LOCUS       NM_001401198            3979 bp    mRNA    linear   ROD 31-DEC-2022
DEFINITION  Mus musculus myotubularin related protein 6 (Mtmr6), transcript
            variant 2, mRNA.
ACCESSION   NM_001401198 XM_006518865
VERSION     NM_001401198.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3979)
  AUTHORS   Maekawa M, Terasaka S, Mochizuki Y, Kawai K, Ikeda Y, Araki N,
            Skolnik EY, Taguchi T and Arai H.
  TITLE     Sequential breakdown of 3-phosphorylated phosphoinositides is
            essential for the completion of macropinocytosis
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), E978-E987 (2014)
   PUBMED   24591580
REFERENCE   2  (bases 1 to 3979)
  AUTHORS   Mochizuki Y, Ohashi R, Kawamura T, Iwanari H, Kodama T, Naito M and
            Hamakubo T.
  TITLE     Phosphatidylinositol 3-phosphatase myotubularin-related protein 6
            (MTMR6) is regulated by small GTPase Rab1B in the early secretory
            and autophagic pathways
  JOURNAL   J Biol Chem 288 (2), 1009-1021 (2013)
   PUBMED   23188820
REFERENCE   3  (bases 1 to 3979)
  AUTHORS   Mochizuki Y and Majerus PW.
  TITLE     Characterization of myotubularin-related protein 7 and its binding
            partner, myotubularin-related protein 9
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9768-9773 (2003)
   PUBMED   12890864
REFERENCE   4  (bases 1 to 3979)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166113.3.
            
            On Feb 4, 2022 this sequence version replaced XM_006518865.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.31491.1,
                                           SRR1660815.20208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC166113.3         57551-57658
            109-299             AC166113.3         62656-62846
            300-416             AC166113.3         69426-69542
            417-579             AC166113.3         72380-72542
            580-737             AC166113.3         74234-74391
            738-866             AC166113.3         77214-77342
            867-1001            AC166113.3         81840-81974
            1002-1134           AC166113.3         84291-84423
            1135-1244           AC166113.3         85215-85324
            1245-1370           AC166113.3         85681-85806
            1371-1420           AC166113.3         88417-88466
            1421-1621           AC166113.3         88871-89071
            1622-1753           AC166113.3         90360-90491
            1754-1880           AC166113.3         91212-91338
            1881-3979           AC166113.3         92570-94668
FEATURES             Location/Qualifiers
     source          1..3979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..3979
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="myotubularin related protein 6"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
     exon            1..108
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            109..299
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    261..263
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="upstream in-frame stop codon"
     CDS             294..2129
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /EC_number="3.1.3.64"
                     /EC_number="3.1.3.95"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase"
                     /codon_start=1
                     /product="myotubularin-related protein 6 isoform 2"
                     /protein_id="NP_001388127.1"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
                     /translation="

MQVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAQQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRIVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDTERRNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYPRELYVPRTASRPVIVGSSNFRSKGRLPVLSYCRQGTEAAICRCSQPLSGFSARCLEDEHLLQAISKANPGNRYMYVVDTRPKLNAIANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGSKGLSVNDFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDPREVSPVFTQFLECVWHLTQQFPQAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLDDKKKYLNPLYSSKSQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLSIIMNMNEQSKQLEEDIKDLEAKIKQCKNGILTKELLHAVHPESPALKTSLCLKEPSLLPVKDTLRAIEGSSPADNRYCDYAEEFSKSEPTVVSLEYGVARMTC"

