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2024-03-28 20:59:06, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_001378990            1832 bp    mRNA    linear   ROD 29-DEC-2022
DEFINITION  Mus musculus ankyrin repeat domain 54 (Ankrd54), transcript variant
            4, mRNA.
ACCESSION   NM_001378990 XM_030248500
VERSION     NM_001378990.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Gustafsson MO, Hussain A, Mohammad DK, Mohamed AJ, Nguyen V,
            Metalnikov P, Colwill K, Pawson T, Smith CI and Nore BF.
  TITLE     Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine
            kinase (Btk) through a novel SH3-dependent interaction with ankyrin
            repeat domain 54 (ANKRD54)
  JOURNAL   Mol Cell Biol 32 (13), 2440-2453 (2012)
   PUBMED   22527282
  REMARK    GeneRIF: Liar is the first protein identified that specifically
            influences the nucleocytoplasmic shuttling of Btk and Txk and
            belongs to a rare group of known proteins carrying out this
            activity in a Crm1-dependent manner.
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 1832)
  AUTHORS   Samuels AL, Klinken SP and Ingley E.
  TITLE     Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein
            that influences erythropoietin-induced differentiation
  JOURNAL   Blood 113 (16), 3845-3856 (2009)
   PUBMED   19064729
  REMARK    GeneRIF: Liar is a novel Lyn-interacting molecule that plays an
            important role in regulating intracellular signaling events
            associated with erythroid terminal differentiation.
REFERENCE   4  (bases 1 to 1832)
  AUTHORS   McClintock TS, Glasser CE, Bose SC and Bergman DA.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Ankrd54 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   5  (bases 1 to 1832)
  AUTHORS   Southard-Smith EM, Collins JE, Ellison JS, Smith KJ, Baxevanis AD,
            Touchman JW, Green ED, Dunham I and Pavan WJ.
  TITLE     Comparative analyses of the Dominant megacolon-SOX10 genomic
            interval in mouse and human
  JOURNAL   Mamm Genome 10 (7), 744-749 (1999)
   PUBMED   10384052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589670.21.
            
            On Mar 17, 2020 this sequence version replaced XM_030248500.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.793322.1,
                                           SRR11927938.3831013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-446               AL589670.21        75000-75445
            447-494             AL589670.21        76707-76754
            495-566             AL589670.21        81833-81904
            567-614             AL589670.21        82376-82423
            615-739             AL589670.21        82502-82626
            740-847             AL589670.21        83315-83422
            848-1832            AL589670.21        83834-84818
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..1832
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /note="ankyrin repeat domain 54"
                     /db_xref="GeneID:223690"
                     /db_xref="MGI:MGI:2444209"
     exon            1..446
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..922
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /note="isoform 4 is encoded by transcript variant 4;
                     ankyrin repeat domain-containing protein 54;
                     lyn-interacting ankyrin repeat protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 54
                     isoform 4"
                     /protein_id="NP_001365919.1"
                     /db_xref="GeneID:223690"
                     /db_xref="MGI:MGI:2444209"
                     /translation="
MAATGGGADDESRSGRSSSDGECAVAPEPLAEAGGLVSFADFGVSLGSGAGLPGRSVGRAQSSLRYLQVLWQQDVEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQLLLDHGADPNQQDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHSQCLEAVRLEVKQIIHMLREYLERLGRHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR"
     misc_feature    470..715
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:432791"
     misc_feature    order(473..481,485..490,500..502,509..511,536..538,
                     542..544,548..550,560..565,572..580,584..589,599..601,
                     608..610,635..637,641..643,647..649,659..664,689..697,
                     701..706,716..718)
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    542..637
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     exon            447..494
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /inference="alignment:Splign:2.1.0"
     exon            495..566
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /inference="alignment:Splign:2.1.0"
     exon            567..614
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /inference="alignment:Splign:2.1.0"
     exon            615..739
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /inference="alignment:Splign:2.1.0"
     exon            740..847
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1832
                     /gene="Ankrd54"
                     /gene_synonym="C730048E16Rik; EST1068184; EST475269; Liar"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
gctgtggttgcaggccccgcccgtccgttcgctgacagcgaggcttctcctggagggaagcgggtccgttggtcggttcggagcgaggctggcgctgccaggcccgcgcctagccgttgccatggcagccaccggcgggggcgcggacgacgagtcgcgatccggccgctcgagctcggacggcgagtgcgcggtggcgccggagcctttggcggaagccggaggcctggtgtctttcgcggacttcggcgtttcgctgggcagcggcgccggcctcccgggccggtcggtgggcagggcccagtcctcgctgcgctacctccaggtcctgtggcagcaggacgtcgagcctcgcgacgaactgcgttgcaagattcccgccgggcggttgaggcgtgccgccaggccccaccgtcggctcgggcccaccggcaaggaggtacacgctctgaagaggctgagggactctgccaatgccaacgacgtagaaacagtgcagctgctcctggaccatggggctgaccccaaccaacaggatggtctgggcaacacgccattgcacctggcggcctgcaccaaccatgttcctgtcatcaccacactgcttcgaggaggggcccgtgtagatgccctagacagagctggccgcacacccctacacctggccaagtcgaagctgaacatcctacaggagggtcattcccagtgtctggaggccgtccgcctggaggtgaagcagatcatccacatgctacgcgagtacctggagcgcctggggcggcatgagcagcgagaacggctagatgacctctgcacccgcctccagatgacaagtaccaaagaacaggtggatgaagtgacggacctcttggccagcttcacctccctcagtctgcagatgcagagtatggagaagaggtagcaagggaggctgctccttgctttgccgccgccctcctgccctctgagctcgctaccgggaaagcccagggaactctggagttcaccttgcccttgcccttagatgccgagggcagaactgacagtctgcgtcatctctctgggtcgggaccacagcccctgctcctgctgcataatgccagcctctgtagccacattccaggcccacacgtgctgttgtagcagacaccactcctcccgtggcctccctgtgcccacagcacacctcagagccctctagttcttcccagccatgggctctgttcctgtcatctggctgacactctgaggccacccgggctgctttgggtctctaagcttgtcctgccccttacaccagcacttcagtgtagccctgctccttccttccaaggaaacactgcactgtctctgagcagaagagggacattgctcaagattaggaaggacctggtttagcccaaagaaagctctgcagctccttcccccgcaatcactgaaacactacgaatgggcgtccgttttgcagcccagttctcagtgattgatagtgggtcatgggctcaggtccttatcccaggatcctctaagccttaggtgttgtggcaagagtctgtacagatatataactagaggtattcagctgagagggtcctggatcacctaggtgagctgggtatcactccagggagccctggaggaggaggcaggaggtgactggcaccatgtggatgtgagatgttgagaaagaagctgggagccggcagaggacaggcagtgggtccctcggaacctccagcagggactggctctgctgacagatacaccagagcccagccagacatgtttttatttctggcctccacaattgtgaaaagaaatctgttggttaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]