattaaatgttcatgcttta

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