     misc_feature    297..578
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:450165"
     misc_feature    663..1568
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:452893"
     exon            300..416
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            417..579
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            580..737
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            738..866
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1001
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1134
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1244
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1370
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1420
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1621
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1753
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1880
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..3979
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agttcctgcgggtggctgtcaccgccccgtttctctcccgatggtgctctcctgaggccagctgcctgcgggcgtcgccccgggatggagcacatccggacaaccaagctttactattagacaacatgggcttcctctctgcgtgcttcctccaggctccatcatctcccaaccacgcctccactgtttccttactcctcggtggttccacctgcccagccgaattttctctgggttgatactgtcagtactactgcacttaaaggcctgtttgtgttccttcatcagataaaatgcaggttgaacaagtaaagttacttgaccggtttagtaccaacaacaagtcactgacaggaacactgtatcttacggccacacacctattatttattgacgctcagcaaaaagaaacctggatactacaccaccatattgcctctgtggagaaacttgctctgaccacttctggatgcccacttgtgattcagtgcaagaacttcaggattgtgcatttcattgttcccagggaaagagattgccacgatatttataactctctcctgcagctatcaaaacaagcaaaatatgaagatctctatgccttctcttataatcccaagcaaaatgatactgaacgacggaatggttggcagcttattgaccttgctgcggagtatgagaggatgggagtgcccaatgcaaactggcaactgtcggatgccaaccgagagtacaaggtctgtgagacttatcccagagagctgtatgttcctcggacagctagccggccggtgatcgtgggcagttccaacttccggagcaagggcagacttccggtcctatcctactgccggcagggcactgaggctgccatttgtcgatgtagtcagccattgtcaggcttcagtgccaggtgcctagaggatgagcatttgcttcaagccattagtaaagccaacccaggaaaccgctacatgtatgttgtggataccaggcccaagctcaatgcaatagctaacagagcagctggaaaaggttatgaaaatgaagacaactattctaatattagatttcagttcgttggaatagaaaatattcatgtcatgagatccagccttcagaaattactggaagtgaatggtagcaaggggctttctgtcaatgatttctactctggtttggaaagttcaggatggcttcgccatatcaaggctgttttggatgctgcaatcttcttagccaaagcaatagtggttgaaaatgcaagtgtgttggtccactgttccgatgggtgggacaggacctcccaagtgtgctccctcggctcactgttgttggattcctactacaggacaatgaaaggattcatggttttaatagaaaaagattggatatcatttgggcataaattttcagagaggtgtggccatttggatggagacccgagggaggtctcaccagtgttcactcagttcttggagtgtgtctggcacctgactcagcagttcccacaagccttcgagttcaacgaagcgtttcttcttcagatccatgagcacattcattcatgccaatttgggaacttccttggcaactgtcagaaggagagagaggaactcaggttaaaggagaaaacttactccctgtggccttttcttttggatgacaaaaagaagtacttaaatcctctctacagttccaaatctcagagactgacagtcttggagccaaatacagcctctttcaattttaagttttggagaaacatgtaccaccagtttgatcggacgctccatcctcggcagtctgtgctgagcataattatgaatatgaatgagcaaagcaagcagttagaggaagacattaaagacctcgaggctaaaattaagcaatgcaaaaatggcatcctaacgaaggagttgctgcatgctgtccaccctgaatcacctgccctgaaaacctcgctgtgtctcaaagagccgagtctgcttcccgtgaaggacacactccgagctatagagggcagcagcccagcagataatcgctactgtgactatgccgaggaattttctaagtcggagcctaccgtggtcagcttggagtacggggtggccagaatgacttgttagcctccttccgtgatccctggatgactgtagtgtaagaaatgtatagttgtgaggatggtctgtacacatgggcaggaggggttgttgagtgactttggggcttagcagtaagtgagaaagtaggtagctgagaaaaggatcatagcaactcttgagaggagtgagtcagctaagtgccatttgtaacaagaacatactcatttctgtaggaagtgagtgctagtgtgtgtatgtactggaaaggggttacacaggactggtgagctgacagtctgttgattcagatgttaattccagccacgctcagtagctttcctctaactctgagaaaacagacctgacaacctgaaccctcagtgactgatgtggcatgtgctttcagttctggagctgtgtgactgtggattttgcagtcacaaaaatccaaatatatagtcaaaaatatagtgacgttttaacattaaagtgccatgaaaagtacttatgggacagccttaaagtagactctcagtttattctgtgggttttatagccgaggacaggatgtttgatctctcctttaatcagccttatttcatatgaagaactaactgcactctgattacttgggggccgcacactgcagtgctccaccatggaaagttgtagacatactctgctagtttgtaattagccagctccacccgtatttaaaatcagtgttaccgaaggctttgttctcgttgtcatttgttccaagctgcagctgacagttcattattcacagcttagaggactcatttcttaggctagtataagcacatttggcatttactttcggcttactgcagtctattaattcttactctgtggttggctttaatcctttgataactgtacatttaaagtggcaaagctctaaagcgttctgagtactaaatacatttttaacttgactgtagctgcctataaactttcaggtaaaggaaaaagggaagtgcgggtagtggagattttgcttggttacgaattctaaagcaatcatttttgtgtggagcatatttccttactcttaatataggaggggcagagaagggagcactgggggagccagctaatgtccaacagaagcagctttgacgcaggaaaaggtttattttgctttataggctcattgttattctgtgcactggggcatacatatcttttctaaaaaatcacttacaactgtcagtattaccagctggctctcaaagtttaatatcattgatggtgtgtgaggtacagttcaggggcactacaaaatctgtgtacattgtcttatatacctcctgaccacacctatatctgtagtatttcttgtgttagttttgaacatatgtatcttttttttttttttgggaaaaaaaaggaaagctttatcgtatatgattttatctagtccttatttttccaattcacttctgtaagaccttatgtaataaaaacactgcattttaaaaagtaacagaaatatactaaaaattacaatgtataatgaacagtgtttagacattgagaaaggaaacttaatctctgtgtccacaacaggagggttttgtgccttggttccagtcaagttgtggttttagacttctgtggcagacttcctagtcatcttctgggttccttatgctaattttcaacttcacatgtatatatgtgtttacatgctcacacagaaaacatcctgagtgacgtacaggacatacgttggcaaaagtctgtgtaaatgtctcataaaattagatttatgttcattgtgttttgggatgtatagcatgtaaattatttcatgtattatttaaaggcaattaaatgttcatgcttta

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