LOCUS       NM_001379454            2715 bp    mRNA    linear   ROD 29-DEC-2022
DEFINITION  Mus musculus WASP family, member 1 (Wasf1), transcript variant 2,
            mRNA.
ACCESSION   NM_001379454 XM_006512933
VERSION     NM_001379454.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2715)
  AUTHORS   Longatti A, Ponzoni L, Moretto E, Giansante G, Lattuada N, Colombo
            MN, Francolini M, Sala M, Murru L and Passafaro M.
  TITLE     Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice
  JOURNAL   Mol Neurobiol 58 (12), 6092-6110 (2021)
   PUBMED   34455539
REFERENCE   2  (bases 1 to 2715)
  AUTHORS   Zhang Y, Kang H, Lee Y, Kim Y, Lee B, Kim JY, Jin C, Kim S, Kim H
            and Han K.
  TITLE     Smaller Body Size, Early Postnatal Lethality, and Cortical
            Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null
            Embryonic Mice
  JOURNAL   Front Mol Neurosci 11, 482 (2019)
   PUBMED   30687000
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2715)
  AUTHORS   Chen Y, Milenkovic M, Horsfall W, Salahpour A, Soderling SH and
            Ramsey AJ.
  TITLE     Restoring striatal WAVE-1 improves maze exploration performance of
            GluN1 knockdown mice
  JOURNAL   PLoS One 13 (10), e0199341 (2018)
   PUBMED   30352064
  REMARK    GeneRIF: WAVE-1 restoration improves maze exploration performance
            of GluN1 knockdown mice
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2715)
  AUTHORS   Fan L, Lu Y, Shen X, Shao H, Suo L and Wu Q.
  TITLE     Alpha protocadherins and Pyk2 kinase regulate cortical neuron
            migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
            complex in mice
  JOURNAL   Elife 7, e35242 (2018)
   PUBMED   29911975
  REMARK    GeneRIF: Data indicate a molecular protocadherin alpha
            (Pcdhalpha)/Wiskott-Aldrich syndrome potein Family
            (WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from
            protocadherin cell-surface receptors to actin cytoskeletal dynamics
            in cortical neuron migration and dendrite morphogenesis in mouse
            brain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2715)
  AUTHORS   Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ,
            Nestler EJ, Nairn AC, Greengard P and Kim Y.
  TITLE     WAVE1 in neurons expressing the D1 dopamine receptor regulates
            cellular and behavioral actions of cocaine
  JOURNAL   Proc Natl Acad Sci U S A 114 (6), 1395-1400 (2017)
   PUBMED   28115704
  REMARK    GeneRIF: Wiskott-Aldrich syndrome protein family (WAVE1) knocked
            out (KO) in neurons expressing the D1 dopamine receptor (D1-KO)
            exhibited a significant decrease in place preference associated
            with cocaine.
REFERENCE   6  (bases 1 to 2715)
  AUTHORS   Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R,
            Raber J and Scott JD.
  TITLE     Loss of WAVE-1 causes sensorimotor retardation and reduced learning
            and memory in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (4), 1723-1728 (2003)
   PUBMED   12578964
  REMARK    GeneRIF: role in causing sensorimotor retardation and reduced
            learning and memory in mice
REFERENCE   7  (bases 1 to 2715)
  AUTHORS   Benachenhou N, Massy I and Vacher J.
  TITLE     Characterization and expression analyses of the mouse
            Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar
  JOURNAL   Gene 290 (1-2), 131-140 (2002)
   PUBMED   12062808
REFERENCE   8  (bases 1 to 2715)
  AUTHORS   Chalhoub N, Benachenhou N and Vacher J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   9  (bases 1 to 2715)
  AUTHORS   Westphal RS, Soderling SH, Alto NM, Langeberg LK and Scott JD.
  TITLE     Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an
            actin-associated multi-kinase scaffold
  JOURNAL   EMBO J 19 (17), 4589-4600 (2000)
   PUBMED   10970852
REFERENCE   10 (bases 1 to 2715)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC174452.2.
            
            On Apr 3, 2020 this sequence version replaced XM_006512933.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2067443.1,
                                           SRR7652917.1221145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC174452.2         112685-112928       c
            245-405             AC174452.2         76347-76507         c
            406-540             AC174452.2         70137-70271         c
            541-694             AC174452.2         65971-66124         c
            695-812             AC174452.2         64722-64839         c
            813-982             AC174452.2         63470-63639         c
            983-1162            AC174452.2         62099-62278         c
            1163-1791           AC174452.2         60017-60645         c
            1792-2715           AC174452.2         58186-59109         c
FEATURES             Location/Qualifiers
     source          1..2715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.07 cM"
     gene            1..2715
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="WASP family, member 1"
                     /db_xref="GeneID:83767"
                     /db_xref="MGI:MGI:1890563"
     exon            1..244
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..405
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    246..248
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="upstream in-frame stop codon"
     CDS             273..1949
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     wiskott-Aldrich syndrome protein family member 1; protein
                     WAVE-1; WASP family protein member 1; WASP family 1; WAS
                     protein family, member 1; actin-binding protein WASF1"
                     /codon_start=1
                     /product="actin-binding protein WASF1 isoform 2"
                     /protein_id="NP_001366383.1"
                     /db_xref="GeneID:83767"
                     /db_xref="MGI:MGI:1890563"
                     /translation="

MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDADLLHKHIEVANGPASHYETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPTPTCISSATGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVAVAALAHPPSGLHPAPSTAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE"

     misc_feature    1086..1469
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1290..1292
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0007744|PubMed:24129315;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q8R5H6.2); methylation site"
     misc_feature    1503..1742
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1722..1946
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1); Region:
                     WH2_WAVE-1; cd22071"
                     /db_xref="CDD:409214"
     misc_feature    1734..1736
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92558; propagated from
                     UniProtKB/Swiss-Prot (Q8R5H6.2); phosphorylation site"
     misc_feature    order(1758..1763,1767..1775,1779..1787,1800..1811)
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409214"
     misc_feature    order(1761..1766,1770..1775,1782..1787,1803..1808,
                     1860..1865,1872..1877,1884..1886,1896..1898)
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="Nap1 binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409214"
     misc_feature    1800..1811
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409214"
     exon            406..540
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..694
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..812
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..982
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1162
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1791
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2715
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agggcagcggctgctcgcggtgttgttcgctcgcgcgtcgagcgcaccgcggctcgggcgagcagtgggcgcccccggcggcattcccggcggcccggcgcctcagccagtgcccggcgcggcttccatcccgcagcccgacgctcccgaggggctcctggtggcgccccagtgcggagccggaccggcggcagccgccgaagcatgtagaaggggtacggcgcgagccccccacggtttcgcggtgagctggttcagtggctgagctcaagatgccgttggtgaaaagaaacatcgaccctcggcacttgtgccacacagcactgcccaggggcattaagaacgaactggaatgtgtaaccaacatttccctggcaaatataattagacaactgagtagcctaagtaagtatgctgaagacatatttggagaattattcaatgaagcacacagtttttccttcagagttaactcgttgcaagagcgcgtggaccgattgtctgttagtgtcacacagcttgatcctaaggaggaagaactgtctttgcaagatataacgatgagaaaggctttccggagctccacaattcaagatcagcagcttttcgaccgcaagacgttgcctattccattgcaagaaacatacgatgtgtgtgagcaacctccgcctctcaatatcctcaccccttacagggatgatggtaaggaagggctgaagttttataccaatccttcatatttctttgatctgtggaaagaaaagatgttgcaagatacagaggacaagaggaaggaaaagagaaagcagaagaaaaatctagaccgtcctcatgaaccagagaaagtgccaagagcacctcatgacaggcggcgggaatggcagaagctggcccaaggtccagagctggctgaggatgacgctgacctcctacacaagcatattgaagttgccaatggcccagcctctcattatgagacaaggccacagacatacgtggatcatatggacggatcgtactcactctctgccttgccattcagtcagatgagtgaacttctgaccagagctgaggagagggtcttagtcagaccccatgaacctcctccgcctccaccaatgcatggagcaggagatgcaaagcccacacccacctgtatcagttctgctacaggtttgatagagaatcgcccccagtccccagctgcaggcagaacacctgtgtttgtgagccccactcccccacctcctcccccacctcttccgtctgccttgtccacttcttcactaagagcttcaatgacctcaactcctcccccaccagtccctcctccgcctcctcccccagccactgctttgcaggccccagcagtgcccccacctccggctcctcttcagattgcccctggtgttcttcacccagctcctcctccaattgctcctcctctagtgcagccctctcccccagtagctcgagctgccccagtatgcgagactgtgccagttcacccactcccgcaaggtgaagtgcaggggctgcctccacccccaccaccgcctcctctacctccgcctggcatccggccatcatctcctgtcgcagttgcagctcttgctcatcctccctctgggctccatccagcaccatctactgccccgggtccccatgctccattaatgcctccatctcctccatcacaagttctacctgcctctgagccaaagcgccatccatccaccctgcctgtaatcagtgacgcaaggagtgtgctgctggaagccatccgaaaaggtattcagcttcgcaaagtggaagagcagcgtgaacaggaagcaaaacacgagcggattgaaaacgacgtggccaccatcctgtctcgccgcattgctgtggagtatagcgactcggaagatgactcggagttcgatgaagtagactggctggagtaagaaagccacagtgacttggaagatgactcggagttcgatgaagtagactggatggagtaagacagccgccttgctctgtattgcaaggctgaatgcacatgtccctcgtggcgcttgttctttgaaaatgttcggtcattctagtgttttgcttcctattcctcataatgaataacccttttcctccattatttttgatttctatgaaaagtattagcatatatttcaaactaaatattttgtggcttaccttaatttttccccctggaaaaatataatttggtccaataaactactaagtattaagcatggaaagccgttattagagtagcagattcagtttttgatattccttaattgtgcactttgtgatttttttttttttttttaaatttgaagaacgcaactgagactggaatcttgaaggcagctgtgtctgggaacgagccttattccgtttcttgatgttttaaatgaagaaacactgcctcgattatatgaatacactcagaaggaacatgtagcttgtagtgttgaattctcttaaaggaatggttagctttggttatcattttgttgtttttgaatacttgccttatttgaacgtttagcagaaccccttcccacttatatattgtgtggtacagttttgcttgcctatagaagtttaaatttttccatgtgaaatactcagaataagcatatgtgtgacttacataatgtgagaattacaatctgatgtaataaacggttcattttaaaggct

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